JP2013545798A5 - - Google Patents
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- JP2013545798A5 JP2013545798A5 JP2013543948A JP2013543948A JP2013545798A5 JP 2013545798 A5 JP2013545798 A5 JP 2013545798A5 JP 2013543948 A JP2013543948 A JP 2013543948A JP 2013543948 A JP2013543948 A JP 2013543948A JP 2013545798 A5 JP2013545798 A5 JP 2013545798A5
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- JP
- Japan
- Prior art keywords
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- hydrogen atom
- chloro
- methyl
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 90
- 150000001875 compounds Chemical class 0.000 claims description 28
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 208000030507 AIDS Diseases 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims description 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 17
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 9
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 claims 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- -1 NH 2 group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- LWHIWNYBTZRFEP-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=CC2=NC=1NC1=NC=CC(C)=C1N LWHIWNYBTZRFEP-UHFFFAOYSA-N 0.000 claims 2
- DEOZHEHMTWAECR-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=NC=CC(C)=C1N DEOZHEHMTWAECR-UHFFFAOYSA-N 0.000 claims 2
- STCNAZVMTAVEOZ-UHFFFAOYSA-N 2-[(3-amino-4-methylpyridin-2-yl)amino]-8-chloro-5-(dimethylsulfamoylamino)quinoline Chemical compound C=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=NC=CC(C)=C1N STCNAZVMTAVEOZ-UHFFFAOYSA-N 0.000 claims 2
- FLGXDPRMCBJQQN-UHFFFAOYSA-N 2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=CC2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 FLGXDPRMCBJQQN-UHFFFAOYSA-N 0.000 claims 2
- CDRBXJDVDCNVCR-UHFFFAOYSA-N 2-[4-[(8-chloroquinolin-2-yl)amino]phenoxy]ethanol Chemical compound C1=CC(OCCO)=CC=C1NC1=CC=C(C=CC=C2Cl)C2=N1 CDRBXJDVDCNVCR-UHFFFAOYSA-N 0.000 claims 2
- UCRMMFCBPWUBIE-UHFFFAOYSA-N 2-n-(3-amino-4-methylpyridin-2-yl)-8-chloro-3-methylquinoline-2,5-diamine Chemical compound CC1=CC=NC(NC=2C(=CC3=C(N)C=CC(Cl)=C3N=2)C)=C1N UCRMMFCBPWUBIE-UHFFFAOYSA-N 0.000 claims 2
- YSOZQQVJTPFTMQ-UHFFFAOYSA-N 2-n-[8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)quinolin-2-yl]-4-methylpyridine-2,3-diamine Chemical compound CC1=CC=NC(NC=2C(=CC3=C(OCCN4CCCCC4)C=CC(Cl)=C3N=2)C)=C1N YSOZQQVJTPFTMQ-UHFFFAOYSA-N 0.000 claims 2
- FPXYLXAMMKEESV-UHFFFAOYSA-N 2-n-[8-chloro-5-(2-morpholin-4-ylethoxy)quinolin-2-yl]-4-methylpyridine-2,3-diamine Chemical compound CC1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCOCC4)C3=CC=2)=C1N FPXYLXAMMKEESV-UHFFFAOYSA-N 0.000 claims 2
- YGWZBJQQLKWYRQ-UHFFFAOYSA-N 8-chloro-2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)-3-methylquinoline Chemical compound CC=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 YGWZBJQQLKWYRQ-UHFFFAOYSA-N 0.000 claims 2
- SHPNFUONBHWVSI-UHFFFAOYSA-N 8-chloro-2-[3-chloro-4-(trifluoromethoxy)anilino]-5-(dimethylsulfamoylamino)quinoline Chemical compound C=1C=C2C(NS(=O)(=O)N(C)C)=CC=C(Cl)C2=NC=1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 SHPNFUONBHWVSI-UHFFFAOYSA-N 0.000 claims 2
- AUTPWUQQIPIRES-UHFFFAOYSA-N 8-chloro-2-n-[3-chloro-4-(trifluoromethoxy)phenyl]-3-methylquinoline-2,5-diamine Chemical compound CC1=CC2=C(N)C=CC(Cl)=C2N=C1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 AUTPWUQQIPIRES-UHFFFAOYSA-N 0.000 claims 2
- LMKDXRLMPNWFJO-UHFFFAOYSA-N 8-chloro-3-methyl-2-n-[4-(trifluoromethyl)pyridin-2-yl]quinoline-2,5-diamine Chemical compound CC1=CC2=C(N)C=CC(Cl)=C2N=C1NC1=CC(C(F)(F)F)=CC=N1 LMKDXRLMPNWFJO-UHFFFAOYSA-N 0.000 claims 2
- AFAFQKALERZORJ-UHFFFAOYSA-N 8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethoxy)phenyl]quinolin-2-amine Chemical compound C1=CC(Cl)=C2N=C(NC=3C=CC(OC(F)(F)F)=CC=3)C(C)=CC2=C1OCCN1CCCCC1 AFAFQKALERZORJ-UHFFFAOYSA-N 0.000 claims 2
- SGTKQHGNCBULSG-UHFFFAOYSA-N 8-chloro-3-methyl-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound C1=CC(Cl)=C2N=C(NC=3N=CC=C(C=3)C(F)(F)F)C(C)=CC2=C1OCCN1CCCCC1 SGTKQHGNCBULSG-UHFFFAOYSA-N 0.000 claims 2
- QJRSHFGNVORSNK-UHFFFAOYSA-N 8-chloro-5-(2-morpholin-4-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound FC(F)(F)C1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCOCC4)C3=CC=2)=C1 QJRSHFGNVORSNK-UHFFFAOYSA-N 0.000 claims 2
- GTIAINXNOUGZHA-UHFFFAOYSA-N 8-chloro-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethoxy)phenyl]quinolin-2-amine Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC1=CC=C(C(OCCN2CCCCC2)=CC=C2Cl)C2=N1 GTIAINXNOUGZHA-UHFFFAOYSA-N 0.000 claims 2
- VFTVHCSXVHUNNI-UHFFFAOYSA-N 8-chloro-5-(2-piperidin-1-ylethoxy)-n-[4-(trifluoromethyl)pyridin-2-yl]quinolin-2-amine Chemical compound FC(F)(F)C1=CC=NC(NC=2N=C3C(Cl)=CC=C(OCCN4CCCCC4)C3=CC=2)=C1 VFTVHCSXVHUNNI-UHFFFAOYSA-N 0.000 claims 2
- ULCABPKCNGZGAZ-UHFFFAOYSA-N 8-chloro-n-(3-chloro-4-methoxyphenyl)-5-(2-morpholin-4-ylethoxy)quinolin-2-amine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=CC=C(C(OCCN2CCOCC2)=CC=C2Cl)C2=N1 ULCABPKCNGZGAZ-UHFFFAOYSA-N 0.000 claims 2
- JREVCPFWYFNPGG-UHFFFAOYSA-N 8-chloro-n-[3-chloro-4-(trifluoromethoxy)phenyl]-5-(2-piperidin-1-ylethoxy)quinolin-2-amine Chemical compound C1=C(Cl)C(OC(F)(F)F)=CC=C1NC1=CC=C(C(OCCN2CCCCC2)=CC=C2Cl)C2=N1 JREVCPFWYFNPGG-UHFFFAOYSA-N 0.000 claims 2
- IICKDKFFDMYJSX-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-(2-morpholin-4-ylethoxy)phenyl]quinolin-2-amine Chemical compound COC1=CC=C(NC=2N=C3C(Cl)=CC=CC3=CC=2)C=C1OCCN1CCOCC1 IICKDKFFDMYJSX-UHFFFAOYSA-N 0.000 claims 2
- IDQIZEYRBHTFBR-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-(2-piperidin-1-ylethoxy)phenyl]quinolin-2-amine Chemical compound COC1=CC=C(NC=2N=C3C(Cl)=CC=CC3=CC=2)C=C1OCCN1CCCCC1 IDQIZEYRBHTFBR-UHFFFAOYSA-N 0.000 claims 2
- SZNXWCCWQXCTNP-UHFFFAOYSA-N 8-chloro-n-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]phenyl]quinolin-2-amine Chemical compound C1=C(OC)C(OCCOCCOC)=CC(NC=2N=C3C(Cl)=CC=CC3=CC=2)=C1 SZNXWCCWQXCTNP-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- GTEQYEMPPBFZQT-UHFFFAOYSA-N n-[3-methyl-2-[[4-(trifluoromethyl)pyridin-2-yl]amino]quinolin-5-yl]methanesulfonamide Chemical compound CC1=CC2=C(NS(C)(=O)=O)C=CC=C2N=C1NC1=CC(C(F)(F)F)=CC=N1 GTEQYEMPPBFZQT-UHFFFAOYSA-N 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- HAVWZAULCLKNBA-UHFFFAOYSA-N n-[2-[3-chloro-4-(trifluoromethoxy)anilino]-3-methylquinolin-5-yl]methanesulfonamide Chemical compound CC1=CC2=C(NS(C)(=O)=O)C=CC=C2N=C1NC1=CC=C(OC(F)(F)F)C(Cl)=C1 HAVWZAULCLKNBA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 0 *c(cc1*)c(*)c(cc2*)c1nc2N(*)c1c(*)c(*)c(*)c(*)c1*=* Chemical compound *c(cc1*)c(*)c(cc2*)c1nc2N(*)c1c(*)c(*)c(*)c(*)c1*=* 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10306417A EP2465502A1 (en) | 2010-12-15 | 2010-12-15 | Compounds useful for treating AIDS |
| EP10306417.6 | 2010-12-15 | ||
| PCT/IB2011/055643 WO2012080953A1 (en) | 2010-12-15 | 2011-12-13 | Compounds useful for treating aids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545798A JP2013545798A (ja) | 2013-12-26 |
| JP2013545798A5 true JP2013545798A5 (enExample) | 2015-02-05 |
| JP6049630B2 JP6049630B2 (ja) | 2016-12-21 |
Family
ID=43755105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543948A Active JP6049630B2 (ja) | 2010-12-15 | 2011-12-13 | Ａｉｄｓを処置する為に有用な化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9061999B2 (enExample) |
| EP (2) | EP2465502A1 (enExample) |
| JP (1) | JP6049630B2 (enExample) |
| KR (1) | KR101749232B1 (enExample) |
| CN (1) | CN103415290B (enExample) |
| AR (1) | AR084277A1 (enExample) |
| AU (1) | AU2011342826B2 (enExample) |
| BR (1) | BR112013014943B1 (enExample) |
| CA (1) | CA2819317C (enExample) |
| CU (1) | CU20130080A7 (enExample) |
| DK (1) | DK2651416T3 (enExample) |
| ES (1) | ES2681539T3 (enExample) |
| HR (1) | HRP20181190T1 (enExample) |
| MX (1) | MX337258B (enExample) |
| PL (1) | PL2651416T3 (enExample) |
| PT (1) | PT2651416T (enExample) |
| RU (1) | RU2598845C2 (enExample) |
| WO (1) | WO2012080953A1 (enExample) |
| ZA (1) | ZA201303922B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
| SI2440547T1 (sl) | 2009-06-12 | 2023-05-31 | Abivax | Nove kemične molekule, ki zavirajo mehanizem spajanja za zdravljenje bolezni, ki so posledica napak pri spajanju |
| EP2757161A1 (en) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 as a biomarker of viral infection |
| CN105530938B (zh) * | 2013-07-05 | 2019-10-22 | Abivax公司 | 用于治疗由逆转录病毒引起的疾病的化合物 |
| EP2974729A1 (en) * | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
| EP2975034A1 (en) * | 2014-07-17 | 2016-01-20 | Abivax | A quinoline derivative for the treatment of inflammatory diseases and AIDS |
| EP3059236A1 (en) | 2015-02-23 | 2016-08-24 | Abivax | A new quinoline derivative for use in the treatment and prevention of viral infections |
| EP3058940A1 (en) * | 2015-02-23 | 2016-08-24 | Abivax | Quinoline derivatives for use in the treatment or prevention of viral infection |
| EP3059591A1 (en) | 2015-02-23 | 2016-08-24 | Abivax | Methods for screening compounds for treating or preventing a viral infection or a virus-related condition |
| EP3337481B1 (en) | 2015-08-21 | 2020-11-11 | The University of Kansas | Quinoline-2-amine derivatives as human tlr8-selective agonists for increasing immune response |
| PT3429998T (pt) | 2016-03-18 | 2021-11-04 | Prosynergia S A R L | Processo para preparação de derivados de quinolin-2-il-fenilamina e seus sais |
| KR101966351B1 (ko) * | 2016-06-08 | 2019-04-08 | 한국과학기술연구원 | 히스톤 메틸전달효소 저해용 퀴놀린 유도체 및 이의 용도 |
| WO2019002228A1 (en) | 2017-06-26 | 2019-01-03 | Institut Pasteur | TREATMENTS TO REMOVE HIV RESERVOIRS AND REDUCE VIRAL LOAD |
| WO2019186277A1 (en) | 2018-03-28 | 2019-10-03 | Institut Pasteur | Ultrasensitive hiv-1 p24 detection assay |
| EP3594205A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl derivatives for treating a rna virus infection |
| EP3594206A1 (en) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-quinoline derivatives for treating a rna virus infection |
| EP3669873A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use ine the traeatment of inflammation diseases |
| WO2020128033A1 (en) | 2018-12-20 | 2020-06-25 | Institut Pasteur | Cellular metabolism of hiv-1 reservoir seeding in cd4+ t cells |
| EP3669874A1 (en) * | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use in the treatment or prevention of cancer |
| CN109776498B (zh) * | 2019-03-13 | 2020-04-07 | 浙江永宁药业股份有限公司 | 一种西洛他唑的制备方法 |
| EP4063351A1 (en) * | 2021-03-26 | 2022-09-28 | Abivax | Preparation method of quinoline derivative compounds |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| EP4215196A1 (en) | 2022-01-24 | 2023-07-26 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a jak inhibitor |
| CN120152971A (zh) * | 2022-11-25 | 2025-06-13 | 江苏恒瑞医药股份有限公司 | 一种喹啉胺类化合物晶型及其制备方法 |
| WO2025027388A1 (en) | 2023-08-01 | 2025-02-06 | Abivax | Obefazimod for treatment of ulcerative colitis |
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| US2419199A (en) * | 1945-02-09 | 1947-04-22 | Parke Davis & Co | Quinoline compounds and process of making same |
| FR2387229A1 (fr) | 1977-04-13 | 1978-11-10 | Anvar | Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| FR2436786A1 (fr) | 1978-09-21 | 1980-04-18 | Anvar | Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments |
| JPS59501318A (ja) * | 1982-07-26 | 1984-07-26 | アメリカン ホスピタル サプライ コ−ポレ−シヨン | ヘテロアリ−ル置換アミノメチルベンゼン誘導体 |
| US4466965A (en) * | 1982-07-26 | 1984-08-21 | American Hospital Supply Corporation | Phthalazine compounds, compositions and use |
| FR2627493B1 (fr) | 1988-02-23 | 1991-10-31 | Sanofi Sa | Procede de preparation de derives d'isoquinoleine |
| FR2645861A1 (fr) | 1989-04-17 | 1990-10-19 | Inst Nat Sante Rech Med | Utilisation de dipyrido (4,3-b) (3,4-f) indoles pour la preparation de medicaments utiles pour le traitement du sida |
| CA2368688C (en) | 1999-04-05 | 2009-08-11 | City Of Hope | Novel inhibitors of formation of advanced glycation endproducts (age's) |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| MXPA04011472A (es) | 2002-05-22 | 2005-02-14 | Amgen Inc | Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor. |
| AU2002950217A0 (en) | 2002-07-16 | 2002-09-12 | Prana Biotechnology Limited | 8- Hydroxy Quinoline Derivatives |
| AU2003256616B2 (en) | 2002-07-19 | 2009-08-27 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| FR2849474B3 (fr) | 2002-12-27 | 2004-12-03 | Olivier Jean Noel Juin | Installation de transformation de l'energie cinetique d'un fluide en energie electrique |
| WO2004078731A1 (en) * | 2003-03-06 | 2004-09-16 | 'chemical Diversity Research Institute', Ltd. | Quinoline-carboxylic acids and the derivatives thereof, a focused library |
| FR2859475A1 (fr) | 2003-09-04 | 2005-03-11 | Centre Nat Rech Scient | Utilisation de composes derives d'ellipticine et d'aza-ellipticine pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
| FR2859474B1 (fr) | 2003-09-04 | 2006-01-13 | Centre Nat Rech Scient | Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage |
| EP1853265B1 (en) | 2005-01-28 | 2016-01-27 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Farnesyltransferase inhibitors for use in the treatment of laminopathies, cellular aging and atherosclerosis |
| FR2903312B1 (fr) | 2006-07-05 | 2008-09-26 | Univ Aix Marseille Ii | Utilisation d'inhibiteurs d'hmg-coa reductase et de farnesyl-pyrophosphate synthase dans la preparation d'un medicament |
| WO2008008234A1 (en) | 2006-07-07 | 2008-01-17 | Targegen, Inc. | 2-amino-5-substituted pyrimidine inhibitors |
| FR2912745A1 (fr) | 2007-02-19 | 2008-08-22 | Centre Nat Rech Scient | Nouveaux composes derives d'indole et compositions pharmaceutiques les contenant |
| WO2008115870A2 (en) | 2007-03-16 | 2008-09-25 | Mount Sinai School Of Medicine | Induction and/or maintenance of tumor dormancy by disruption of urokinase plasminogen activator receptor-integrin interaction |
| CN101679150B (zh) | 2007-05-17 | 2013-05-15 | Lg化学株式会社 | 蒽衍生物和使用该蒽衍生物的有机电子器件 |
| CN101801194A (zh) | 2007-08-15 | 2010-08-11 | 记忆医药公司 | 具有5-ht6受体亲和力的3’取代的化合物 |
| FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
| SI2440547T1 (sl) | 2009-06-12 | 2023-05-31 | Abivax | Nove kemične molekule, ki zavirajo mehanizem spajanja za zdravljenje bolezni, ki so posledica napak pri spajanju |
-
2010
- 2010-12-15 EP EP10306417A patent/EP2465502A1/en not_active Withdrawn
-
2011
- 2011-12-13 JP JP2013543948A patent/JP6049630B2/ja active Active
- 2011-12-13 RU RU2013126947/04A patent/RU2598845C2/ru active
- 2011-12-13 US US13/993,990 patent/US9061999B2/en active Active
- 2011-12-13 BR BR112013014943-4A patent/BR112013014943B1/pt active IP Right Grant
- 2011-12-13 ES ES11805230.7T patent/ES2681539T3/es active Active
- 2011-12-13 MX MX2013006322A patent/MX337258B/es active IP Right Grant
- 2011-12-13 PL PL11805230T patent/PL2651416T3/pl unknown
- 2011-12-13 PT PT118052307T patent/PT2651416T/pt unknown
- 2011-12-13 CA CA2819317A patent/CA2819317C/en active Active
- 2011-12-13 EP EP11805230.7A patent/EP2651416B1/en active Active
- 2011-12-13 KR KR1020137018457A patent/KR101749232B1/ko not_active Expired - Fee Related
- 2011-12-13 AU AU2011342826A patent/AU2011342826B2/en active Active
- 2011-12-13 DK DK11805230.7T patent/DK2651416T3/en active
- 2011-12-13 HR HRP20181190TT patent/HRP20181190T1/hr unknown
- 2011-12-13 WO PCT/IB2011/055643 patent/WO2012080953A1/en not_active Ceased
- 2011-12-13 CN CN201180060026.XA patent/CN103415290B/zh active Active
- 2011-12-14 AR ARP110104670A patent/AR084277A1/es active IP Right Grant
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2013
- 2013-05-29 ZA ZA2013/03922A patent/ZA201303922B/en unknown
- 2013-06-13 CU CUP2013000080A patent/CU20130080A7/es unknown
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