JP7089480B2 - Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 - Google Patents

Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 Download PDF

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JP7089480B2
JP7089480B2 JP2018554765A JP2018554765A JP7089480B2 JP 7089480 B2 JP7089480 B2 JP 7089480B2 JP 2018554765 A JP2018554765 A JP 2018554765A JP 2018554765 A JP2018554765 A JP 2018554765A JP 7089480 B2 JP7089480 B2 JP 7089480B2
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acid
nad
derivatives
derivative
mitochondrial
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JP2019514874A (ja
JP2019514874A5 (enExample
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デリンジャー，ライアン
ローンマス，トロイ
モリス，マーク
エリクソン，アロン
カシアー，ハディ
ミゴード，マリー，イー．
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Chromadex Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
JP2018554765A 2016-04-20 2017-04-20 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用 Active JP7089480B2 (ja)

Priority Applications (2)

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JP2021117648A JP2021176871A (ja) 2016-04-20 2021-07-16 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用
JP2022167877A JP7493007B2 (ja) 2016-04-20 2022-10-19 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用

Applications Claiming Priority (3)

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US201662325264P 2016-04-20 2016-04-20
US62/325,264 2016-04-20
PCT/US2017/028673 WO2017184885A1 (en) 2016-04-20 2017-04-20 Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors

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JP2021117648A Division JP2021176871A (ja) 2016-04-20 2021-07-16 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用

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JP2019514874A5 JP2019514874A5 (enExample) 2020-05-28
JP7089480B2 true JP7089480B2 (ja) 2022-06-22

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JP2021117648A Pending JP2021176871A (ja) 2016-04-20 2021-07-16 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用
JP2022167877A Active JP7493007B2 (ja) 2016-04-20 2022-10-19 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用

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JP2022167877A Active JP7493007B2 (ja) 2016-04-20 2022-10-19 Ｎａｄ＋を増大させる前駆体としてのニコチン酸リボシド又はニコチンアミドリボシド誘導体、及びその還元誘導体の使用

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US (1) US10183036B2 (enExample)
EP (1) EP3445359B8 (enExample)
JP (3) JP7089480B2 (enExample)
KR (1) KR20190008246A (enExample)
CN (1) CN109640984A (enExample)
AU (2) AU2017254657A1 (enExample)
BR (1) BR112018071573A2 (enExample)
CA (1) CA3021571C (enExample)
ES (1) ES2948968T3 (enExample)
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NZ (1) NZ747693A (enExample)
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GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
NZ803738A (en) 2016-11-11 2024-05-31 Chromadex Inc Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
WO2018191771A1 (en) * 2017-04-18 2018-10-25 Victor Chang Cardiac Research Institute Detection and treatment of congenital malformations
SG11201912267SA (en) 2017-06-19 2020-01-30 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
JP2021525279A (ja) * 2018-05-22 2021-09-24 ジャンプスタート ファーティリティ ピーティーワイ リミテッド 抗加齢剤としてのニコチン酸リボシドのアミノ酸塩
US11833167B2 (en) 2018-12-17 2023-12-05 Mitopower Llc Nicotinyl riboside compounds and their uses
CN113727987A (zh) * 2019-02-21 2021-11-30 可劳迈戴斯有限公司 烟酰胺核苷、烟酸核苷、还原型烟酰基核苷化合物和烟酰基核苷化合物衍生物在制品的用途
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
CA3139615A1 (en) * 2019-06-05 2020-12-10 Societe Des Produits Nestle S.A. Reduced nicotinamideribosides for the treatment/prevention of liver disease
CN113784720A (zh) * 2019-06-05 2021-12-10 雀巢产品有限公司 用于治疗/预防骨骼肌疾病的还原型烟酰胺核糖核苷
EP3980026B1 (en) * 2019-06-05 2024-07-31 Société des Produits Nestlé S.A. Reduced nicotinamide ribosides for treating or preventing kidney disease
CN110973260A (zh) * 2019-12-11 2020-04-10 杨力 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用
WO2021123245A1 (en) 2019-12-19 2021-06-24 Leibniz-Institut Für Alternsforschung - Fritz-Lipmann-Institut E.V. (Fli) Nad-precursors and dietary restriction for treating age-related medical conditions
WO2021180732A1 (en) * 2020-03-09 2021-09-16 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions
US20230095103A1 (en) * 2020-03-09 2023-03-30 Societe Des Produits Nestle S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of lung diseases and conditions
US20230119002A1 (en) * 2020-03-09 2023-04-20 Societe Des Produits Nestle S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions
WO2021180741A1 (en) * 2020-03-09 2021-09-16 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions
CN114561342B (zh) * 2020-11-27 2024-12-20 西安交通大学医学院第一附属医院 Nad信号通路激动剂在体外胚胎培养中的应用
CN115669929A (zh) * 2021-01-15 2023-02-03 江苏恒正合生命科学有限公司 辅助改善记忆的功能性食品其制备方法
US20240245714A1 (en) * 2021-05-05 2024-07-25 Societe Des Produits Nestle S.A. Composition and methods using combination of narh and nr to produce intracellular nicotinamide adenine dinucleotide (nad+)
CN117545488A (zh) 2021-05-27 2024-02-09 麦德龙国际生物科技有限责任公司 烟酸单核苷酸及其酯的结晶固体以及其制作和使用方法
JP2024523126A (ja) * 2021-06-18 2024-06-28 ミトパワー エルエルシー Ｎｒｈ、ｎａｒｈ、及びそれらの還元誘導体を用いた免疫関連障害、腎障害、肝障害、溶血性障害、及び酸化的ストレス関連障害の処置
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法
US20240415862A1 (en) * 2021-10-27 2024-12-19 Elysium Health Inc. Methods for treatment of menopausal syndromes
WO2023150072A1 (en) 2022-02-01 2023-08-10 Sinclair David A Compositions and methods for the preservation of plant matter
WO2023150667A2 (en) * 2022-02-04 2023-08-10 Elysium Health Inc. Ribose linkers and conjugates thereof
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs

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WO2003101198A1 (en) 2002-05-30 2003-12-11 Albert Einstein College Of Medicine Of Zeshiva University Improved inhibitors of adp-ribosyl transferases, cyclases, and hydrolases
US20050042736A1 (en) 2003-08-22 2005-02-24 Ka-Yiu San High molar succinate yield bacteria by increasing the intracellular NADH availability
US20050267023A1 (en) 2002-08-09 2005-12-01 Sinclair David A Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
WO2015066382A1 (en) 2013-10-30 2015-05-07 ChromaDex Inc. Nicotinamide riboside compositions for topical use in treating skin conditions
WO2015186114A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof

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US10392414B2 (en) 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
EA035664B1 (ru) 2015-08-05 2020-07-23 МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи Производные никотинамидмононуклеотида и их применение для лечения заболевания или расстройства, связанного с биосинтезом над+
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US20050267023A1 (en) 2002-08-09 2005-12-01 Sinclair David A Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
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AU2022221384C1 (en) 2023-08-03
AU2017254657A1 (en) 2018-11-15
CA3021571C (en) 2023-01-03
KR20190008246A (ko) 2019-01-23
AU2022221384A1 (en) 2022-09-22
MX393076B (es) 2025-03-24
US20170304338A1 (en) 2017-10-26
JP2019514874A (ja) 2019-06-06
EP3445359B8 (en) 2023-09-06
BR112018071573A2 (pt) 2019-02-12
AU2022221384B2 (en) 2023-03-23
US10183036B2 (en) 2019-01-22
CA3021571A1 (en) 2017-10-26
EP3445359C0 (en) 2023-06-07
CN109640984A (zh) 2019-04-16
JP2023002685A (ja) 2023-01-10
MX2018012849A (es) 2019-08-29
EP3445359A4 (en) 2019-12-25
JP7493007B2 (ja) 2024-05-30
ZA201807736B (en) 2020-05-27
EP3445359A1 (en) 2019-02-27
JP2021176871A (ja) 2021-11-11
ES2948968T3 (es) 2023-09-22
WO2017184885A8 (en) 2023-08-24
NZ747693A (en) 2023-07-28
WO2017184885A1 (en) 2017-10-26
EP3445359B1 (en) 2023-06-07

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