MX352881B - Metodos y compuestos utiles en la sintesis de antagonistas del receptor de orexina 2. - Google Patents

Metodos y compuestos utiles en la sintesis de antagonistas del receptor de orexina 2.

Info

Publication number
MX352881B
MX352881B MX2014009917A MX2014009917A MX352881B MX 352881 B MX352881 B MX 352881B MX 2014009917 A MX2014009917 A MX 2014009917A MX 2014009917 A MX2014009917 A MX 2014009917A MX 352881 B MX352881 B MX 352881B
Authority
MX
Mexico
Prior art keywords
orexin
methods
receptor antagonists
synthesis
compounds useful
Prior art date
Application number
MX2014009917A
Other languages
English (en)
Other versions
MX2014009917A (es
Inventor
Yoshimitsu Naoe
Taro Terauchi
Huiming Zhang
George Anthony Moniz
Annie Zhu Wilcoxen
Farid Benayoud
Jaemoon Lee
Ayumi Takemura
Yu Yoshida
Toshiaki Tanaka
Keiichi Sorimachi
Yuji Kazuta
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2014009917A publication Critical patent/MX2014009917A/es
Publication of MX352881B publication Critical patent/MX352881B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Abstract

La presente descripción provee compuestos y métodos que son útiles para la preparación de compuestos útiles como antagonistas del receptor de orexina 2.
MX2014009917A 2012-02-17 2013-02-14 Metodos y compuestos utiles en la sintesis de antagonistas del receptor de orexina 2. MX352881B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261600109P 2012-02-17 2012-02-17
PCT/US2013/026204 WO2013123240A1 (en) 2012-02-17 2013-02-14 Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

Publications (2)

Publication Number Publication Date
MX2014009917A MX2014009917A (es) 2014-11-13
MX352881B true MX352881B (es) 2017-12-13

Family

ID=47755050

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014009917A MX352881B (es) 2012-02-17 2013-02-14 Metodos y compuestos utiles en la sintesis de antagonistas del receptor de orexina 2.

Country Status (13)

Country Link
US (3) US9416109B2 (es)
EP (1) EP2814798B1 (es)
JP (1) JP6147279B2 (es)
CN (1) CN104114524B (es)
BR (1) BR112014019909B1 (es)
CA (1) CA2861493C (es)
ES (1) ES2733750T3 (es)
HU (1) HUE043995T2 (es)
IL (1) IL232949A (es)
MX (1) MX352881B (es)
RU (1) RU2617696C2 (es)
SG (1) SG11201403216UA (es)
WO (1) WO2013123240A1 (es)

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ES2672732T3 (es) 2012-02-07 2018-06-15 Eolas Therapeutics Inc. Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
RU2617696C2 (ru) * 2012-02-17 2017-04-26 ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД Способы и соединения, которые можно использовать для синтеза антагонистов рецепторов орексина-2
EP3178814B1 (en) 2014-08-06 2019-04-10 Eisai R&D Management Co., Ltd. Method for producing pyrimidin-1-ol compound, and intermediate thereof
US10221170B2 (en) 2014-08-13 2019-03-05 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
RS63471B1 (sr) 2016-02-12 2022-08-31 Astrazeneca Ab Halo-supstituisani piperidini kao modulatori receptora oreksina
CN110799501B (zh) * 2017-08-01 2022-11-22 博健制药有限责任公司 一种食欲素受体拮抗剂的晶型及其制备方法和用途
GB201807898D0 (en) * 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
JP7384810B2 (ja) 2018-09-07 2023-11-21 住友化学株式会社 シクロプロパン化合物の製造方法
KR20220008804A (ko) 2019-05-15 2022-01-21 에자이 알앤드디 매니지먼트 가부시키가이샤 오렉신-2 수용체 길항제의 제조에 유용한 방법 및 화합물, 및 약간의 불순물을 갖는 렘보렉산트
JP7335362B2 (ja) 2019-06-12 2023-08-29 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
WO2020249692A1 (en) * 2019-06-12 2020-12-17 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream
JP7336541B2 (ja) 2019-06-12 2023-08-31 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
WO2020263253A1 (en) * 2019-06-26 2020-12-30 Moline Margaret Lemborexant for treating sleep issues
US20240010629A1 (en) 2019-12-11 2024-01-11 Teva Czech Industries S.R.O Solid state form of lemborexant
BR112022012246A2 (pt) 2019-12-20 2022-08-30 Eisai R&D Man Co Ltd Uso de lemborexant para tratar insônia
JPWO2021145373A1 (es) 2020-01-16 2021-07-22
ES2933074B2 (es) * 2021-07-26 2023-09-29 Moehs Iberica Sl Procedimiento de sintesis de 2,4-dimetilpirimidin-5-ol, nuevos intermedios de dicho procedimiento y uso del producto en la sintesis de lemborexant
WO2023178693A1 (zh) * 2022-03-25 2023-09-28 浙江华海药业股份有限公司 一种莱博雷生及其中间体的制备方法
WO2023178702A1 (zh) * 2022-03-25 2023-09-28 浙江华海药业股份有限公司 莱博雷生及其中间体化合物的制备方法
CN114778745B (zh) * 2022-06-21 2022-09-16 南京威凯尔生物医药科技有限公司 一种高效液相色谱法检测仑布雷生中间体及其对映体杂质的方法

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FR2302994A1 (fr) * 1975-03-06 1976-10-01 Fabre Sa Pierre Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique
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Also Published As

Publication number Publication date
JP6147279B2 (ja) 2017-06-14
EP2814798A1 (en) 2014-12-24
BR112014019909A2 (es) 2017-06-20
US20180044285A1 (en) 2018-02-15
CA2861493A1 (en) 2013-08-22
US20150025237A1 (en) 2015-01-22
IL232949A0 (en) 2014-08-03
US20160318858A1 (en) 2016-11-03
BR112014019909B1 (pt) 2020-01-28
IL232949A (en) 2016-08-31
CN104114524B (zh) 2016-08-17
SG11201403216UA (en) 2014-12-30
EP2814798B1 (en) 2019-04-03
WO2013123240A1 (en) 2013-08-22
HUE043995T2 (hu) 2019-09-30
US9416109B2 (en) 2016-08-16
CA2861493C (en) 2019-09-24
US9828336B2 (en) 2017-11-28
ES2733750T3 (es) 2019-12-02
RU2617696C2 (ru) 2017-04-26
RU2014137470A (ru) 2016-04-10
BR112014019909A8 (pt) 2017-07-11
CN104114524A (zh) 2014-10-22
MX2014009917A (es) 2014-11-13
JP2015509939A (ja) 2015-04-02

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