JP2013540713A5 - - Google Patents
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- Publication number
- JP2013540713A5 JP2013540713A5 JP2013526475A JP2013526475A JP2013540713A5 JP 2013540713 A5 JP2013540713 A5 JP 2013540713A5 JP 2013526475 A JP2013526475 A JP 2013526475A JP 2013526475 A JP2013526475 A JP 2013526475A JP 2013540713 A5 JP2013540713 A5 JP 2013540713A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chal
- alkyl
- compound
- hydrocarbon group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004429 atom Chemical group 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 6
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- -1 X is CN Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001258 synovial membrane Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1014633.0A GB201014633D0 (en) | 2010-09-02 | 2010-09-02 | Rheumatoid arthritis treatment |
| GB1014633.0 | 2010-09-02 | ||
| PCT/EP2011/065123 WO2012028688A1 (en) | 2010-09-02 | 2011-09-01 | Rheumatoid arthritis treatment using polyunsaturated long chain ketones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016216524A Division JP2017075148A (ja) | 2010-09-02 | 2016-11-04 | ポリ不飽和長鎖ケトンを用いるリウマチ性関節炎の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540713A JP2013540713A (ja) | 2013-11-07 |
| JP2013540713A5 true JP2013540713A5 (enExample) | 2016-05-12 |
| JP6082347B2 JP6082347B2 (ja) | 2017-02-15 |
Family
ID=43013608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526475A Expired - Fee Related JP6082347B2 (ja) | 2010-09-02 | 2011-09-01 | ポリ不飽和長鎖ケトンを用いるリウマチ性関節炎の治療 |
| JP2016216524A Withdrawn JP2017075148A (ja) | 2010-09-02 | 2016-11-04 | ポリ不飽和長鎖ケトンを用いるリウマチ性関節炎の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016216524A Withdrawn JP2017075148A (ja) | 2010-09-02 | 2016-11-04 | ポリ不飽和長鎖ケトンを用いるリウマチ性関節炎の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9682930B2 (enExample) |
| EP (1) | EP2611432A1 (enExample) |
| JP (2) | JP6082347B2 (enExample) |
| KR (1) | KR20130112880A (enExample) |
| CN (2) | CN103249408A (enExample) |
| AU (1) | AU2011298340B2 (enExample) |
| CA (1) | CA2810102A1 (enExample) |
| GB (1) | GB201014633D0 (enExample) |
| IL (1) | IL224963A (enExample) |
| WO (1) | WO2012028688A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| MX377251B (es) | 2010-03-24 | 2025-03-07 | Jazz Pharmaceuticals Inc Star | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas. |
| GB201205394D0 (en) | 2012-03-27 | 2012-05-09 | Adlens Ltd | Improvements in or relating to deformable non-round membrane assemblies |
| GB201221329D0 (en) * | 2012-11-27 | 2013-01-09 | Avexxin As | Dermatitis treatment |
| GB201313238D0 (en) | 2013-07-24 | 2013-09-04 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| GB201409363D0 (en) * | 2014-05-27 | 2014-07-09 | Avexxin As | Skin cancer treatment |
| GB201501144D0 (en) | 2015-01-23 | 2015-03-11 | Avexxin As | Process for the preparation of a polyunsaturated ketone compound |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| CN109789111B (zh) * | 2016-09-21 | 2021-11-16 | 埃维克辛公司 | 药物组合物 |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| EP3638221B1 (en) * | 2017-06-16 | 2021-09-29 | Avexxin AS | Compositions and methods for treatment of a fibrotic disease |
| BR112021006027A2 (pt) | 2018-11-19 | 2021-06-29 | Jazz Pharmaceuticals Ireland Limited | formulações de fármaco resistente a álcool |
| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| GB201910644D0 (en) | 2019-07-25 | 2019-09-11 | Coegin Pharma As | Cancer Treatment |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| US20210311022A1 (en) * | 2020-03-27 | 2021-10-07 | Organogenesis, Inc. | Methods, kits and compositions for characterizing an anti-inflammatory response of a product |
| WO2022076824A1 (en) | 2020-10-08 | 2022-04-14 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| AU2022242840A1 (en) * | 2021-03-23 | 2023-09-28 | Organogenesis, Inc. | Methods kits and compositions for characterizing an anti-inflammatory response of a product |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| JP2026513019A (ja) | 2023-02-03 | 2026-04-22 | トリス・フアルマ・インコーポレーテツド | １晩１回の低ナトリウムオキシベート組成物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670465A (en) * | 1986-05-21 | 1987-06-02 | Syntex (U.S.A.) Inc. | Arachidonic acid analogs |
| JPH0987176A (ja) | 1995-09-26 | 1997-03-31 | Shiseido Co Ltd | 糸球体腎炎抑制剤 |
| JPH09268153A (ja) | 1996-04-02 | 1997-10-14 | Sagami Chem Res Center | トリフルオロメチルケトン誘導体及びホスホリパーゼａ２阻害剤 |
| EP0904072A4 (en) * | 1996-04-12 | 2003-07-30 | Peptide Technology Pty Ltd | METHOD FOR TREATING IMMUNO PATHOLOGIES USING MULTIPLE UNSATURATED FETAL ACIDS |
| AU730364B2 (en) | 1997-09-23 | 2001-03-08 | Bristol-Myers Squibb Company | Selective cPLA2 inhibitors |
| US6107334A (en) | 1998-02-23 | 2000-08-22 | Wake Forest University | Dietary control of arachidonic acid metabolism |
| AU4994899A (en) | 1998-07-13 | 2000-02-01 | University Of South Florida | Modulation of the phospholipase a2 pathway as a therapeutic |
| US6031014A (en) | 1998-12-08 | 2000-02-29 | Crivello; James V. | Initiator compositions and methods for their synthesis and use |
| CA2379208A1 (en) | 1999-07-19 | 2001-01-25 | Eli Lilly & Company | Spla2 inhibitors |
| US20020165119A1 (en) * | 2001-01-31 | 2002-11-07 | Alan Leff | Method of treating inflammatory conditions by inhibiting cytosolic phospholipase A2 |
| EP1243524A3 (en) | 2001-03-16 | 2004-04-07 | Pfizer Products Inc. | Pharmaceutical kit for oxygen-sensitive drugs |
| US7101875B2 (en) * | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| GB0202002D0 (en) * | 2002-01-29 | 2002-03-13 | Leiv Eiriksson Nyotek A S | Use |
| MY131170A (en) | 2002-03-28 | 2007-07-31 | Nissan Chemical Ind Ltd | Therapeutic agent for glomerular disease |
| US20040111957A1 (en) | 2002-12-13 | 2004-06-17 | Filippini Brian B. | Water blended fuel composition |
| WO2006106438A2 (en) * | 2005-01-11 | 2006-10-12 | Evolva Sa | Modulators of ppar activity |
| US20060246115A1 (en) * | 2005-03-04 | 2006-11-02 | Ricardo Rueda | Nutritional products for ameliorating symptoms of rheumatoid arthritis |
| NZ552238A (en) | 2006-12-20 | 2009-07-31 | Seperex Nutritionals Ltd | An extract |
| WO2008075366A2 (en) | 2006-12-20 | 2008-06-26 | Medwell Laboratories Ltd. | Novel conjugates of polyunsaturated fatty acids with amines and therapeutic uses thereof |
| WO2009038671A2 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Oxylipin compounds for treating autoimmune diseases |
| US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
| US8211947B2 (en) * | 2008-01-28 | 2012-07-03 | Guillermo Selman-Housein Sosa | Composition and method for treating and preventing musculoskeletal and connective tissue disorders |
| EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| JP5843755B2 (ja) * | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスＰｒｏｎｏｖａ ＢｉｏＰｈａｒｍａ Ｎｏｒｇｅ ＡＳ | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
| GB0909643D0 (en) * | 2009-06-04 | 2009-07-22 | Avexxin As | Glomerulonephritis treatment |
| US20130137767A1 (en) * | 2010-02-02 | 2013-05-30 | Dsm Ip Assets B.V. | Methods and Compositions for Treating Arthritis with Docosahexaenoic Acid |
-
2010
- 2010-09-02 GB GBGB1014633.0A patent/GB201014633D0/en not_active Ceased
-
2011
- 2011-09-01 CN CN2011800520405A patent/CN103249408A/zh active Pending
- 2011-09-01 CN CN201811592300.8A patent/CN109893518A/zh active Pending
- 2011-09-01 EP EP11757227.1A patent/EP2611432A1/en not_active Ceased
- 2011-09-01 AU AU2011298340A patent/AU2011298340B2/en not_active Ceased
- 2011-09-01 WO PCT/EP2011/065123 patent/WO2012028688A1/en not_active Ceased
- 2011-09-01 JP JP2013526475A patent/JP6082347B2/ja not_active Expired - Fee Related
- 2011-09-01 CA CA2810102A patent/CA2810102A1/en not_active Abandoned
- 2011-09-01 KR KR1020137008287A patent/KR20130112880A/ko not_active Abandoned
-
2013
- 2013-02-27 IL IL224963A patent/IL224963A/en active IP Right Grant
- 2013-03-01 US US13/783,088 patent/US9682930B2/en not_active Expired - Fee Related
-
2016
- 2016-11-04 JP JP2016216524A patent/JP2017075148A/ja not_active Withdrawn
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