NZ751713A - Aminopyrimidines as alk inhibitors - Google Patents
Aminopyrimidines as alk inhibitorsInfo
- Publication number
- NZ751713A NZ751713A NZ751713A NZ75171317A NZ751713A NZ 751713 A NZ751713 A NZ 751713A NZ 751713 A NZ751713 A NZ 751713A NZ 75171317 A NZ75171317 A NZ 75171317A NZ 751713 A NZ751713 A NZ 751713A
- Authority
- NZ
- New Zealand
- Prior art keywords
- phenyl
- isopropylsulfonyl
- diamine
- pyrimidine
- chloro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380818P | 2016-08-29 | 2016-08-29 | |
| PCT/US2017/048845 WO2018044767A2 (en) | 2016-08-29 | 2017-08-28 | Aminopyrimidines as alk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ751713A true NZ751713A (en) | 2022-07-01 |
Family
ID=59846649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ751713A NZ751713A (en) | 2016-08-29 | 2017-08-28 | Aminopyrimidines as alk inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10709705B2 (enExample) |
| EP (2) | EP4001273A3 (enExample) |
| JP (2) | JP7094566B2 (enExample) |
| KR (1) | KR102530871B1 (enExample) |
| CN (2) | CN109715620B (enExample) |
| AU (2) | AU2017319135B2 (enExample) |
| IL (1) | IL264638B (enExample) |
| MX (2) | MX389265B (enExample) |
| NZ (1) | NZ751713A (enExample) |
| SG (2) | SG10201914030UA (enExample) |
| WO (1) | WO2018044767A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772638B (zh) * | 2018-07-31 | 2021-02-23 | 苏州亚盛药业有限公司 | Alk抑制剂与egfr抑制剂在制备治疗癌症的药物中的用途 |
| CN111171033B (zh) * | 2018-11-09 | 2021-11-02 | 天津大学 | 一种嘧啶衍生物及其合成方法和应用 |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| CN110143947B (zh) * | 2019-05-29 | 2021-10-15 | 华东师范大学 | 一种色瑞替尼类似物的制备方法 |
| US20220117964A1 (en) * | 2019-06-25 | 2022-04-21 | Ascentage Pharma (Suzhu) Co., Ltd. | Combination of fak inhibitor and btk inhibitor for treating a disease |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN116261455B (zh) * | 2020-09-25 | 2024-11-01 | 苏州亚盛药业有限公司 | 一种药物组合物及其在治疗癌症中的用途 |
| US20240316051A1 (en) * | 2021-04-19 | 2024-09-26 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical combination and use thereof |
| CA3238857A1 (en) * | 2021-12-09 | 2023-06-15 | Oncobix Co., Ltd. | Novel heterocyclic-substituted pyrimidine derivative exhibiting cancer cell growth inhibitory effect, and pharmaceutical composition containing same |
| CN116332919B (zh) * | 2022-03-30 | 2025-08-26 | 苏州亚盛药业有限公司 | 一种alk抑制剂化合物及其中间体的制备方法 |
| AU2024210803A1 (en) * | 2023-01-20 | 2025-07-03 | Ascentage Pharma (Suzhou) Co., Ltd. | Crystal form of alk inhibitor or salt and solvate thereof, preparation method therefor, and use thereof |
| WO2024193693A1 (zh) * | 2023-03-22 | 2024-09-26 | 苏州亚盛药业有限公司 | 药物组合及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| BR122019017579B8 (pt) | 2003-08-15 | 2021-07-27 | Novartis Ag | 2,4-pirimidinadiaminas, seus usos, combinação e composição farmacêutica |
| US20070105839A1 (en) * | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| PL2253614T3 (pl) * | 2004-04-07 | 2013-03-29 | Novartis Ag | Inhibitory IAP |
| NZ590601A (en) | 2006-12-08 | 2011-09-30 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
| EA018282B1 (ru) | 2008-04-07 | 2013-06-28 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| MX2013004086A (es) | 2010-10-14 | 2013-07-05 | Ariad Pharma Inc | Metodos para inhibir proliferacion celular en cancers accionados por egfr. |
| CA2824092C (en) | 2011-02-02 | 2020-06-30 | Irm Llc | Use of alk inhibitors for the treatment of eml4-alk+ non-small cell lung cancer |
| CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
-
2017
- 2017-08-28 CN CN201780057518.0A patent/CN109715620B/zh active Active
- 2017-08-28 MX MX2019002393A patent/MX389265B/es unknown
- 2017-08-28 EP EP21212760.9A patent/EP4001273A3/en not_active Withdrawn
- 2017-08-28 NZ NZ751713A patent/NZ751713A/en unknown
- 2017-08-28 SG SG10201914030UA patent/SG10201914030UA/en unknown
- 2017-08-28 CN CN202210533398.XA patent/CN115043821B/zh active Active
- 2017-08-28 AU AU2017319135A patent/AU2017319135B2/en active Active
- 2017-08-28 SG SG11201901251SA patent/SG11201901251SA/en unknown
- 2017-08-28 KR KR1020197007075A patent/KR102530871B1/ko active Active
- 2017-08-28 US US15/559,445 patent/US10709705B2/en active Active
- 2017-08-28 WO PCT/US2017/048845 patent/WO2018044767A2/en not_active Ceased
- 2017-08-28 EP EP17764949.8A patent/EP3504203B1/en active Active
- 2017-08-28 JP JP2019511664A patent/JP7094566B2/ja active Active
-
2019
- 2019-02-04 IL IL264638A patent/IL264638B/en unknown
- 2019-02-27 MX MX2022000376A patent/MX2022000376A/es unknown
-
2020
- 2020-06-29 US US16/914,518 patent/US11110090B2/en active Active
-
2021
- 2021-05-14 AU AU2021203098A patent/AU2021203098B2/en active Active
-
2022
- 2022-06-15 JP JP2022096630A patent/JP2022120151A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022120151A (ja) | 2022-08-17 |
| CN115043821A (zh) | 2022-09-13 |
| AU2021203098B2 (en) | 2023-05-25 |
| WO2018044767A3 (en) | 2018-04-12 |
| MX2022000376A (es) | 2022-02-10 |
| WO2018044767A2 (en) | 2018-03-08 |
| US20190175595A1 (en) | 2019-06-13 |
| IL264638B (en) | 2021-08-31 |
| MX389265B (es) | 2025-03-20 |
| EP3504203A2 (en) | 2019-07-03 |
| MX2019002393A (es) | 2019-07-08 |
| JP2019528307A (ja) | 2019-10-10 |
| CN115043821B (zh) | 2024-08-06 |
| CA3033223A1 (en) | 2018-03-08 |
| BR112019003897A2 (pt) | 2019-05-21 |
| US10709705B2 (en) | 2020-07-14 |
| AU2017319135A1 (en) | 2019-04-04 |
| CN109715620B (zh) | 2022-05-06 |
| CN109715620A (zh) | 2019-05-03 |
| EP4001273A2 (en) | 2022-05-25 |
| KR20190039760A (ko) | 2019-04-15 |
| AU2021203098A1 (en) | 2021-06-10 |
| AU2017319135B2 (en) | 2021-03-18 |
| SG11201901251SA (en) | 2019-03-28 |
| KR102530871B1 (ko) | 2023-05-09 |
| EP3504203B1 (en) | 2022-09-28 |
| SG10201914030UA (en) | 2020-03-30 |
| EP4001273A3 (en) | 2022-08-24 |
| JP7094566B2 (ja) | 2022-07-04 |
| US11110090B2 (en) | 2021-09-07 |
| US20200330464A1 (en) | 2020-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 AUG 2024 BY BIRGIT KNAACK Effective date: 20230808 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 AUG 2025 BY BIRGIT KNAACK Effective date: 20240815 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 28 AUG 2026 BY BIRGIT KNAACK Effective date: 20250819 |