MA37894B1 - Protéines de fusion d'interleukine-2 et leurs utilisations - Google Patents
Protéines de fusion d'interleukine-2 et leurs utilisationsInfo
- Publication number
- MA37894B1 MA37894B1 MA37894A MA37894A MA37894B1 MA 37894 B1 MA37894 B1 MA 37894B1 MA 37894 A MA37894 A MA 37894A MA 37894 A MA37894 A MA 37894A MA 37894 B1 MA37894 B1 MA 37894B1
- Authority
- MA
- Morocco
- Prior art keywords
- fusion proteins
- interleukin
- methods
- present
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne en général des protéines de fusion d'immunoglobulines et d'interleukine-2 (il-2). De plus, la présente invention concerne des polynucléotides codant pour de telles protéines de fusion, et des vecteurs et cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des protéines de fusion de l'invention, et leurs procédés d'utilisation dans le traitement d'une maladie.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681676P | 2012-08-10 | 2012-08-10 | |
| PCT/EP2013/066516 WO2014023752A1 (fr) | 2012-08-10 | 2013-08-07 | Protéines de fusion d'interleukine-2 et leurs utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37894A1 MA37894A1 (fr) | 2018-07-31 |
| MA37894B1 true MA37894B1 (fr) | 2020-01-31 |
Family
ID=48948417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37894A MA37894B1 (fr) | 2012-08-10 | 2013-08-07 | Protéines de fusion d'interleukine-2 et leurs utilisations |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20140044675A1 (fr) |
| EP (1) | EP2882458B1 (fr) |
| JP (1) | JP6526561B2 (fr) |
| KR (1) | KR20150041628A (fr) |
| CN (2) | CN111635460A (fr) |
| AR (1) | AR092089A1 (fr) |
| AU (1) | AU2013301562B2 (fr) |
| BR (1) | BR112015002765A2 (fr) |
| CA (1) | CA2873291A1 (fr) |
| CL (1) | CL2014003322A1 (fr) |
| CO (1) | CO7121348A2 (fr) |
| CR (1) | CR20140532A (fr) |
| EA (1) | EA201500206A1 (fr) |
| HK (1) | HK1208827A1 (fr) |
| IL (1) | IL236933A0 (fr) |
| MA (1) | MA37894B1 (fr) |
| MX (1) | MX2015001749A (fr) |
| PE (1) | PE20150752A1 (fr) |
| PH (1) | PH12014502767A1 (fr) |
| SG (1) | SG11201407579QA (fr) |
| TW (1) | TW201420607A (fr) |
| WO (1) | WO2014023752A1 (fr) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9266938B2 (en) | 2011-02-10 | 2016-02-23 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| JP2016500255A (ja) | 2012-12-11 | 2016-01-12 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ハイスループットなレセプター:リガンド同定の方法 |
| CN111423513A (zh) | 2014-02-06 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 白介素-2融合蛋白和其用途 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| SG11201700629TA (en) * | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN115925939A (zh) * | 2015-08-06 | 2023-04-07 | 新加坡科技研究局 | IL2Rβ/通用γ链抗体 |
| EP3383891A1 (fr) | 2015-12-04 | 2018-10-10 | Novartis AG | Compositions à greffe de cytokine-anticorps et procédés d'utilisation pour l'immunorégulation |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| JP7071288B2 (ja) | 2016-05-18 | 2022-05-18 | キュー バイオファーマ, インコーポレイテッド | T細胞調節多量体ポリペプチド及びその使用方法 |
| US11339201B2 (en) | 2016-05-18 | 2022-05-24 | Albert Einstein College Of Medicine | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| WO2018089420A1 (fr) | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Variants d'il-2 pour le traitement de maladies auto-immunes |
| MX2019007611A (es) | 2016-12-22 | 2020-07-29 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos t y métodos para su uso. |
| EP3565829A4 (fr) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs de lymphocytes t et leurs procédés d'utilisation |
| CN118453840A (zh) | 2017-03-15 | 2024-08-09 | 库尔生物制药有限公司 | 用于调节免疫应答的方法 |
| CN108623693B (zh) * | 2017-03-20 | 2022-03-25 | 徐寒梅 | 一种融合蛋白及其制备方法和其在制备治疗眼科疾病、抗炎、抗肿瘤药物中的应用 |
| IL322309A (en) | 2017-05-24 | 2025-09-01 | Novartis Ag | IL2 antibody grafted proteins and methods of use in cancer treatment |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| EP3728302A1 (fr) | 2017-12-19 | 2020-10-28 | Xencor, Inc. | Protéines de fusion il-2 fc modifiées |
| WO2019139896A1 (fr) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs de lymphocytes t et leurs procédés d'utilisation |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| CN112105632A (zh) * | 2018-01-24 | 2020-12-18 | 北京智康博药肿瘤医学研究有限公司 | 细胞因子融合蛋白 |
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| BR112020018709A2 (pt) | 2018-03-28 | 2021-01-05 | Bristol-Myers Squibb Company | Proteínas de fusão do receptor alfa de interleucina-2/interleucina-2 e métodos de uso |
| WO2020007937A1 (fr) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Utilisation de l'interleukine-2 pour le traitement de la sclérose systémique |
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| US20220002370A1 (en) * | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
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| JP2023526282A (ja) | 2020-05-13 | 2023-06-21 | ボナム セラピューティクス,インク. | タンパク質複合体の組成物及びその使用方法 |
| CN113912734B (zh) * | 2020-07-08 | 2025-02-28 | 南京师范大学 | 融合多肽及其用途 |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ, インコーポレイテッド | 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
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| CN112724259B (zh) * | 2020-11-16 | 2022-12-20 | 天津林达生物科技有限公司 | 人血清白蛋白与白介素2的融合蛋白及其用途 |
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| CA3265946A1 (fr) | 2022-09-12 | 2024-03-21 | Sorbonne Universite | Interleukine-2 pour le traitement des troubles du spectre autistique |
| KR20240055222A (ko) * | 2022-10-19 | 2024-04-29 | 주식회사 에이프릴바이오 | 인터루킨-2 변이 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도 |
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| EP4630035A1 (fr) | 2022-12-05 | 2025-10-15 | Centre Hospitalier Universitaire de Nimes | Interleukine-2 humaine à faible dose pour traitement de la sclérose latérale amyotrophique dans un sous-groupe de patients |
| WO2024151515A2 (fr) | 2023-01-09 | 2024-07-18 | Odyssey Therapeutics, Inc. | Protéines de liaison à l'antigène anti-tnfr2 et leurs utilisations |
| WO2025217240A1 (fr) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Protéines de liaison à l'antigène anti-tnfr2 et leurs utilisations |
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| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| US20060110398A1 (en) * | 2004-11-24 | 2006-05-25 | Schering Corporation | DAP-10 and uses thereof |
| CA2656700A1 (fr) * | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions et procedes destines a ameliorer l'efficacite de reponses immunitaires a mediation par il-2 |
| WO2009013543A2 (fr) | 2007-07-25 | 2009-01-29 | Astrazeneca Ab | Agents de liaisons ciblés dirigés vers kdr, et utilisations de ceux-ci - 035 |
| WO2009061853A2 (fr) | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Polypeptides d'interleukine-2 (il-2) mutants |
| ES2564523T3 (es) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| AU2010206840B2 (en) | 2009-01-21 | 2015-02-05 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| SG187746A1 (en) | 2010-08-13 | 2013-03-28 | Roche Glycart Ag | Anti-fap antibodies and methods of use |
| CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| US9266938B2 (en) | 2011-02-10 | 2016-02-23 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| DK2683395T3 (en) | 2011-03-11 | 2018-11-19 | Hopitaux Paris Assist Publique | USE OF LOW DOSAGE IL-2 FOR TREATMENT OF TYPE 1 DIABETES |
| BR112013024574B1 (pt) | 2011-03-29 | 2022-08-09 | Roche Glycart Ag | Anticorpo e uso do anticorpo |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
| CN111423513A (zh) | 2014-02-06 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 白介素-2融合蛋白和其用途 |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
-
2013
- 2013-08-06 US US13/960,149 patent/US20140044675A1/en not_active Abandoned
- 2013-08-07 JP JP2015525869A patent/JP6526561B2/ja not_active Expired - Fee Related
- 2013-08-07 EA EA201500206A patent/EA201500206A1/ru unknown
- 2013-08-07 CN CN202010331382.1A patent/CN111635460A/zh active Pending
- 2013-08-07 MX MX2015001749A patent/MX2015001749A/es unknown
- 2013-08-07 WO PCT/EP2013/066516 patent/WO2014023752A1/fr not_active Ceased
- 2013-08-07 KR KR20157003397A patent/KR20150041628A/ko not_active Withdrawn
- 2013-08-07 AU AU2013301562A patent/AU2013301562B2/en not_active Ceased
- 2013-08-07 CN CN201380041053.1A patent/CN104507504A/zh active Pending
- 2013-08-07 HK HK15109669.4A patent/HK1208827A1/xx unknown
- 2013-08-07 PE PE2014002251A patent/PE20150752A1/es not_active Application Discontinuation
- 2013-08-07 EP EP13745844.4A patent/EP2882458B1/fr active Active
- 2013-08-07 MA MA37894A patent/MA37894B1/fr unknown
- 2013-08-07 CA CA2873291A patent/CA2873291A1/fr not_active Abandoned
- 2013-08-07 SG SG11201407579QA patent/SG11201407579QA/en unknown
- 2013-08-07 BR BR112015002765A patent/BR112015002765A2/pt active Search and Examination
- 2013-08-09 TW TW102128732A patent/TW201420607A/zh unknown
- 2013-08-09 AR ARP130102839A patent/AR092089A1/es unknown
-
2014
- 2014-10-31 CO CO14241630A patent/CO7121348A2/es unknown
- 2014-11-20 CR CR20140532A patent/CR20140532A/es unknown
- 2014-12-04 CL CL2014003322A patent/CL2014003322A1/es unknown
- 2014-12-10 PH PH12014502767A patent/PH12014502767A1/en unknown
-
2015
- 2015-01-26 IL IL236933A patent/IL236933A0/en unknown
- 2015-12-11 US US14/967,019 patent/US20160090407A1/en not_active Abandoned
-
2017
- 2017-09-05 US US15/695,899 patent/US10562949B2/en not_active Expired - Fee Related
-
2020
- 2020-02-05 US US16/783,141 patent/US11365232B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015530984A (ja) | 2015-10-29 |
| CA2873291A1 (fr) | 2014-02-13 |
| CO7121348A2 (es) | 2014-11-20 |
| JP6526561B2 (ja) | 2019-06-05 |
| MX2015001749A (es) | 2015-06-05 |
| SG11201407579QA (en) | 2014-12-30 |
| US20140044675A1 (en) | 2014-02-13 |
| PH12014502767A1 (en) | 2015-02-09 |
| US20160090407A1 (en) | 2016-03-31 |
| CR20140532A (es) | 2015-01-12 |
| IL236933A0 (en) | 2015-03-31 |
| EP2882458A1 (fr) | 2015-06-17 |
| AU2013301562B2 (en) | 2017-04-06 |
| CL2014003322A1 (es) | 2015-02-13 |
| US20200172591A1 (en) | 2020-06-04 |
| EP2882458B1 (fr) | 2018-07-11 |
| BR112015002765A2 (pt) | 2018-03-13 |
| MA37894A1 (fr) | 2018-07-31 |
| TW201420607A (zh) | 2014-06-01 |
| EA201500206A1 (ru) | 2016-04-29 |
| KR20150041628A (ko) | 2015-04-16 |
| PE20150752A1 (es) | 2015-05-15 |
| US20180009868A1 (en) | 2018-01-11 |
| HK1208827A1 (en) | 2016-03-18 |
| WO2014023752A1 (fr) | 2014-02-13 |
| US10562949B2 (en) | 2020-02-18 |
| CN111635460A (zh) | 2020-09-08 |
| CN104507504A (zh) | 2015-04-08 |
| AU2013301562A1 (en) | 2014-11-20 |
| AR092089A1 (es) | 2015-03-25 |
| US11365232B2 (en) | 2022-06-21 |
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