JP2019528307A5 - - Google Patents
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- Publication number
- JP2019528307A5 JP2019528307A5 JP2019511664A JP2019511664A JP2019528307A5 JP 2019528307 A5 JP2019528307 A5 JP 2019528307A5 JP 2019511664 A JP2019511664 A JP 2019511664A JP 2019511664 A JP2019511664 A JP 2019511664A JP 2019528307 A5 JP2019528307 A5 JP 2019528307A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diamine
- isopropylsulfonyl
- pyrimidine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(CC(c(cc1O*)c(*)cc1Nc1ncc(*)c(*(c2c3cccc2)=S3(I*)=O)n1)=C1)(*=C)N(*)C1(*)I Chemical compound *C(CC(c(cc1O*)c(*)cc1Nc1ncc(*)c(*(c2c3cccc2)=S3(I*)=O)n1)=C1)(*=C)N(*)C1(*)I 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022096630A JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380818P | 2016-08-29 | 2016-08-29 | |
| US62/380,818 | 2016-08-29 | ||
| PCT/US2017/048845 WO2018044767A2 (en) | 2016-08-29 | 2017-08-28 | Aminopyrimidines as alk inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096630A Division JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528307A JP2019528307A (ja) | 2019-10-10 |
| JP2019528307A5 true JP2019528307A5 (enExample) | 2020-10-01 |
| JP7094566B2 JP7094566B2 (ja) | 2022-07-04 |
Family
ID=59846649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511664A Active JP7094566B2 (ja) | 2016-08-29 | 2017-08-28 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
| JP2022096630A Pending JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096630A Pending JP2022120151A (ja) | 2016-08-29 | 2022-06-15 | Ａｌｋ阻害剤としてのアミノピリミジン類 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10709705B2 (enExample) |
| EP (2) | EP3504203B1 (enExample) |
| JP (2) | JP7094566B2 (enExample) |
| KR (1) | KR102530871B1 (enExample) |
| CN (2) | CN115043821B (enExample) |
| AU (2) | AU2017319135B2 (enExample) |
| IL (1) | IL264638B (enExample) |
| MX (2) | MX389265B (enExample) |
| NZ (1) | NZ751713A (enExample) |
| SG (2) | SG11201901251SA (enExample) |
| WO (1) | WO2018044767A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI726363B (zh) * | 2018-07-31 | 2021-05-01 | 大陸商蘇州亞盛藥業有限公司 | Fak/alk/ros1抑制劑與egfr抑制劑的組合治療癌症的方法 |
| CN111171033B (zh) * | 2018-11-09 | 2021-11-02 | 天津大学 | 一种嘧啶衍生物及其合成方法和应用 |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110143947B (zh) * | 2019-05-29 | 2021-10-15 | 华东师范大学 | 一种色瑞替尼类似物的制备方法 |
| US20220117964A1 (en) * | 2019-06-25 | 2022-04-21 | Ascentage Pharma (Suzhu) Co., Ltd. | Combination of fak inhibitor and btk inhibitor for treating a disease |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230381176A1 (en) * | 2020-09-25 | 2023-11-30 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical composition and use thereof for treatment of cancer |
| WO2022222932A1 (en) * | 2021-04-19 | 2022-10-27 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical combination and use thereof |
| CA3238857A1 (en) * | 2021-12-09 | 2023-06-15 | Oncobix Co., Ltd. | Novel heterocyclic-substituted pyrimidine derivative exhibiting cancer cell growth inhibitory effect, and pharmaceutical composition containing same |
| CN116332919B (zh) * | 2022-03-30 | 2025-08-26 | 苏州亚盛药业有限公司 | 一种alk抑制剂化合物及其中间体的制备方法 |
| WO2024153228A1 (zh) * | 2023-01-20 | 2024-07-25 | 苏州亚盛药业有限公司 | Alk抑制剂或其盐、溶剂合物的结晶形式及其制备方法和应用 |
| AU2024238523A1 (en) * | 2023-03-22 | 2025-10-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and use thereof |
| WO2025157162A1 (zh) | 2024-01-22 | 2025-07-31 | 应世生物科技(南京)有限公司 | Fak抑制剂与kras g12c抑制剂的联用 |
| WO2025232723A1 (en) * | 2024-05-06 | 2025-11-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Treatment method with focal adhesion kinase inhibitor |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| ATE542801T1 (de) | 2003-08-15 | 2012-02-15 | Novartis Ag | Zur behandlung von neoplastischen krankheiten, entzündlichen erkrankungen und erkrankungen des immunsystems geeignete 2,4-pyrimidindiamine |
| AU2004272288B2 (en) * | 2003-09-18 | 2008-11-13 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| PL2253614T3 (pl) * | 2004-04-07 | 2013-03-29 | Novartis Ag | Inhibitory IAP |
| EA019941B1 (ru) | 2006-12-08 | 2014-07-30 | АйАрЭм ЭлЭлСи | Соединения и композиции в качестве ингибиторов протеинкиназы |
| AU2009233964B2 (en) | 2008-04-07 | 2012-06-07 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| KR20130139999A (ko) | 2010-10-14 | 2013-12-23 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 방법 |
| PT2670401E (pt) | 2011-02-02 | 2015-10-12 | Novartis Ag | Métodos de utilização de inibidores de alk |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
-
2017
- 2017-08-28 SG SG11201901251SA patent/SG11201901251SA/en unknown
- 2017-08-28 US US15/559,445 patent/US10709705B2/en active Active
- 2017-08-28 AU AU2017319135A patent/AU2017319135B2/en active Active
- 2017-08-28 JP JP2019511664A patent/JP7094566B2/ja active Active
- 2017-08-28 EP EP17764949.8A patent/EP3504203B1/en active Active
- 2017-08-28 WO PCT/US2017/048845 patent/WO2018044767A2/en not_active Ceased
- 2017-08-28 KR KR1020197007075A patent/KR102530871B1/ko active Active
- 2017-08-28 NZ NZ751713A patent/NZ751713A/en unknown
- 2017-08-28 SG SG10201914030UA patent/SG10201914030UA/en unknown
- 2017-08-28 CN CN202210533398.XA patent/CN115043821B/zh active Active
- 2017-08-28 MX MX2019002393A patent/MX389265B/es unknown
- 2017-08-28 EP EP21212760.9A patent/EP4001273A3/en not_active Withdrawn
- 2017-08-28 CN CN201780057518.0A patent/CN109715620B/zh active Active
-
2019
- 2019-02-04 IL IL264638A patent/IL264638B/en unknown
- 2019-02-27 MX MX2022000376A patent/MX2022000376A/es unknown
-
2020
- 2020-06-29 US US16/914,518 patent/US11110090B2/en active Active
-
2021
- 2021-05-14 AU AU2021203098A patent/AU2021203098B2/en active Active
-
2022
- 2022-06-15 JP JP2022096630A patent/JP2022120151A/ja active Pending
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