HUE051661T2 - Készítmények és gyógyászati felhasználások a TCR újraprogramozására fúziós fehérjék felhasználásával - Google Patents

Készítmények és gyógyászati felhasználások a TCR újraprogramozására fúziós fehérjék felhasználásával

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Publication number
HUE051661T2
HUE051661T2 HUE16797244A HUE16797244A HUE051661T2 HU E051661 T2 HUE051661 T2 HU E051661T2 HU E16797244 A HUE16797244 A HU E16797244A HU E16797244 A HUE16797244 A HU E16797244A HU E051661 T2 HUE051661 T2 HU E051661T2
Authority
HU
Hungary
Prior art keywords
compositions
fusion proteins
medical uses
reprogramming
tcr
Prior art date
Application number
HUE16797244A
Other languages
English (en)
Inventor
Patrick Baeuerle
Gregory Sieczkiewicz
Robert Hofmeister
Original Assignee
Tcr2 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57320750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE051661(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tcr2 Therapeutics Inc filed Critical Tcr2 Therapeutics Inc
Publication of HUE051661T2 publication Critical patent/HUE051661T2/hu

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells

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HUE16797244A 2015-05-18 2016-05-18 Készítmények és gyógyászati felhasználások a TCR újraprogramozására fúziós fehérjék felhasználásával HUE051661T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562163342P 2015-05-18 2015-05-18

Publications (1)

Publication Number Publication Date
HUE051661T2 true HUE051661T2 (hu) 2021-03-29

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ID=57320750

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Application Number Title Priority Date Filing Date
HUE16797244A HUE051661T2 (hu) 2015-05-18 2016-05-18 Készítmények és gyógyászati felhasználások a TCR újraprogramozására fúziós fehérjék felhasználásával

Country Status (20)

Country Link
US (7) US10442849B2 (hu)
EP (3) EP3770168A1 (hu)
JP (4) JP2018515123A (hu)
KR (1) KR20180029201A (hu)
CN (2) CN114634943A (hu)
AU (2) AU2016264323B2 (hu)
BR (1) BR112017024757A2 (hu)
CA (1) CA2986254A1 (hu)
DK (1) DK3298033T4 (hu)
EA (2) EA035618B1 (hu)
ES (1) ES2819976T5 (hu)
FI (1) FI3298033T4 (hu)
HK (1) HK1252643A1 (hu)
HU (1) HUE051661T2 (hu)
IL (2) IL303905A (hu)
MX (1) MX2017014822A (hu)
PL (1) PL3298033T5 (hu)
PT (1) PT3298033T (hu)
SG (1) SG10201914069SA (hu)
WO (1) WO2016187349A1 (hu)

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