MX2018001363A - Derivados del mononucleotido de nicotinamida y sus usos. - Google Patents
Derivados del mononucleotido de nicotinamida y sus usos.Info
- Publication number
- MX2018001363A MX2018001363A MX2018001363A MX2018001363A MX2018001363A MX 2018001363 A MX2018001363 A MX 2018001363A MX 2018001363 A MX2018001363 A MX 2018001363A MX 2018001363 A MX2018001363 A MX 2018001363A MX 2018001363 A MX2018001363 A MX 2018001363A
- Authority
- MX
- Mexico
- Prior art keywords
- nicotinamide mononucleotide
- relates
- derivatives
- methods
- nicotinamide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Abstract
La invención se refiere a composiciones de derivados del mononucleótido de nicotinamida y sus métodos de uso. La invención también se refiere a métodos para preparar derivados del mononucleótido de nicotinamida. La invención se refiere a composiciones farmacéuticas y suplementos nutricionales que contienen un derivado de mononucleótido de nicotinamida. La invención se refiere a métodos de uso derivados del mononucleótido de nicotinamida que promueven el incremento de niveles intracelulares de nicotinamida adenina dinucleótida (NAD+) en células y tejidos para tratar enfermedades y mejorar la supervivencia de células y tejidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562201447P | 2015-08-05 | 2015-08-05 | |
PCT/US2016/045855 WO2017024255A1 (en) | 2015-08-05 | 2016-08-05 | Nicotinamide mononucleotide derivatives and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018001363A true MX2018001363A (es) | 2018-11-29 |
Family
ID=57944181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018001363A MX2018001363A (es) | 2015-08-05 | 2016-08-05 | Derivados del mononucleotido de nicotinamida y sus usos. |
Country Status (17)
Country | Link |
---|---|
US (5) | US9855289B2 (es) |
EP (1) | EP3331894B1 (es) |
JP (1) | JP6949002B6 (es) |
KR (1) | KR102354784B1 (es) |
CN (1) | CN108137639B (es) |
AU (1) | AU2016302005B2 (es) |
BR (1) | BR112018002168B1 (es) |
CA (1) | CA2994553C (es) |
DK (1) | DK3331894T3 (es) |
EA (1) | EA035664B1 (es) |
ES (1) | ES2862170T3 (es) |
IL (1) | IL257327B (es) |
MX (1) | MX2018001363A (es) |
PL (1) | PL3331894T3 (es) |
PT (1) | PT3331894T (es) |
WO (1) | WO2017024255A1 (es) |
ZA (1) | ZA201801196B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3331894T3 (da) | 2015-08-05 | 2021-03-22 | Metro Int Biotech Llc | Nicotinamidmononukleotidderivater og anvendelser deraf |
GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
US10611790B2 (en) | 2015-11-02 | 2020-04-07 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
MX2018012849A (es) | 2016-04-20 | 2019-08-29 | Chromadex Inc | Uso de derivados de ribósido de ácido nocotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores de que incementan nad+. |
US20200009170A1 (en) * | 2016-09-13 | 2020-01-09 | Megumi Tanaka | Sleep display agent property and method for improving sleep disorders |
WO2018236814A2 (en) * | 2017-06-19 | 2018-12-27 | Gangadhara Ganapati | NICOTINAMIDE RIBOSID DERIVATIVES AND USES THEREOF |
AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
EP3770250A4 (en) * | 2018-03-22 | 2021-11-24 | Oriental Yeast Co., Ltd. | DIFFERENTIATION PROMOTER FOR PLURIPOTENT STEM CELLS |
US10654883B2 (en) | 2018-05-15 | 2020-05-19 | Jumpstart Fertility Pty Ltd | Inorganic salts of nicotinic acid mononucleotide as anti-aging agents |
EP3897666A2 (en) * | 2018-12-17 | 2021-10-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
US11491175B2 (en) | 2019-02-25 | 2022-11-08 | Celagenex Research (India) Pvt. Ltd. | Synergistic bioactive compositions for enhancing cellular energy |
US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
BR112022000963A2 (pt) | 2019-07-19 | 2022-04-05 | Biosynth Ag | Método de fabricação de sais de nicotinamida ribofuranosídeo, sais de nicotinamida ribofuranosídeo como tal e usos dos mesmos |
US20220323477A1 (en) | 2019-09-09 | 2022-10-13 | Nuvamid Sa | Use of nmn for the prevention and/or treatment of pain, and corresponding compositions |
FR3100449B1 (fr) | 2019-09-09 | 2022-08-26 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement de la douleur et compositions correspondantes |
FR3102058A1 (fr) * | 2019-10-18 | 2021-04-23 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement de la polyarthrite rhumatoïde et compositions correspondantes |
CN112823778A (zh) * | 2019-11-21 | 2021-05-21 | 百瑞全球有限公司 | 毛发护理组合物及其制备方法 |
FR3103702B1 (fr) * | 2019-11-28 | 2022-02-11 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement de la spondylarthrite ankylosante et compositions correspondantes |
FR3106056B1 (fr) * | 2020-01-13 | 2021-12-17 | Nuvamid | Utilisation de NMN pour la prévention et/ou le traitement d’une douleur articulaire induite par l’activité physique et compositions correspondantes |
FR3107897B1 (fr) * | 2020-03-06 | 2023-05-26 | Nuvamid Sa | Dérivés de nicotinamide mononucléotides |
FR3108031B1 (fr) | 2020-03-12 | 2024-02-16 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement d’une douleur dorsale et compositions correspondantes |
FR3108032B1 (fr) | 2020-03-12 | 2024-02-16 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement d’une douleur musculaire, ligamentaire ou tendineuse induite par l’activité physique et compositions correspondantes |
JP2023522383A (ja) * | 2020-04-24 | 2023-05-30 | ヌヴァミド エスアー | ニコチンアミドモノヌクレオチド及びニコチンアミドリボシド誘導体、並びに特にインフルエンザウィルス又はコロナウィルスによって引き起こされるウィルス感染症及び呼吸器合併症の治療におけるそれらの使用 |
EP3901160A1 (en) * | 2020-04-25 | 2021-10-27 | Nuvamid SA | Nicotinamide mononucleotide and nicotinamide riboside derivatives and use thereof in the treatment of viral infections and respiratory complications, in particular caused by influenzavirus or coronavirus |
KR20230006803A (ko) * | 2020-05-05 | 2023-01-11 | 코나겐 인크. | 미생물 공정을 통한 nmn 및 이의 유도체 생산 |
US20230210746A1 (en) | 2020-05-20 | 2023-07-06 | Nuvamid Sa | Anti-aging cosmetic compositions comprising nmn |
FR3110410A1 (fr) | 2020-05-20 | 2021-11-26 | Nuvamid Sa | Compositions cosmétiques anti-âge comprenant de la NMN |
FR3110836B1 (fr) | 2020-05-29 | 2023-06-16 | Nuvamid | Utilisation de NMN pour réduire l’immunodépression et l’immunosénescence |
CN111548383B (zh) * | 2020-06-11 | 2023-04-18 | 湖南和泰康瑞生物技术有限公司 | 一种β-烟酰胺单核苷酸的工艺制备方法 |
CN111956670A (zh) * | 2020-08-31 | 2020-11-20 | 杭州伊瑟奇生物科技有限公司 | 一种间充质干细胞及其活性因子复合物冻干品的制备方法 |
WO2022047779A1 (zh) * | 2020-09-07 | 2022-03-10 | 音芙医药科技(上海)有限公司 | 烟酰胺单核苷酸在制备提高损伤皮肤肌膜中Na+-K+-ATP酶水平试剂中的应用 |
CN112094362B (zh) * | 2020-09-29 | 2022-04-12 | 四川大学华西医院 | 烟酰胺核糖或单核苷酸类似物-大分子载体轭合物及制法和应用 |
WO2022094916A1 (zh) * | 2020-11-06 | 2022-05-12 | 中国科学院深圳先进技术研究院 | 一种提高烟酰胺磷酸核糖转移酶活性的方法及其组合物 |
CN112500445B (zh) * | 2020-12-04 | 2022-11-29 | 黄冈鲁班药业股份有限公司 | β-烟酰胺核糖的制备方法 |
IT202100005054A1 (it) * | 2021-03-04 | 2022-09-04 | Azienda Ospedaliero Univ Di Parma | Composto farmaceutico per l’uso in un trattamento terapeutico dell’infezione cronica da hbv e metodo per l’identificazione di linfociti esauriti |
KR102633321B1 (ko) * | 2021-05-11 | 2024-02-05 | 연세대학교 산학협력단 | 노인성 황반변성의 예방 또는 치료를 위한 약학 조성물 |
EP4346842A1 (en) | 2021-05-27 | 2024-04-10 | Metro International Biotech, LLC | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
CN115304655A (zh) * | 2021-11-23 | 2022-11-08 | 中立安(北京)医药科技有限公司 | 烟酰胺单核苷类衍生物及其制备方法和应用 |
WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
WO2023122190A1 (en) | 2021-12-22 | 2023-06-29 | Metro International Biotech, Llc | Compositions for treatment of inflammation |
CN114540283B (zh) * | 2022-01-27 | 2023-10-20 | 中国农业科学院北京畜牧兽医研究所 | 用于牛体外胚胎生产的高效玻璃化冷冻方法 |
US11746087B1 (en) | 2022-03-18 | 2023-09-05 | Enveric Biosciences Canada Inc. | C4-carboxylic acid-substituted tryptamine derivatives and methods of using |
CN115611960A (zh) * | 2022-11-18 | 2023-01-17 | 翔鹏(北京)生物科技有限公司 | 一种人体辅酶i前体的制备方法 |
Family Cites Families (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3201389A (en) | 1962-09-24 | 1965-08-17 | Kyowa Hakko Kogyo Kk | Method for preparing ribonucleoside-5'-phosphates or their salts from ribonucleosides |
US3451997A (en) | 1965-11-30 | 1969-06-24 | Kyowa Hakko Kogyo Kk | Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives |
US4411995A (en) | 1981-09-28 | 1983-10-25 | Massachusetts Institute Of Technology | Synthesis of nicotinamide cofactors |
US5318508A (en) | 1991-03-15 | 1994-06-07 | Elvira Osthold | Nail corrective brace |
EA200301204A1 (ru) | 2001-04-30 | 2004-04-29 | Тромсдорф ГмбХ унд Ко.КГ Арцнаймиттель | Фармацевтически активные производные нуклеозида, способ их получения, их применение (варианты) и содержащая их фармацевтическая композиция, способ профилактики и/или лечения заболеваний и нарушений млекопитающих (варианты), комбинация лекарственных средств и ее применение (варианты) |
US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US20040224039A1 (en) | 2003-02-12 | 2004-11-11 | Donald Brucker | Compositions and methods for the treatment of diseases and disorder associated with oxidative damage |
US20090035275A1 (en) | 2003-10-31 | 2009-02-05 | John Geoffrey Pickering | Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD |
PT3006040T (pt) | 2004-06-04 | 2018-03-28 | Univ Washington | Métodos e composições para o tratamento de neuropatias |
EP1877054A2 (en) | 2005-03-30 | 2008-01-16 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
BRPI0615157A2 (pt) | 2005-08-12 | 2016-09-13 | Merck & Co Inc | composto, composição farmacêutica, métodos para inibir a replicação viral em um paciente humano, e para tratar uma infecção viral em um paciente humano, e, uso de um composto |
EP3730507A1 (en) | 2005-11-18 | 2020-10-28 | Cornell Research Foundation, Inc. | Nicotinoyl riboside and nicotinamide riboside compositions for use in reducing toxicity induced by hmg-coa reductase inhibitors |
US20080318892A1 (en) | 2006-04-28 | 2008-12-25 | John Geoffrey Pickering | Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of nad |
CL2008003511A1 (es) | 2007-11-29 | 2010-02-19 | Metabasis Therapeutics Inc | Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c. |
CN101497638B (zh) | 2008-01-30 | 2012-09-26 | 中国科学院大连化学物理研究所 | 一种nad+类似物及其合成和应用 |
AR071395A1 (es) | 2008-04-23 | 2010-06-16 | Gilead Sciences Inc | Analogos carba-nucleosidos 1'-sustituidos para tratamiento antiviral |
CN101601679B (zh) | 2009-03-17 | 2011-08-10 | 中国人民解放军第二军医大学 | 一种烟酰胺单核苷酸的应用 |
US20100297079A1 (en) * | 2009-05-20 | 2010-11-25 | Chimerix, Inc. | Compounds, compositions and methods for treating viral infection |
TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
WO2012004917A1 (ja) | 2010-07-06 | 2012-01-12 | Kaminishi Hidenori | 神経突起伸長剤 |
MX342838B (es) | 2010-09-03 | 2016-10-14 | Forma Tm Llc * | Compuestos y composiciones de guanidina para la inhibicion de nampt. |
CN103384668B (zh) | 2010-09-03 | 2017-05-31 | 福马Tm有限责任公司 | 用于抑制nampt的化合物和组合物 |
EP2611777B1 (en) | 2010-09-03 | 2016-05-11 | Forma TM, LLC. | N-(4-{[pyridin-3-yl-methyl)carbamoyl]amino}benzene-sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer |
WO2012094343A1 (en) * | 2011-01-05 | 2012-07-12 | Trilink Biotechnologies | Chemically substituted thermosensitive probes and cofactors for hot start ligation |
US20140065099A1 (en) | 2011-02-15 | 2014-03-06 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of Treating Mitochondrial Dysfunction |
US20120107888A1 (en) | 2011-02-17 | 2012-05-03 | Qteros, Inc. | Modulation of fermentation products through vitamin supplementation |
KR20140027366A (ko) | 2011-05-04 | 2014-03-06 | 포르마 티엠, 엘엘씨. | Nampt의 억제를 위한 신규 화합물 및 조성물 |
US20120328526A1 (en) * | 2011-06-27 | 2012-12-27 | University Of Maryland, Baltimore | Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof |
US20130143835A1 (en) | 2011-12-05 | 2013-06-06 | Medivir Ab | HCV Polymerase Inhibitors |
WO2013130943A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Alkyl-and di-substituted amido-benzyl sulfonamide derivatives |
WO2013127268A1 (en) | 2012-03-02 | 2013-09-06 | Genentech,Inc. | Amido-benzyl sulfone and sulfonamide derivatives |
EP2820018A4 (en) | 2012-03-02 | 2015-09-02 | Genentech Inc | AMIDO-BENZYLIC SULFOXIDE AND SULFONES DERIVATIVES |
EP2820008B1 (en) | 2012-03-02 | 2016-12-14 | Genentech, Inc. | Amido spirocyclic amide and sulfonamide derivatives |
WO2013127267A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives |
CA2873315A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharamaceuticals, Inc. | D-amino acid compounds for liver disease |
JP6289460B2 (ja) | 2012-07-16 | 2018-03-07 | コーネル ユニヴァーシティー | 難聴を治療するためのニコチンアミドリボシド |
US9877981B2 (en) | 2012-10-09 | 2018-01-30 | President And Fellows Of Harvard College | NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
CN102876759A (zh) | 2012-10-29 | 2013-01-16 | 尚科生物医药(上海)有限公司 | 尼克酰胺腺嘌呤二核苷酸的制备方法 |
WO2014074715A1 (en) | 2012-11-07 | 2014-05-15 | Genentech, Inc. | Cyclopropyl amide derivatives |
WO2014111906A1 (en) | 2013-01-21 | 2014-07-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Bioluminescence imaging of small biomolecules |
US20140271355A1 (en) | 2013-03-15 | 2014-09-18 | Sabre Intellectual Property Holdings Llc | Apparatus and process for focused gas phase application of biocide |
WO2014146044A1 (en) | 2013-03-15 | 2014-09-18 | Washington University | Administration of nicotinamide mononucleotide in the treatment of disease |
GB201313465D0 (en) | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
US20160287621A1 (en) | 2013-11-06 | 2016-10-06 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
US10272091B2 (en) | 2013-11-12 | 2019-04-30 | Ortho-Nutra, Llc | Theacrine-based supplement and method of use thereof |
US10398701B2 (en) | 2013-11-12 | 2019-09-03 | Ortho-Nutra, Llc | Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine |
CN104367587B (zh) | 2013-12-06 | 2018-06-29 | 中国人民解放军第二军医大学 | 烟酰胺单核苷酸在制备促脑缺血后神经再生药物中的应用 |
WO2015138969A1 (en) | 2014-03-13 | 2015-09-17 | Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
US20150258052A1 (en) | 2014-03-13 | 2015-09-17 | Salk Institute For Biological Studies | Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue |
RU2016149764A (ru) | 2014-06-02 | 2018-07-17 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Получение и применение кристаллического бета-d-никотинамида рибозида |
KR20170008320A (ko) | 2014-06-06 | 2017-01-23 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 니코틴아미드 리보시드 유사체 및 그의 제약 조성물 및 용도 |
US10323058B2 (en) | 2014-07-24 | 2019-06-18 | W. R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
PL3268379T3 (pl) | 2015-03-09 | 2024-03-18 | W.R. Grace & Co. - Conn. | Forma krystaliczna rybozydu nikotynamidu |
CN104817604B (zh) | 2015-03-16 | 2017-08-04 | 邦泰生物工程(深圳)有限公司 | 一种β‑烟酰胺单核苷酸的纯化方法 |
EP3271456A1 (en) | 2015-03-18 | 2018-01-24 | The Regents of the University of California | Methods of preventing and reversing stem cell aging |
WO2016196941A1 (en) | 2015-06-04 | 2016-12-08 | Chromadex, Inc. | Selective solvent free phosphorylation |
DK3331894T3 (da) | 2015-08-05 | 2021-03-22 | Metro Int Biotech Llc | Nicotinamidmononukleotidderivater og anvendelser deraf |
TW201713774A (zh) | 2015-08-06 | 2017-04-16 | Kohjin Life Sciences Co Ltd | 含有β-菸鹼醯胺單核苷酸的酵母萃取物及其製造方法 |
GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
SG11201802933YA (en) | 2015-10-07 | 2018-05-30 | Joel Huizenga | Resetting biological pathways for defending against and repairing deterioration from human aging |
US10611790B2 (en) | 2015-11-02 | 2020-04-07 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
JP6803854B2 (ja) | 2015-12-21 | 2020-12-23 | 昭和電工株式会社 | ニコチンアミドモノヌクレオチド誘導体、その塩、その製造方法、皮膚外用剤、化粧料、食品添加剤 |
EP3187180A1 (en) | 2015-12-28 | 2017-07-05 | Ludwig-Maximilians-Universität München | Adenosylhomocysteinase binding substances for medical use |
US11248018B2 (en) | 2016-02-23 | 2022-02-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent |
CA3017254C (en) | 2016-03-16 | 2023-08-22 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
MX2018012849A (es) | 2016-04-20 | 2019-08-29 | Chromadex Inc | Uso de derivados de ribósido de ácido nocotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores de que incementan nad+. |
WO2017218580A1 (en) | 2016-06-14 | 2017-12-21 | Rejuvenation Therapeutics Corporation | Synthetic methods for the preparation of nicotinamide riboside and related compounds |
CN107889504B (zh) | 2016-07-30 | 2021-07-27 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸的方法 |
WO2018023210A1 (zh) | 2016-07-30 | 2018-02-08 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸的方法 |
CN108026130B (zh) | 2016-07-30 | 2021-04-02 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸的方法 |
WO2018023208A1 (zh) | 2016-07-30 | 2018-02-08 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸的方法 |
WO2018023209A1 (zh) | 2016-07-30 | 2018-02-08 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸的方法 |
CN108026132B (zh) | 2016-07-30 | 2021-08-13 | 邦泰生物工程(深圳)有限公司 | 一种烟酰胺单核苷酸的纯化方法 |
WO2018047715A1 (ja) | 2016-09-06 | 2018-03-15 | 協和発酵バイオ株式会社 | β-ニコチンアミドモノヌクレオチドの結晶及びその製造方法 |
JP7002713B2 (ja) | 2016-09-09 | 2022-01-20 | 日本電気株式会社 | 量子鍵配送システム用の送信装置、受信装置、量子鍵配送方法、および量子鍵配送プログラム |
US20200009170A1 (en) | 2016-09-13 | 2020-01-09 | Megumi Tanaka | Sleep display agent property and method for improving sleep disorders |
WO2018052019A1 (ja) | 2016-09-13 | 2018-03-22 | めぐみ 田中 | 視覚機能改善剤及び視覚機能の改善方法 |
NZ753674A (en) | 2016-11-11 | 2024-01-26 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
CN106755209B (zh) | 2016-12-29 | 2021-07-23 | 苏州汉酶生物技术有限公司 | 一种酶法制备β-烟酰胺单核苷酸的方法 |
WO2018132833A1 (en) | 2017-01-13 | 2018-07-19 | The Regents Of The University Of Colorado, A Body Corporate | Methods for treating hypertension and arterial stiffness |
WO2018143258A1 (ja) | 2017-01-31 | 2018-08-09 | オリエンタル酵母工業株式会社 | 多分化能性幹細胞増殖促進剤 |
JP6920071B2 (ja) | 2017-02-16 | 2021-08-18 | ワシントン・ユニバーシティWashington University | アディポネクチン分泌向上剤 |
SI3606929T1 (sl) | 2017-04-05 | 2021-11-30 | Cornell University | Nukleotidi beta-nikotinat estra in postopki za pripravo le-teh |
CA3071561A1 (en) | 2017-07-31 | 2019-02-07 | Newsouth Innovations Pty Limited | Methods for increasing fertility |
AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
MX2021006788A (es) | 2018-12-10 | 2022-04-01 | Chromadex Inc | Formas cristalinas de los ribósidos de nicotinoílo y derivados de estos, y métodos de preparación de estas. |
CN113811310B (zh) | 2019-03-22 | 2023-03-24 | 麦德龙国际生物科技有限责任公司 | 包括烟酰胺核苷的磷衍生物的组合物以及用于调节烟酰胺腺嘌呤二核苷酸的方法 |
US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
EP4346842A1 (en) | 2021-05-27 | 2024-04-10 | Metro International Biotech, LLC | Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use |
-
2016
- 2016-08-05 DK DK16833957.0T patent/DK3331894T3/da active
- 2016-08-05 EP EP16833957.0A patent/EP3331894B1/en active Active
- 2016-08-05 MX MX2018001363A patent/MX2018001363A/es unknown
- 2016-08-05 ES ES16833957T patent/ES2862170T3/es active Active
- 2016-08-05 BR BR112018002168-7A patent/BR112018002168B1/pt active IP Right Grant
- 2016-08-05 WO PCT/US2016/045855 patent/WO2017024255A1/en active Application Filing
- 2016-08-05 US US15/512,388 patent/US9855289B2/en active Active
- 2016-08-05 KR KR1020187006160A patent/KR102354784B1/ko active IP Right Grant
- 2016-08-05 JP JP2018505479A patent/JP6949002B6/ja active Active
- 2016-08-05 PL PL16833957T patent/PL3331894T3/pl unknown
- 2016-08-05 CA CA2994553A patent/CA2994553C/en active Active
- 2016-08-05 PT PT168339570T patent/PT3331894T/pt unknown
- 2016-08-05 CN CN201680059161.5A patent/CN108137639B/zh active Active
- 2016-08-05 EA EA201890435A patent/EA035664B1/ru unknown
- 2016-08-05 AU AU2016302005A patent/AU2016302005B2/en active Active
-
2017
- 2017-03-20 US US15/463,683 patent/US9919003B2/en active Active
-
2018
- 2018-01-23 US US15/877,597 patent/US10548913B2/en active Active
- 2018-02-04 IL IL257327A patent/IL257327B/en unknown
- 2018-02-21 ZA ZA2018/01196A patent/ZA201801196B/en unknown
-
2019
- 2019-12-13 US US16/713,711 patent/US11464796B2/en active Active
-
2022
- 2022-07-26 US US17/873,577 patent/US11878027B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2018001363A (es) | Derivados del mononucleotido de nicotinamida y sus usos. | |
MX2017011851A (es) | Composiciones de acido nicotinico ribosido o de nicotinamida ribosido, derivados reducidos de los mismos, y su uso. | |
MX2018012849A (es) | Uso de derivados de ribósido de ácido nocotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores de que incementan nad+. | |
MX2022015604A (es) | Expresion transgenica selectiva de tejidos. | |
MX2022014648A (es) | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b. | |
MX2016005574A (es) | Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. | |
PE20150223A1 (es) | Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos | |
GB2570593A (en) | Methods relating to intestinal organ-on-a-chip | |
MX2017002656A (es) | Compuestos que inhiben la proteína mcl-1. | |
TW201613593A (en) | Molecules for administration to ROS1 mutant cancer cells | |
MX2017004890A (es) | Metodos y composiciones para la generación o el mantenimiento de células pluripotentes. | |
MX363243B (es) | Composiciones para tratar cáncer y usos de dichas composiciones. | |
MX360634B (es) | Inhibidores de 3-haloalilamina sustituidos de ssao y uso de los mismos. | |
MX2014009219A (es) | Compuestos de purinona como inhibidores de quinasas. | |
MX347765B (es) | Inhibidores macrociclicos de la quinasa flt3. | |
IN2015DN01151A (es) | ||
PH12017500481A1 (en) | Novel soluble guanylate cyclase activators and their use | |
WO2019090347A8 (en) | Adenosine pathway inhibitors for cancer treatment | |
MX2014010713A (es) | Activacion de procaspasa 3 mediante terapia de combinacion. | |
MX2016016388A (es) | Uso de compuestos de tienotriazolodiazepina para el tratamiento de cancer de pulmon de celula no pequeña y/o cancer de pulmon de celula pequeña. | |
MX2018002816A (es) | Metodos de tratamiento de mieloma multiple y leucemia de celulas plasmaticas mediante terapia de celulas t. | |
SG10201909412RA (en) | Composition for suppressing muscular fatty change | |
SG194753A1 (en) | Induction of il-12 using immunotherapy | |
MX2019000677A (es) | Células miméticas de células b. | |
IN2014DN08443A (es) |