EA201891084A1 - Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение - Google Patents

Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение

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EA201891084A1
EA201891084A1 EA201891084A EA201891084A EA201891084A1 EA 201891084 A1 EA201891084 A1 EA 201891084A1 EA 201891084 A EA201891084 A EA 201891084A EA 201891084 A EA201891084 A EA 201891084A EA 201891084 A1 EA201891084 A1 EA 201891084A1
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il1rap
antibodies
antigen binding
proposed
cancer
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EA201891084A
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract

В настоящем документе предлагаются антитела, специфически связывающиеся с IL1RAP. Также описываются родственные полинуклеотиды, способные кодировать предложенные IL1RAP-специфические антитела или антигенсвязывающие фрагменты, клетки, экспрессирующие предложенные антитела или антигенсвязывающие фрагменты, а также соответствующие векторы и меченные с возможностью обнаружения антитела или антигенсвязывающие фрагменты. Кроме того, описаны способы применения предложенных антител. Например, предложенные антитела можно использовать для диагностики, лечения или контроля прогрессирования, регрессирования или стабильности течения рака с экспрессией IL1RAP; для определения того, следует ли проводить лечение рака у пациента; или для определения того, поражен ли субъект раковым заболеванием с экспрессией IL1RAP и, следовательно, ответит ли он на лечение IL1RAP-специфическим противораковым препаратом, например мультиспецифическими антителами к IL1RAP и CD3, описанными в настоящем документе.
EA201891084A 2015-11-02 2016-11-01 Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение EA201891084A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562249466P 2015-11-02 2015-11-02
PCT/US2016/059842 WO2017079121A2 (en) 2015-11-02 2016-11-01 Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof

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EA201891084A1 true EA201891084A1 (ru) 2019-10-31

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US (2) US20170121420A1 (ru)
EP (1) EP3371220A2 (ru)
JP (1) JP2018534933A (ru)
KR (1) KR20180072820A (ru)
CN (1) CN108431042A (ru)
AR (1) AR106555A1 (ru)
AU (1) AU2016350705A1 (ru)
BR (1) BR112018008908A2 (ru)
CA (1) CA3003899A1 (ru)
CL (1) CL2018001175A1 (ru)
CO (1) CO2018005695A2 (ru)
CR (1) CR20180250A (ru)
EA (1) EA201891084A1 (ru)
EC (1) ECSP18040535A (ru)
IL (1) IL259082A (ru)
JO (1) JO3800B1 (ru)
MA (1) MA43164A (ru)
MX (1) MX2018005545A (ru)
NI (1) NI201800057A (ru)
PE (1) PE20181310A1 (ru)
PH (1) PH12018500938A1 (ru)
SG (1) SG11201803675RA (ru)
TW (1) TW201734045A (ru)
UY (1) UY36974A (ru)
WO (1) WO2017079121A2 (ru)

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