MX2009005398A - Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf. - Google Patents
Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf.Info
- Publication number
- MX2009005398A MX2009005398A MX2009005398A MX2009005398A MX2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A MX 2009005398 A MX2009005398 A MX 2009005398A
- Authority
- MX
- Mexico
- Prior art keywords
- chronic inflammatory
- methods
- inflammatory diseases
- treating chronic
- csf antagonist
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
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- Neurology (AREA)
- Pulmonology (AREA)
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- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
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- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
La invención está basada en el descubrimiento de que se pueden usar antagonistas de GM-CSF para el tratamiento de enfermedades inflamatorias crónicas tales como artritis reumatoide. Así, la invención proporciona métodos para administrar un antagonista de GM-CSF, por ejemplo un anticuerpo de GM-CSF y compuestos anit-foliato, por ejemplo, metotrexato, a un paciente que tiene RA y composiciones farmacéuticas que comprenden tales antagonistas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86078006P | 2006-11-21 | 2006-11-21 | |
US90274207P | 2007-02-21 | 2007-02-21 | |
PCT/US2007/085402 WO2008064321A2 (en) | 2006-11-21 | 2007-11-21 | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005398A true MX2009005398A (es) | 2009-08-20 |
Family
ID=39386167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005398A MX2009005398A (es) | 2006-11-21 | 2007-11-21 | Metodos para el tratamiento de enfermedades inflamatorias cronicas usando antagonista de gm-csf. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20080206241A1 (es) |
EP (2) | EP2101780B1 (es) |
JP (1) | JP5410293B2 (es) |
KR (1) | KR101517251B1 (es) |
CN (2) | CN105435223A (es) |
AU (1) | AU2007323541B2 (es) |
BR (1) | BRPI0719109A2 (es) |
CA (1) | CA2670288C (es) |
EA (1) | EA200900709A1 (es) |
ES (1) | ES2432173T3 (es) |
IL (1) | IL198829A0 (es) |
MX (1) | MX2009005398A (es) |
NZ (1) | NZ598345A (es) |
SG (1) | SG176503A1 (es) |
WO (1) | WO2008064321A2 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0719109A2 (pt) | 2006-11-21 | 2013-12-10 | Kalobios Pharmaceuticals Inc | Métodos para tratar doenças inflamatórias crônicas usando um antagonista de gm-csf |
AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
TW200918553A (en) | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
EP2215119B1 (en) | 2007-11-13 | 2012-12-26 | Evec Inc. | Monoclonal antibodies that bind to hgm-csf and medical compositions comprising same |
JP2011510015A (ja) * | 2008-01-15 | 2011-03-31 | カロバイオス ファーマシューティカルズ インコーポレイティッド | Gm−csfアンタゴニストを用いて骨減少障害を治療する方法 |
US8075885B2 (en) * | 2008-04-07 | 2011-12-13 | Kalobios Pharmaceuticals, Inc. | Methods of treating heart failure using an anti-GM-CSF antibody |
NZ588850A (en) * | 2008-04-28 | 2012-12-21 | Kalobios Pharmaceuticals Inc | Antibodies to granulocyte-macrophage colony-stimulating factor |
AU2015224416B2 (en) * | 2008-12-22 | 2017-04-20 | The University Of Melbourne | Osteoarthritis treatment |
RU2011127334A (ru) * | 2008-12-22 | 2013-01-27 | Де Юниверсити Оф Мельбурн | Лечение остеоартрита |
EP3381471B1 (en) * | 2008-12-22 | 2024-03-20 | The University of Melbourne | Pain treatment |
WO2010093814A1 (en) * | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
CN102459340A (zh) * | 2009-04-23 | 2012-05-16 | 特罗科隆科学有限公司 | 粒性白血细胞-巨噬细胞菌落-刺激因子(gm-csf)中和抗体 |
AU2010244525B2 (en) * | 2009-05-05 | 2013-03-28 | Morphosys Ag | Treatment for multiple sclerosis |
EP2729498A1 (en) * | 2011-07-06 | 2014-05-14 | MorphoSys AG | Therapeutic combinations of anti -cd20 and anti - gm - csf antibodies and uses thereof |
KR20210021153A (ko) * | 2012-09-20 | 2021-02-24 | 모르포시스 아게 | 류마티스 관절염에 대한 치료 |
KR20150056846A (ko) * | 2012-09-20 | 2015-05-27 | 모르포시스 아게 | 류마티스 관절염에 대한 치료 |
AR093297A1 (es) * | 2012-10-31 | 2015-05-27 | Amgen Res (Munich) Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
US10745475B2 (en) * | 2013-08-30 | 2020-08-18 | Takeda Gmbh | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
JP6360696B2 (ja) * | 2014-03-18 | 2018-07-18 | 日本光電工業株式会社 | 血液検査装置および血液検査方法 |
JP2017515828A (ja) * | 2014-05-19 | 2017-06-15 | メディミューン リミテッド | 関節リウマチのための治療 |
US20180236098A1 (en) * | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
US10647767B2 (en) | 2016-09-19 | 2020-05-12 | I-Mab Biopharma Co., Ltd. | Anti-GM-CSF antibodies and uses thereof |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
CA3078349A1 (en) | 2017-10-02 | 2019-04-11 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a gm-csf antagonist |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
US20220040229A1 (en) * | 2018-10-31 | 2022-02-10 | Humanigen, Inc. | Materials and methods for treating cancer |
MX2022011111A (es) * | 2020-03-08 | 2023-03-02 | Humanigen Inc | Métodos para tratar infección de coronavirus y lesión pulmonar inducida por inflamación resultante. |
KR20230124910A (ko) * | 2020-12-04 | 2023-08-28 | 씨에스엘 이노베이션 피티와이 엘티디 | 염증성 피부 상태 치료 방법 |
WO2022192093A1 (en) * | 2021-03-08 | 2022-09-15 | Humanigen, Inc. | Methods for treating coronavirus infection and resulting inflammation-induced lung injury |
WO2023138499A1 (zh) * | 2022-01-20 | 2023-07-27 | 舒泰神(北京)生物制药股份有限公司 | 一种特异性地识别粒细胞-巨噬细胞集落刺激因子受体的抗体制剂及其应用 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
WO1991001330A1 (en) * | 1989-07-14 | 1991-02-07 | Schering Corporation | Antagonists of gm-csf derived from the carboxyl terminus |
US5747032A (en) | 1990-08-10 | 1998-05-05 | Amrad Corporation Limited | Monoclonal antibody to human granulocyte macrophage colony stimulating factor |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
SI9720020B (en) | 1996-02-09 | 2001-12-31 | Basf Ag | Human antibodies that bind human TNF alpha |
US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
EP1051432B1 (en) | 1998-12-08 | 2007-01-24 | Biovation Limited | Method for reducing immunogenicity of proteins |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7108852B2 (en) * | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
US7714113B2 (en) * | 2002-02-13 | 2010-05-11 | Ludwig Institute For Cancer Research | Fusion proteins of humanized g250 specific antibodies and uses thereof |
GB0224082D0 (en) * | 2002-10-16 | 2002-11-27 | Celltech R&D Ltd | Biological products |
EP1615659B1 (en) * | 2003-03-12 | 2014-04-16 | Genentech, Inc. | Use of bv8 and/or eg-vegf to promote hematopoiesis |
CA2533594C (en) * | 2003-07-23 | 2013-04-02 | Synta Pharmaceuticals, Corp. | Compounds for inflammation and immune-related uses |
CA2553692C (en) | 2004-01-20 | 2014-10-07 | Kalobios, Inc. | Antibody specificity transfer using minimal essential binding determinants |
PL1772145T3 (pl) * | 2004-07-16 | 2011-08-31 | Kyorin Seiyaku Kk | Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym |
WO2006055778A2 (en) | 2004-11-16 | 2006-05-26 | Kalobios, Inc. | Immunoglobulin variable region cassette exchange |
AU2006249062B2 (en) | 2005-05-18 | 2012-12-20 | Morphosys Ag | Anti-GM-CSF antibodies and uses therefor |
US20080305079A1 (en) * | 2006-01-06 | 2008-12-11 | Mount Sinai School Of Medicine Of New York University | Myeloid Suppressor Cells, Methods For Preparing Them, and Methods For Using Them For Treating Autoimmunity |
KR101486183B1 (ko) * | 2006-02-08 | 2015-01-28 | 모르포테크, 인크. | 항원성 gm-csf 펩티드 및 gm-csf에 대한 항체 |
SI1999152T1 (sl) * | 2006-03-27 | 2013-02-28 | Medimmune Limited | Vezni äślen za gm-csf receptor |
DE102006033837A1 (de) * | 2006-07-21 | 2008-01-31 | Medac Gesellschaft für klinische Spezialpräparate m.b.H | Konzentrierte Methotrexat-Lösungen |
BRPI0719109A2 (pt) | 2006-11-21 | 2013-12-10 | Kalobios Pharmaceuticals Inc | Métodos para tratar doenças inflamatórias crônicas usando um antagonista de gm-csf |
-
2007
- 2007-11-21 BR BRPI0719109-0A2A patent/BRPI0719109A2/pt not_active IP Right Cessation
- 2007-11-21 EA EA200900709A patent/EA200900709A1/ru unknown
- 2007-11-21 AU AU2007323541A patent/AU2007323541B2/en not_active Ceased
- 2007-11-21 MX MX2009005398A patent/MX2009005398A/es active IP Right Grant
- 2007-11-21 ES ES07868831T patent/ES2432173T3/es active Active
- 2007-11-21 CN CN201510674256.5A patent/CN105435223A/zh active Pending
- 2007-11-21 US US11/944,162 patent/US20080206241A1/en not_active Abandoned
- 2007-11-21 KR KR1020097012906A patent/KR101517251B1/ko not_active IP Right Cessation
- 2007-11-21 NZ NZ598345A patent/NZ598345A/xx not_active IP Right Cessation
- 2007-11-21 SG SG2011085834A patent/SG176503A1/en unknown
- 2007-11-21 JP JP2009538506A patent/JP5410293B2/ja not_active Expired - Fee Related
- 2007-11-21 EP EP07868831.4A patent/EP2101780B1/en not_active Revoked
- 2007-11-21 EP EP11182971A patent/EP2402013A1/en not_active Withdrawn
- 2007-11-21 CN CNA2007800495322A patent/CN101605547A/zh active Pending
- 2007-11-21 CA CA2670288A patent/CA2670288C/en not_active Expired - Fee Related
- 2007-11-21 WO PCT/US2007/085402 patent/WO2008064321A2/en active Application Filing
-
2009
- 2009-05-19 IL IL198829A patent/IL198829A0/en unknown
-
2015
- 2015-05-14 US US14/712,627 patent/US20150246121A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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EA200900709A1 (ru) | 2009-12-30 |
AU2007323541B2 (en) | 2012-01-19 |
US20150246121A1 (en) | 2015-09-03 |
EP2402013A1 (en) | 2012-01-04 |
CA2670288C (en) | 2015-10-27 |
KR20090110827A (ko) | 2009-10-22 |
WO2008064321A2 (en) | 2008-05-29 |
NZ598345A (en) | 2013-09-27 |
ES2432173T3 (es) | 2013-12-02 |
AU2007323541A1 (en) | 2008-05-29 |
JP2010510323A (ja) | 2010-04-02 |
CA2670288A1 (en) | 2008-05-29 |
EP2101780A2 (en) | 2009-09-23 |
JP5410293B2 (ja) | 2014-02-05 |
BRPI0719109A2 (pt) | 2013-12-10 |
KR101517251B1 (ko) | 2015-05-07 |
US20080206241A1 (en) | 2008-08-28 |
EP2101780B1 (en) | 2013-10-09 |
SG176503A1 (en) | 2011-12-29 |
CN105435223A (zh) | 2016-03-30 |
CN101605547A (zh) | 2009-12-16 |
WO2008064321A3 (en) | 2008-10-02 |
IL198829A0 (en) | 2010-02-17 |
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