JP2013545798A5 - - Google Patents
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- JP2013545798A5 JP2013545798A5 JP2013543948A JP2013543948A JP2013545798A5 JP 2013545798 A5 JP2013545798 A5 JP 2013545798A5 JP 2013543948 A JP2013543948 A JP 2013543948A JP 2013543948 A JP2013543948 A JP 2013543948A JP 2013545798 A5 JP2013545798 A5 JP 2013545798A5
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- JP
- Japan
- Prior art keywords
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- hydrogen atom
- chloro
- methyl
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 90
- 150000001875 compounds Chemical class 0.000 claims description 28
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 208000030507 AIDS Diseases 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims description 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 17
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 9
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 claims 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- -1 NH 2 group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- LWHIWNYBTZRFEP-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=CC2=NC=1NC1=NC=CC(C)=C1N LWHIWNYBTZRFEP-UHFFFAOYSA-N 0.000 claims 2
- DEOZHEHMTWAECR-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=NC=CC(C)=C1N DEOZHEHMTWAECR-UHFFFAOYSA-N 0.000 claims 2
- STCNAZVMTAVEOZ-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-(dimethylsulfamoylamino)quinoline Chemical compound C=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=NC=CC(C)=C1N STCNAZVMTAVEOZ-UHFFFAOYSA-N 0.000 claims 2
- FLGXDPRMCBJQQN-UHFFFAOYSA-N 2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=CC2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 FLGXDPRMCBJQQN-UHFFFAOYSA-N 0.000 claims 2
- CDRBXJDVDCNVCR-UHFFFAOYSA-N 2-[4-[(8-chloroquinolin-2-yl)amino]phenoxy]ethanol Chemical compound C1=CC(OCCO)=CC=C1NC1=CC=C(C=CC=C2Cl)C2=N1 CDRBXJDVDCNVCR-UHFFFAOYSA-N 0.000 claims 2
- UCRMMFCBPWUBIE-UHFFFAOYSA-N 2-n-(3-amino-4-methylpyridin-2-yl)-8-chloro-3-methylquinoline-2,5-diamine Chemical compound CC1=CC=NC(NC=2C(=CC3=C(N)C=CC(Cl)=C3N=2)C)=C1N UCRMMFCBPWUBIE-UHFFFAOYSA-N 0.000 claims 2
- YSOZQQVJTPFTMQ-UHFFFAOYSA-N 2-n-[8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)quinolin-2-yl]-4-methylpyridine-2,3-diamine Chemical compound CC1=CC=NC(NC=2C(=CC3=C(OCCN4CCCCC4)C=CC(Cl)=C3N=2)C)=C1N YSOZQQVJTPFTMQ-UHFFFAOYSA-N 0.000 claims 2
- FPXYLXAMMKEESV-UHFFFAOYSA-N 2-n-[8-chloro-5-(2-morpholin-4-ylethoxy)quinolin-2-yl]-4-methylpyridine-2,3-diamine Chemical compound CC1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCOCC4)C3=CC=2)=C1N FPXYLXAMMKEESV-UHFFFAOYSA-N 0.000 claims 2
- YGWZBJQQLKWYRQ-UHFFFAOYSA-N 8-chloro-2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 YGWZBJQQLKWYRQ-UHFFFAOYSA-N 0.000 claims 2
- SHPNFUONBHWVSI-UHFFFAOYSA-N 8-chloro-2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)quinoline Chemical compound C=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 SHPNFUONBHWVSI-UHFFFAOYSA-N 0.000 claims 2
- AUTPWUQQIPIRES-UHFFFAOYSA-N 8-chloro-2-n-[3-chloro-4-(trifluoromethoxy)phenyl]-3-methylquinoline-2,5-diamine Chemical compound CC1=CC2=C(N)C=CC(Cl)=C2N=C1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 AUTPWUQQIPIRES-UHFFFAOYSA-N 0.000 claims 2
- LMKDXRLMPNWFJO-UHFFFAOYSA-N 8-chloro-3-methyl-2-n-[4-(trifluoromethyl)pyridin-2-yl]quinoline-2,5-diamine Chemical compound CC1=CC2=C(N)C=CC(Cl)=C2N=C1NC1=CC(C(F)(F)F)=CC=N1 LMKDXRLMPNWFJO-UHFFFAOYSA-N 0.000 claims 2
- AFAFQKALERZORJ-UHFFFAOYSA-N 8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethoxy)phenyl]quinolin-2-amine Chemical compound C1=CC(Cl)=C2N=C(NC=3C=CC(OC(F)(F)F)=CC=3)C(C)=CC2=C1OCCN1CCCCC1 AFAFQKALERZORJ-UHFFFAOYSA-N 0.000 claims 2
- SGTKQHGNCBULSG-UHFFFAOYSA-N 8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound C1=CC(Cl)=C2N=C(NC=3N=CC=C(C=3)C(F)(F)F)C(C)=CC2=C1OCCN1CCCCC1 SGTKQHGNCBULSG-UHFFFAOYSA-N 0.000 claims 2
- QJRSHFGNVORSNK-UHFFFAOYSA-N 8-chloro-5-(2-morpholin-4-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound FC(F)(F)C1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCOCC4)C3=CC=2)=C1 QJRSHFGNVORSNK-UHFFFAOYSA-N 0.000 claims 2
- GTIAINXNOUGZHA-UHFFFAOYSA-N 8-chloro-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethoxy)phenyl]quinolin-2-amine Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC1=CC=C(C(OCCN2CCCCC2)=CC=C2Cl)C2=N1 GTIAINXNOUGZHA-UHFFFAOYSA-N 0.000 claims 2
- VFTVHCSXVHUNNI-UHFFFAOYSA-N 8-chloro-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound FC(F)(F)C1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCCCC4)C3=CC=2)=C1 VFTVHCSXVHUNNI-UHFFFAOYSA-N 0.000 claims 2
- ULCABPKCNGZGAZ-UHFFFAOYSA-N 8-chloro-n-(3-chloro-4-methoxyphenyl)-5-(2-morpholin-4-ylethoxy)quinolin-2-amine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=CC=C(C(OCCN2CCOCC2)=CC=C2Cl)C2=N1 ULCABPKCNGZGAZ-UHFFFAOYSA-N 0.000 claims 2
- JREVCPFWYFNPGG-UHFFFAOYSA-N 8-chloro-n-[3-chloro-4-(trifluoromethoxy)phenyl]-5-(2-piperidin-1-ylethoxy)quinolin-2-amine Chemical compound C1=C(Cl)C(OC(F)(F)F)=CC=C1NC1=CC=C(C(OCCN2CCCCC2)=CC=C2Cl)C2=N1 JREVCPFWYFNPGG-UHFFFAOYSA-N 0.000 claims 2
- IICKDKFFDMYJSX-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-(2-morpholin-4-ylethoxy)phenyl]quinolin-2-amine Chemical compound COC1=CC=C(NC=2N=C3C(Cl)=CC=CC3=CC=2)C=C1OCCN1CCOCC1 IICKDKFFDMYJSX-UHFFFAOYSA-N 0.000 claims 2
- IDQIZEYRBHTFBR-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-(2-piperidin-1-ylethoxy)phenyl]quinolin-2-amine Chemical compound COC1=CC=C(NC=2N=C3C(Cl)=CC=CC3=CC=2)C=C1OCCN1CCCCC1 IDQIZEYRBHTFBR-UHFFFAOYSA-N 0.000 claims 2
- SZNXWCCWQXCTNP-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]phenyl]quinolin-2-amine Chemical compound C1=C(OC)C(OCCOCCOC)=CC(NC=2N=C3C(Cl)=CC=CC3=CC=2)=C1 SZNXWCCWQXCTNP-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- GTEQYEMPPBFZQT-UHFFFAOYSA-N n-[3-methyl-2-[[4-(trifluoromethyl)pyridin-2-yl]amino]quinolin-5-yl]methanesulfonamide Chemical compound CC1=CC2=C(NS(C)(=O)=O)C=CC=C2N=C1NC1=CC(C(F)(F)F)=CC=N1 GTEQYEMPPBFZQT-UHFFFAOYSA-N 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- HAVWZAULCLKNBA-UHFFFAOYSA-N n-[2-[3-chloro-4-(trifluoromethoxy)anilino]-3-methylquinolin-5-yl]methanesulfonamide Chemical compound CC1=CC2=C(NS(C)(=O)=O)C=CC=C2N=C1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 HAVWZAULCLKNBA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 0 *c(cc1*)c(*)c(cc2*)c1nc2N(*)c1c(*)c(*)c(*)c(*)c1*=* Chemical compound *c(cc1*)c(*)c(cc2*)c1nc2N(*)c1c(*)c(*)c(*)c(*)c1*=* 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10306417A EP2465502A1 (en) | 2010-12-15 | 2010-12-15 | Compounds useful for treating AIDS |
| EP10306417.6 | 2010-12-15 | ||
| PCT/IB2011/055643 WO2012080953A1 (en) | 2010-12-15 | 2011-12-13 | Compounds useful for treating aids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545798A JP2013545798A (ja) | 2013-12-26 |
| JP2013545798A5 true JP2013545798A5 (enExample) | 2015-02-05 |
| JP6049630B2 JP6049630B2 (ja) | 2016-12-21 |
Family
ID=43755105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543948A Active JP6049630B2 (ja) | 2010-12-15 | 2011-12-13 | Ａｉｄｓを処置する為に有用な化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9061999B2 (enExample) |
| EP (2) | EP2465502A1 (enExample) |
| JP (1) | JP6049630B2 (enExample) |
| KR (1) | KR101749232B1 (enExample) |
| CN (1) | CN103415290B (enExample) |
| AR (1) | AR084277A1 (enExample) |
| AU (1) | AU2011342826B2 (enExample) |
| BR (1) | BR112013014943B1 (enExample) |
| CA (1) | CA2819317C (enExample) |
| CU (1) | CU20130080A7 (enExample) |
| DK (1) | DK2651416T3 (enExample) |
| ES (1) | ES2681539T3 (enExample) |
| HR (1) | HRP20181190T1 (enExample) |
| MX (1) | MX337258B (enExample) |
| PL (1) | PL2651416T3 (enExample) |
| PT (1) | PT2651416T (enExample) |
| RU (1) | RU2598845C2 (enExample) |
| WO (1) | WO2012080953A1 (enExample) |
| ZA (1) | ZA201303922B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
| KR102016889B1 (ko) | 2009-06-12 | 2019-08-30 | 아비박스 | 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물 |
| EP2757161A1 (en) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 as a biomarker of viral infection |
| JP6895251B2 (ja) * | 2013-07-05 | 2021-06-30 | アビバックス | レトロウイルスにより引き起こされる疾患を処理する為に有用な化合物 |
| EP2975034A1 (en) * | 2014-07-17 | 2016-01-20 | Abivax | A quinoline derivative for the treatment of inflammatory diseases and AIDS |
| EP2974729A1 (en) * | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
| EP3059591A1 (en) * | 2015-02-23 | 2016-08-24 | Abivax | Methods for screening compounds for treating or preventing a viral infection or a virus-related condition |
| EP3059236A1 (en) | 2015-02-23 | 2016-08-24 | Abivax | A new quinoline derivative for use in the treatment and prevention of viral infections |
| EP3058940A1 (en) * | 2015-02-23 | 2016-08-24 | Abivax | Quinoline derivatives for use in the treatment or prevention of viral infection |
| US11130736B2 (en) * | 2015-08-21 | 2021-09-28 | University Of Kansas | Human TLR8-selective agonists |
| WO2017158201A1 (en) * | 2016-03-18 | 2017-09-21 | Ratiopharm Gmbh | Process for preparing quinolin-2-yl-phenylamine derivatives and their salts |
| KR101966351B1 (ko) * | 2016-06-08 | 2019-04-08 | 한국과학기술연구원 | 히스톤 메틸전달효소 저해용 퀴놀린 유도체 및 이의 용도 |
| WO2019002228A1 (en) | 2017-06-26 | 2019-01-03 | Institut Pasteur | TREATMENTS TO REMOVE HIV RESERVOIRS AND REDUCE VIRAL LOAD |
| WO2019186277A1 (en) | 2018-03-28 | 2019-10-03 | Institut Pasteur | Ultrasensitive hiv-1 p24 detection assay |
| EP3594206A1 (en) * | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
| EP3594205A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
| EP3669874A1 (en) * | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use in the treatment or prevention of cancer |
| EP3669873A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use ine the traeatment of inflammation diseases |
| WO2020128033A1 (en) | 2018-12-20 | 2020-06-25 | Institut Pasteur | Cellular metabolism of hiv-1 reservoir seeding in cd4+ t cells |
| CN109776498B (zh) * | 2019-03-13 | 2020-04-07 | 浙江永宁药业股份有限公司 | 一种西洛他唑的制备方法 |
| EP4063351A1 (en) * | 2021-03-26 | 2022-09-28 | Abivax | Preparation method of quinoline derivative compounds |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| EP4215196A1 (en) | 2022-01-24 | 2023-07-26 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a jak inhibitor |
| WO2024109936A1 (zh) * | 2022-11-25 | 2024-05-30 | 江苏恒瑞医药股份有限公司 | 一种喹啉胺类化合物晶型及其制备方法 |
| WO2025027388A1 (en) | 2023-08-01 | 2025-02-06 | Abivax | Obefazimod for treatment of ulcerative colitis |
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| US2419199A (en) * | 1945-02-09 | 1947-04-22 | Parke Davis & Co | Quinoline compounds and process of making same |
| FR2387229A1 (fr) | 1977-04-13 | 1978-11-10 | Anvar | Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| FR2436786A1 (fr) | 1978-09-21 | 1980-04-18 | Anvar | Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments |
| JPS59501318A (ja) * | 1982-07-26 | 1984-07-26 | アメリカン ホスピタル サプライ コ−ポレ−シヨン | ヘテロアリ−ル置換アミノメチルベンゼン誘導体 |
| US4466965A (en) * | 1982-07-26 | 1984-08-21 | American Hospital Supply Corporation | Phthalazine compounds, compositions and use |
| FR2627493B1 (fr) | 1988-02-23 | 1991-10-31 | Sanofi Sa | Procede de preparation de derives d'isoquinoleine |
| FR2645861A1 (fr) | 1989-04-17 | 1990-10-19 | Inst Nat Sante Rech Med | Utilisation de dipyrido (4,3-b) (3,4-f) indoles pour la preparation de medicaments utiles pour le traitement du sida |
| ATE260099T1 (de) | 1999-04-05 | 2004-03-15 | Hope City | Neue hemmern von fortgeschrittenen glykosilierung-endprodukten |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| ATE493987T1 (de) | 2002-05-22 | 2011-01-15 | Amgen Inc | Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen |
| AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| WO2004009552A1 (en) | 2002-07-19 | 2004-01-29 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| WO2006081444A2 (en) | 2005-01-28 | 2006-08-03 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services | Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis |
| FR2849474B3 (fr) | 2002-12-27 | 2004-12-03 | Olivier Jean Noel Juin | Installation de transformation de l'energie cinetique d'un fluide en energie electrique |
| WO2004078731A1 (en) * | 2003-03-06 | 2004-09-16 | 'chemical Diversity Research Institute', Ltd. | Quinoline-carboxylic acids and the derivatives thereof, a focused library |
| FR2859474B1 (fr) | 2003-09-04 | 2006-01-13 | Centre Nat Rech Scient | Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
| FR2859475A1 (fr) | 2003-09-04 | 2005-03-11 | Centre Nat Rech Scient | Utilisation de composes derives d'ellipticine et d'aza-ellipticine pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
| FR2903312B1 (fr) | 2006-07-05 | 2008-09-26 | Univ Aix Marseille Ii | Utilisation d'inhibiteurs d'hmg-coa reductase et de farnesyl-pyrophosphate synthase dans la preparation d'un medicament |
| US8030487B2 (en) | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| FR2912745A1 (fr) | 2007-02-19 | 2008-08-22 | Centre Nat Rech Scient | Nouveaux composes derives d'indole et compositions pharmaceutiques les contenant |
| CA2681481A1 (en) | 2007-03-16 | 2008-09-25 | Mount Sinai School Of Medicine | Induction and/or maintenance of tumor dormancy by disruption of urokinase plasminogen activator receptor-integrin interaction |
| JP5603233B2 (ja) | 2007-05-17 | 2014-10-08 | エルジー・ケム・リミテッド | 新規なアントラセン誘導体およびそれを用いた有機電子素子 |
| CN101801194A (zh) | 2007-08-15 | 2010-08-11 | 记忆医药公司 | 具有5-ht6受体亲和力的3’取代的化合物 |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| KR102016889B1 (ko) | 2009-06-12 | 2019-08-30 | 아비박스 | 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물 |
-
2010
- 2010-12-15 EP EP10306417A patent/EP2465502A1/en not_active Withdrawn
-
2011
- 2011-12-13 CA CA2819317A patent/CA2819317C/en active Active
- 2011-12-13 DK DK11805230.7T patent/DK2651416T3/en active
- 2011-12-13 ES ES11805230.7T patent/ES2681539T3/es active Active
- 2011-12-13 RU RU2013126947/04A patent/RU2598845C2/ru active
- 2011-12-13 AU AU2011342826A patent/AU2011342826B2/en active Active
- 2011-12-13 BR BR112013014943-4A patent/BR112013014943B1/pt active IP Right Grant
- 2011-12-13 HR HRP20181190TT patent/HRP20181190T1/hr unknown
- 2011-12-13 MX MX2013006322A patent/MX337258B/es active IP Right Grant
- 2011-12-13 PL PL11805230T patent/PL2651416T3/pl unknown
- 2011-12-13 US US13/993,990 patent/US9061999B2/en active Active
- 2011-12-13 KR KR1020137018457A patent/KR101749232B1/ko active Active
- 2011-12-13 PT PT118052307T patent/PT2651416T/pt unknown
- 2011-12-13 WO PCT/IB2011/055643 patent/WO2012080953A1/en not_active Ceased
- 2011-12-13 JP JP2013543948A patent/JP6049630B2/ja active Active
- 2011-12-13 CN CN201180060026.XA patent/CN103415290B/zh active Active
- 2011-12-13 EP EP11805230.7A patent/EP2651416B1/en active Active
- 2011-12-14 AR ARP110104670A patent/AR084277A1/es active IP Right Grant
-
2013
- 2013-05-29 ZA ZA2013/03922A patent/ZA201303922B/en unknown
- 2013-06-13 CU CUP2013000080A patent/CU20130080A7/es unknown
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