CY1121795T1 - Αντισωματα κατα toy cd52 - Google Patents
Αντισωματα κατα toy cd52Info
- Publication number
- CY1121795T1 CY1121795T1 CY20191100066T CY191100066T CY1121795T1 CY 1121795 T1 CY1121795 T1 CY 1121795T1 CY 20191100066 T CY20191100066 T CY 20191100066T CY 191100066 T CY191100066 T CY 191100066T CY 1121795 T1 CY1121795 T1 CY 1121795T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- fragments
- antibodies against
- cancer
- treat
- Prior art date
Links
- 102000013135 CD52 Antigen Human genes 0.000 title 1
- 108010065524 CD52 Antigen Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 101000980814 Homo sapiens CAMPATH-1 antigen Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 102000043738 human CD52 Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Παρέχονται αντισώματα κατά του ανθρώπινου CD52 και θραύσματα δέσμευσης αντιγόνων αυτών. Επίσης, παρέχονται απομονωμένα νουκλεϊνικά οξέα, ανασυνδυασμένα οχήματα και κύτταρα ξενιστές για την κατασκευή των αντισωμάτων και των θραυσμάτων. Τα αντισώματα και τα θραύσματα μπορούν να χρησιμοποιηθούν σε θεραπευτικές εφαρμογές, προκειμένου να αντιμετωπιστούν θεραπευτικά, για παράδειγμα, αυτοάνοσα νοσήματα, ο καρκίνος και η απόρριψη μοσχεύματος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361794576P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/026159 WO2014151644A2 (en) | 2013-03-15 | 2014-03-13 | Anti-cd52 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121795T1 true CY1121795T1 (el) | 2020-07-31 |
Family
ID=50391542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100066T CY1121795T1 (el) | 2013-03-15 | 2019-01-17 | Αντισωματα κατα toy cd52 |
Country Status (36)
Country | Link |
---|---|
US (2) | US9708407B2 (el) |
EP (1) | EP2970467B1 (el) |
JP (2) | JP6482524B2 (el) |
KR (1) | KR20150131286A (el) |
CN (1) | CN105209495B (el) |
AR (1) | AR095199A1 (el) |
AU (1) | AU2014233685B2 (el) |
BR (1) | BR112015022464A2 (el) |
CA (1) | CA2906539A1 (el) |
CL (1) | CL2015002705A1 (el) |
CR (1) | CR20150547A (el) |
CY (1) | CY1121795T1 (el) |
DK (1) | DK2970467T3 (el) |
DO (1) | DOP2015000211A (el) |
EA (1) | EA031730B1 (el) |
ES (1) | ES2710976T3 (el) |
GT (1) | GT201500267A (el) |
HK (1) | HK1219963A1 (el) |
HR (1) | HRP20190085T1 (el) |
HU (1) | HUE041796T2 (el) |
IL (1) | IL241410A0 (el) |
LT (1) | LT2970467T (el) |
MA (1) | MA38485A1 (el) |
MX (1) | MX2015012991A (el) |
NZ (1) | NZ631473A (el) |
PE (1) | PE20151757A1 (el) |
PH (1) | PH12015501932A1 (el) |
PL (1) | PL2970467T3 (el) |
PT (1) | PT2970467T (el) |
SG (1) | SG11201506932SA (el) |
SI (1) | SI2970467T1 (el) |
TN (1) | TN2015000415A1 (el) |
TR (1) | TR201900638T4 (el) |
TW (1) | TWI644923B (el) |
UY (1) | UY35440A (el) |
WO (1) | WO2014151644A2 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2761885A1 (en) | 2009-05-13 | 2010-11-18 | Genzyme Corporation | Methods and compositions for treating lupus |
CA2939492C (en) | 2009-05-13 | 2019-03-19 | Genzyme Corporation | Anti-human cd52 immunoglobulins |
PL3691169T3 (pl) * | 2014-01-28 | 2022-07-25 | Huawei Technologies Co., Ltd. | Sposób wskazywania transmisji danych, punkt dostępowy i terminal |
US20200299399A1 (en) * | 2017-04-21 | 2020-09-24 | Genzyme Corporation | Treatment of Multiple Sclerosis with Anti-CD52 Antibodies |
BR112020015915A8 (pt) * | 2018-02-13 | 2023-01-31 | Merck Sharp & Dohme | Usos de um anticorpo anti-pd-1 e um anticorpo anti-ctla4 ou fragmentos de ligação ao antígeno dos mesmos, bem como kit para tratamento de um paciente com câncer |
WO2021022044A1 (en) * | 2019-07-31 | 2021-02-04 | Forty Seven, Inc. | Depletion regimes for engineered t-cell or nk-cell therapy |
WO2024038839A1 (ja) * | 2022-08-15 | 2024-02-22 | 国立大学法人 東京大学 | 糸状菌を用いた免疫グロブリンまたは多量体免疫グロブリンの製造方法 |
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BRPI0416141B8 (pt) | 2003-11-01 | 2021-05-25 | Biovation Ltd | anticorpo anti-cd52 modificado, composição farmacêutica, vetores de expressão, e método para preparar uma imunoglobulina |
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CA2761885A1 (en) | 2009-05-13 | 2010-11-18 | Genzyme Corporation | Methods and compositions for treating lupus |
CA2939492C (en) | 2009-05-13 | 2019-03-19 | Genzyme Corporation | Anti-human cd52 immunoglobulins |
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-
2014
- 2014-03-10 AR ARP140100806A patent/AR095199A1/es unknown
- 2014-03-13 JP JP2016502067A patent/JP6482524B2/ja not_active Expired - Fee Related
- 2014-03-13 DK DK14714135.2T patent/DK2970467T3/en active
- 2014-03-13 MX MX2015012991A patent/MX2015012991A/es unknown
- 2014-03-13 PL PL14714135T patent/PL2970467T3/pl unknown
- 2014-03-13 SI SI201431047T patent/SI2970467T1/sl unknown
- 2014-03-13 HU HUE14714135A patent/HUE041796T2/hu unknown
- 2014-03-13 PE PE2015001992A patent/PE20151757A1/es not_active Application Discontinuation
- 2014-03-13 US US14/774,911 patent/US9708407B2/en active Active
- 2014-03-13 TW TW103108914A patent/TWI644923B/zh not_active IP Right Cessation
- 2014-03-13 CA CA2906539A patent/CA2906539A1/en not_active Abandoned
- 2014-03-13 CN CN201480028098.XA patent/CN105209495B/zh not_active Expired - Fee Related
- 2014-03-13 KR KR1020157029345A patent/KR20150131286A/ko not_active Application Discontinuation
- 2014-03-13 WO PCT/US2014/026159 patent/WO2014151644A2/en active Application Filing
- 2014-03-13 LT LTEP14714135.2T patent/LT2970467T/lt unknown
- 2014-03-13 AU AU2014233685A patent/AU2014233685B2/en not_active Ceased
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- 2014-03-13 ES ES14714135T patent/ES2710976T3/es active Active
- 2014-03-13 SG SG11201506932SA patent/SG11201506932SA/en unknown
- 2014-03-13 EP EP14714135.2A patent/EP2970467B1/en active Active
- 2014-03-13 EA EA201591796A patent/EA031730B1/ru not_active IP Right Cessation
- 2014-03-13 TR TR2019/00638T patent/TR201900638T4/tr unknown
- 2014-03-13 MA MA38485A patent/MA38485A1/fr unknown
- 2014-03-13 NZ NZ631473A patent/NZ631473A/en not_active IP Right Cessation
- 2014-03-13 BR BR112015022464A patent/BR112015022464A2/pt not_active Application Discontinuation
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2015
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2016
- 2016-07-11 HK HK16108030.7A patent/HK1219963A1/zh not_active IP Right Cessation
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2017
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2018
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2019
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