JP2013508288A5 - - Google Patents
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- JP2013508288A5 JP2013508288A5 JP2012534357A JP2012534357A JP2013508288A5 JP 2013508288 A5 JP2013508288 A5 JP 2013508288A5 JP 2012534357 A JP2012534357 A JP 2012534357A JP 2012534357 A JP2012534357 A JP 2012534357A JP 2013508288 A5 JP2013508288 A5 JP 2013508288A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- pharmaceutically acceptable
- prodrug
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 68
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 239000000651 prodrug Substances 0.000 claims description 27
- 229940002612 prodrug Drugs 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 25
- 208000002193 Pain Diseases 0.000 claims description 14
- 230000036407 pain Effects 0.000 claims description 10
- 102000004222 Sepiapterin reductase Human genes 0.000 claims description 8
- 108020001302 Sepiapterin reductase Proteins 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
- 125000006414 CCl Chemical group ClC* 0.000 claims description 2
- 208000000094 Chronic Pain Diseases 0.000 claims description 2
- 208000005298 acute pain Diseases 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000002981 neuropathic effect Effects 0.000 claims description 2
- 230000003040 nociceptive effect Effects 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25201309P | 2009-10-15 | 2009-10-15 | |
| US61/252,013 | 2009-10-15 | ||
| PCT/US2010/052674 WO2011047156A1 (en) | 2009-10-15 | 2010-10-14 | Sepiapterin reductase inhibitors for the treatment of pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508288A JP2013508288A (ja) | 2013-03-07 |
| JP2013508288A5 true JP2013508288A5 (enExample) | 2013-12-05 |
| JP5758395B2 JP5758395B2 (ja) | 2015-08-05 |
Family
ID=43876540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534357A Expired - Fee Related JP5758395B2 (ja) | 2009-10-15 | 2010-10-14 | 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9169234B2 (enExample) |
| EP (1) | EP2488025A4 (enExample) |
| JP (1) | JP5758395B2 (enExample) |
| AU (1) | AU2010306750B2 (enExample) |
| CA (1) | CA2777782C (enExample) |
| WO (1) | WO2011047156A1 (enExample) |
Families Citing this family (22)
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| EP2049520A4 (en) | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | indole compounds |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| CN102329263A (zh) * | 2011-10-17 | 2012-01-25 | 上海化学试剂研究所 | 一种n-乙酰基-5-甲氧基色胺的制备方法 |
| KR102227271B1 (ko) | 2013-04-15 | 2021-03-12 | 에프엠씨 코포레이션 | 살진균성 아미드 |
| BR112016010568B1 (pt) * | 2013-11-15 | 2021-09-21 | Bayer Cropscience Aktiengesellschaft | Processo para preparação de um derivado de 2-etilaminopiridina substituída |
| US10365267B2 (en) * | 2014-10-31 | 2019-07-30 | Children's Medical Center Corporation | Methods and assays relating to sepiapterin reductase inhibition |
| CA3038280A1 (en) | 2015-09-30 | 2017-04-06 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. - Generalverwaltung | Heteroaryl derivatives as sepiapterin reductase inhibitors |
| CN108699033A (zh) * | 2016-01-26 | 2018-10-23 | 阿塔特克大学科学研究项目单元 | N3，n6-双(2-(5-甲氧基-1h-吲哚-3-基)乙基)-2，6-二甲基-4-(2-硝基苯基)吡啶-3，5-二甲酰胺及其在神经毒性领域的应用 |
| US20170291372A1 (en) * | 2016-04-09 | 2017-10-12 | Velo3D, Inc. | Generating three-dimensional objects by three-dimensional printing with rotation |
| CA3017645C (en) | 2016-04-27 | 2021-07-13 | University Of Puerto Rico | 1,5-disubstituted 1,2,3-triazoles are inhibitors of rac/cdc42 gtpases |
| MX2019007640A (es) | 2016-12-21 | 2019-09-06 | Bayer Cropscience Ag | Hidrogenacion catalitica de nitrilos. |
| WO2019175332A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity |
| CN108689856A (zh) * | 2018-07-09 | 2018-10-23 | 上海华堇生物技术有限责任公司 | 一种3-羟基-β-硝基苯乙烯的新制备方法 |
| US10720217B1 (en) * | 2019-01-29 | 2020-07-21 | Silicon Storage Technology, Inc. | Memory device and method for varying program state separation based upon frequency of use |
| US20240092784A1 (en) | 2020-04-14 | 2024-03-21 | Nissan Chemical Corporation | Condensed heterocyclic compound |
| WO2022104475A1 (en) | 2020-11-19 | 2022-05-27 | Magicmed Industries Inc. | Nitrilated psilocybin derivatives and methods of using |
| AU2022268420A1 (en) * | 2021-05-05 | 2023-12-21 | Kare Chemical Technologies Inc. | Catalytic tryptamine processes and precursors |
| CN113214133B (zh) * | 2021-05-08 | 2023-03-07 | 河北维达康生物科技有限公司 | 一种褪黑素的合成方法 |
| CN113960317A (zh) * | 2021-08-19 | 2022-01-21 | 深圳市辅酶医科技有限公司 | 一种测量生物样品中nad+浓度的生物传感器及方法 |
| CN113788780B (zh) * | 2021-10-15 | 2023-06-16 | 河北维达康生物科技有限公司 | 一种n-乙酰基-5-甲氧基色胺的合成方法 |
| US20250325516A1 (en) | 2022-07-08 | 2025-10-23 | Institut Curie | Serotonin analogues for use in treating metalloptosis-associated disorders |
| JP2025172328A (ja) * | 2024-05-13 | 2025-11-26 | 和彦 中村 | Ｉｇｆ－１産生促進剤およびその応用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2437398A1 (fr) * | 1978-06-20 | 1980-04-25 | Commissariat Energie Atomique | Compose iode utilisable comme traceur en radio-immunologie |
| DE3613623A1 (de) * | 1986-04-23 | 1987-10-29 | Bayer Ag | N-dihydroindolylethyl-sulfonamide |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP0620222A3 (en) | 1993-04-14 | 1995-04-12 | Lilly Co Eli | Tetrahydro-beta-carbolines. |
| AU680740B2 (en) | 1994-02-22 | 1997-08-07 | Merrell Pharmaceuticals Inc. | Novel indole derivatives useful to treat estrogen-related neoplasms and disorders |
| EP0885210B2 (en) * | 1996-03-08 | 2008-06-18 | Takeda Pharmaceutical Company Limited | Tricylic compounds having binding affinity for melatonin receptors, their production and use |
| RU2141483C1 (ru) * | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
| US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| GB0031315D0 (en) | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
| US6593331B2 (en) | 2001-04-17 | 2003-07-15 | Laboratories Upsa | Method for treatment of pain |
| JP2004535433A (ja) * | 2001-06-20 | 2004-11-25 | メルク エンド カムパニー インコーポレーテッド | 糖尿病治療用のジペプチジルペプチダーゼ阻害薬 |
| PT1451154E (pt) * | 2001-12-03 | 2008-04-21 | Wyeth Corp | Inibidores de fosfolipase a2 citossólica |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| US7084154B2 (en) * | 2003-02-11 | 2006-08-01 | Pharmacopeia Drug Disclovery, Inc. | 2-(aminomethyl) arylamide analgesics |
| US7906520B2 (en) * | 2003-11-13 | 2011-03-15 | The General Hospital Corporation | Methods for treating pain |
| US7074775B2 (en) * | 2004-09-14 | 2006-07-11 | Miller Landon C G | Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders |
| EP1828171B1 (en) | 2004-12-10 | 2014-03-12 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| EP1904473A1 (en) * | 2005-07-12 | 2008-04-02 | Bayer CropScience S.A. | Benzoheterocyclylethylcarboxamide derivatives |
| JP2009504656A (ja) | 2005-08-10 | 2009-02-05 | ノバルティス アクチエンゲゼルシャフト | デアセチラーゼ阻害剤の使用法 |
| US7902251B2 (en) * | 2005-10-19 | 2011-03-08 | Allergan, Inc. | Method for treating pain |
| EP1957483A1 (en) * | 2005-12-01 | 2008-08-20 | F.Hoffmann-La Roche Ag | Novel vinylogous acids derivatives |
| CA2630468C (en) | 2005-12-05 | 2015-01-20 | Otsuka Pharmaceutical Co., Ltd. | Medicinal drug |
| JP5142513B2 (ja) * | 2005-12-05 | 2013-02-13 | 大塚製薬株式会社 | 医薬 |
| JP5089185B2 (ja) * | 2006-02-02 | 2012-12-05 | 大塚製薬株式会社 | コラーゲン産生抑制剤。 |
| FR2898358B1 (fr) * | 2006-03-08 | 2008-05-30 | Macef Sa | Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux |
| RU2303597C1 (ru) * | 2006-05-12 | 2007-07-27 | Иващенко Андрей Александрович | Фармацевтическая композиция, способы ее получения и применения |
| US20080009485A1 (en) | 2006-05-26 | 2008-01-10 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis |
| US7893055B2 (en) * | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| BRPI0714409A2 (pt) * | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| EP2049520A4 (en) | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | indole compounds |
| JP2008115175A (ja) * | 2006-10-13 | 2008-05-22 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| AR063302A1 (es) | 2006-10-13 | 2009-01-21 | Otsuka Pharma Co Ltd | Derivados de 4-benzo[b]tiofen-4-il-piperazin-1-il con accion antagonista del receptor 5-ht2a de serotonina y receptor de adrenalina alfa1 y agonista parcial del receptor d2, una composicion farmaceutica que lo comprende y un proceso para producirla. |
| FR2907451B1 (fr) * | 2006-10-18 | 2008-12-12 | Servier Lab | "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| CN101679297B (zh) | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
| US20080287452A1 (en) * | 2007-05-16 | 2008-11-20 | Wyeth | Heteroaryl/aryl pyrimidine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| TW201242961A (en) | 2007-06-20 | 2012-11-01 | Ironwood Pharmaceuticals Inc | FAAH inhibitors |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
-
2010
- 2010-10-14 AU AU2010306750A patent/AU2010306750B2/en not_active Ceased
- 2010-10-14 US US13/501,932 patent/US9169234B2/en not_active Expired - Fee Related
- 2010-10-14 JP JP2012534357A patent/JP5758395B2/ja not_active Expired - Fee Related
- 2010-10-14 CA CA2777782A patent/CA2777782C/en not_active Expired - Fee Related
- 2010-10-14 WO PCT/US2010/052674 patent/WO2011047156A1/en not_active Ceased
- 2010-10-14 EP EP10824093A patent/EP2488025A4/en not_active Withdrawn
-
2015
- 2015-09-14 US US14/853,709 patent/US10059664B2/en not_active Expired - Fee Related