MX2022009512A - Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc). - Google Patents

Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc).

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Publication number
MX2022009512A
MX2022009512A MX2022009512A MX2022009512A MX2022009512A MX 2022009512 A MX2022009512 A MX 2022009512A MX 2022009512 A MX2022009512 A MX 2022009512A MX 2022009512 A MX2022009512 A MX 2022009512A MX 2022009512 A MX2022009512 A MX 2022009512A
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MX
Mexico
Prior art keywords
zfns
cell receptor
targeted disruption
polynucleotides encoding
mhc cell
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Application number
MX2022009512A
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English (en)
Inventor
Lei Zhang
Gary K Lee
David Paschon
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Sangamo Therapeutics Inc
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Publication date
Application filed by Sangamo Therapeutics Inc filed Critical Sangamo Therapeutics Inc
Publication of MX2022009512A publication Critical patent/MX2022009512A/es

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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N15/62DNA sequences coding for fusion proteins
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    • C12N9/14Hydrolases (3)
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    • C12N2510/00Genetically modified cells

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Abstract

En la presente solicitud se describen métodos y composiciones para inactivar los genes de MHC, utilizando nucleasas de dedo de zinc (ZFN) que comprenden una proteína de dedo de zinc y un dominio de corte o semidominio de corte en condiciones capaces de conservar la viabilidad de la célula. También se proveen polinucleótidos que codifican para las ZFN, vectores que comprenden los polinucleótidos que codifican para las ZFN y células que comprenden los polinucleótidos que codifican para las ZFN y/o células que comprenden las ZFN.
MX2022009512A 2015-12-18 2018-06-18 Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc). MX2022009512A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562269410P 2015-12-18 2015-12-18
US201662305097P 2016-03-08 2016-03-08
US201662329439P 2016-04-29 2016-04-29

Publications (1)

Publication Number Publication Date
MX2022009512A true MX2022009512A (es) 2022-09-02

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Family Applications (2)

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MX2018007519A MX2018007519A (es) 2015-12-18 2016-12-15 Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc).
MX2022009512A MX2022009512A (es) 2015-12-18 2018-06-18 Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc).

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MX2018007519A MX2018007519A (es) 2015-12-18 2016-12-15 Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc).

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US (3) US10500229B2 (es)
EP (1) EP3390437A4 (es)
JP (3) JP2018537112A (es)
KR (1) KR20180088911A (es)
CN (2) CN117137947A (es)
AU (2) AU2016374253B2 (es)
BR (1) BR112018012235A2 (es)
CA (1) CA3008382A1 (es)
EA (1) EA201891212A1 (es)
IL (2) IL259935B2 (es)
MX (2) MX2018007519A (es)
NZ (1) NZ743429A (es)
SG (2) SG11201805157TA (es)
WO (1) WO2017106537A2 (es)

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