MX2022015604A - Expresion transgenica selectiva de tejidos. - Google Patents

Expresion transgenica selectiva de tejidos.

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Publication number
MX2022015604A
MX2022015604A MX2022015604A MX2022015604A MX2022015604A MX 2022015604 A MX2022015604 A MX 2022015604A MX 2022015604 A MX2022015604 A MX 2022015604A MX 2022015604 A MX2022015604 A MX 2022015604A MX 2022015604 A MX2022015604 A MX 2022015604A
Authority
MX
Mexico
Prior art keywords
transgene
transgene expression
selective expression
tissue selective
selective transgene
Prior art date
Application number
MX2022015604A
Other languages
English (en)
Inventor
Kartik Ramamoorthi
Andrew Young
Stephanie Tagliatela
Szu-Ying Chen
David Oberkofler
Original Assignee
Encoded Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encoded Therapeutics Inc filed Critical Encoded Therapeutics Inc
Publication of MX2022015604A publication Critical patent/MX2022015604A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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Abstract

En la presente se proporcionan composiciones y métodos para la expresión selectiva de un transgén. Las composiciones y métodos para la expresión selectiva de un transgén comprenden uno o más elementos reguladores humanos, los cuales, cuando son ligados operativamente a un transgén, pueden facilitar la expresión selectiva de un transgén (por ejemplo, expresión selectiva del tipo de células) en una célula blanco en comparación con al menos una o más células no blanco.
MX2022015604A 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos. MX2022015604A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762480998P 2017-04-03 2017-04-03

Publications (1)

Publication Number Publication Date
MX2022015604A true MX2022015604A (es) 2023-02-09

Family

ID=63713399

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2019011772A MX2019011772A (es) 2017-04-03 2018-04-03 Expresion transgenica selectiva de tejidos.
MX2022015604A MX2022015604A (es) 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos.
MX2022015603A MX2022015603A (es) 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos.
MX2022015605A MX2022015605A (es) 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019011772A MX2019011772A (es) 2017-04-03 2018-04-03 Expresion transgenica selectiva de tejidos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022015603A MX2022015603A (es) 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos.
MX2022015605A MX2022015605A (es) 2017-04-03 2019-09-30 Expresion transgenica selectiva de tejidos.

Country Status (19)

Country Link
US (6) US10287608B2 (es)
EP (2) EP4403642A3 (es)
JP (2) JP7246359B2 (es)
KR (1) KR102604159B1 (es)
CN (2) CN117821509A (es)
AU (1) AU2018250161B2 (es)
BR (1) BR112019020777A2 (es)
CA (1) CA3058189A1 (es)
CL (2) CL2019002805A1 (es)
CO (1) CO2019011450A2 (es)
EA (1) EA201992358A1 (es)
ES (1) ES2981970T3 (es)
IL (1) IL269767A (es)
MX (4) MX2019011772A (es)
PL (1) PL3607073T3 (es)
SA (1) SA519410244B1 (es)
SG (1) SG11201909203WA (es)
TW (3) TWI848486B (es)
WO (1) WO2018187363A1 (es)

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WO2020163102A1 (en) * 2019-02-05 2020-08-13 The Broad Institute, Inc. Interneuron-specific therapeutics for normalizing neuronal cell excitability and treating dravet syndrome
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BR112021018819A2 (pt) * 2019-03-22 2021-11-23 Encoded Therapeutics Inc Multiplexar elementos regulatórios para identificar elementos regulatórios específicos do tipo de célula
JP7432621B2 (ja) * 2019-05-29 2024-02-16 エンコーデッド セラピューティクス， インコーポレイテッド 選択的遺伝子調節のための組成物および方法
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WO2022011390A1 (en) * 2020-07-08 2022-01-13 Baylor College Of Medicine Gene therapy for stxbp1 encephalopathy
KR20230037586A (ko) * 2020-07-09 2023-03-16 가부시키가이샤 모달리스 Mapt 유전자를 표적으로 하는 알츠하이머병의 치료 방법
KR20240099360A (ko) * 2021-10-28 2024-06-28 유씨비 바이오파마 에스알엘 핵산 구축물, 바이러스 벡터 및 바이러스 입자

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