EA201792420A1 - Композиции и способы перепрограммирования tcr с помощью гибридных белков - Google Patents

Композиции и способы перепрограммирования tcr с помощью гибридных белков

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Publication number
EA201792420A1
EA201792420A1 EA201792420A EA201792420A EA201792420A1 EA 201792420 A1 EA201792420 A1 EA 201792420A1 EA 201792420 A EA201792420 A EA 201792420A EA 201792420 A EA201792420 A EA 201792420A EA 201792420 A1 EA201792420 A1 EA 201792420A1
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Eurasian Patent Office
Prior art keywords
methods
compositions
hybrid proteins
tcr
reprogramming
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EA201792420A
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English (en)
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EA035618B1 (ru
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Патрик Баеуерле
Грегори Сичкевич
Роберт Хофмайстер
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Тср2 Терапьютикс Инк.
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Application filed by Тср2 Терапьютикс Инк. filed Critical Тср2 Терапьютикс Инк.
Publication of EA201792420A1 publication Critical patent/EA201792420A1/ru
Publication of EA035618B1 publication Critical patent/EA035618B1/ru

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Abstract

В настоящем изобретении предложены гибридные белки (TFP) T-клеточного рецептора (TCR), T-клетки, модифицированные для экспрессии одного или более TFP, и способы их применения для лечения заболеваний, включая рак.
EA201792420A 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков EA035618B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562163342P 2015-05-18 2015-05-18
PCT/US2016/033146 WO2016187349A1 (en) 2015-05-18 2016-05-18 Compositions and methods for tcr reprogramming using fusion proteins

Publications (2)

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EA201792420A1 true EA201792420A1 (ru) 2018-04-30
EA035618B1 EA035618B1 (ru) 2020-07-16

Family

ID=57320750

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EA201792420A EA035618B1 (ru) 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков
EA202090931A EA202090931A3 (ru) 2015-05-18 2016-05-18 Композиции и способы перепрограммирования tcr с помощью гибридных белков

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US (6) US10442849B2 (ru)
EP (3) EP3466967A1 (ru)
JP (4) JP2018515123A (ru)
KR (1) KR20180029201A (ru)
CN (2) CN114634943A (ru)
AU (2) AU2016264323B2 (ru)
BR (1) BR112017024757A2 (ru)
CA (1) CA2986254A1 (ru)
DK (1) DK3298033T4 (ru)
EA (2) EA035618B1 (ru)
ES (1) ES2819976T5 (ru)
FI (1) FI3298033T4 (ru)
HK (1) HK1252643A1 (ru)
HU (1) HUE051661T2 (ru)
IL (2) IL255697B2 (ru)
MX (1) MX2017014822A (ru)
PL (1) PL3298033T5 (ru)
PT (1) PT3298033T (ru)
SG (1) SG10201914069SA (ru)
WO (1) WO2016187349A1 (ru)

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