CN102459227B - Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 - Google Patents

Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 Download PDF

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CN102459227B
CN102459227B CN201080027641.6A CN201080027641A CN102459227B CN 102459227 B CN102459227 B CN 102459227B CN 201080027641 A CN201080027641 A CN 201080027641A CN 102459227 B CN102459227 B CN 102459227B
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alkyl
phenyl
prepared
azetidine
trifluoromethyl
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CN102459227A (zh
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张旭庆
H·R·赫夫奈格尔
侯翠玢
D·L·约翰森
隋治华
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Janssen Pharmaceutica NV
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CN201080027641.6A 2009-04-17 2010-04-15 Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂 Expired - Fee Related CN102459227B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17030709P 2009-04-17 2009-04-17
US61/170307 2009-04-17
US61/170,307 2009-04-17
PCT/US2010/031265 WO2010121046A1 (en) 2009-04-17 2010-04-15 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

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CN102459227A CN102459227A (zh) 2012-05-16
CN102459227B true CN102459227B (zh) 2014-08-20

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US (2) US20100267689A1 (enExample)
EP (1) EP2419419B1 (enExample)
JP (1) JP5675773B2 (enExample)
KR (1) KR20120006544A (enExample)
CN (1) CN102459227B (enExample)
AR (1) AR076328A1 (enExample)
AU (1) AU2010236346B2 (enExample)
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KR102677442B1 (ko) 2017-09-25 2024-06-20 케모센트릭스, 인크. 케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법
JP2021503936A (ja) 2017-11-30 2021-02-15 ランドス バイオファーマ インコーポレイテッド ランチオニンｃ様タンパク質２リガンドによる治療及びそれにより調製された細胞
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US8513229B2 (en) 2013-08-20
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NZ595432A (en) 2013-12-20
US20100267689A1 (en) 2010-10-21
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