BR112018016281A2 - molécula biespecífica ativadora de célula t ativável por protease, polipeptídeo idiotipo-específico, composição farmacêutica, usos da molécula biespecífica e método de tratamento de uma doença em um indivíduo - Google Patents
molécula biespecífica ativadora de célula t ativável por protease, polipeptídeo idiotipo-específico, composição farmacêutica, usos da molécula biespecífica e método de tratamento de uma doença em um indivíduoInfo
- Publication number
- BR112018016281A2 BR112018016281A2 BR112018016281A BR112018016281A BR112018016281A2 BR 112018016281 A2 BR112018016281 A2 BR 112018016281A2 BR 112018016281 A BR112018016281 A BR 112018016281A BR 112018016281 A BR112018016281 A BR 112018016281A BR 112018016281 A2 BR112018016281 A2 BR 112018016281A2
- Authority
- BR
- Brazil
- Prior art keywords
- bispecific
- idiotype
- molecule
- cell activating
- disease
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a presente invenção diz respeito, de modo geral, a novas moléculas biespecíficas ativadoras de células t ativáveis por protease e polipeptídeos idiotipo-específicos. a presente invenção também diz respeito a polinucleotídeos que codificam tais moléculas biespecíficas ativadoras de célula t ativadas por protease e polipeptídeos idiotipo-específicos, e vetores e células hospedeiras compreendendo tais polinucleotídeos. a invenção diz respeito ainda a métodos para produzir as moléculas biespecíficas ativadoras de célula t ativáveis por protease e os polipeptídeos idiotipo-específicos da invenção; e a métodos de uso destas moléculas biespecíficas ativadoras de célula t ativáveis por protease e polipeptídeos idiotipo-específicos no tratamento de doenças.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16161740 | 2016-03-22 | ||
US201662433327P | 2016-12-13 | 2016-12-13 | |
PCT/EP2017/056556 WO2017162587A1 (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018016281A2 true BR112018016281A2 (pt) | 2019-01-02 |
Family
ID=55646332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018016281A BR112018016281A2 (pt) | 2016-03-22 | 2017-03-20 | molécula biespecífica ativadora de célula t ativável por protease, polipeptídeo idiotipo-específico, composição farmacêutica, usos da molécula biespecífica e método de tratamento de uma doença em um indivíduo |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3433280B1 (pt) |
KR (1) | KR102444614B1 (pt) |
CN (1) | CN108884170A (pt) |
AR (2) | AR107946A1 (pt) |
AU (1) | AU2017237376B2 (pt) |
BR (1) | BR112018016281A2 (pt) |
CA (1) | CA3012422A1 (pt) |
CO (1) | CO2018007556A2 (pt) |
CR (1) | CR20180453A (pt) |
MA (1) | MA43724B1 (pt) |
PE (1) | PE20181891A1 (pt) |
PT (1) | PT3433280T (pt) |
SG (1) | SG11201808085WA (pt) |
WO (1) | WO2017162587A1 (pt) |
Families Citing this family (32)
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CN110177875B (zh) | 2016-11-28 | 2023-11-28 | 中外制药株式会社 | 包含抗原结合结构域和运送部分的多肽 |
JP2020508663A (ja) * | 2017-02-22 | 2020-03-26 | アレタ・バイオセラピューティクス・インコーポレイテッドAleta Biotherapeutics Inc. | 癌の治療のための組成物及び方法 |
US10927180B2 (en) | 2017-10-13 | 2021-02-23 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
WO2019075405A1 (en) | 2017-10-14 | 2019-04-18 | Cytomx Therapeutics, Inc. | ANTIBODIES, ACTIVISTIC ANTIBODIES, BISPECIFIC ANTIBODIES, AND BISPECIFICALLY ACTIVATED ANTIBODIES AND METHODS OF USE THEREOF |
JP7482630B2 (ja) * | 2017-11-28 | 2024-05-14 | 中外製薬株式会社 | 抗原結合ドメインおよび運搬部分を含むポリペプチド |
AU2018376309A1 (en) * | 2017-11-28 | 2020-06-25 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand-binding activity |
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KR20230005952A (ko) | 2020-05-04 | 2023-01-10 | 임뮤노라이즌 엘티디. | 전구체 삼중-특이적 항체 구조체 및 그의 이용 방법 |
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BR112017018111A2 (pt) * | 2015-03-17 | 2018-04-10 | Tilt Biotherapeutics Oy | adenovírus oncolítico codificando para anticorpos bi-específicos e métodos e usos relacionados ao mesmo |
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2017
- 2017-03-20 MA MA43724A patent/MA43724B1/fr unknown
- 2017-03-20 CR CR20180453A patent/CR20180453A/es unknown
- 2017-03-20 SG SG11201808085WA patent/SG11201808085WA/en unknown
- 2017-03-20 PT PT177112232T patent/PT3433280T/pt unknown
- 2017-03-20 CA CA3012422A patent/CA3012422A1/en active Pending
- 2017-03-20 PE PE2018001324A patent/PE20181891A1/es unknown
- 2017-03-20 CN CN201780018328.8A patent/CN108884170A/zh active Pending
- 2017-03-20 KR KR1020187027293A patent/KR102444614B1/ko active IP Right Grant
- 2017-03-20 BR BR112018016281A patent/BR112018016281A2/pt unknown
- 2017-03-20 WO PCT/EP2017/056556 patent/WO2017162587A1/en active Application Filing
- 2017-03-20 EP EP17711223.2A patent/EP3433280B1/en active Active
- 2017-03-20 AU AU2017237376A patent/AU2017237376B2/en active Active
- 2017-03-22 AR ARP170100708A patent/AR107946A1/es unknown
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2018
- 2018-07-18 CO CONC2018/0007556A patent/CO2018007556A2/es unknown
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2020
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Also Published As
Publication number | Publication date |
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CA3012422A1 (en) | 2017-09-28 |
AR107946A1 (es) | 2018-06-28 |
EP3433280B1 (en) | 2023-04-19 |
PE20181891A1 (es) | 2018-12-11 |
PT3433280T (pt) | 2023-06-15 |
AU2017237376B2 (en) | 2024-03-07 |
AR120543A2 (es) | 2022-02-23 |
KR20180128407A (ko) | 2018-12-03 |
EP3433280A1 (en) | 2019-01-30 |
AU2017237376A1 (en) | 2018-08-02 |
SG11201808085WA (en) | 2018-10-30 |
MA43724A (fr) | 2018-11-28 |
KR102444614B1 (ko) | 2022-09-21 |
WO2017162587A1 (en) | 2017-09-28 |
CN108884170A (zh) | 2018-11-23 |
CR20180453A (es) | 2018-12-05 |
CO2018007556A2 (es) | 2018-07-31 |
MA43724B1 (fr) | 2023-06-28 |
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