MA20150232A1 - Protéines de fusion de l'interleukine-10 et leurs utilisations - Google Patents
Protéines de fusion de l'interleukine-10 et leurs utilisationsInfo
- Publication number
- MA20150232A1 MA20150232A1 MA37793A MA37793A MA20150232A1 MA 20150232 A1 MA20150232 A1 MA 20150232A1 MA 37793 A MA37793 A MA 37793A MA 37793 A MA37793 A MA 37793A MA 20150232 A1 MA20150232 A1 MA 20150232A1
- Authority
- MA
- Morocco
- Prior art keywords
- interleukin
- fusion
- proteins
- fusion proteins
- methods
- Prior art date
Links
- 102000003814 Interleukin-10 Human genes 0.000 title abstract 2
- 108090000174 Interleukin-10 Proteins 0.000 title abstract 2
- 229940076144 interleukin-10 Drugs 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne en général des protéines de fusion d'anticorps et d'interleukine-10 (il-10). De plus, la présente invention concerne des polynucléotides codant pour de telles protéines de fusion, et des vecteurs et cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des protéines de fusion de l'invention et des procédés d'utilisation de celles-ci dans le traitement d'une maladie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12179709 | 2012-08-08 | ||
PCT/EP2013/066342 WO2014023673A1 (fr) | 2012-08-08 | 2013-08-05 | Protéines de fusion de l'interleukine-10 et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
MA20150232A1 true MA20150232A1 (fr) | 2015-07-31 |
Family
ID=48917543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37793A MA20150232A1 (fr) | 2012-08-08 | 2013-08-05 | Protéines de fusion de l'interleukine-10 et leurs utilisations |
Country Status (23)
Country | Link |
---|---|
US (2) | US9346872B2 (fr) |
EP (1) | EP2882774B1 (fr) |
JP (3) | JP2015530983A (fr) |
KR (1) | KR20150038012A (fr) |
CN (1) | CN104540848B (fr) |
AR (1) | AR092050A1 (fr) |
AU (1) | AU2013301656A1 (fr) |
BR (1) | BR112015002085A2 (fr) |
CA (1) | CA2876285A1 (fr) |
CL (1) | CL2014003605A1 (fr) |
CO (1) | CO7151522A2 (fr) |
CR (1) | CR20140565A (fr) |
EA (1) | EA201500208A1 (fr) |
HK (1) | HK1209439A1 (fr) |
IL (1) | IL236809A0 (fr) |
MA (1) | MA20150232A1 (fr) |
MX (1) | MX2015001675A (fr) |
PE (1) | PE20150645A1 (fr) |
PH (1) | PH12015500284A1 (fr) |
SG (1) | SG11201408526SA (fr) |
TW (1) | TW201418283A (fr) |
WO (1) | WO2014023673A1 (fr) |
ZA (1) | ZA201409304B (fr) |
Families Citing this family (57)
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SI2603530T1 (en) | 2010-08-13 | 2018-02-28 | Roche Glycart Ag | Anti-FAP antibodies and methods of use |
HUE055284T2 (hu) | 2011-02-10 | 2021-11-29 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
US9550819B2 (en) | 2012-03-27 | 2017-01-24 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
JP6272907B2 (ja) | 2013-01-30 | 2018-01-31 | エヌジーエム バイオファーマシューティカルズ インコーポレイテッド | 代謝障害の処置における組成物及び使用方法 |
US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
EP3062889A2 (fr) | 2013-11-01 | 2016-09-07 | Spherium Biomed S.L. | Corps d'inclusion pour administration transdermique d'agents thérapeutiques et cosmétiques |
MX2016010174A (es) * | 2014-02-06 | 2016-11-15 | Hoffmann La Roche | Proteinas de fusion de interleucina-10 y usos de las mismas. |
EP3142691A4 (fr) | 2014-05-16 | 2018-04-11 | Baylor Research Institute | Méthodes et compositions de traitement de maladies auto-immunes et inflammatoires |
JP6704358B2 (ja) | 2014-07-30 | 2020-06-03 | エヌジーエム バイオファーマシューティカルズ インコーポレイテッド | 代謝障害を治療するための組成物および使用方法 |
US9920118B2 (en) | 2014-10-31 | 2018-03-20 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
HUE049982T2 (hu) | 2014-11-14 | 2020-11-30 | Hoffmann La Roche | TNF-családba tartozó ligandum-trimert tartalmazó antigénkötõ molekulák |
ES2824151T3 (es) | 2014-12-19 | 2021-05-11 | Alkermes Inc | Proteínas de fusión Fc monocatenarias |
JP6996979B2 (ja) | 2015-03-31 | 2022-02-04 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 三量体tnfファミリーリガンドを含む抗原結合分子 |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
EP3356403A2 (fr) | 2015-10-02 | 2018-08-08 | H. Hoffnabb-La Roche Ag | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
US11219645B2 (en) | 2015-11-18 | 2022-01-11 | Duke University | Tumor infiltrating lymphocytes for treatment of cancer |
US10144768B2 (en) * | 2015-12-04 | 2018-12-04 | Novartis Ag | Antibody cytokine engrafted compositions and methods of use for immunoregulation |
CN106349393B (zh) * | 2015-12-21 | 2020-10-30 | 合肥立方制药股份有限公司 | 一种增强抗体药物稳定性的结构 |
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EP3474884A4 (fr) | 2016-06-22 | 2020-08-19 | Alkermes, Inc. | Compositions et méthodes permettant de moduler les propriétés immunostimulantes et anti-inflammatoires de l'il-10 |
CN112142859A (zh) * | 2017-05-22 | 2020-12-29 | 杭州博虎生物科技有限公司 | 一种人白细胞介素10-Fc融合蛋白及其编码基因与应用 |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
CA3063983A1 (fr) | 2017-05-24 | 2018-11-29 | Novartis Ag | Proteines greffees d'anticorps-cytokine et procedes d'utilisation dans le traitement du cancer |
CN111132998B (zh) * | 2017-09-25 | 2024-01-30 | 苏州丁孚靶点生物技术有限公司 | 用于癌症治疗的方法和组合物 |
US11987609B2 (en) | 2017-09-25 | 2024-05-21 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
CN112996805A (zh) | 2018-08-30 | 2021-06-18 | Hcw生物科技公司 | 多链嵌合多肽和其用途 |
WO2020047473A1 (fr) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Polypeptides chimères à chaîne unique et à chaînes multiples et leurs utilisations |
AU2019328313A1 (en) | 2018-08-30 | 2021-02-25 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
TW202033766A (zh) * | 2018-11-26 | 2020-09-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種人白細胞介素10變體及其衍生物 |
US11084857B2 (en) | 2018-12-05 | 2021-08-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Nsp-interleukin-10 proteins and uses thereof |
WO2020160244A1 (fr) * | 2019-02-01 | 2020-08-06 | Uab Research Foundation | Procédés et compositions pour antagonisme de la signalisation induite par l'il10 |
CN113811549A (zh) | 2019-02-21 | 2021-12-17 | Xencor股份有限公司 | 非靶向和靶向性il-10 fc融合蛋白 |
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CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
CN112618698B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白的注射制剂 |
EP4103601A2 (fr) | 2020-02-11 | 2022-12-21 | HCW Biologics, Inc. | Méthodes de traitement de maladies liées à l'âge et inflammatoires |
CA3169243A1 (fr) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methodes d'activation de lymphocytes t regulateurs |
JP2023519106A (ja) | 2020-02-11 | 2023-05-10 | エイチシーダブリュー バイオロジックス インコーポレイテッド | クロマトグラフィー樹脂およびその使用 |
CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
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IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
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2013
- 2013-08-05 MX MX2015001675A patent/MX2015001675A/es unknown
- 2013-08-05 MA MA37793A patent/MA20150232A1/fr unknown
- 2013-08-05 KR KR1020157003225A patent/KR20150038012A/ko not_active Application Discontinuation
- 2013-08-05 PE PE2015000169A patent/PE20150645A1/es not_active Application Discontinuation
- 2013-08-05 SG SG11201408526SA patent/SG11201408526SA/en unknown
- 2013-08-05 AU AU2013301656A patent/AU2013301656A1/en not_active Abandoned
- 2013-08-05 BR BR112015002085A patent/BR112015002085A2/pt not_active Application Discontinuation
- 2013-08-05 CN CN201380041222.1A patent/CN104540848B/zh active Active
- 2013-08-05 US US13/959,051 patent/US9346872B2/en not_active Expired - Fee Related
- 2013-08-05 EA EA201500208A patent/EA201500208A1/ru unknown
- 2013-08-05 WO PCT/EP2013/066342 patent/WO2014023673A1/fr active Application Filing
- 2013-08-05 CA CA2876285A patent/CA2876285A1/fr not_active Abandoned
- 2013-08-05 JP JP2015525845A patent/JP2015530983A/ja active Pending
- 2013-08-05 EP EP13745407.0A patent/EP2882774B1/fr active Active
- 2013-08-06 AR ARP130102781A patent/AR092050A1/es unknown
- 2013-08-07 TW TW102128385A patent/TW201418283A/zh unknown
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2014
- 2014-12-05 CR CR20140565A patent/CR20140565A/es unknown
- 2014-12-12 CO CO14273530A patent/CO7151522A2/es unknown
- 2014-12-17 ZA ZA2014/09304A patent/ZA201409304B/en unknown
- 2014-12-31 CL CL2014003605A patent/CL2014003605A1/es unknown
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2015
- 2015-01-19 IL IL236809A patent/IL236809A0/en unknown
- 2015-02-09 PH PH12015500284A patent/PH12015500284A1/en unknown
- 2015-10-20 HK HK15110298.1A patent/HK1209439A1/xx not_active IP Right Cessation
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2016
- 2016-04-27 US US15/140,414 patent/US10040843B2/en active Active
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2018
- 2018-10-05 JP JP2018190250A patent/JP6985232B2/ja active Active
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2021
- 2021-01-26 JP JP2021009946A patent/JP2021087426A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2021087426A (ja) | 2021-06-10 |
CN104540848B (zh) | 2019-05-31 |
SG11201408526SA (en) | 2015-03-30 |
PE20150645A1 (es) | 2015-05-11 |
JP2015530983A (ja) | 2015-10-29 |
EA201500208A1 (ru) | 2015-07-30 |
CR20140565A (es) | 2015-02-12 |
HK1209439A1 (en) | 2016-04-01 |
AU2013301656A1 (en) | 2015-01-15 |
KR20150038012A (ko) | 2015-04-08 |
JP6985232B2 (ja) | 2021-12-22 |
CL2014003605A1 (es) | 2015-04-06 |
CN104540848A (zh) | 2015-04-22 |
BR112015002085A2 (pt) | 2017-12-19 |
US9346872B2 (en) | 2016-05-24 |
US20160340413A1 (en) | 2016-11-24 |
WO2014023673A1 (fr) | 2014-02-13 |
AR092050A1 (es) | 2015-03-18 |
EP2882774B1 (fr) | 2018-10-03 |
CO7151522A2 (es) | 2014-12-29 |
TW201418283A (zh) | 2014-05-16 |
US10040843B2 (en) | 2018-08-07 |
ZA201409304B (en) | 2017-09-27 |
JP2019033755A (ja) | 2019-03-07 |
CA2876285A1 (fr) | 2014-02-13 |
EP2882774A1 (fr) | 2015-06-17 |
PH12015500284A1 (en) | 2015-04-27 |
IL236809A0 (en) | 2015-03-31 |
MX2015001675A (es) | 2015-04-10 |
US20140044674A1 (en) | 2014-02-13 |
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