EA201792204A1 - Ингибиторы ido - Google Patents

Ингибиторы ido

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Publication number
EA201792204A1
EA201792204A1 EA201792204A EA201792204A EA201792204A1 EA 201792204 A1 EA201792204 A1 EA 201792204A1 EA 201792204 A EA201792204 A EA 201792204A EA 201792204 A EA201792204 A EA 201792204A EA 201792204 A1 EA201792204 A1 EA 201792204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
ido inhibitors
ido
indoleamine
dioxygenase
Prior art date
Application number
EA201792204A
Other languages
English (en)
Inventor
Джеймс Аарон Балог
Эмили Шарлотт Черни
Вейвей Гуо
Аудрис Хуанг
Джей А Маркволдер
Стивен П. Зайц
Вэйфан Шан
Дэвид К. Уилльямс
Натесан Муругесан
Сушеел Джетхананд Нара
Саумия Рой
Судамани Тхангавел
Рамеш Кумар Систла
Сринивас Черуку
Сринивасан Тангатирупати
Ядагири Каниябойна
Нагалакшми Пуличарла
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55702190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201792204(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201792204A1 publication Critical patent/EA201792204A1/ru

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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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Abstract

Раскрыты соединения, которые модулируют или ингибируют ферментативную активность индоламин-2,3-диоксигеназы (IDO), к фармацевтическим композициям, содержащим указанные соединения, а также к способам лечения пролиферативных расстройств, таких как злокачественная опухоль, вирусные инфекции и/или воспалительные нарушения, с использованием соединений в соответствии с настоящим изобретением.
EA201792204A 2015-04-03 2016-04-01 Ингибиторы ido EA201792204A1 (ru)

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