MX2013004792A - Receptor cd27 quimericos para redirigir celulas t a malignidades cd70-positivas. - Google Patents

Receptor cd27 quimericos para redirigir celulas t a malignidades cd70-positivas.

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Publication number
MX2013004792A
MX2013004792A MX2013004792A MX2013004792A MX2013004792A MX 2013004792 A MX2013004792 A MX 2013004792A MX 2013004792 A MX2013004792 A MX 2013004792A MX 2013004792 A MX2013004792 A MX 2013004792A MX 2013004792 A MX2013004792 A MX 2013004792A
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Mexico
Prior art keywords
cells
positive
redirecting
chimeric
receptors
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MX2013004792A
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English (en)
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Stephen M G Gottschalk
Donald R Shaffer
David M Spencer
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Baylor College Medicine
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Publication of MX2013004792A publication Critical patent/MX2013004792A/es

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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Abstract

La presente invención se refiere a métodos y composiciones relacionadas con células T redirigidas contra CD70 para la inmunoterapia de malignidades CD70-positivas. En aspectos de la invención, se emplean células T específicas de CD70. En aspectos particulares, existen células T que expresan una molécula novedosa que comprende el receptor CD70 de longitud completa (CD27) fusionado al dominio de señalización zeta del complejo del receptor de célula T. Dichas células T reconocen células tumorales CD70-positivas y tienen actividad citolítica contra células cancerosas CD70-positivas.
MX2013004792A 2010-10-27 2011-10-27 Receptor cd27 quimericos para redirigir celulas t a malignidades cd70-positivas. MX2013004792A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40718910P 2010-10-27 2010-10-27
PCT/US2011/058135 WO2012058460A2 (en) 2010-10-27 2011-10-27 Chimeric cd27 receptors for redirecting t cells to cd70-positive malignancies

Publications (1)

Publication Number Publication Date
MX2013004792A true MX2013004792A (es) 2013-08-27

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ID=45994771

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MX2013004792A MX2013004792A (es) 2010-10-27 2011-10-27 Receptor cd27 quimericos para redirigir celulas t a malignidades cd70-positivas.
MX2018006096A MX2018006096A (es) 2010-10-27 2013-04-26 Receptores cd27 quimericos para redirigir celulas t a malignidades cd70-positivas.

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MX2018006096A MX2018006096A (es) 2010-10-27 2013-04-26 Receptores cd27 quimericos para redirigir celulas t a malignidades cd70-positivas.

Country Status (11)

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US (2) US20130323214A1 (es)
EP (2) EP3372244A3 (es)
JP (3) JP6109741B2 (es)
KR (1) KR20140002649A (es)
CN (2) CN108424462A (es)
AU (1) AU2011319727B2 (es)
CA (1) CA2816379A1 (es)
IL (1) IL226018A0 (es)
MX (2) MX2013004792A (es)
NZ (5) NZ706016A (es)
WO (1) WO2012058460A2 (es)

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