JP2016535769A5 - - Google Patents
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- JP2016535769A5 JP2016535769A5 JP2016551037A JP2016551037A JP2016535769A5 JP 2016535769 A5 JP2016535769 A5 JP 2016535769A5 JP 2016551037 A JP2016551037 A JP 2016551037A JP 2016551037 A JP2016551037 A JP 2016551037A JP 2016535769 A5 JP2016535769 A5 JP 2016535769A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- represents hydrogen
- here
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC(C1)=CC=C/C=C/[C@](C2)C1=CC=C2*=C Chemical compound CC(C1)=CC=C/C=C/[C@](C2)C1=CC=C2*=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13192183 | 2013-11-08 | ||
| EP13192183.5 | 2013-11-08 | ||
| PCT/EP2014/073800 WO2015067651A1 (de) | 2013-11-08 | 2014-11-05 | Substituierte uracile als chymase inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535769A JP2016535769A (ja) | 2016-11-17 |
| JP2016535769A5 true JP2016535769A5 (enExample) | 2017-12-14 |
Family
ID=49582563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551037A Ceased JP2016535769A (ja) | 2013-11-08 | 2014-11-05 | キマーゼ阻害薬としての置換されているウラシル類 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9695131B2 (enExample) |
| EP (1) | EP3066096A1 (enExample) |
| JP (1) | JP2016535769A (enExample) |
| CN (1) | CN105873919A (enExample) |
| CA (1) | CA2929763A1 (enExample) |
| HK (1) | HK1224288A1 (enExample) |
| WO (1) | WO2015067651A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2929780C (en) * | 2013-11-08 | 2022-03-22 | Bayer Pharma Aktiengesellschaft | Salts of 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1r)-4-(trifluormethyl)-2,3-dihydro-1h-inden-1-yl]-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid |
| EP3338780A1 (de) | 2016-12-20 | 2018-06-27 | Bayer Pharma Aktiengesellschaft | Verwendung von chymaseinhibitoren zur behandlung von endometriose, post-operativer fibrose und erkrankungen die durch fibrosebildung gekennzeichnet sind |
| EP3615031A1 (en) * | 2017-04-27 | 2020-03-04 | Bayer Aktiengesellschaft | Selective adrenoreceptor alpha2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad) |
| WO2021000933A1 (zh) * | 2019-07-03 | 2021-01-07 | 南京明德新药研发有限公司 | 作为糜酶抑制剂的嘧啶酮类化合物及其应用 |
| GB201918414D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
| WO2022135502A1 (zh) * | 2020-12-25 | 2022-06-30 | 广东东阳光药业有限公司 | 多取代的尿嘧啶衍生物及其用途 |
| CN114671878B (zh) * | 2020-12-25 | 2023-08-04 | 广东东阳光药业有限公司 | 取代的含氮双环化合物及其用途 |
| CN114685472B (zh) * | 2020-12-25 | 2024-04-26 | 广东东阳光药业股份有限公司 | 多取代的尿嘧啶衍生物及其用途 |
| JP2025511834A (ja) | 2022-04-05 | 2025-04-16 | ソクプラ シオンス ソンテ エ ユーメン エス．ウ．シ． | 血栓性または血栓塞栓性障害における血栓の選択的溶解に使用するためのキマーゼの阻害剤 |
| CN118994100A (zh) * | 2023-05-22 | 2024-11-22 | 苏州大学 | 一种二酮类化合物及其制备方法与应用 |
| CN119019341B (zh) * | 2023-05-23 | 2025-11-18 | 苏州大学 | 一种腈类化合物及其制备方法与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0721944B1 (en) * | 1994-07-29 | 2001-01-17 | Suntory Limited | Imidazolidine derivative and use thereof |
| CA2219364A1 (en) * | 1995-04-27 | 1996-10-31 | Hideki Okunishi | Heterocyclic amide compounds and pharmaceutical use thereof |
| JP4199309B2 (ja) * | 1996-09-06 | 2008-12-17 | 日本化薬株式会社 | 新規アセトアミド誘導体およびプロテアーゼ阻害 |
| JPH10195063A (ja) | 1996-10-21 | 1998-07-28 | Dai Ichi Seiyaku Co Ltd | エチニルチアゾール誘導体 |
| CN1088706C (zh) * | 1996-10-25 | 2002-08-07 | 卫福有限公司 | 新型杂环酰胺化合物及其医药用途 |
| US6300337B1 (en) * | 1998-02-17 | 2001-10-09 | Nippon Kayaku Kabushiki Kaisha | Acetamide derivative and use thereof |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| KR20010109356A (ko) * | 2000-02-22 | 2001-12-08 | 도리이 신이치로 | 키마제 억제제를 유효성분으로 함유하는 피부염의 예방또는 치료제 |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| EP1968950A4 (en) | 2005-12-19 | 2010-04-28 | Genentech Inc | PYRIMIDINKINASEINHIBITOREN |
| WO2007122634A2 (en) * | 2006-04-24 | 2007-11-01 | Jubilant Biosys Limited | Pyrimidinediones as tyrosine kinase inhibitors |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| GB0622472D0 (en) | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
| EP2114898A2 (en) | 2007-02-16 | 2009-11-11 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
| WO2009049112A1 (en) | 2007-10-10 | 2009-04-16 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
| DE102008030091B4 (de) | 2008-06-25 | 2011-03-03 | Resprotect Gmbh | Uracilderivate und deren Verwendung |
| PL2318006T3 (pl) | 2008-08-15 | 2017-06-30 | Nivalis Therapeutics, Inc. | Nowe inhibitory pirolowe reduktazy S-nitrozoglutationu jako środki terapeutyczne |
| ES2614824T3 (es) | 2011-11-14 | 2017-06-02 | Ignyta, Inc. | Derivados de uracil como inhibidores de la quinasa axl y c-met |
| UA112897C2 (uk) * | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
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2014
- 2014-11-05 EP EP14799368.7A patent/EP3066096A1/de not_active Withdrawn
- 2014-11-05 JP JP2016551037A patent/JP2016535769A/ja not_active Ceased
- 2014-11-05 WO PCT/EP2014/073800 patent/WO2015067651A1/de not_active Ceased
- 2014-11-05 CA CA2929763A patent/CA2929763A1/en not_active Abandoned
- 2014-11-05 HK HK16112522.4A patent/HK1224288A1/zh unknown
- 2014-11-05 US US15/034,995 patent/US9695131B2/en active Active
- 2014-11-05 CN CN201480071681.9A patent/CN105873919A/zh active Pending
-
2017
- 2017-06-01 US US15/611,467 patent/US20170267648A1/en not_active Abandoned