EA201891212A1 - Адресная дезорганизация клеточного рецептора гкгс - Google Patents

Адресная дезорганизация клеточного рецептора гкгс

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Publication number
EA201891212A1
EA201891212A1 EA201891212A EA201891212A EA201891212A1 EA 201891212 A1 EA201891212 A1 EA 201891212A1 EA 201891212 A EA201891212 A EA 201891212A EA 201891212 A EA201891212 A EA 201891212A EA 201891212 A1 EA201891212 A1 EA 201891212A1
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Eurasian Patent Office
Prior art keywords
zfn
gkgs
disorganization
address
polynucleotides encoding
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Application number
EA201891212A
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English (en)
Inventor
Гэри К. Ли
Дэвид Пащен
Лей Чжан
Original Assignee
Сангамо Терапьютикс, Инк.
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Publication of EA201891212A1 publication Critical patent/EA201891212A1/ru

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

В настоящем документе раскрыты способы и композиции для инактивации генов ГКГС (МНС) с применением нуклеаз с мотивом цинкового пальца (ZFN), содержащих белок с мотивом цинкового пальца и расщепляющий домен или расщепляющий полудомен, в условиях, позволяющих сохранять жизнеспособность клеток. Кроме того, предложены полинуклеотиды, кодирующие ZFN, векторы, содержащие полинуклеотиды, кодирующие ZFN, и клетки, содержащие полинуклеотиды, кодирующие ZFN, и/или клетки, содержащие ZFN.
EA201891212A 2015-12-18 2016-12-15 Адресная дезорганизация клеточного рецептора гкгс EA201891212A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562269410P 2015-12-18 2015-12-18
US201662305097P 2016-03-08 2016-03-08
US201662329439P 2016-04-29 2016-04-29
PCT/US2016/066988 WO2017106537A2 (en) 2015-12-18 2016-12-15 Targeted disruption of the mhc cell receptor

Publications (1)

Publication Number Publication Date
EA201891212A1 true EA201891212A1 (ru) 2019-01-31

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EA201891212A EA201891212A1 (ru) 2015-12-18 2016-12-15 Адресная дезорганизация клеточного рецептора гкгс

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Country Link
US (3) US10500229B2 (ru)
EP (1) EP3390437A4 (ru)
JP (3) JP2018537112A (ru)
KR (1) KR20180088911A (ru)
CN (2) CN108699132B (ru)
AU (2) AU2016374253B2 (ru)
BR (1) BR112018012235A2 (ru)
CA (1) CA3008382A1 (ru)
EA (1) EA201891212A1 (ru)
IL (2) IL297018A (ru)
MX (2) MX2018007519A (ru)
NZ (1) NZ743429A (ru)
SG (2) SG10202005640UA (ru)
WO (1) WO2017106537A2 (ru)

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