CL2013002394A1 - Compuestos derivados de 6,7-dialcoxi-3-isoquinolinol sustituidos, inhibidores de la pde10a; composicion farmaceutica que los comprende; y su uso en el tratamiento de trastornos metabolicos, trastornos del snc tales como enfermedad de alzheimer, demencia, depresion y trastornos neurodegenerativos tales como esclerosis multiple, entre otros. - Google Patents
Compuestos derivados de 6,7-dialcoxi-3-isoquinolinol sustituidos, inhibidores de la pde10a; composicion farmaceutica que los comprende; y su uso en el tratamiento de trastornos metabolicos, trastornos del snc tales como enfermedad de alzheimer, demencia, depresion y trastornos neurodegenerativos tales como esclerosis multiple, entre otros.Info
- Publication number
- CL2013002394A1 CL2013002394A1 CL2013002394A CL2013002394A CL2013002394A1 CL 2013002394 A1 CL2013002394 A1 CL 2013002394A1 CL 2013002394 A CL2013002394 A CL 2013002394A CL 2013002394 A CL2013002394 A CL 2013002394A CL 2013002394 A1 CL2013002394 A1 CL 2013002394A1
- Authority
- CL
- Chile
- Prior art keywords
- disorders
- isoquinolinol
- pde10a
- dialkoxy
- dementia
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Obesity (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444566P | 2011-02-18 | 2011-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002394A1 true CL2013002394A1 (es) | 2014-07-04 |
Family
ID=45787353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002394A CL2013002394A1 (es) | 2011-02-18 | 2013-08-19 | Compuestos derivados de 6,7-dialcoxi-3-isoquinolinol sustituidos, inhibidores de la pde10a; composicion farmaceutica que los comprende; y su uso en el tratamiento de trastornos metabolicos, trastornos del snc tales como enfermedad de alzheimer, demencia, depresion y trastornos neurodegenerativos tales como esclerosis multiple, entre otros. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8772316B2 (enExample) |
| EP (1) | EP2675791B1 (enExample) |
| JP (1) | JP2014510055A (enExample) |
| KR (1) | KR20140009372A (enExample) |
| CN (1) | CN103476757A (enExample) |
| AU (1) | AU2012219316A1 (enExample) |
| BR (1) | BR112013021180A2 (enExample) |
| CA (1) | CA2827724A1 (enExample) |
| CL (1) | CL2013002394A1 (enExample) |
| IL (1) | IL228008A0 (enExample) |
| MX (1) | MX2013009575A (enExample) |
| RU (1) | RU2013142364A (enExample) |
| SG (1) | SG192839A1 (enExample) |
| WO (1) | WO2012112946A1 (enExample) |
| ZA (1) | ZA201306416B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192839A1 (en) | 2011-02-18 | 2013-09-30 | Allergan Inc | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| JP6272604B2 (ja) * | 2013-12-27 | 2018-01-31 | 日本サプリメント株式会社 | 糖取り込み促進剤 |
| CN104370813A (zh) * | 2014-10-22 | 2015-02-25 | 上海大学 | 异喹啉-6-甲醛的制备方法 |
| DK3413892T3 (da) * | 2016-02-12 | 2022-05-23 | Cytokinetics Inc | Tetrahydroisoquinolinderivater |
| ES2837396T3 (es) | 2016-11-23 | 2021-06-30 | Bayer Cropscience Ag | Derivados de 2-[3-(alquilsulfonil)-2H-indazol-2-il]-3H-imidazo[4,5-b]piridina y compuestos similares como pesticidas |
| US12234217B2 (en) | 2018-12-03 | 2025-02-25 | Fmc Corporation | Method for preparing N-phenylpyrazole-1-carboxamides |
| CN113376287A (zh) * | 2021-06-15 | 2021-09-10 | 劲牌有限公司 | 基于高效液相色谱法检测环核苷酸磷酸二酯酶抑制剂活性的方法 |
| WO2025149629A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2026008750A1 (en) | 2024-07-05 | 2026-01-08 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| GB0008694D0 (en) * | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| DE10130167A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Imidazotriazine |
| WO2003014116A1 (en) | 2001-08-06 | 2003-02-20 | Bayer Corporation | Pyrrolo[2.1-a]isoquinoline derivatives |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| WO2004002484A1 (ja) | 2002-06-26 | 2004-01-08 | Kyowa Hakko Kogyo Co., Ltd. | ホスホジエステラーゼ阻害剤 |
| DE10230605A1 (de) | 2002-07-08 | 2004-01-29 | Bayer Ag | Substituierte Imidazotriazine |
| DE10230604A1 (de) | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| DE602004022415D1 (de) | 2003-06-30 | 2009-09-17 | Nycomed Gmbh | Pyrrolo-dihydroisochinolin-derivate als pde10-inhibitoren |
| CN1809565A (zh) | 2003-06-30 | 2006-07-26 | 奥坦纳医药公司 | 用于治疗癌症的吡咯并二氢异喹啉 |
| WO2005012485A2 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| BRPI0507839A (pt) | 2004-02-18 | 2007-05-08 | Pfizer Prod Inc | derivados tetraidroisoquinolinil de quinazolina e isoquinolina |
| WO2005120514A1 (en) | 2004-06-07 | 2005-12-22 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| WO2006028957A1 (en) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
| WO2006034512A2 (en) | 2004-09-23 | 2006-03-30 | Bayer Pharmaceuticals Corporation | Phenyl-substituted quinoline and quinazoline compounds for the treatment of diabetes |
| US7576080B2 (en) | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| US20060183763A1 (en) | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
| ATE472543T1 (de) | 2005-01-07 | 2010-07-15 | Pfizer Prod Inc | Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren |
| JP2008526817A (ja) | 2005-01-12 | 2008-07-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のピロロジヒドロイソキノリン |
| US20080161338A1 (en) | 2005-01-12 | 2008-07-03 | Altana Pharma Ag | Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors |
| CA2619462A1 (en) | 2005-08-16 | 2007-02-22 | Amgen, Inc. | Phosphodiesterase 10 inhibitors |
| JP2009524637A (ja) | 2006-01-27 | 2009-07-02 | ファイザー・プロダクツ・インク | アミノフタラジン誘導体化合物 |
| EP1991540A1 (en) | 2006-02-21 | 2008-11-19 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| AU2007217750A1 (en) | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| JP2009527542A (ja) | 2006-02-23 | 2009-07-30 | ファイザー・プロダクツ・インク | Ｐｄｅ１０阻害薬としての置換キナゾリン |
| JP2009528365A (ja) | 2006-02-28 | 2009-08-06 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン及びキナゾリン誘導体 |
| US20090099175A1 (en) | 2006-03-01 | 2009-04-16 | Arrington Mark P | Phosphodiesterase 10 inhibitors |
| US20070265258A1 (en) | 2006-03-06 | 2007-11-15 | Ruiping Liu | Quinazoline derivatives as phosphodiesterase 10 inhibitors |
| US20070299067A1 (en) | 2006-03-08 | 2007-12-27 | Ruiping Liu | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| TW200817400A (en) | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| TW200815436A (en) | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| US20080090834A1 (en) | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| JP2009542732A (ja) * | 2006-07-10 | 2009-12-03 | ハー・ルンドベック・アクチエゼルスカベット | ６，７−ジアルコキシキナゾリン、６，７−ジアルコキシフタラジンおよび６，７−ジアルコキシイソキノリンの（３−アリール−ピペラジン−１−イル）、（２−アリール−モルホリン−４−イル）および（２−アリール−チオモルホリン−４−イル）誘導体 |
| WO2008020302A2 (en) | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
| CA2663178C (en) | 2006-09-11 | 2016-01-12 | Matrix Laboratories Ltd. | Dibenzofuran derivatives as inhibitors of pde-4 and pde-10 |
| CN101166128A (zh) | 2006-10-16 | 2008-04-23 | 琥珀技术有限公司 | 一种提供第三方服务的方法及相应的系统 |
| EP2083819B1 (en) | 2006-11-21 | 2017-02-22 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| US7786139B2 (en) | 2006-11-21 | 2010-08-31 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| WO2009025823A1 (en) | 2007-08-21 | 2009-02-26 | Amgen Inc. | Phosphodiesterase 10 inhibitors |
| WO2009025839A2 (en) | 2007-08-22 | 2009-02-26 | Amgen Inc. | Phosphodiesterase 10 inhibitors |
| WO2009029214A1 (en) | 2007-08-23 | 2009-03-05 | Amgen Inc. | Isoquinolone derivatives as phosphodiesterase 10 inhibitors |
| TW200918519A (en) | 2007-09-19 | 2009-05-01 | Lundbeck & Co As H | Cyanoisoquinoline |
| US7875618B2 (en) | 2007-11-30 | 2011-01-25 | Wyeth | Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders |
| CA2706986A1 (en) | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10 |
| WO2009070583A1 (en) | 2007-11-30 | 2009-06-04 | Wyeth | Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10 |
| WO2009143178A2 (en) | 2008-05-20 | 2009-11-26 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| CN102131798A (zh) | 2008-06-25 | 2011-07-20 | 英维沃医药有限公司 | 用作磷酸二酯酶10抑制剂的二取代的苯基化合物 |
| JP5658664B2 (ja) | 2008-06-25 | 2015-01-28 | フォルム ファーマシューティカルズ、インコーポレイテッド | １，２−二置換複素環式化合物 |
| WO2010006130A2 (en) | 2008-07-09 | 2010-01-14 | Envivo Pharmaceuticals, Inc. | Pde-10 inhibitors |
| CN102143752B (zh) | 2008-08-05 | 2014-12-10 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
| KR101324329B1 (ko) | 2008-09-04 | 2013-10-31 | 미쓰비시 타나베 파마 코퍼레이션 | 삼치환된 피리미딘 화합물 및 ｐｄｅ10 억제제로서의 그의 용도 |
| AU2009320125A1 (en) | 2008-10-28 | 2010-06-03 | Schering Corporation | Substituted pyrazoloquinolines and derivatives thereof |
| US20100120762A1 (en) | 2008-11-07 | 2010-05-13 | Wyeth | Triazine derivatives as inhibitors of phosphodiesterases |
| US20100120763A1 (en) | 2008-11-07 | 2010-05-13 | Wyeth | Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases |
| TW201030001A (en) | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
| WO2010063610A1 (en) | 2008-12-04 | 2010-06-10 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives |
| WO2010077992A1 (en) | 2008-12-17 | 2010-07-08 | Amgen Inc. | Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors |
| US8916566B2 (en) | 2009-02-05 | 2014-12-23 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds as phosphodiesterase inhibitors and methods of treating disorders |
| US9187455B2 (en) | 2009-02-23 | 2015-11-17 | Hoffmann-La Roche Inc. | Substituted pyridazines as PDE10A inhibitors |
| US20110305637A1 (en) | 2009-02-24 | 2011-12-15 | Janssen Pharmaceutica N.V. | Radiolabelled pde10 ligands |
| EP2417135A1 (en) | 2009-04-07 | 2012-02-15 | Schering Corporation | Substituted triazolopyridines and analogs thereof |
| CA2761032A1 (en) | 2009-05-07 | 2010-11-11 | Envivo Pharmaceuticals, Inc. | Phenoxymethyl heterocyclic compounds |
| US8492392B2 (en) | 2009-05-27 | 2013-07-23 | Merck Sharp & Dohme Corp. | Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors |
| CA2763130C (en) | 2009-05-29 | 2017-01-17 | Merck Sharp & Dohme Corp. | Radiolabeled pde10 inhibitors |
| TW201111383A (en) | 2009-05-29 | 2011-04-01 | Wyeth Llc | Substituted imidazo[1,5-a]quinoxalines as inhibitors of phosphodiesterase 10 |
| WO2010138585A1 (en) | 2009-05-29 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pyrimidinones as pde10 inhibitors |
| US8691827B2 (en) | 2009-08-17 | 2014-04-08 | Merck Sharp & Dohme Corp. | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors |
| PE20121438A1 (es) | 2009-09-24 | 2012-10-26 | Hoffmann La Roche | Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10a |
| CA2776240C (en) | 2009-10-30 | 2017-06-13 | Janssen Pharmaceutica Nv | Radiolabelled pde10 ligands |
| ES2651296T3 (es) | 2009-10-30 | 2018-01-25 | Janssen Pharmaceutica, N.V. | Derivados de imidazo[1,2-b]piridacina y su uso como inhibidores de PDE10 |
| EP2493308A4 (en) | 2009-10-30 | 2013-05-15 | Merck Sharp & Dohme | ARYLAMINOPYRIDIN PDE10 INHIBITORS |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
| TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| US8470820B2 (en) | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
| PH12012501643A1 (en) | 2010-02-26 | 2017-07-19 | Mitsubishi Tanabe Pharma Corp | Pyrazolopyrimidine compounds and their use as pde 10 inhibitors |
| JP2011201873A (ja) | 2010-03-03 | 2011-10-13 | Mitsubishi Tanabe Pharma Corp | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| NZ724645A (en) | 2010-03-12 | 2018-04-27 | Omeros Corp | Pde10 inhibitors and related compositions and methods |
| US8410117B2 (en) | 2010-03-26 | 2013-04-02 | Hoffmann-La Roche Inc. | Imidazopyrimidine derivatives |
| WO2011132051A2 (en) | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceuticals S.A. | Tricycle compounds as phosphodiesterase-10 inhibitors |
| WO2011132048A1 (en) | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceutical S.A. | Heteroaryl compounds as pde10a inhibitors |
| WO2011138657A1 (en) | 2010-05-04 | 2011-11-10 | Glenmark Pharmaceuticals S.A. | Aryl substituted olefinic compounds as pde10a inhibitors |
| MX2012013124A (es) | 2010-05-13 | 2013-01-18 | Amgen Inc | Compuestos heteroariloxicarbociclico como inhibidores pde10. |
| WO2011143495A1 (en) | 2010-05-13 | 2011-11-17 | Amgen Inc. | Heteroaryloxyheterocyclyl compounds as pde10 inhibitors |
| CN103221404B (zh) | 2010-05-13 | 2015-12-16 | 安姆根有限公司 | 可用作pde10抑制剂的不饱和氮杂环化合物 |
| EP3318561B1 (en) | 2010-05-26 | 2021-12-22 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| US8703768B2 (en) | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| TWI546302B (zh) | 2010-06-24 | 2016-08-21 | 武田藥品工業股份有限公司 | 稠合雜環化合物 |
| TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
| TW201206935A (en) | 2010-07-16 | 2012-02-16 | Lundbeck & Co As H | Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor |
| SG192839A1 (en) | 2011-02-18 | 2013-09-30 | Allergan Inc | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9200016B2 (en) * | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
-
2012
- 2012-02-17 SG SG2013062807A patent/SG192839A1/en unknown
- 2012-02-17 EP EP12706983.9A patent/EP2675791B1/en not_active Not-in-force
- 2012-02-17 AU AU2012219316A patent/AU2012219316A1/en not_active Abandoned
- 2012-02-17 JP JP2013554657A patent/JP2014510055A/ja active Pending
- 2012-02-17 WO PCT/US2012/025731 patent/WO2012112946A1/en not_active Ceased
- 2012-02-17 BR BR112013021180A patent/BR112013021180A2/pt not_active IP Right Cessation
- 2012-02-17 RU RU2013142364/04A patent/RU2013142364A/ru not_active Application Discontinuation
- 2012-02-17 CA CA2827724A patent/CA2827724A1/en not_active Abandoned
- 2012-02-17 CN CN2012800184663A patent/CN103476757A/zh active Pending
- 2012-02-17 KR KR1020137024525A patent/KR20140009372A/ko not_active Withdrawn
- 2012-02-17 US US13/399,351 patent/US8772316B2/en active Active
- 2012-02-17 MX MX2013009575A patent/MX2013009575A/es not_active Application Discontinuation
-
2013
- 2013-08-18 IL IL228008A patent/IL228008A0/en unknown
- 2013-08-19 CL CL2013002394A patent/CL2013002394A1/es unknown
- 2013-08-26 ZA ZA2013/06416A patent/ZA201306416B/en unknown
-
2014
- 2014-06-25 US US14/314,930 patent/US9670181B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2675791A1 (en) | 2013-12-25 |
| US9670181B2 (en) | 2017-06-06 |
| KR20140009372A (ko) | 2014-01-22 |
| MX2013009575A (es) | 2014-10-14 |
| WO2012112946A1 (en) | 2012-08-23 |
| BR112013021180A2 (pt) | 2019-09-24 |
| RU2013142364A (ru) | 2015-03-27 |
| IL228008A0 (en) | 2013-09-30 |
| CN103476757A (zh) | 2013-12-25 |
| US20140309253A1 (en) | 2014-10-16 |
| SG192839A1 (en) | 2013-09-30 |
| JP2014510055A (ja) | 2014-04-24 |
| ZA201306416B (en) | 2014-04-30 |
| EP2675791B1 (en) | 2016-02-17 |
| CA2827724A1 (en) | 2012-08-23 |
| US20120214837A1 (en) | 2012-08-23 |
| AU2012219316A1 (en) | 2013-10-03 |
| US8772316B2 (en) | 2014-07-08 |
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