JP2018516238A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516238A5 JP2018516238A5 JP2017551647A JP2017551647A JP2018516238A5 JP 2018516238 A5 JP2018516238 A5 JP 2018516238A5 JP 2017551647 A JP2017551647 A JP 2017551647A JP 2017551647 A JP2017551647 A JP 2017551647A JP 2018516238 A5 JP2018516238 A5 JP 2018516238A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- compound according
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 201000010208 Seminoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 208000020352 skin basal cell carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142589P | 2015-04-03 | 2015-04-03 | |
| US62/142,589 | 2015-04-03 | ||
| PCT/US2016/025554 WO2016161286A1 (en) | 2015-04-03 | 2016-04-01 | Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516238A JP2018516238A (ja) | 2018-06-21 |
| JP2018516238A5 true JP2018516238A5 (enExample) | 2019-05-09 |
Family
ID=55702190
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551647A Pending JP2018516238A (ja) | 2015-04-03 | 2016-04-01 | 癌の治療のためのインドールアミン−２，３−ジオキシゲナーゼの阻害剤およびそれらの使用方法 |
| JP2017551629A Withdrawn JP2018515438A (ja) | 2015-04-03 | 2016-04-01 | 癌の治療のためのインドールアミン−２，３−ジオキシゲナーゼの阻害剤およびそれらの使用方法 |
| JP2017551628A Withdrawn JP2018519245A (ja) | 2015-04-03 | 2016-04-01 | 癌の治療のためのインドールアミン−２，３−ジオキシゲナーゼの阻害剤およびそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551629A Withdrawn JP2018515438A (ja) | 2015-04-03 | 2016-04-01 | 癌の治療のためのインドールアミン−２，３−ジオキシゲナーゼの阻害剤およびそれらの使用方法 |
| JP2017551628A Withdrawn JP2018519245A (ja) | 2015-04-03 | 2016-04-01 | 癌の治療のためのインドールアミン−２，３−ジオキシゲナーゼの阻害剤およびそれらの使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10399932B2 (enExample) |
| EP (3) | EP3277671A1 (enExample) |
| JP (3) | JP2018516238A (enExample) |
| KR (3) | KR20170134981A (enExample) |
| CN (3) | CN108093636A (enExample) |
| AR (1) | AR104176A1 (enExample) |
| AU (3) | AU2016243937A1 (enExample) |
| BR (3) | BR112017020895A2 (enExample) |
| CA (3) | CA2981660A1 (enExample) |
| CL (1) | CL2017002494A1 (enExample) |
| CO (1) | CO2017011183A2 (enExample) |
| EA (3) | EA033395B1 (enExample) |
| HK (1) | HK1247922A1 (enExample) |
| IL (3) | IL254720A0 (enExample) |
| MX (3) | MX2017012729A (enExample) |
| PE (1) | PE20180117A1 (enExample) |
| SG (3) | SG11201807980QA (enExample) |
| TW (1) | TW201700453A (enExample) |
| UY (1) | UY36601A (enExample) |
| WO (3) | WO2016161279A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| NZ723203A (en) | 2014-02-13 | 2020-08-28 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
| PH12020552066A1 (en) | 2014-02-13 | 2022-05-11 | Incyte Corp | Cyclopropylamines as lsd1 inhibitors |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| TW201700453A (zh) * | 2015-04-03 | 2017-01-01 | 必治妥美雅史谷比公司 | Ｉｄｏ抑制劑 |
| TWI714567B (zh) | 2015-04-03 | 2021-01-01 | 美商英塞特公司 | 作為lsd1抑制劑之雜環化合物 |
| LT3334709T (lt) | 2015-08-12 | 2025-03-10 | Incyte Holdings Corporation | Lsd1 inhibitoriaus druskos |
| BR112018005870A2 (pt) * | 2015-09-24 | 2018-10-16 | Glaxosmithkline Ip No 2 Ltd | composto, e, método de prevenção e/ou tratamento do hiv. |
| JP2020502189A (ja) * | 2016-12-20 | 2020-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | インドールアミン２，３−ジオキシゲナーゼのモジュレーター |
| EP3558966A1 (en) * | 2016-12-20 | 2019-10-30 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| AU2017382405B2 (en) | 2016-12-22 | 2021-12-16 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| WO2018136437A2 (en) | 2017-01-17 | 2018-07-26 | Tesaro, Inc. | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| US20200188482A1 (en) * | 2017-04-28 | 2020-06-18 | The Brigham And Women`S Hospital, Inc. | Targeting gamma-delta t cells in obesity and cachexia |
| EP3618818A4 (en) | 2017-05-03 | 2020-12-09 | Vivace Therapeutics, Inc. | NON-CONDENSED TRICYCLIC COMPOUNDS |
| EP3632893A4 (en) * | 2017-06-02 | 2020-12-09 | Shenyang Research Institute of Chemical Industry Co., Ltd. | VINYLARENE DERIVATIVE AND ITS USE |
| JP2020525486A (ja) * | 2017-06-28 | 2020-08-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | インドールアミン２，３−ジオキシゲナーゼのモジュレーター |
| CN107325019B (zh) * | 2017-08-11 | 2019-11-22 | 石河子大学 | 芳胺基苯甲酰胺类化合物及n-芳基-芳胺基苯甲酰胺类化合物的制备方法 |
| EP3691623B1 (en) | 2017-08-21 | 2022-10-05 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| US11180497B2 (en) * | 2017-10-18 | 2021-11-23 | Angex Pharmaceutical, Inc. | Cyclic compounds as immunomodulating agents |
| CN109836356B (zh) * | 2017-11-24 | 2022-03-08 | 沈阳化工研究院有限公司 | 一种芳甲醚衍生物及其应用 |
| WO2019113236A1 (en) | 2017-12-06 | 2019-06-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
| AU2019205904A1 (en) | 2018-01-05 | 2020-06-18 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| US11447449B2 (en) | 2018-01-05 | 2022-09-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2019222431A1 (en) | 2018-05-16 | 2019-11-21 | Vivace Therapeutics, Inc. | Oxadiazole compounds |
| CA3104398A1 (en) * | 2018-07-06 | 2020-01-09 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| WO2020023355A1 (en) * | 2018-07-23 | 2020-01-30 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
| CN109608334B (zh) * | 2019-01-11 | 2021-07-13 | 盐城通海生物科技有限公司 | 一种合成4-甲氧基巴豆酸甲酯的方法 |
| CA3128064A1 (en) * | 2019-02-01 | 2020-08-06 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments for cancer comprising belantamab mafodotin and an anti ox40 antibody and uses and methods thereof |
| KR102386849B1 (ko) * | 2019-10-14 | 2022-04-13 | 포항공과대학교 산학협력단 | 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법 |
| WO2021102618A1 (en) * | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| CN113214138A (zh) * | 2020-02-04 | 2021-08-06 | 中国医学科学院药物研究所 | 苯丙酸类衍生物、及其制法和药物组合物与用途 |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
| CN112174891B (zh) * | 2020-11-02 | 2022-02-01 | 浙江省农业科学院 | 一种氟唑菌苯胺代谢物的制备方法 |
| JP2024016314A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | 一般式（ｉ－ａ）で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および／またはｅｐ４受容体拮抗薬との組み合わせ |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| JP2024510949A (ja) | 2021-03-05 | 2024-03-12 | ウニヴェルシタット・バーゼル | Ｅｂｖ関連疾患又は状態の治療用組成物 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3622337A (en) * | 1968-08-02 | 1971-11-23 | Gaf Corp | Cyan color formers for color photography |
| US4252894A (en) * | 1975-10-22 | 1981-02-24 | Gaf Corporation | Hydrophilic color coupler composition containing diepoxide |
| US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
| WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CN1882529A (zh) * | 2003-09-24 | 2006-12-20 | 梅特希尔基因公司 | 组蛋白脱乙酰基酶抑制剂 |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| WO2006105021A2 (en) | 2005-03-25 | 2006-10-05 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
| SG10201809390QA (en) | 2005-05-10 | 2018-11-29 | Incyte Holdings Corp | Modulators of indoleamine 2,3-dioxygenase and methods of using the same |
| AU2006265108C1 (en) | 2005-07-01 | 2013-01-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
| EP1971583B1 (en) | 2005-12-20 | 2015-03-25 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CA2649043C (en) * | 2006-04-19 | 2013-09-17 | Astellas Pharma Inc. | Azolecarboxamide derivative |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| JP5319532B2 (ja) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼのモジュレーターとしてのｎ−ヒドロキシアミジノヘテロサイクル |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| WO2009009116A2 (en) | 2007-07-12 | 2009-01-15 | Tolerx, Inc. | Combination therapies employing gitr binding molecules |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| WO2009073620A2 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics | Ido inhibitors |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| KR20190069615A (ko) | 2008-12-09 | 2019-06-19 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| CN102574924A (zh) | 2009-09-03 | 2012-07-11 | 先灵公司 | 抗-gitr抗体 |
| EP2493862B1 (en) | 2009-10-28 | 2016-10-05 | Newlink Genetics Corporation | Imidazole derivatives as ido inhibitors |
| KR101434070B1 (ko) | 2009-12-10 | 2014-08-25 | 에프. 호프만-라 로슈 아게 | 인간 ｃｓｆ-1ｒ 세포외 도메인 4에 우선적으로 결합하는 항체 및 그의 용도 |
| US9150656B2 (en) | 2010-03-04 | 2015-10-06 | Macrogenics, Inc. | Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
| WO2011107553A1 (en) | 2010-03-05 | 2011-09-09 | F. Hoffmann-La Roche Ag | Antibodies against human csf-1r and uses thereof |
| KR101647871B1 (ko) | 2010-03-05 | 2016-08-11 | 에프. 호프만-라 로슈 아게 | 인간 ｃｓｆ-1ｒ에 대한 항체 및 이의 용도 |
| EP3357510B1 (en) | 2010-05-04 | 2020-08-05 | Five Prime Therapeutics, Inc. | Antibodies that bind csf1r |
| SG10201506906VA (en) | 2010-09-09 | 2015-10-29 | Pfizer | 4-1bb binding molecules |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| RS57324B1 (sr) | 2011-04-20 | 2018-08-31 | Medimmune Llc | Antitela i drugi molekuli koji vezuju b7-h1 i pd-1 |
| WO2013079174A1 (en) | 2011-11-28 | 2013-06-06 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
| CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| WO2013119716A1 (en) | 2012-02-06 | 2013-08-15 | Genentech, Inc. | Compositions and methods for using csf1r inhibitors |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| CA2871445C (en) | 2012-05-11 | 2020-07-07 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| HK1212214A1 (en) | 2012-08-31 | 2016-06-10 | 戊瑞治疗有限公司 | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| SI2970155T1 (en) * | 2013-03-15 | 2018-06-29 | Bristol-Myers Squibb Company | INHIBITORS INDOLEAMIN 2,3-DIOXYGENESIS (IDO) |
| MX2015012056A (es) | 2013-03-15 | 2015-12-16 | Squibb Bristol Myers Co | Inhibidores de indolamina-2,3-dioxigenasa (ido). |
| WO2015031295A1 (en) * | 2013-08-27 | 2015-03-05 | Bristol-Myers Squibb Company | Ido inhibitors |
| TW201700453A (zh) * | 2015-04-03 | 2017-01-01 | 必治妥美雅史谷比公司 | Ｉｄｏ抑制劑 |
-
2016
- 2016-04-01 TW TW105110690A patent/TW201700453A/zh unknown
- 2016-04-01 WO PCT/US2016/025544 patent/WO2016161279A1/en not_active Ceased
- 2016-04-01 EA EA201792231A patent/EA033395B1/ru not_active IP Right Cessation
- 2016-04-01 KR KR1020177031598A patent/KR20170134981A/ko not_active Withdrawn
- 2016-04-01 US US15/564,146 patent/US10399932B2/en active Active
- 2016-04-01 KR KR1020177031542A patent/KR20170136557A/ko not_active Withdrawn
- 2016-04-01 JP JP2017551647A patent/JP2018516238A/ja active Pending
- 2016-04-01 EP EP16715778.3A patent/EP3277671A1/en not_active Withdrawn
- 2016-04-01 US US15/564,153 patent/US10399933B2/en active Active
- 2016-04-01 BR BR112017020895A patent/BR112017020895A2/pt not_active Application Discontinuation
- 2016-04-01 AU AU2016243937A patent/AU2016243937A1/en not_active Abandoned
- 2016-04-01 CN CN201680032165.4A patent/CN108093636A/zh active Pending
- 2016-04-01 HK HK18107390.1A patent/HK1247922A1/zh unknown
- 2016-04-01 AU AU2016242973A patent/AU2016242973A1/en not_active Abandoned
- 2016-04-01 MX MX2017012729A patent/MX2017012729A/es unknown
- 2016-04-01 CA CA2981660A patent/CA2981660A1/en not_active Abandoned
- 2016-04-01 EA EA201792186A patent/EA201792186A1/ru unknown
- 2016-04-01 JP JP2017551629A patent/JP2018515438A/ja not_active Withdrawn
- 2016-04-01 SG SG11201807980QA patent/SG11201807980QA/en unknown
- 2016-04-01 CA CA2981584A patent/CA2981584A1/en not_active Abandoned
- 2016-04-01 EP EP16715777.5A patent/EP3277670A1/en not_active Withdrawn
- 2016-04-01 UY UY0001036601A patent/UY36601A/es unknown
- 2016-04-01 CN CN201680032102.9A patent/CN107743481A/zh active Pending
- 2016-04-01 MX MX2017012730A patent/MX2017012730A/es unknown
- 2016-04-01 US US15/088,211 patent/US9790169B2/en active Active
- 2016-04-01 BR BR112017020999A patent/BR112017020999A2/pt not_active Application Discontinuation
- 2016-04-01 BR BR112017021021A patent/BR112017021021A2/pt not_active Application Discontinuation
- 2016-04-01 CN CN201680032158.4A patent/CN107743490A/zh active Pending
- 2016-04-01 PE PE2017001828A patent/PE20180117A1/es unknown
- 2016-04-01 WO PCT/US2016/025554 patent/WO2016161286A1/en not_active Ceased
- 2016-04-01 EP EP16715779.1A patent/EP3277672A1/en not_active Withdrawn
- 2016-04-01 EA EA201792204A patent/EA201792204A1/ru unknown
- 2016-04-01 MX MX2017012738A patent/MX2017012738A/es unknown
- 2016-04-01 AU AU2016242978A patent/AU2016242978A1/en not_active Abandoned
- 2016-04-01 SG SG11201707948WA patent/SG11201707948WA/en unknown
- 2016-04-01 AR ARP160100897A patent/AR104176A1/es unknown
- 2016-04-01 WO PCT/US2016/025531 patent/WO2016161269A1/en not_active Ceased
- 2016-04-01 KR KR1020177031596A patent/KR20170134980A/ko not_active Withdrawn
- 2016-04-01 SG SG11201708097SA patent/SG11201708097SA/en unknown
- 2016-04-01 JP JP2017551628A patent/JP2018519245A/ja not_active Withdrawn
- 2016-04-01 CA CA2981657A patent/CA2981657A1/en not_active Abandoned
-
2017
- 2017-05-02 US US15/584,818 patent/US10167254B2/en active Active
- 2017-09-26 IL IL254720A patent/IL254720A0/en unknown
- 2017-09-26 IL IL254722A patent/IL254722A0/en unknown
- 2017-09-26 IL IL254719A patent/IL254719A0/en unknown
- 2017-10-03 CL CL2017002494A patent/CL2017002494A1/es unknown
- 2017-10-31 CO CONC2017/0011183A patent/CO2017011183A2/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516238A5 (enExample) | ||
| JP2018519245A5 (enExample) | ||
| JP2018515438A5 (enExample) | ||
| JP2016528197A5 (enExample) | ||
| JP2020517616A5 (enExample) | ||
| JP2016519653A5 (enExample) | ||
| JP2019529484A5 (enExample) | ||
| JP2016518324A5 (enExample) | ||
| JP2017537080A5 (enExample) | ||
| JP2013056930A5 (enExample) | ||
| JP2014508804A5 (enExample) | ||
| JP2014525438A5 (enExample) | ||
| JP2016503799A5 (enExample) | ||
| JP2014518544A5 (enExample) | ||
| JP2017509689A5 (enExample) | ||
| JP2016536286A5 (enExample) | ||
| JP2017528498A5 (enExample) | ||
| JP2015503625A5 (enExample) | ||
| JP2017502940A5 (enExample) | ||
| JP2017526726A5 (enExample) | ||
| JP2014521688A5 (enExample) | ||
| RU2017111200A (ru) | Циклогексилэтилзамещенные диаза- и триаза-трициклические соединения в качестве антагонистов индоламин-2,3-диоксигеназы для лечения рака | |
| JP2016537366A5 (enExample) | ||
| JP2011524422A5 (enExample) | ||
| JP2016513660A5 (enExample) |