JP2004175807A5 - - Google Patents
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- Publication number
- JP2004175807A5 JP2004175807A5 JP2004027473A JP2004027473A JP2004175807A5 JP 2004175807 A5 JP2004175807 A5 JP 2004175807A5 JP 2004027473 A JP2004027473 A JP 2004027473A JP 2004027473 A JP2004027473 A JP 2004027473A JP 2004175807 A5 JP2004175807 A5 JP 2004175807A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- formula
- ring
- pharmaceutically acceptable
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000651 prodrug Substances 0.000 claims 33
- 229940002612 prodrug Drugs 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 33
- 239000012453 solvate Substances 0.000 claims 32
- 125000001424 substituent group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000002947 alkylene group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000003107 substituted aryl group Chemical group 0.000 claims 14
- 125000004429 atom Chemical group 0.000 claims 13
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- -1 hydroxy, mercapto Chemical group 0.000 claims 11
- 150000001540 azides Chemical class 0.000 claims 10
- 125000004450 alkenylene group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000004509 1,3,4-oxadiazol-2-yl group Chemical group O1C(=NN=C1)* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- YIBBMDDEXKBIAM-UHFFFAOYSA-M potassium;pentoxymethanedithioate Chemical compound [K+].CCCCCOC([S-])=S YIBBMDDEXKBIAM-UHFFFAOYSA-M 0.000 claims 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 4
- 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000005368 heteroarylthio group Chemical group 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000005164 aryl thioalkyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 2
- IRSGOAFJPADUHK-UHFFFAOYSA-N 1-(5-benzyl-8-hydroxyquinolin-7-yl)ethanone Chemical compound C=12C=CC=NC2=C(O)C(C(=O)C)=CC=1CC1=CC=CC=C1 IRSGOAFJPADUHK-UHFFFAOYSA-N 0.000 claims 1
- JZVCTHJWXFRYKG-UHFFFAOYSA-N 1-(8-hydroxy-5-phenylquinolin-7-yl)ethanone Chemical compound C=12C=CC=NC2=C(O)C(C(=O)C)=CC=1C1=CC=CC=C1 JZVCTHJWXFRYKG-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000003084 hiv integrase inhibitor Substances 0.000 claims 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
- LHKVDVFVJMYULK-UHFFFAOYSA-N nitrosylazide Chemical compound [N-]=[N+]=NN=O LHKVDVFVJMYULK-UHFFFAOYSA-N 0.000 claims 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000000464 thioxo group Chemical group S=* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004027473A JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001057037 | 2001-03-01 | ||
| JP2001243530 | 2001-08-10 | ||
| JP2001395022 | 2001-12-26 | ||
| JP2004027473A JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Division JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004175807A JP2004175807A (ja) | 2004-06-24 |
| JP2004175807A5 true JP2004175807A5 (enExample) | 2005-06-23 |
| JP4367762B2 JP4367762B2 (ja) | 2009-11-18 |
Family
ID=27346141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Expired - Fee Related JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
| JP2004027473A Expired - Fee Related JP4367762B2 (ja) | 2001-03-01 | 2004-02-04 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569806A Expired - Fee Related JP3616628B2 (ja) | 2001-03-01 | 2002-02-27 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7148237B2 (enExample) |
| EP (2) | EP2033952B1 (enExample) |
| JP (2) | JP3616628B2 (enExample) |
| KR (1) | KR20030078958A (enExample) |
| CN (1) | CN1659143A (enExample) |
| AT (1) | ATE411292T1 (enExample) |
| BR (1) | BR0207809A (enExample) |
| CA (1) | CA2439666A1 (enExample) |
| CZ (1) | CZ20032332A3 (enExample) |
| DE (1) | DE60229364D1 (enExample) |
| HU (1) | HUP0400175A2 (enExample) |
| IL (1) | IL157638A0 (enExample) |
| MX (1) | MXPA03007765A (enExample) |
| NO (1) | NO20033848L (enExample) |
| PL (1) | PL365027A1 (enExample) |
| WO (1) | WO2002070486A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ511255A (en) * | 2001-04-20 | 2003-12-19 | Deep Video Imaging Ltd | Multi-focal plane display having an optical retarder and a diffuser interposed between its screens |
| ATE530520T1 (de) | 2001-08-10 | 2011-11-15 | Shionogi & Co | Antivirales mittel |
| DE10145457A1 (de) * | 2001-09-14 | 2003-04-03 | Basf Ag | Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen |
| DE122009000048I1 (de) * | 2001-10-26 | 2010-04-08 | Angeletti P Ist Richerche Bio | N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase |
| CA2463975A1 (en) * | 2001-10-26 | 2003-05-01 | Maria Emilia Di Francesco | Dihydroxypyrimidine carboxamide inhibitors of hiv integrase |
| WO2003077857A2 (en) * | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
| ATE404537T1 (de) | 2002-08-13 | 2008-08-15 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung |
| PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
| US7176220B2 (en) | 2002-11-20 | 2007-02-13 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as pharmaceutical agent |
| CA2513141A1 (en) | 2003-01-27 | 2004-08-12 | Pfizer Inc. | Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use |
| JP2006528694A (ja) * | 2003-05-13 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | ナフチリジンインテグラーゼインヒビター |
| CN1240700C (zh) * | 2003-06-18 | 2006-02-08 | 复旦大学 | 芳杂环羧酸衍生物，制备方法及在药学上的应用 |
| CN1976915A (zh) | 2004-02-11 | 2007-06-06 | 史密丝克莱恩比彻姆公司 | Hiv整合酶抑制剂 |
| WO2005087768A1 (en) * | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| BRPI0510319A (pt) | 2004-04-26 | 2007-10-16 | Pfizer | inibidores da enzima integrase de hiv |
| DE602005002746T2 (de) | 2004-04-26 | 2008-02-07 | Pfizer Inc. | Inhibitoren des hiv-integrase-enzyms |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| US8633219B2 (en) * | 2004-05-21 | 2014-01-21 | Japan Tobacco Inc. | Combination therapy |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| CN101076531A (zh) | 2004-10-12 | 2007-11-21 | 解码遗传学公司 | 用于阻塞性血管疾病的羧酸迫位取代的双环化合物 |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| JP2008542352A (ja) * | 2005-06-01 | 2008-11-27 | ビオアリアンス ファルマ | キノリン化合物及び他のｈｉｖ感染治療薬を含む相乗作用のコンビネーション |
| ES2399061T3 (es) * | 2005-09-30 | 2013-03-25 | Pulmagen Therapeutics (Asthma) Limited | Quinolinas y su uso terapéutico |
| JP5094725B2 (ja) * | 2005-10-04 | 2012-12-12 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | Ｈｉｖインテグラーゼ阻害剤 |
| EP1978960A4 (en) * | 2006-02-01 | 2009-12-02 | Japan Tobacco Inc | USE OF 6- (3-CHLORO-2-FLUORBENZYL) -1 - [(2S) -1-HYDROXY-3-METHYLBUTAN-2-YL [-7-METHOXY-4-OXO-1,4-DIHYDROCHINOLINE-3- CARBOXYLIC ACID OR SALT THEREOF FOR THE TREATMENT OF RETROVIRUS INFECTION |
| CN102633783A (zh) * | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| JP4669040B2 (ja) | 2006-03-06 | 2011-04-13 | 日本たばこ産業株式会社 | ４−オキソキノリン化合物の製造方法 |
| EP2010520B1 (en) * | 2006-04-20 | 2012-09-12 | Pfizer Products Inc. | Heterobicyclic amides for the prevention and treatment of glucokinase-mediated diseases |
| EP2079699A1 (en) * | 2006-07-25 | 2009-07-22 | Envivo Pharmaceuticals, Inc. | Quinoline derivatives |
| ATE554085T1 (de) * | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP2010535804A (ja) * | 2007-08-09 | 2010-11-25 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体 |
| JP2012507530A (ja) * | 2008-10-29 | 2012-03-29 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病剤である新規な環状ベンズイミダゾール誘導体 |
| FR2938538B1 (fr) * | 2008-11-17 | 2011-08-05 | Univ Nice Sophia Antipolis | Procede de preparation d'acides et d'esters boroniques en presence de magnesium metallique |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| EP2448938B9 (en) | 2009-06-29 | 2015-06-10 | Incyte Corporation | Pyrimidinones as pi3k inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
| WO2011076765A1 (en) * | 2009-12-23 | 2011-06-30 | Katholieke Universiteit Leuven | Novel antiviral compounds |
| EP2345643A1 (en) | 2009-12-29 | 2011-07-20 | Polichem S.A. | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof |
| EP2345642A1 (en) | 2009-12-29 | 2011-07-20 | Polichem S.A. | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents |
| EP2345641A1 (en) | 2009-12-29 | 2011-07-20 | Polichem S.A. | New secondary 8-hydroxyquinoline-7-carboxamide derivatives |
| ES2586231T3 (es) * | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| JP5744021B2 (ja) | 2010-06-30 | 2015-07-01 | 富士フイルム株式会社 | 新規なニコチンアミド誘導体またはその塩 |
| US8633200B2 (en) * | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| KR20140003438A (ko) | 2010-11-15 | 2014-01-09 | 카톨리에케 유니버시테이트 루벤 | 항바이러스성 축합 헤테로사이클릭 화합물 |
| JP5961187B2 (ja) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| MX389479B (es) | 2011-09-02 | 2025-03-20 | Incyte Holdings Corp | Heterociclilaminas como inhibidores de fosfoinositida 3-cinasas (pi3k) |
| US9089574B2 (en) | 2011-11-30 | 2015-07-28 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| KR102307566B1 (ko) | 2013-06-21 | 2021-10-05 | 제니쓰 에피제네틱스 리미티드 | 신규한 바이사이클릭 브로모도메인 억제제 |
| CN105473581B (zh) | 2013-06-21 | 2019-04-23 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新取代的双环化合物 |
| CA2919948C (en) | 2013-07-31 | 2020-07-21 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
| CN103554019B (zh) * | 2013-09-30 | 2015-08-05 | 浙江工业大学 | 一种甲溴羟喹的合成方法 |
| CN104140402B (zh) * | 2014-05-27 | 2016-01-20 | 天津市斯芬克司药物研发有限公司 | 一种苯并噻唑类化合物及其制备方法 |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| CN104447543B (zh) * | 2014-11-10 | 2016-08-24 | 苏州康润医药有限公司 | 3-氨基-7，8-二氟喹啉及其中间体的合成方法 |
| CN104447547B (zh) * | 2014-11-10 | 2017-04-19 | 苏州康润医药有限公司 | 4‑氨基异喹啉‑8‑甲酸甲酯的合成方法 |
| HK1245246A1 (zh) | 2014-12-01 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 作为溴域抑制剂的取代吡啶酮 |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| CN107406438B (zh) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| SG10201912302VA (en) | 2015-02-27 | 2020-02-27 | Incyte Corp | Salts of pi3k inhibitor and processes for their preparation |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| IL278889B2 (en) | 2018-06-01 | 2025-11-01 | Incyte Corp | Dosing regimen for the treatment of pi3k related disorders |
| JP7337174B2 (ja) | 2018-09-18 | 2023-09-01 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体 |
| WO2025264844A1 (en) * | 2024-06-20 | 2025-12-26 | Lieber Institute, Inc. | Heterocyclic gpr52 modulators and methods of use thereof |
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| JPS587637B2 (ja) * | 1973-12-27 | 1983-02-10 | 住友化学工業株式会社 | シンキペニシリンノ セイホウ |
| JPS5227794A (en) | 1975-08-29 | 1977-03-02 | Sumitomo Chem Co Ltd | Preparation of synthesis of nnacylaminoo arylacetamido cephalosporin s |
| JPS5268193A (en) * | 1975-11-28 | 1977-06-06 | Sumitomo Chem Co Ltd | Synthesis of novel cephalosporin derivatives |
| JPS5293790A (en) | 1976-02-02 | 1977-08-06 | Sumitomo Chem Co Ltd | 7-(n-acylamino-alpha-arylacetamide) cephalosporins |
| JPH0527385A (ja) | 1991-07-24 | 1993-02-05 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| US5681832A (en) * | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
| AU4172197A (en) | 1996-09-10 | 1998-04-02 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| FR2761687B1 (fr) | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| IL137974A0 (en) | 1998-03-26 | 2001-10-31 | Shionogi & Co | Indole derivatives having antiviral activity |
| AU757409B2 (en) | 1998-06-03 | 2003-02-20 | Merck & Co., Inc. | Hiv integrase inhibitors |
| AU4225499A (en) | 1998-06-03 | 1999-12-20 | Merck & Co., Inc. | Hiv integrase inhibitors |
| WO1999062513A1 (en) | 1998-06-03 | 1999-12-09 | Merck & Co., Inc. | Hiv integrase inhibitors |
| WO2001000578A1 (en) | 1999-06-25 | 2001-01-04 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
| US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| JP2004517860A (ja) | 2000-10-12 | 2004-06-17 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類 |
| AU1532802A (en) | 2000-10-12 | 2002-04-22 | Merck & Co Inc | Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors |
| EP1326865B1 (en) * | 2000-10-12 | 2009-05-06 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| AU2002230392A1 (en) | 2000-10-12 | 2002-05-15 | Merck & Co., Inc. | AZA-and polyaza-naphthalenyl ketones useful as HIV integrase inhibitors |
-
2002
- 2002-02-27 CN CN028089219A patent/CN1659143A/zh active Pending
- 2002-02-27 PL PL02365027A patent/PL365027A1/xx not_active Application Discontinuation
- 2002-02-27 AT AT02701583T patent/ATE411292T1/de not_active IP Right Cessation
- 2002-02-27 JP JP2002569806A patent/JP3616628B2/ja not_active Expired - Fee Related
- 2002-02-27 CA CA002439666A patent/CA2439666A1/en not_active Abandoned
- 2002-02-27 HU HU0400175A patent/HUP0400175A2/hu unknown
- 2002-02-27 DE DE60229364T patent/DE60229364D1/de not_active Expired - Lifetime
- 2002-02-27 MX MXPA03007765A patent/MXPA03007765A/es unknown
- 2002-02-27 EP EP08166487A patent/EP2033952B1/en not_active Expired - Lifetime
- 2002-02-27 US US10/469,364 patent/US7148237B2/en not_active Expired - Fee Related
- 2002-02-27 IL IL15763802A patent/IL157638A0/xx unknown
- 2002-02-27 BR BR0207809-0A patent/BR0207809A/pt not_active Application Discontinuation
- 2002-02-27 EP EP02701583A patent/EP1375486B1/en not_active Expired - Lifetime
- 2002-02-27 KR KR10-2003-7011406A patent/KR20030078958A/ko not_active Withdrawn
- 2002-02-27 CZ CZ20032332A patent/CZ20032332A3/cs unknown
- 2002-02-27 WO PCT/JP2002/001778 patent/WO2002070486A1/ja not_active Ceased
-
2003
- 2003-08-29 NO NO20033848A patent/NO20033848L/no not_active Application Discontinuation
-
2004
- 2004-02-04 JP JP2004027473A patent/JP4367762B2/ja not_active Expired - Fee Related
-
2006
- 2006-08-08 US US11/500,387 patent/US7759372B2/en not_active Expired - Fee Related
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