JP2009534404A5 - - Google Patents
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- Publication number
- JP2009534404A5 JP2009534404A5 JP2009506740A JP2009506740A JP2009534404A5 JP 2009534404 A5 JP2009534404 A5 JP 2009534404A5 JP 2009506740 A JP2009506740 A JP 2009506740A JP 2009506740 A JP2009506740 A JP 2009506740A JP 2009534404 A5 JP2009534404 A5 JP 2009534404A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- och
- conhch
- pyridyl
- propenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 93
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004076 pyridyl group Chemical group 0.000 claims 9
- -1 2-methylpyridyl Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical class 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical class 0.000 claims 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical class 0.000 claims 1
- 0 C*1CC(*)CC1 Chemical compound C*1CC(*)CC1 0.000 description 2
- ULZCOWMSBOJCLT-UHFFFAOYSA-N CN(CC1)CCS1(=O)=O Chemical compound CN(CC1)CCS1(=O)=O ULZCOWMSBOJCLT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79369406P | 2006-04-20 | 2006-04-20 | |
| US60/793,694 | 2006-04-20 | ||
| US87117106P | 2006-12-21 | 2006-12-21 | |
| US60/871,171 | 2006-12-21 | ||
| PCT/US2007/066864 WO2007124318A1 (en) | 2006-04-20 | 2007-04-18 | Inhibitors of c-fms kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228539A Division JP5932754B2 (ja) | 2006-04-20 | 2013-11-01 | ｃ−ｆｍｓキナーゼの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534404A JP2009534404A (ja) | 2009-09-24 |
| JP2009534404A5 true JP2009534404A5 (enExample) | 2010-05-13 |
| JP5480619B2 JP5480619B2 (ja) | 2014-04-23 |
Family
ID=38457966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506740A Expired - Fee Related JP5480619B2 (ja) | 2006-04-20 | 2007-04-18 | ｃ−ｆｍｓキナーゼの阻害剤 |
| JP2013228539A Expired - Fee Related JP5932754B2 (ja) | 2006-04-20 | 2013-11-01 | ｃ−ｆｍｓキナーゼの阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228539A Expired - Fee Related JP5932754B2 (ja) | 2006-04-20 | 2013-11-01 | ｃ−ｆｍｓキナーゼの阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8674100B2 (enExample) |
| EP (2) | EP2021329B1 (enExample) |
| JP (2) | JP5480619B2 (enExample) |
| KR (1) | KR101462393B1 (enExample) |
| AR (1) | AR060609A1 (enExample) |
| AU (1) | AU2007240439B2 (enExample) |
| CA (1) | CA2649919C (enExample) |
| ES (1) | ES2581600T3 (enExample) |
| MX (1) | MX2008013532A (enExample) |
| NZ (1) | NZ572201A (enExample) |
| PE (1) | PE20080076A1 (enExample) |
| TW (1) | TW200808736A (enExample) |
| UY (1) | UY30298A1 (enExample) |
| WO (1) | WO2007124318A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2881078C (en) | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| EP2021329B1 (en) * | 2006-04-20 | 2016-04-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| SI3330255T1 (sl) * | 2009-03-20 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi |
| CN101624376B (zh) * | 2009-08-19 | 2011-09-14 | 沈阳中海药业有限公司 | 取代酰肼类化合物及其应用 |
| US8735589B2 (en) * | 2009-08-20 | 2014-05-27 | Cipla Limited | Process for the synthesis of naratriptan |
| EP2627650A2 (en) * | 2010-05-26 | 2013-08-21 | Merck Sharp & Dohme Corp. | N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1 |
| EP2819670B1 (en) | 2012-02-27 | 2026-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical Composition and Their Administration |
| AU2013299922B2 (en) | 2012-08-07 | 2018-06-21 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| ES2607807T3 (es) | 2012-08-07 | 2017-04-04 | Janssen Pharmaceutica Nv | Procedimiento para la preparación de los inibidores de las quinasas c-fms |
| KR101676208B1 (ko) * | 2012-09-17 | 2016-11-14 | 에프. 호프만-라 로슈 아게 | 트라이아졸 카복스아미드 유도체 |
| JP6318467B2 (ja) * | 2013-04-18 | 2018-05-09 | Jsr株式会社 | 液晶配向剤、液晶配向膜、液晶表示素子、位相差フィルム、位相差フィルムの製造方法及び重合体 |
| US10959987B2 (en) | 2019-04-15 | 2021-03-30 | King Abdulaziz University | Imidazole-based compounds as hepatitis C virus inhibitors |
| WO2021144360A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3226993A (en) * | 1991-11-27 | 1993-06-28 | E.I. Du Pont De Nemours And Company | Herbicidal acylated amino-(phenyl- or pyridinyl- or thienyl-)-phenyl derivatives |
| WO1996011932A1 (en) | 1994-10-14 | 1996-04-25 | Smithkline Beecham Plc | 2-(imidazol-4-yl)carbapeneme derivatives, intermediates thereof and use as antibacterials |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1997020822A1 (en) | 1995-12-01 | 1997-06-12 | Novartis Ag | Quinazolin-2,4-diazirines as npy receptor antagonist |
| US6100254A (en) * | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| DK1140938T3 (da) | 1999-01-11 | 2003-12-22 | Univ Princeton | Højaffinitetsinhibitorer for målvalidering og anvendelser heraf |
| US6346625B1 (en) | 1999-06-23 | 2002-02-12 | Astrazeneca Ab | Protein kinase inhibitors |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| CA2396693A1 (en) | 1999-12-28 | 2001-07-05 | Stephen T. Wrobleski | Cytokine, especially tnf-alpha, inhibitors |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| MXPA05011503A (es) * | 2003-04-25 | 2006-05-31 | Johnson & Johnson | Inhibidores de la c-fms cinasa. |
| US20050113566A1 (en) * | 2003-04-25 | 2005-05-26 | Player Mark R. | Inhibitors of C-FMS kinase |
| US7427683B2 (en) * | 2003-04-25 | 2008-09-23 | Ortho-Mcneil Pharmaceutical, Inc. | c-fms kinase inhibitors |
| US7790724B2 (en) * | 2003-04-25 | 2010-09-07 | Janssen Pharmaceutica N.V. | c-fms kinase inhibitors |
| US7645755B2 (en) * | 2004-10-22 | 2010-01-12 | Janssen Pharmaceutical N.V. | Inhibitors of c-fms kinase |
| CN101084208A (zh) * | 2004-10-22 | 2007-12-05 | 詹森药业有限公司 | 作为c－fms激酶抑制剂的芳族酰胺 |
| NZ555289A (en) * | 2004-10-22 | 2010-10-29 | Janssen Pharmaceutica Nv | Inhibitors of c-fms kinase |
| CN101421280A (zh) * | 2006-04-12 | 2009-04-29 | 惠氏公司 | 作为5-羟色胺-6配体的经取代二氢[1,4]噁嗪并[2.3.4-hi]吲唑衍生物 |
| EP2016070B1 (en) * | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| EP2021329B1 (en) * | 2006-04-20 | 2016-04-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| KR101367645B1 (ko) * | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| FR2966596B1 (fr) * | 2010-10-26 | 2012-12-07 | Commissariat Energie Atomique | Dispositif de detection d'un rayonnement electromagnetique. |
-
2007
- 2007-04-18 EP EP07760837.0A patent/EP2021329B1/en not_active Not-in-force
- 2007-04-18 CA CA2649919A patent/CA2649919C/en not_active Expired - Fee Related
- 2007-04-18 MX MX2008013532A patent/MX2008013532A/es active IP Right Grant
- 2007-04-18 EP EP13179745.8A patent/EP2687516A1/en not_active Withdrawn
- 2007-04-18 AU AU2007240439A patent/AU2007240439B2/en not_active Ceased
- 2007-04-18 WO PCT/US2007/066864 patent/WO2007124318A1/en not_active Ceased
- 2007-04-18 JP JP2009506740A patent/JP5480619B2/ja not_active Expired - Fee Related
- 2007-04-18 NZ NZ572201A patent/NZ572201A/en not_active IP Right Cessation
- 2007-04-18 KR KR1020087028215A patent/KR101462393B1/ko not_active Expired - Fee Related
- 2007-04-18 US US11/736,635 patent/US8674100B2/en not_active Expired - Fee Related
- 2007-04-18 ES ES07760837.0T patent/ES2581600T3/es active Active
- 2007-04-19 TW TW096113728A patent/TW200808736A/zh unknown
- 2007-04-19 AR ARP070101690A patent/AR060609A1/es unknown
- 2007-04-19 UY UY30298A patent/UY30298A1/es not_active Application Discontinuation
- 2007-04-20 PE PE2007000493A patent/PE20080076A1/es not_active Application Discontinuation
-
2013
- 2013-11-01 JP JP2013228539A patent/JP5932754B2/ja not_active Expired - Fee Related
-
2014
- 2014-01-30 US US14/168,670 patent/US9221797B2/en not_active Expired - Fee Related
-
2015
- 2015-10-30 US US14/927,855 patent/US9452996B2/en not_active Expired - Fee Related
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