MX2016011690A - Edicion del genoma sin nucleasas. - Google Patents
Edicion del genoma sin nucleasas.Info
- Publication number
- MX2016011690A MX2016011690A MX2016011690A MX2016011690A MX2016011690A MX 2016011690 A MX2016011690 A MX 2016011690A MX 2016011690 A MX2016011690 A MX 2016011690A MX 2016011690 A MX2016011690 A MX 2016011690A MX 2016011690 A MX2016011690 A MX 2016011690A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- nucleases
- genome editing
- methods
- nuclease
- Prior art date
Links
- 101710163270 Nuclease Proteins 0.000 title abstract 3
- 238000010362 genome editing Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se proporcionan métodos y composiciones para editar el genoma de una célula sin el uso de una nucleasa proporcionada de forma exógena; aspectos de los métodos incluyen poner en contacto una célula con un vector de focalización que comprende una secuencia de ácido nucleico a ser integrada en el locus objetivo, en donde la célula no es puesta en contacto con una nucleasa; adicionalmente, se proporcionan reactivos, dispositivos y kits de los mismos que encuentran uso en la práctica los métodos objeto de la invención.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461969013P | 2014-03-21 | 2014-03-21 | |
US201461969709P | 2014-03-24 | 2014-03-24 | |
US201462044145P | 2014-08-29 | 2014-08-29 | |
US201462045451P | 2014-09-03 | 2014-09-03 | |
PCT/US2015/021501 WO2015143177A1 (en) | 2014-03-21 | 2015-03-19 | Genome editing without nucleases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016011690A true MX2016011690A (es) | 2016-11-07 |
Family
ID=54145325
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011690A MX2016011690A (es) | 2014-03-21 | 2015-03-19 | Edicion del genoma sin nucleasas. |
MX2022002624A MX2022002624A (es) | 2014-03-21 | 2016-09-08 | Edicion del genoma sin nucleasas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002624A MX2022002624A (es) | 2014-03-21 | 2016-09-08 | Edicion del genoma sin nucleasas. |
Country Status (11)
Country | Link |
---|---|
US (3) | US10612041B2 (es) |
EP (1) | EP3119895B1 (es) |
JP (2) | JP2017509328A (es) |
KR (3) | KR20220100728A (es) |
CN (1) | CN106460009A (es) |
AU (2) | AU2015231231B2 (es) |
BR (1) | BR112016019940A2 (es) |
CA (1) | CA2939847C (es) |
IL (1) | IL247581B (es) |
MX (2) | MX2016011690A (es) |
WO (1) | WO2015143177A1 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
MX2016011690A (es) | 2014-03-21 | 2016-11-07 | Univ Leland Stanford Junior | Edicion del genoma sin nucleasas. |
US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
CN113667696A (zh) | 2014-09-24 | 2021-11-19 | 希望之城 | 用于高效基因组编辑的腺相关病毒载体变异体和其方法 |
WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
WO2018083606A1 (en) | 2016-11-01 | 2018-05-11 | Novartis Ag | Methods and compositions for enhancing gene editing |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
KR20190130613A (ko) | 2017-03-23 | 2019-11-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
EP3640335A4 (en) * | 2017-06-15 | 2021-03-31 | Toolgen Incorporated | PLATFORM FOR EXPRESSION OF A PROTEIN OF INTEREST IN THE LIVER |
CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
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JP2020182450A (ja) | 2020-11-12 |
KR20210013372A (ko) | 2021-02-03 |
IL247581B (en) | 2020-06-30 |
US10612041B2 (en) | 2020-04-07 |
US20170088856A1 (en) | 2017-03-30 |
WO2015143177A1 (en) | 2015-09-24 |
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