PE20150752A1 - Proteinas de fusion de interleuquina-2 y usos de las mismas - Google Patents
Proteinas de fusion de interleuquina-2 y usos de las mismasInfo
- Publication number
- PE20150752A1 PE20150752A1 PE2014002251A PE2014002251A PE20150752A1 PE 20150752 A1 PE20150752 A1 PE 20150752A1 PE 2014002251 A PE2014002251 A PE 2014002251A PE 2014002251 A PE2014002251 A PE 2014002251A PE 20150752 A1 PE20150752 A1 PE 20150752A1
- Authority
- PE
- Peru
- Prior art keywords
- fusion proteins
- interleuquin
- methods
- present
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invencion se refiere de manera general a proteinas de fusion de inmunoglobulinas e interleuquina-2 (IL-2). Ademas, la presente invencion se refiere a polinucleotidos codificantes de dichas proteinas de fusion, y a vectores y celulas huesped que comprenden dichos polinucleotidos. La invencion se refiere ademas a metodos para producir las proteinas de fusion de la invencion, y a metodos de utilizacion de los mismos en el tratamiento o profilaxis de enfermedades autoinmunologicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261681676P | 2012-08-10 | 2012-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150752A1 true PE20150752A1 (es) | 2015-05-15 |
Family
ID=48948417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2014002251A PE20150752A1 (es) | 2012-08-10 | 2013-08-07 | Proteinas de fusion de interleuquina-2 y usos de las mismas |
Country Status (22)
Country | Link |
---|---|
US (4) | US20140044675A1 (es) |
EP (1) | EP2882458B1 (es) |
JP (1) | JP6526561B2 (es) |
KR (1) | KR20150041628A (es) |
CN (2) | CN111635460A (es) |
AR (1) | AR092089A1 (es) |
AU (1) | AU2013301562B2 (es) |
BR (1) | BR112015002765A2 (es) |
CA (1) | CA2873291A1 (es) |
CL (1) | CL2014003322A1 (es) |
CO (1) | CO7121348A2 (es) |
CR (1) | CR20140532A (es) |
EA (1) | EA201500206A1 (es) |
HK (1) | HK1208827A1 (es) |
IL (1) | IL236933A0 (es) |
MA (1) | MA37894B1 (es) |
MX (1) | MX2015001749A (es) |
PE (1) | PE20150752A1 (es) |
PH (1) | PH12014502767A1 (es) |
SG (1) | SG11201407579QA (es) |
TW (1) | TW201420607A (es) |
WO (1) | WO2014023752A1 (es) |
Families Citing this family (51)
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UA117294C2 (uk) | 2011-02-10 | 2018-07-10 | Рош Глікарт Аг | Імунокон'югат |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
CA2894511C (en) | 2012-12-11 | 2021-12-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for high throughput receptor:ligand identification |
SI3102595T1 (sl) | 2014-02-06 | 2019-02-28 | F. Hoffmann-La Roche Ag | Fuzijske beljakovine z interlevkinom-2 in njihova uporaba |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
EP3482766B1 (en) * | 2014-08-11 | 2020-05-20 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
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MX2020006322A (es) | 2017-12-19 | 2020-09-18 | Xencor Inc | Proteinas de fusion il-2 fc modificadas. |
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JP7534215B2 (ja) * | 2018-01-24 | 2024-08-14 | ベイジン パーカンズ オンコロジー カンパニー リミテッド | サイトカイン融合タンパク質 |
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EP3626739A1 (en) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
SI3102595T1 (sl) | 2014-02-06 | 2019-02-28 | F. Hoffmann-La Roche Ag | Fuzijske beljakovine z interlevkinom-2 in njihova uporaba |
MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
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2013
- 2013-08-06 US US13/960,149 patent/US20140044675A1/en not_active Abandoned
- 2013-08-07 PE PE2014002251A patent/PE20150752A1/es not_active Application Discontinuation
- 2013-08-07 KR KR20157003397A patent/KR20150041628A/ko not_active Application Discontinuation
- 2013-08-07 EA EA201500206A patent/EA201500206A1/ru unknown
- 2013-08-07 CN CN202010331382.1A patent/CN111635460A/zh active Pending
- 2013-08-07 JP JP2015525869A patent/JP6526561B2/ja not_active Expired - Fee Related
- 2013-08-07 SG SG11201407579QA patent/SG11201407579QA/en unknown
- 2013-08-07 AU AU2013301562A patent/AU2013301562B2/en not_active Ceased
- 2013-08-07 EP EP13745844.4A patent/EP2882458B1/en active Active
- 2013-08-07 CA CA2873291A patent/CA2873291A1/en not_active Abandoned
- 2013-08-07 MA MA37894A patent/MA37894B1/fr unknown
- 2013-08-07 WO PCT/EP2013/066516 patent/WO2014023752A1/en active Application Filing
- 2013-08-07 CN CN201380041053.1A patent/CN104507504A/zh active Pending
- 2013-08-07 MX MX2015001749A patent/MX2015001749A/es unknown
- 2013-08-07 BR BR112015002765A patent/BR112015002765A2/pt active Search and Examination
- 2013-08-09 TW TW102128732A patent/TW201420607A/zh unknown
- 2013-08-09 AR ARP130102839A patent/AR092089A1/es unknown
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2014
- 2014-10-31 CO CO14241630A patent/CO7121348A2/es unknown
- 2014-11-20 CR CR20140532A patent/CR20140532A/es unknown
- 2014-12-04 CL CL2014003322A patent/CL2014003322A1/es unknown
- 2014-12-10 PH PH12014502767A patent/PH12014502767A1/en unknown
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2015
- 2015-01-26 IL IL236933A patent/IL236933A0/en unknown
- 2015-10-02 HK HK15109669.4A patent/HK1208827A1/xx unknown
- 2015-12-11 US US14/967,019 patent/US20160090407A1/en not_active Abandoned
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2017
- 2017-09-05 US US15/695,899 patent/US10562949B2/en not_active Expired - Fee Related
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2020
- 2020-02-05 US US16/783,141 patent/US11365232B2/en active Active
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Publication number | Publication date |
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CN111635460A (zh) | 2020-09-08 |
CR20140532A (es) | 2015-01-12 |
CL2014003322A1 (es) | 2015-02-13 |
SG11201407579QA (en) | 2014-12-30 |
EA201500206A1 (ru) | 2016-04-29 |
WO2014023752A1 (en) | 2014-02-13 |
EP2882458B1 (en) | 2018-07-11 |
CN104507504A (zh) | 2015-04-08 |
KR20150041628A (ko) | 2015-04-16 |
IL236933A0 (en) | 2015-03-31 |
AU2013301562B2 (en) | 2017-04-06 |
JP2015530984A (ja) | 2015-10-29 |
AU2013301562A1 (en) | 2014-11-20 |
MA37894B1 (fr) | 2020-01-31 |
EP2882458A1 (en) | 2015-06-17 |
TW201420607A (zh) | 2014-06-01 |
JP6526561B2 (ja) | 2019-06-05 |
BR112015002765A2 (pt) | 2018-03-13 |
US11365232B2 (en) | 2022-06-21 |
CA2873291A1 (en) | 2014-02-13 |
MX2015001749A (es) | 2015-06-05 |
AR092089A1 (es) | 2015-03-25 |
US20160090407A1 (en) | 2016-03-31 |
HK1208827A1 (en) | 2016-03-18 |
US20180009868A1 (en) | 2018-01-11 |
US20140044675A1 (en) | 2014-02-13 |
MA37894A1 (fr) | 2018-07-31 |
CO7121348A2 (es) | 2014-11-20 |
US10562949B2 (en) | 2020-02-18 |
US20200172591A1 (en) | 2020-06-04 |
PH12014502767A1 (en) | 2015-02-09 |
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