JO3800B1 - الأجسام المضادة لمضادات "اي ال1 ار ايه بيه" وجزيئات ربط المستضدات ثنائية الاجسام المضادة التي تربط ما بين "اي ال1 ار ايه بيه" و "سي دي 3" والاستخدامات الخاصة بها - Google Patents

الأجسام المضادة لمضادات "اي ال1 ار ايه بيه" وجزيئات ربط المستضدات ثنائية الاجسام المضادة التي تربط ما بين "اي ال1 ار ايه بيه" و "سي دي 3" والاستخدامات الخاصة بها

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JO3800B1
JO3800B1 JOP/2016/0235A JOP20160235A JO3800B1 JO 3800 B1 JO3800 B1 JO 3800B1 JO P20160235 A JOP20160235 A JO P20160235A JO 3800 B1 JO3800 B1 JO 3800B1
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Jordan
Prior art keywords
il1rap
antibodies
antigen
binding fragments
antigen binding
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JOP/2016/0235A
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Nishioka Walter
Gaudet Francois
E Salvati Mark
Cardoso Rosa
Attar Ricardo
Nemeth-Seay Jennifer
Heidrich Bradley
Dinh Thai
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Janssen Pharmaceutica Nv
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Abstract

<strong><span dir="RTL">تم بهذه الوثيقة توفير أجسام مضادة ترتبط نوعيًا بـ</span> IL1RAP. <span dir="RTL">ورد أيضًا وصف للبولي نوكليوتيدات ذات الصلة التي يمكنها تشفير الأجسام المضادة التي تم توفيرها والتي لها نوعية تجاه</span> IL1RAP <span dir="RTL">أو الشظايا الرابطة لمولِّدات الضد، أو خلايا تعبر عن الأجسام المضادة التي تم توفيرها أو الشظايا الرابطة لمولدات الضد، وكذلك النواقل المرتبطة والأجسام المضادة المرقَّمة بصورة قابلة للكشف والشظايا الرابطة لمولدات الضد. إضافةً إلى ذلك، تم وصف طرق لاستخدام الأجسام المضادة التي تم توفيرها. فعلى سبيل المثال، قد يتم استخدام الأجسام المضادة المتوفرة لتشخيص أو معالجة أو مراقبة مدى تقدم السرطان الذي يعبر عن</span> IL1RAP <span dir="RTL">أو تراجعه أو استقراره؛ أو لتحديد ما إذا كان من الضروري علاج المريض من السرطان أم لا، أو لتحديد إذا ما كان الشخص موضوع الدراسة مصابًا بسرطان يعبر عن</span> IL1RAP <span dir="RTL">ومن ثم اتخاذ قرار حول ما إذا كان من المناسب علاجه بدواء مضاد للسرطان خاص بـ</span> IL1RAP<span dir="RTL">، مثل الأجسام المضادة متعددة النوعية تجاه</span> IL1RAP <span dir="RTL">و</span>CD3 <span dir="RTL">اللذين ورد وصفهما هنا</span>.</strong>
JOP/2016/0235A 2015-11-02 2016-11-02 الأجسام المضادة لمضادات "اي ال1 ار ايه بيه" وجزيئات ربط المستضدات ثنائية الاجسام المضادة التي تربط ما بين "اي ال1 ار ايه بيه" و "سي دي 3" والاستخدامات الخاصة بها JO3800B1 (ar)

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US201562249466P 2015-11-02 2015-11-02

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US (2) US20170121420A1 (ar)
EP (1) EP3371220A2 (ar)
JP (1) JP2018534933A (ar)
KR (1) KR20180072820A (ar)
CN (1) CN108431042A (ar)
AR (1) AR106555A1 (ar)
AU (1) AU2016350705A1 (ar)
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