MX2022000376A - Aminopirimidinas como inhibidores de alk. - Google Patents
Aminopirimidinas como inhibidores de alk.Info
- Publication number
- MX2022000376A MX2022000376A MX2022000376A MX2022000376A MX2022000376A MX 2022000376 A MX2022000376 A MX 2022000376A MX 2022000376 A MX2022000376 A MX 2022000376A MX 2022000376 A MX2022000376 A MX 2022000376A MX 2022000376 A MX2022000376 A MX 2022000376A
- Authority
- MX
- Mexico
- Prior art keywords
- aminopyrimidines
- alk inhibitors
- formula
- present disclosure
- provides compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente divulgación proporciona compuestos representados por la Fórmula I: (ver Fórmula) y sus sales, hidratos y solvatos aceptables desde el punto de vista farmacéutico, en donde R1a, R1b, R2a, R2b, R3, R4, R5, R6 y R7 son como se definen en la memoria descriptiva. La presente divulgación también proporciona compuestos de la Fórmula I para usarse en el tratamiento de una afección o trastorno que responde a la inhibición de ALK tal como el cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662380818P | 2016-08-29 | 2016-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000376A true MX2022000376A (es) | 2022-02-10 |
Family
ID=59846649
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002393A MX2019002393A (es) | 2016-08-29 | 2017-08-28 | Aminopirimidinas como inhibidores de alk. |
MX2022000376A MX2022000376A (es) | 2016-08-29 | 2019-02-27 | Aminopirimidinas como inhibidores de alk. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002393A MX2019002393A (es) | 2016-08-29 | 2017-08-28 | Aminopirimidinas como inhibidores de alk. |
Country Status (13)
Country | Link |
---|---|
US (2) | US10709705B2 (es) |
EP (2) | EP3504203B1 (es) |
JP (2) | JP7094566B2 (es) |
KR (1) | KR102530871B1 (es) |
CN (2) | CN109715620B (es) |
AU (2) | AU2017319135B2 (es) |
BR (1) | BR112019003897A2 (es) |
CA (1) | CA3033223A1 (es) |
IL (1) | IL264638B (es) |
MX (2) | MX2019002393A (es) |
NZ (1) | NZ751713A (es) |
SG (2) | SG11201901251SA (es) |
WO (1) | WO2018044767A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11478477B2 (en) | 2018-07-31 | 2022-10-25 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for treating cancer by combination of FAK/ALK/ROS1 inhibitor and EGFR inhibitor |
CN111171033B (zh) * | 2018-11-09 | 2021-11-02 | 天津大学 | 一种嘧啶衍生物及其合成方法和应用 |
MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
CN110143947B (zh) * | 2019-05-29 | 2021-10-15 | 华东师范大学 | 一种色瑞替尼类似物的制备方法 |
US20220117964A1 (en) * | 2019-06-25 | 2022-04-21 | Ascentage Pharma (Suzhu) Co., Ltd. | Combination of fak inhibitor and btk inhibitor for treating a disease |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US20230381176A1 (en) * | 2020-09-25 | 2023-11-30 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical composition and use thereof for treatment of cancer |
WO2022222932A1 (en) * | 2021-04-19 | 2022-10-27 | Ascentage Pharma (Suzhou) Co., Ltd. | A pharmaceutical combination and use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
ES2424881T3 (es) | 2003-08-15 | 2013-10-09 | Novartis Ag | 2,4-Di(fenilamino)-pirimidinas útiles en el tratamiento de enfermedades neoplásicas, trastornos inflamatorios y del sistema inmunitario |
CN100584832C (zh) * | 2003-09-18 | 2010-01-27 | 诺瓦提斯公司 | 可用于治疗增殖性病症的2,4-二(苯基氨基)嘧啶类 |
RS52545B (en) * | 2004-04-07 | 2013-04-30 | Novartis Ag | INHIBITORI PROTEIN APOPTOZE (IAP) |
ES2524009T3 (es) | 2006-12-08 | 2014-12-03 | Irm Llc | Compuestos y composiciones como inhibidores de la proteína quinasa |
US8592432B2 (en) | 2008-04-07 | 2013-11-26 | Bei Chen | Compounds and compositions as protein kinase inhibitors |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
EP2627179A4 (en) | 2010-10-14 | 2014-04-02 | Ariad Pharma Inc | METHODS OF INHIBITING CELL PROLIFERATION IN EGFR-INDUCED CANCERS |
EP2670401B1 (en) * | 2011-02-02 | 2015-06-10 | Novartis AG | Methods of using alk inhibitors |
CN104672214B (zh) * | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
KR101656382B1 (ko) * | 2014-02-28 | 2016-09-09 | 한국화학연구원 | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 |
-
2017
- 2017-08-28 BR BR112019003897-3A patent/BR112019003897A2/pt unknown
- 2017-08-28 CN CN201780057518.0A patent/CN109715620B/zh active Active
- 2017-08-28 CA CA3033223A patent/CA3033223A1/en active Pending
- 2017-08-28 MX MX2019002393A patent/MX2019002393A/es unknown
- 2017-08-28 WO PCT/US2017/048845 patent/WO2018044767A2/en unknown
- 2017-08-28 AU AU2017319135A patent/AU2017319135B2/en active Active
- 2017-08-28 KR KR1020197007075A patent/KR102530871B1/ko active IP Right Grant
- 2017-08-28 JP JP2019511664A patent/JP7094566B2/ja active Active
- 2017-08-28 EP EP17764949.8A patent/EP3504203B1/en active Active
- 2017-08-28 SG SG11201901251SA patent/SG11201901251SA/en unknown
- 2017-08-28 EP EP21212760.9A patent/EP4001273A3/en not_active Withdrawn
- 2017-08-28 NZ NZ751713A patent/NZ751713A/en unknown
- 2017-08-28 CN CN202210533398.XA patent/CN115043821A/zh active Pending
- 2017-08-28 US US15/559,445 patent/US10709705B2/en active Active
- 2017-08-28 SG SG10201914030UA patent/SG10201914030UA/en unknown
-
2019
- 2019-02-04 IL IL264638A patent/IL264638B/en unknown
- 2019-02-27 MX MX2022000376A patent/MX2022000376A/es unknown
-
2020
- 2020-06-29 US US16/914,518 patent/US11110090B2/en active Active
-
2021
- 2021-05-14 AU AU2021203098A patent/AU2021203098B2/en active Active
-
2022
- 2022-06-15 JP JP2022096630A patent/JP2022120151A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20190039760A (ko) | 2019-04-15 |
WO2018044767A3 (en) | 2018-04-12 |
CA3033223A1 (en) | 2018-03-08 |
IL264638B (en) | 2021-08-31 |
AU2021203098A1 (en) | 2021-06-10 |
NZ751713A (en) | 2022-07-01 |
SG11201901251SA (en) | 2019-03-28 |
AU2021203098B2 (en) | 2023-05-25 |
JP7094566B2 (ja) | 2022-07-04 |
WO2018044767A2 (en) | 2018-03-08 |
US20190175595A1 (en) | 2019-06-13 |
AU2017319135B2 (en) | 2021-03-18 |
EP3504203B1 (en) | 2022-09-28 |
MX2019002393A (es) | 2019-07-08 |
EP3504203A2 (en) | 2019-07-03 |
US20200330464A1 (en) | 2020-10-22 |
SG10201914030UA (en) | 2020-03-30 |
CN115043821A (zh) | 2022-09-13 |
US11110090B2 (en) | 2021-09-07 |
KR102530871B1 (ko) | 2023-05-09 |
CN109715620A (zh) | 2019-05-03 |
CN109715620B (zh) | 2022-05-06 |
JP2022120151A (ja) | 2022-08-17 |
BR112019003897A2 (pt) | 2019-05-21 |
JP2019528307A (ja) | 2019-10-10 |
US10709705B2 (en) | 2020-07-14 |
EP4001273A2 (en) | 2022-05-25 |
AU2017319135A1 (en) | 2019-04-04 |
EP4001273A3 (en) | 2022-08-24 |
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