AR120543A2 - Moléculas biespecíficas de células t activadas por proteasas - Google Patents
Moléculas biespecíficas de células t activadas por proteasasInfo
- Publication number
- AR120543A2 AR120543A2 ARP200103258A ARP200103258A AR120543A2 AR 120543 A2 AR120543 A2 AR 120543A2 AR P200103258 A ARP200103258 A AR P200103258A AR P200103258 A ARP200103258 A AR P200103258A AR 120543 A2 AR120543 A2 AR 120543A2
- Authority
- AR
- Argentina
- Prior art keywords
- protease
- idiotype
- activatable
- bispecific
- molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente se refiere en general a moléculas biespecíficas activadoras de células T activables por proteasas y polipéptidos específicos de idiotipo. La presente también se refiere a polinucleótidos que codifican dichas moléculas biespecíficas activadoras de células T activables por proteasas y polipéptidos específicos de idiotipo, y a vectores y células hospedadoras que comprenden dichos polinucleótidos. La presente se refiere además a métodos para producir las moléculas biespecíficas activadoras de células T activables por proteasas y polipéptidos específicos de idiotipo de la misma, y a métodos para usar estas moléculas biespecíficas activadoras de células T activables por proteasas y polipéptidos específicos de idiotipo en el tratamiento de enfermedades.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16161740 | 2016-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR120543A2 true AR120543A2 (es) | 2022-02-23 |
Family
ID=55646332
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170100708A AR107946A1 (es) | 2016-03-22 | 2017-03-22 | Moléculas biespecíficas de células t activadas por proteasas |
ARP200103258A AR120543A2 (es) | 2016-03-22 | 2020-11-24 | Moléculas biespecíficas de células t activadas por proteasas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170100708A AR107946A1 (es) | 2016-03-22 | 2017-03-22 | Moléculas biespecíficas de células t activadas por proteasas |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3433280B1 (es) |
KR (1) | KR102444614B1 (es) |
CN (1) | CN108884170A (es) |
AR (2) | AR107946A1 (es) |
AU (1) | AU2017237376B2 (es) |
BR (1) | BR112018016281A2 (es) |
CA (1) | CA3012422A1 (es) |
CO (1) | CO2018007556A2 (es) |
CR (1) | CR20180453A (es) |
MA (1) | MA43724B1 (es) |
PE (1) | PE20181891A1 (es) |
PT (1) | PT3433280T (es) |
SG (1) | SG11201808085WA (es) |
WO (1) | WO2017162587A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI3298033T4 (fi) | 2015-05-18 | 2023-09-22 | Tcr2 Therapeutics Inc | Koostumuksia ja lääkinnällisiä käyttöjä fuusioproteiineja käyttävälle tcr:n uudelleenohjelmoinnille |
CA3041279A1 (en) | 2016-11-28 | 2018-05-31 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding domain, and polypeptide including conveying section |
MA47613A (fr) * | 2017-02-22 | 2020-01-01 | Aleta Biotherapeutics Inc | Compositions et procédés de traitement du cancer |
AU2018346955A1 (en) | 2017-10-13 | 2020-04-30 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
KR20200064096A (ko) | 2017-10-14 | 2020-06-05 | 싸이톰스 테라퓨틱스, 인크. | 항체, 활성화 가능한 항체, 이중특이적 항체 및 이중특이적 활성화 가능한 항체 및 이들의 사용 방법 |
US20210206845A1 (en) * | 2017-11-28 | 2021-07-08 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand-binding activity |
TW202348632A (zh) * | 2017-11-28 | 2023-12-16 | 日商中外製藥股份有限公司 | 含有抗原結合域及運輸部分之多胜肽 |
US20200385440A1 (en) * | 2017-12-07 | 2020-12-10 | Janux Therapeutics, Inc. | Modified bispecific t cell receptors |
BR112020016169A2 (pt) * | 2018-02-08 | 2020-12-15 | Genentech, Inc. | Moléculas de ligação ao antígeno biespecíficas, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir a molécula de ligação, conjunto de ácidos nucleicos isolados, conjunto de vetores, conjunto de células hospedeiras, imunoconjugado, composição, uso da molécula de ligação, métodos para tratar ou retardar a progressão de um câncer, métodos para aperfeiçoar a função imune e kit |
WO2019222275A2 (en) * | 2018-05-14 | 2019-11-21 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using inducible fusion proteins |
BR112020023330A2 (pt) * | 2018-05-14 | 2021-04-20 | Harpoon Therapeutics, Inc. | porção de ligação para ativação condicional de moléculas de imunoglobulina |
AU2019288484A1 (en) | 2018-06-22 | 2021-01-21 | Cugene Inc. | Cytokine-based bioactivatable drugs and methods of uses thereof |
EP3834849A4 (en) * | 2018-07-24 | 2022-08-03 | CRAGE medical Co., Limited | METHOD OF TREATMENT OF A TUMOR USING AN IMMUNE EFFECTOR CELL |
JP7425049B2 (ja) | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス,インク. | Dll3結合タンパク質および使用方法 |
CN113260379B (zh) * | 2018-12-21 | 2022-09-02 | 浙江时迈药业有限公司 | 蛋白酶可切割的双特异性抗体及其用途 |
BR112021019478A2 (pt) * | 2019-03-29 | 2021-11-30 | Green Cross Corp | Primeira, segunda e terceira proteínas de fusão compreendendo anticorpos anti-mesotelina, anti-cd3 e anti-egfr, anticorpos biespecífico e triespecífico, composição farmacêutica que compreende os mesmos e usos das ditas proteínas e anticorpos, bem como da dita composição farmacêutica para tratar câncer |
GB201906685D0 (en) * | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
EP4023230A4 (en) * | 2019-06-05 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | ANTIBODY CLEAVAGE SITE BINDING MOLECULE |
KR20220020879A (ko) * | 2019-06-12 | 2022-02-21 | 에스크진 파마, 아이엔씨. | 새로운 il-15 프로드럭 및 이를 사용하는 방법 |
WO2021013068A1 (en) * | 2019-07-19 | 2021-01-28 | Wuxi Biologics (Shanghai) Co., Ltd. | Polypeptide complex for conjugation and use thereof |
KR20220166814A (ko) | 2020-04-09 | 2022-12-19 | 싸이톰스 테라퓨틱스, 인크. | 활성화 가능한 항체를 함유하는 조성물 |
EP4146695A1 (en) | 2020-05-04 | 2023-03-15 | Immunorizon Ltd. | Precursor tri-specific antibody constructs and methods of use thereof |
CR20220604A (es) * | 2020-06-19 | 2023-01-23 | Hoffmann La Roche | Anticuerpos biespecíficos para linfocitos t activados por proteasa |
WO2022170619A1 (en) * | 2021-02-11 | 2022-08-18 | Adagene Pte. Ltd. | Anti-cd3 antibodies and methods of use thereof |
TW202323282A (zh) * | 2021-10-15 | 2023-06-16 | 美商賽特艾克斯生物製藥公司 | 可活化之多肽複合物 |
TW202330611A (zh) * | 2021-10-15 | 2023-08-01 | 美商賽特艾克斯生物製藥公司 | 可活化之多肽複合物 |
WO2023186760A1 (en) * | 2022-03-28 | 2023-10-05 | F. Hoffmann-La Roche Ag | Improved folr1 protease-activatable t cell bispecific antibodies |
WO2023192973A1 (en) * | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Activatable multispecific molecules and methods of use thereof |
WO2023220647A1 (en) | 2022-05-11 | 2023-11-16 | Regeneron Pharmaceuticals, Inc. | Multispecific binding molecule proproteins and uses thereof |
WO2023222580A1 (en) | 2022-05-16 | 2023-11-23 | Byondis B.V. | Novel masked antibodies |
CN116462768B (zh) * | 2023-06-13 | 2023-09-22 | 浙江时迈药业有限公司 | 针对folr1的双特异性抗体及其用途 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7802170A (nl) | 1977-04-18 | 1978-10-20 | Hitachi Metals Ltd | Sierraad. |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
PT1034298E (pt) | 1997-12-05 | 2012-02-03 | Scripps Research Inst | Humanização de anticorpo murino |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
ATE303445T1 (de) | 1999-10-04 | 2005-09-15 | Medicago Inc | Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff |
US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
JP5128935B2 (ja) | 2004-03-31 | 2013-01-23 | ジェネンテック, インコーポレイテッド | ヒト化抗TGF−β抗体 |
DK1737891T3 (da) | 2004-04-13 | 2013-03-25 | Hoffmann La Roche | Anti-p-selectin-antistoffer |
TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
CN103981190A (zh) | 2005-02-07 | 2014-08-13 | 罗氏格黎卡特股份公司 | 结合egfr的抗原结合分子,编码它的载体,及其应用 |
WO2006099141A2 (en) * | 2005-03-10 | 2006-09-21 | Morphotek, Inc. | Anti-mesothelin antibodies |
PL2235064T3 (pl) | 2008-01-07 | 2016-06-30 | Amgen Inc | Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych |
ES2692268T3 (es) | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
GB201203442D0 (en) * | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
WO2014004549A2 (en) * | 2012-06-27 | 2014-01-03 | Amgen Inc. | Anti-mesothelin binding proteins |
EP2970484B2 (en) * | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimeric bispecific antibodies |
US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
US20140308285A1 (en) * | 2013-03-15 | 2014-10-16 | Amgen Inc. | Heterodimeric bispecific antibodies |
NZ715896A (en) * | 2013-07-05 | 2022-02-25 | Genmab As | Humanized or chimeric cd3 antibodies |
EP4067383A1 (en) * | 2013-07-25 | 2022-10-05 | Cytomx Therapeutics Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
WO2015048272A1 (en) * | 2013-09-25 | 2015-04-02 | Amgen Inc. | V-c-fc-v-c antibody |
CN107108738A (zh) * | 2014-07-25 | 2017-08-29 | 西托姆克斯治疗公司 | 抗cd3抗体、可活化抗cd3抗体、多特异性抗cd3抗体、多特异性可活化抗cd3抗体及其使用方法 |
EP2982692A1 (en) * | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
SG11201703803WA (en) * | 2014-11-11 | 2017-06-29 | Amunix Operating Inc | Targeted xten conjugate compositions and methods of making same |
CN107207609B (zh) * | 2014-11-20 | 2022-07-19 | 豪夫迈·罗氏有限公司 | 共同轻链和使用方法 |
JP6754532B2 (ja) * | 2015-03-17 | 2020-09-16 | ティーアイエルティー・バイオセラピューティクス・オーワイTILT Biotherapeutics Oy | 二重特異性抗体をコードする腫瘍溶解性アデノウイルスおよびそれに関連する方法と使用 |
-
2017
- 2017-03-20 EP EP17711223.2A patent/EP3433280B1/en active Active
- 2017-03-20 CR CR20180453A patent/CR20180453A/es unknown
- 2017-03-20 PE PE2018001324A patent/PE20181891A1/es unknown
- 2017-03-20 SG SG11201808085WA patent/SG11201808085WA/en unknown
- 2017-03-20 PT PT177112232T patent/PT3433280T/pt unknown
- 2017-03-20 MA MA43724A patent/MA43724B1/fr unknown
- 2017-03-20 KR KR1020187027293A patent/KR102444614B1/ko active IP Right Grant
- 2017-03-20 AU AU2017237376A patent/AU2017237376B2/en active Active
- 2017-03-20 CN CN201780018328.8A patent/CN108884170A/zh active Pending
- 2017-03-20 WO PCT/EP2017/056556 patent/WO2017162587A1/en active Application Filing
- 2017-03-20 CA CA3012422A patent/CA3012422A1/en active Pending
- 2017-03-20 BR BR112018016281A patent/BR112018016281A2/pt unknown
- 2017-03-22 AR ARP170100708A patent/AR107946A1/es unknown
-
2018
- 2018-07-18 CO CONC2018/0007556A patent/CO2018007556A2/es unknown
-
2020
- 2020-11-24 AR ARP200103258A patent/AR120543A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20180128407A (ko) | 2018-12-03 |
EP3433280B1 (en) | 2023-04-19 |
MA43724A (fr) | 2018-11-28 |
WO2017162587A1 (en) | 2017-09-28 |
AU2017237376A1 (en) | 2018-08-02 |
BR112018016281A2 (pt) | 2019-01-02 |
SG11201808085WA (en) | 2018-10-30 |
MA43724B1 (fr) | 2023-06-28 |
CR20180453A (es) | 2018-12-05 |
CO2018007556A2 (es) | 2018-07-31 |
PE20181891A1 (es) | 2018-12-11 |
CA3012422A1 (en) | 2017-09-28 |
AU2017237376B2 (en) | 2024-03-07 |
KR102444614B1 (ko) | 2022-09-21 |
EP3433280A1 (en) | 2019-01-30 |
PT3433280T (pt) | 2023-06-15 |
AR107946A1 (es) | 2018-06-28 |
CN108884170A (zh) | 2018-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR120543A2 (es) | Moléculas biespecíficas de células t activadas por proteasas | |
CL2018002507A1 (es) | Moléculas biespecíficas de células t activadas por proteasas. | |
CO2017003048A2 (es) | Moléculas de unión a antígeno biespecíficas activadoras de células t que se unen a cd3 y al receptor 1 de folato (folr1) | |
CO2017013710A2 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t. | |
AR109771A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
CL2018001971A1 (es) | Ror1 composiciones de anticuerpos y métodos relacionados | |
CR20170032A (es) | Moleculas biespecíficas de unión a antígeno activadoras de células t | |
AR105444A1 (es) | Anticuerpos terapéuticos que se unen a la proteína codificada por el gen de activación de linfocitos 3 (lag3) | |
CO2018012374A2 (es) | Moléculas de anticuerpo para el tratamiento del cáncer | |
CO2018001524A2 (es) | Anticuerpos anti-bcma, moléculas de unión a antígenos biespecíficas que se unen a bcma y cd3, y usos de estos | |
UY36687A (es) | Anticuerpos contra ox40 y sus usos | |
PE20151410A1 (es) | Moleculas biespecificas de union a antigeno activadoras de celulas t | |
PE20190563A1 (es) | Genes de mini-distrofina optimizados y casetes de expresion y su uso | |
PE20150752A1 (es) | Proteinas de fusion de interleuquina-2 y usos de las mismas | |
BR112015022625A2 (pt) | micromatrizes para entrega de agente terapêutico e métodos de uso | |
CL2018002754A1 (es) | Proceso de produccion de raav a base de columnas completamente escalable. | |
PE20150645A1 (es) | Proteinas de fusion de interleuquina 10 y usos de las mismas | |
CL2019002368A1 (es) | Composiciones y métodos para el tratamiento de cáncer. | |
MX2020004801A (es) | Polipeptidos de fusion biespecificos y sus metodos de uso. | |
BR112017018522A2 (pt) | composições e métodos para diagnóstico e tratamento do câncer | |
DOP2016000202A (es) | Proteínas de fusión uti | |
CO2019010164A2 (es) | Anticuerpos que se unen a steap-1 | |
UY37630A (es) | Combinación farmacéutica, kit, célula huésped que la produce y su uso en métodos para el tratamiento del cáncer | |
AR119972A2 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
UY36277A (es) | Proteínas de fusión uti |