PE20181310A1 - Anticuerpos anti-il1rap, moleculas de union a antigenos biespecificas que se unen a il1rap y cd3, y usos de estos - Google Patents

Anticuerpos anti-il1rap, moleculas de union a antigenos biespecificas que se unen a il1rap y cd3, y usos de estos

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Publication number
PE20181310A1
PE20181310A1 PE2018000723A PE2018000723A PE20181310A1 PE 20181310 A1 PE20181310 A1 PE 20181310A1 PE 2018000723 A PE2018000723 A PE 2018000723A PE 2018000723 A PE2018000723 A PE 2018000723A PE 20181310 A1 PE20181310 A1 PE 20181310A1
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PE
Peru
Prior art keywords
antibodies
il1rap
rap
antigen
binding
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Application number
PE2018000723A
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English (en)
Inventor
Bradley J Heidrich
Jennifer F Nemeth
Jr Walter K Nishioka
Thai Dinh
Rosa Maria Fernandes Cardoso
Ricardo Marcos Attar
Francois Gaudet
Mark E Salvati
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20181310A1 publication Critical patent/PE20181310A1/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

Referido a un anticuerpo recombinante, o un fragmento de union al antigeno de este, que se une especificamente a la Proteina accesoria del receptor de interleucina-1 (IL1 RAP). Tambien, se refiere a anticuerpos multiespecificos que se unen especificamente a IL1 RAP y al determinante agregado 3 (CD3); a polinucleotidos relacionados capaces de codificar los anticuerpos especificos de IL1 RAP o de union al antigeno proporcionados, celulas que expresan los anticuerpos o fragmentos de union al antigeno proporcionados, asi como los vectores asociados y los anticuerpos o fragmentos de union a antigeno, marcados de forma detectable. Ademas, se refiere a su uso para diagnosticar, tratar o monitorear la progresion, la regresion o la estabilidad del cancer que expresa IL1RAP; metodos para usar dichos anticuerpos en el tratamiento de enfermedades donde el cancer que expresa IL1 RAP es Leucemia mieloide aguda (LMA), Sindrome mielodisplasico (MDS), Leucemia Linfocitica aguda, entre otros.
PE2018000723A 2015-11-02 2016-11-01 Anticuerpos anti-il1rap, moleculas de union a antigenos biespecificas que se unen a il1rap y cd3, y usos de estos PE20181310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562249466P 2015-11-02 2015-11-02

Publications (1)

Publication Number Publication Date
PE20181310A1 true PE20181310A1 (es) 2018-08-10

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PE2018000723A PE20181310A1 (es) 2015-11-02 2016-11-01 Anticuerpos anti-il1rap, moleculas de union a antigenos biespecificas que se unen a il1rap y cd3, y usos de estos

Country Status (25)

Country Link
US (2) US20170121420A1 (es)
EP (1) EP3371220A2 (es)
JP (1) JP2018534933A (es)
KR (1) KR20180072820A (es)
CN (1) CN108431042A (es)
AR (1) AR106555A1 (es)
AU (1) AU2016350705A1 (es)
BR (1) BR112018008908A2 (es)
CA (1) CA3003899A1 (es)
CL (1) CL2018001175A1 (es)
CO (1) CO2018005695A2 (es)
CR (1) CR20180250A (es)
EA (1) EA201891084A1 (es)
EC (1) ECSP18040535A (es)
IL (1) IL259082A (es)
JO (1) JO3800B1 (es)
MA (1) MA43164A (es)
MX (1) MX2018005545A (es)
NI (1) NI201800057A (es)
PE (1) PE20181310A1 (es)
PH (1) PH12018500938A1 (es)
SG (1) SG11201803675RA (es)
TW (1) TW201734045A (es)
UY (1) UY36974A (es)
WO (1) WO2017079121A2 (es)

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