JP2019514874A5 - - Google Patents
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- Publication number
- JP2019514874A5 JP2019514874A5 JP2018554765A JP2018554765A JP2019514874A5 JP 2019514874 A5 JP2019514874 A5 JP 2019514874A5 JP 2018554765 A JP2018554765 A JP 2018554765A JP 2018554765 A JP2018554765 A JP 2018554765A JP 2019514874 A5 JP2019514874 A5 JP 2019514874A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- hydrogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 10
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 claims 3
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 1
- 0 *C[C@@]([C@](*)[C@]1*)O[C@]1N(C=CC1)C=C1C(N)=O Chemical compound *C[C@@]([C@](*)[C@]1*)O[C@]1N(C=CC1)C=C1C(N)=O 0.000 description 4
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021117648A JP2021176871A (ja) | 2016-04-20 | 2021-07-16 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
| JP2022167877A JP7493007B2 (ja) | 2016-04-20 | 2022-10-19 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662325264P | 2016-04-20 | 2016-04-20 | |
| US62/325,264 | 2016-04-20 | ||
| PCT/US2017/028673 WO2017184885A1 (en) | 2016-04-20 | 2017-04-20 | Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021117648A Division JP2021176871A (ja) | 2016-04-20 | 2021-07-16 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514874A JP2019514874A (ja) | 2019-06-06 |
| JP2019514874A5 true JP2019514874A5 (enExample) | 2020-05-28 |
| JP7089480B2 JP7089480B2 (ja) | 2022-06-22 |
Family
ID=60088650
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554765A Active JP7089480B2 (ja) | 2016-04-20 | 2017-04-20 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
| JP2021117648A Pending JP2021176871A (ja) | 2016-04-20 | 2021-07-16 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
| JP2022167877A Active JP7493007B2 (ja) | 2016-04-20 | 2022-10-19 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021117648A Pending JP2021176871A (ja) | 2016-04-20 | 2021-07-16 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
| JP2022167877A Active JP7493007B2 (ja) | 2016-04-20 | 2022-10-19 | Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10183036B2 (enExample) |
| EP (1) | EP3445359B8 (enExample) |
| JP (3) | JP7089480B2 (enExample) |
| KR (1) | KR20190008246A (enExample) |
| CN (1) | CN109640984A (enExample) |
| AU (2) | AU2017254657A1 (enExample) |
| BR (1) | BR112018071573A2 (enExample) |
| CA (1) | CA3021571C (enExample) |
| ES (1) | ES2948968T3 (enExample) |
| MX (1) | MX393076B (enExample) |
| NZ (1) | NZ747693A (enExample) |
| WO (1) | WO2017184885A1 (enExample) |
| ZA (1) | ZA201807736B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10392414B2 (en) | 2015-07-15 | 2019-08-27 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| AU2016302005B2 (en) | 2015-08-05 | 2021-03-04 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| EP3538099A4 (en) | 2016-11-11 | 2020-06-17 | The Queen's University of Belfast | EFFICIENT AND SCALABLE SYNTHESIS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS OF THEM, ADENYLYDINUCLEOTIDE CONJUGATES THEREOF AND NEW-WAY CRYSTALS |
| EP3554285A4 (en) | 2016-11-29 | 2021-01-20 | University of Iowa Research Foundation | USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018191771A1 (en) * | 2017-04-18 | 2018-10-25 | Victor Chang Cardiac Research Institute | Detection and treatment of congenital malformations |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| WO2019152416A1 (en) * | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN113490675B (zh) * | 2018-05-22 | 2026-01-09 | 江普斯塔特生育有限公司 | 作为抗衰老剂的烟酸核苷的氨基酸盐 |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| EP3927715A4 (en) * | 2019-02-21 | 2023-03-01 | Chromadex, Inc. | Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| JP2022534872A (ja) * | 2019-06-05 | 2022-08-04 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 肝疾患の治療のための還元型ニコチンアミドリボシド |
| AU2020286602B2 (en) * | 2019-06-05 | 2025-04-03 | Société des Produits Nestlé S.A. | Reduced nicotinamideribosides for treating or preventing kidney disease |
| BR112021021690A2 (pt) * | 2019-06-05 | 2022-02-15 | Nestle Sa | Ribosídeos de nicotinamida reduzidos para tratamento/prevenção de doenças do músculo esquelético |
| CN110973260A (zh) * | 2019-12-11 | 2020-04-10 | 杨力 | 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用 |
| EP4076458A1 (en) | 2019-12-19 | 2022-10-26 | Leibniz-lnstitut Für Altersforschung | Nad-precursors and dietary restriction for treating age-related medical conditions |
| EP4117681A1 (en) * | 2020-03-09 | 2023-01-18 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions |
| WO2021180731A1 (en) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions |
| US20230114280A1 (en) * | 2020-03-09 | 2023-04-13 | Societe Des Produits Nestle S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions |
| EP4117680A1 (en) * | 2020-03-09 | 2023-01-18 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of lung diseases and conditions |
| CN114561342B (zh) * | 2020-11-27 | 2024-12-20 | 西安交通大学医学院第一附属医院 | Nad信号通路激动剂在体外胚胎培养中的应用 |
| CN112716969B (zh) * | 2021-01-15 | 2022-11-29 | 江苏恒正合生命科学有限公司 | 治疗阿尔茨海默症的组合物及其制备方法、应用 |
| CN118201621A (zh) * | 2021-05-05 | 2024-06-14 | 雀巢产品有限公司 | 使用narh和nr的组合来产生细胞内烟酰胺腺嘌呤二核苷酸（nad+）的组合物和方法 |
| IL308577A (en) | 2021-05-27 | 2024-01-01 | Metro Int Biotech Llc | Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use |
| CA3224544A1 (en) * | 2021-06-18 | 2022-12-22 | Mitopower Llc | Treatment of immune-related disorders, kidney disorders, liver disorders, hemolytic disorders, and oxidative stress-associated disorders using nrh, narh and reduced derivatives thereof |
| JP7111878B1 (ja) | 2021-10-27 | 2022-08-02 | 旭化成ファーマ株式会社 | ニコチンアミドモノヌクレオチドの製造方法 |
| EP4422644A4 (en) * | 2021-10-27 | 2025-08-27 | Elysium Health Inc | METHODS OF TREATING MENOPAUSAL SYNDROMES |
| WO2023150072A1 (en) | 2022-02-01 | 2023-08-10 | Sinclair David A | Compositions and methods for the preservation of plant matter |
| EP4472993A2 (en) * | 2022-02-04 | 2024-12-11 | Elysium Health, Inc. | Ribose linkers and conjugates thereof |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022680B2 (en) * | 2002-05-30 | 2006-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7927859B2 (en) * | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005077091A2 (en) | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
| PT1755391E (pt) | 2004-06-04 | 2016-02-03 | Univ Washington | Métodos e composições para o tratamento de neuropatias |
| ES2670927T3 (es) * | 2005-11-18 | 2018-06-04 | Cornell Research Foundation, Inc. | Composiciones de nicotinoil ribósido y métodos de uso |
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| KR20210107895A (ko) | 2013-10-30 | 2021-09-01 | 크로마덱스 아이엔씨. | 피부 질환 치료에서의 국소적 사용을 위한 니코틴아미드 리보사이드 조성물 |
| RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
| BR112017019696A2 (pt) * | 2015-03-16 | 2018-09-04 | ChromaDex Inc. | composto e usos de um composto |
| US10392414B2 (en) | 2015-07-15 | 2019-08-27 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| AU2016302005B2 (en) | 2015-08-05 | 2021-03-04 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| ES2981479T3 (es) * | 2016-04-14 | 2024-10-09 | Chromadex Inc | Fórmula para lactantes que comprende ribósido de nicotinamida |
-
2017
- 2017-04-20 MX MX2018012849A patent/MX393076B/es unknown
- 2017-04-20 AU AU2017254657A patent/AU2017254657A1/en not_active Abandoned
- 2017-04-20 EP EP17786649.8A patent/EP3445359B8/en active Active
- 2017-04-20 US US15/492,952 patent/US10183036B2/en active Active
- 2017-04-20 ES ES17786649T patent/ES2948968T3/es active Active
- 2017-04-20 BR BR112018071573-5A patent/BR112018071573A2/pt not_active Application Discontinuation
- 2017-04-20 CA CA3021571A patent/CA3021571C/en active Active
- 2017-04-20 KR KR1020187033413A patent/KR20190008246A/ko not_active Ceased
- 2017-04-20 NZ NZ747693A patent/NZ747693A/en unknown
- 2017-04-20 JP JP2018554765A patent/JP7089480B2/ja active Active
- 2017-04-20 CN CN201780038245.5A patent/CN109640984A/zh active Pending
- 2017-04-20 WO PCT/US2017/028673 patent/WO2017184885A1/en not_active Ceased
-
2018
- 2018-11-16 ZA ZA2018/07736A patent/ZA201807736B/en unknown
-
2021
- 2021-07-16 JP JP2021117648A patent/JP2021176871A/ja active Pending
-
2022
- 2022-08-22 AU AU2022221384A patent/AU2022221384C1/en active Active
- 2022-10-19 JP JP2022167877A patent/JP7493007B2/ja active Active
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