EA201500208A1 - Слитые белки, содержащие интерлейкин-10, и их применения - Google Patents
Слитые белки, содержащие интерлейкин-10, и их примененияInfo
- Publication number
- EA201500208A1 EA201500208A1 EA201500208A EA201500208A EA201500208A1 EA 201500208 A1 EA201500208 A1 EA 201500208A1 EA 201500208 A EA201500208 A EA 201500208A EA 201500208 A EA201500208 A EA 201500208A EA 201500208 A1 EA201500208 A1 EA 201500208A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- applications
- proteins containing
- containing interleukin
- fusion proteins
- slit proteins
- Prior art date
Links
- 102000003814 Interleukin-10 Human genes 0.000 title abstract 3
- 108090000174 Interleukin-10 Proteins 0.000 title abstract 3
- 229940076144 interleukin-10 Drugs 0.000 title abstract 3
- SQEHCNOBYLQFTG-UHFFFAOYSA-M lithium;thiophene-2-carboxylate Chemical compound [Li+].[O-]C(=O)C1=CC=CS1 SQEHCNOBYLQFTG-UHFFFAOYSA-M 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
В заявке описаны в целом слитые белки антител и интерлейкина-10 (IL-10). Кроме того, в настоящей заявке описаны полинуклеотиды, кодирующие указанные слитые белки, векторы и клетки-хозяева, содержащие указанные полинуклеотиды. В заявке описаны также способы получения слитых белков, предлагаемых в изобретении, и способы их применения для лечения заболевания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12179709 | 2012-08-08 | ||
PCT/EP2013/066342 WO2014023673A1 (en) | 2012-08-08 | 2013-08-05 | Interleukin-10 fusion proteins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201500208A1 true EA201500208A1 (ru) | 2015-07-30 |
Family
ID=48917543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500208A EA201500208A1 (ru) | 2012-08-08 | 2013-08-05 | Слитые белки, содержащие интерлейкин-10, и их применения |
Country Status (23)
Country | Link |
---|---|
US (2) | US9346872B2 (ru) |
EP (1) | EP2882774B1 (ru) |
JP (3) | JP2015530983A (ru) |
KR (1) | KR20150038012A (ru) |
CN (1) | CN104540848B (ru) |
AR (1) | AR092050A1 (ru) |
AU (1) | AU2013301656A1 (ru) |
BR (1) | BR112015002085A2 (ru) |
CA (1) | CA2876285A1 (ru) |
CL (1) | CL2014003605A1 (ru) |
CO (1) | CO7151522A2 (ru) |
CR (1) | CR20140565A (ru) |
EA (1) | EA201500208A1 (ru) |
HK (1) | HK1209439A1 (ru) |
IL (1) | IL236809A0 (ru) |
MA (1) | MA20150232A1 (ru) |
MX (1) | MX2015001675A (ru) |
PE (1) | PE20150645A1 (ru) |
PH (1) | PH12015500284A1 (ru) |
SG (1) | SG11201408526SA (ru) |
TW (1) | TW201418283A (ru) |
WO (1) | WO2014023673A1 (ru) |
ZA (1) | ZA201409304B (ru) |
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EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
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2013
- 2013-08-05 WO PCT/EP2013/066342 patent/WO2014023673A1/en active Application Filing
- 2013-08-05 PE PE2015000169A patent/PE20150645A1/es not_active Application Discontinuation
- 2013-08-05 CA CA2876285A patent/CA2876285A1/en not_active Abandoned
- 2013-08-05 MX MX2015001675A patent/MX2015001675A/es unknown
- 2013-08-05 SG SG11201408526SA patent/SG11201408526SA/en unknown
- 2013-08-05 AU AU2013301656A patent/AU2013301656A1/en not_active Abandoned
- 2013-08-05 EP EP13745407.0A patent/EP2882774B1/en active Active
- 2013-08-05 MA MA37793A patent/MA20150232A1/fr unknown
- 2013-08-05 EA EA201500208A patent/EA201500208A1/ru unknown
- 2013-08-05 US US13/959,051 patent/US9346872B2/en active Active
- 2013-08-05 KR KR1020157003225A patent/KR20150038012A/ko not_active Application Discontinuation
- 2013-08-05 CN CN201380041222.1A patent/CN104540848B/zh active Active
- 2013-08-05 BR BR112015002085A patent/BR112015002085A2/pt not_active Application Discontinuation
- 2013-08-05 JP JP2015525845A patent/JP2015530983A/ja active Pending
- 2013-08-06 AR ARP130102781A patent/AR092050A1/es unknown
- 2013-08-07 TW TW102128385A patent/TW201418283A/zh unknown
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2014
- 2014-12-05 CR CR20140565A patent/CR20140565A/es unknown
- 2014-12-12 CO CO14273530A patent/CO7151522A2/es unknown
- 2014-12-17 ZA ZA2014/09304A patent/ZA201409304B/en unknown
- 2014-12-31 CL CL2014003605A patent/CL2014003605A1/es unknown
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2015
- 2015-01-19 IL IL236809A patent/IL236809A0/en unknown
- 2015-02-09 PH PH12015500284A patent/PH12015500284A1/en unknown
- 2015-10-20 HK HK15110298.1A patent/HK1209439A1/xx not_active IP Right Cessation
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2016
- 2016-04-27 US US15/140,414 patent/US10040843B2/en active Active
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2018
- 2018-10-05 JP JP2018190250A patent/JP6985232B2/ja active Active
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2021
- 2021-01-26 JP JP2021009946A patent/JP2021087426A/ja not_active Withdrawn
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ZA201409304B (en) | 2017-09-27 |
US20160340413A1 (en) | 2016-11-24 |
JP2021087426A (ja) | 2021-06-10 |
JP6985232B2 (ja) | 2021-12-22 |
US20140044674A1 (en) | 2014-02-13 |
EP2882774A1 (en) | 2015-06-17 |
HK1209439A1 (en) | 2016-04-01 |
CO7151522A2 (es) | 2014-12-29 |
PH12015500284A1 (en) | 2015-04-27 |
CN104540848A (zh) | 2015-04-22 |
AR092050A1 (es) | 2015-03-18 |
US10040843B2 (en) | 2018-08-07 |
KR20150038012A (ko) | 2015-04-08 |
JP2015530983A (ja) | 2015-10-29 |
TW201418283A (zh) | 2014-05-16 |
PE20150645A1 (es) | 2015-05-11 |
SG11201408526SA (en) | 2015-03-30 |
US9346872B2 (en) | 2016-05-24 |
EP2882774B1 (en) | 2018-10-03 |
CL2014003605A1 (es) | 2015-04-06 |
JP2019033755A (ja) | 2019-03-07 |
MA20150232A1 (fr) | 2015-07-31 |
BR112015002085A2 (pt) | 2017-12-19 |
AU2013301656A1 (en) | 2015-01-15 |
MX2015001675A (es) | 2015-04-10 |
CN104540848B (zh) | 2019-05-31 |
CA2876285A1 (en) | 2014-02-13 |
WO2014023673A1 (en) | 2014-02-13 |
IL236809A0 (en) | 2015-03-31 |
CR20140565A (es) | 2015-02-12 |
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