BR112018071573A2 - composto, método e composto nrta - Google Patents
composto, método e composto nrtaInfo
- Publication number
- BR112018071573A2 BR112018071573A2 BR112018071573-5A BR112018071573A BR112018071573A2 BR 112018071573 A2 BR112018071573 A2 BR 112018071573A2 BR 112018071573 A BR112018071573 A BR 112018071573A BR 112018071573 A2 BR112018071573 A2 BR 112018071573A2
- Authority
- BR
- Brazil
- Prior art keywords
- ribofuranosyl
- nicotinamide
- riboside
- derivatives
- triacetyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 9
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 4
- 235000005152 nicotinamide Nutrition 0.000 abstract 4
- 239000011570 nicotinamide Substances 0.000 abstract 4
- 229960003966 nicotinamide Drugs 0.000 abstract 4
- 150000008223 ribosides Chemical class 0.000 abstract 4
- HMFHBZSHGGEWLO-TXICZTDVSA-N beta-D-ribose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-TXICZTDVSA-N 0.000 abstract 3
- 239000011664 nicotinic acid Substances 0.000 abstract 3
- 229960003512 nicotinic acid Drugs 0.000 abstract 3
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 abstract 3
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- QGZHUIXTGFZHJT-OTVLKRCQSA-N 1-[(2R,3R,4R,5R)-3,4-diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)oxolan-2-yl]-4H-pyridine-3-carboxamide Chemical compound C(C)(=O)[C@@]1([C@@H](O[C@@H]([C@]1(O)C(C)=O)C(O)C(C)=O)N1C=C(C(=O)N)CC=C1)O QGZHUIXTGFZHJT-OTVLKRCQSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 230000037041 intracellular level Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662325264P | 2016-04-20 | 2016-04-20 | |
| US62/325,264 | 2016-04-20 | ||
| PCT/US2017/028673 WO2017184885A1 (en) | 2016-04-20 | 2017-04-20 | Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018071573A2 true BR112018071573A2 (pt) | 2019-02-12 |
Family
ID=60088650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018071573-5A BR112018071573A2 (pt) | 2016-04-20 | 2017-04-20 | composto, método e composto nrta |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10183036B2 (enExample) |
| EP (1) | EP3445359B8 (enExample) |
| JP (3) | JP7089480B2 (enExample) |
| KR (1) | KR20190008246A (enExample) |
| CN (1) | CN109640984A (enExample) |
| AU (2) | AU2017254657A1 (enExample) |
| BR (1) | BR112018071573A2 (enExample) |
| CA (1) | CA3021571C (enExample) |
| ES (1) | ES2948968T3 (enExample) |
| MX (1) | MX393076B (enExample) |
| NZ (1) | NZ747693A (enExample) |
| WO (1) | WO2017184885A1 (enExample) |
| ZA (1) | ZA201807736B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3322419B1 (en) | 2015-07-15 | 2025-09-03 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| MX2018001363A (es) | 2015-08-05 | 2018-11-29 | Metro Int Biotech Llc | Derivados del mononucleotido de nicotinamida y sus usos. |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| US10689411B2 (en) | 2016-11-11 | 2020-06-23 | The Queen's University Of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| MX2019006278A (es) | 2016-11-29 | 2019-08-21 | Univ Iowa Res Found | Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia. |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| WO2018191771A1 (en) * | 2017-04-18 | 2018-10-25 | Victor Chang Cardiac Research Institute | Detection and treatment of congenital malformations |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| WO2019152416A1 (en) * | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| EP3797110A1 (en) * | 2018-05-22 | 2021-03-31 | Jumpstart Fertility Pty Ltd | Amino acid salts of nicotinic acid ribosides as anti-aging agents |
| EP3897666A2 (en) | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| MX2021010043A (es) | 2019-02-21 | 2022-07-19 | Chromadex Inc | Uso de nicotinamida ribósido, ácido nicotinico ribósido, compuestos de nicotinil ribósido reducido y derivados de compuestos de nicotinil ribósido en formulaciones. |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| JP7610531B2 (ja) * | 2019-06-05 | 2025-01-08 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 腎疾患を治療又は予防するための還元型ニコチンアミドリボシド |
| JP2022534872A (ja) * | 2019-06-05 | 2022-08-04 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 肝疾患の治療のための還元型ニコチンアミドリボシド |
| BR112021021690A2 (pt) * | 2019-06-05 | 2022-02-15 | Nestle Sa | Ribosídeos de nicotinamida reduzidos para tratamento/prevenção de doenças do músculo esquelético |
| CN110973260A (zh) * | 2019-12-11 | 2020-04-10 | 杨力 | 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用 |
| US20230000888A1 (en) | 2019-12-19 | 2023-01-05 | Leibniz-Institut Für Alternsforschung - Fritz-Lipmann-Institut E.V. (Fli) | Nad-precursors and dietary restriction for treating age related medical conditions |
| US20230119002A1 (en) * | 2020-03-09 | 2023-04-20 | Societe Des Produits Nestle S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions |
| WO2021180741A1 (en) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions |
| JP2023517835A (ja) * | 2020-03-09 | 2023-04-27 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | ウイルス感染症及び細菌感染症の予防及び治療のために還元型ニコチンアミドリボシドを含有する組成物及び方法 |
| US20230114280A1 (en) * | 2020-03-09 | 2023-04-13 | Societe Des Produits Nestle S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions |
| CN114561342B (zh) * | 2020-11-27 | 2024-12-20 | 西安交通大学医学院第一附属医院 | Nad信号通路激动剂在体外胚胎培养中的应用 |
| CN112716969B (zh) * | 2021-01-15 | 2022-11-29 | 江苏恒正合生命科学有限公司 | 治疗阿尔茨海默症的组合物及其制备方法、应用 |
| EP4333858A2 (en) * | 2021-05-05 | 2024-03-13 | Société des Produits Nestlé S.A. | Composition and methods using combination of narh and nr to produce intracellular nicotinamide adenine dinucleotide (nad+) |
| WO2022251491A1 (en) | 2021-05-27 | 2022-12-01 | Metro International Biotech, Llc | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
| EP4313067A4 (en) * | 2021-06-18 | 2024-12-18 | Mitopower LLC | TREATMENT OF IMMUNITY-RELATED DISORDERS, RENAL DISORDERS, LIVER DISORDERS, HEMOLYTIC DISORDERS AND OXIDATIVE STRESS-RELATED DISORDERS USING NRH, NARH AND THEIR REDUCED DERIVATIVES |
| JP7111878B1 (ja) | 2021-10-27 | 2022-08-02 | 旭化成ファーマ株式会社 | ニコチンアミドモノヌクレオチドの製造方法 |
| WO2023076804A1 (en) * | 2021-10-27 | 2023-05-04 | Elysium Health Inc. | Methods for treatment of menopausal syndromes |
| WO2023150072A1 (en) | 2022-02-01 | 2023-08-10 | Sinclair David A | Compositions and methods for the preservation of plant matter |
| EP4472993A2 (en) * | 2022-02-04 | 2024-12-11 | Elysium Health, Inc. | Ribose linkers and conjugates thereof |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022680B2 (en) * | 2002-05-30 | 2006-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7927859B2 (en) * | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| EP1723227A4 (en) | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
| AU2005257883A1 (en) | 2004-06-04 | 2006-01-05 | Washington University | Methods and compositions for treating neuropathies |
| DK1957086T3 (en) * | 2005-11-18 | 2018-06-06 | Cornell Res Foundation Inc | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE |
| GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| CN105873937A (zh) * | 2013-10-30 | 2016-08-17 | 可劳迈戴斯有限公司 | 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 |
| BR112016028672A2 (pt) * | 2014-06-06 | 2017-08-22 | Glaxosmithkline Ip No 2 Ltd | análogos de ribosídeo de nicotinamida e composições farmacêuticas e usos do mesmo |
| MX390185B (es) * | 2015-03-16 | 2025-03-20 | Chromadex Inc | Composiciones de acido nicotinico ribosido o de nicotinamida ribosido, derivados reducidos de los mismos, y su uso. |
| EP3322419B1 (en) | 2015-07-15 | 2025-09-03 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| MX2018001363A (es) | 2015-08-05 | 2018-11-29 | Metro Int Biotech Llc | Derivados del mononucleotido de nicotinamida y sus usos. |
| AU2017248818B2 (en) * | 2016-04-14 | 2023-01-12 | ChromaDex Inc. | Use of nicotinamide riboside, nicotinic acid riboside, nicotinamide mononucleotide, and nicotinoyl compound derivatives in infant formula |
-
2017
- 2017-04-20 KR KR1020187033413A patent/KR20190008246A/ko not_active Ceased
- 2017-04-20 ES ES17786649T patent/ES2948968T3/es active Active
- 2017-04-20 MX MX2018012849A patent/MX393076B/es unknown
- 2017-04-20 EP EP17786649.8A patent/EP3445359B8/en active Active
- 2017-04-20 NZ NZ747693A patent/NZ747693A/en unknown
- 2017-04-20 CN CN201780038245.5A patent/CN109640984A/zh active Pending
- 2017-04-20 AU AU2017254657A patent/AU2017254657A1/en not_active Abandoned
- 2017-04-20 US US15/492,952 patent/US10183036B2/en active Active
- 2017-04-20 BR BR112018071573-5A patent/BR112018071573A2/pt not_active Application Discontinuation
- 2017-04-20 WO PCT/US2017/028673 patent/WO2017184885A1/en not_active Ceased
- 2017-04-20 CA CA3021571A patent/CA3021571C/en active Active
- 2017-04-20 JP JP2018554765A patent/JP7089480B2/ja active Active
-
2018
- 2018-11-16 ZA ZA2018/07736A patent/ZA201807736B/en unknown
-
2021
- 2021-07-16 JP JP2021117648A patent/JP2021176871A/ja active Pending
-
2022
- 2022-08-22 AU AU2022221384A patent/AU2022221384C1/en active Active
- 2022-10-19 JP JP2022167877A patent/JP7493007B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3021571C (en) | 2023-01-03 |
| JP7493007B2 (ja) | 2024-05-30 |
| AU2022221384B2 (en) | 2023-03-23 |
| US10183036B2 (en) | 2019-01-22 |
| JP7089480B2 (ja) | 2022-06-22 |
| EP3445359C0 (en) | 2023-06-07 |
| US20170304338A1 (en) | 2017-10-26 |
| CA3021571A1 (en) | 2017-10-26 |
| KR20190008246A (ko) | 2019-01-23 |
| JP2021176871A (ja) | 2021-11-11 |
| EP3445359B1 (en) | 2023-06-07 |
| WO2017184885A1 (en) | 2017-10-26 |
| ES2948968T3 (es) | 2023-09-22 |
| JP2019514874A (ja) | 2019-06-06 |
| CN109640984A (zh) | 2019-04-16 |
| AU2022221384C1 (en) | 2023-08-03 |
| ZA201807736B (en) | 2020-05-27 |
| MX2018012849A (es) | 2019-08-29 |
| AU2022221384A1 (en) | 2022-09-22 |
| EP3445359A1 (en) | 2019-02-27 |
| AU2017254657A1 (en) | 2018-11-15 |
| MX393076B (es) | 2025-03-24 |
| EP3445359A4 (en) | 2019-12-25 |
| WO2017184885A8 (en) | 2023-08-24 |
| EP3445359B8 (en) | 2023-09-06 |
| NZ747693A (en) | 2023-07-28 |
| JP2023002685A (ja) | 2023-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |