MA38485A1 - Anticorps anti-cd52 humains pour une utilisation dans le traitement, par exemple, des maladies auto-immunes, le cancer, et le rejet de greffe - Google Patents
Anticorps anti-cd52 humains pour une utilisation dans le traitement, par exemple, des maladies auto-immunes, le cancer, et le rejet de greffeInfo
- Publication number
- MA38485A1 MA38485A1 MA38485A MA38485A MA38485A1 MA 38485 A1 MA38485 A1 MA 38485A1 MA 38485 A MA38485 A MA 38485A MA 38485 A MA38485 A MA 38485A MA 38485 A1 MA38485 A1 MA 38485A1
- Authority
- MA
- Morocco
- Prior art keywords
- antibodies
- cancer
- autoimmune diseases
- transplant rejection
- human anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne des anticorps anti-cd52 humains et les fragments de liaison à l'antigène de ceux-ci. L'invention concerne aussi des acides nucléiques isolés, des vecteurs recombinés et des cellules hôtes pour fabriquer des anticorps et des fragments. Les anticorps et les fragments peuvent être utilisés dans des applications thérapeutiques pour traiter, par exemple, des maladies auto-immunes, le cancer, et le rejet de greffe.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361794576P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/026159 WO2014151644A2 (fr) | 2013-03-15 | 2014-03-13 | Anticorps anti-cd52 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38485A1 true MA38485A1 (fr) | 2017-06-30 |
Family
ID=50391542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38485A MA38485A1 (fr) | 2013-03-15 | 2014-03-13 | Anticorps anti-cd52 humains pour une utilisation dans le traitement, par exemple, des maladies auto-immunes, le cancer, et le rejet de greffe |
Country Status (36)
Country | Link |
---|---|
US (2) | US9708407B2 (fr) |
EP (1) | EP2970467B1 (fr) |
JP (2) | JP6482524B2 (fr) |
KR (1) | KR20150131286A (fr) |
CN (1) | CN105209495B (fr) |
AR (1) | AR095199A1 (fr) |
AU (1) | AU2014233685B2 (fr) |
BR (1) | BR112015022464A2 (fr) |
CA (1) | CA2906539A1 (fr) |
CL (1) | CL2015002705A1 (fr) |
CR (1) | CR20150547A (fr) |
CY (1) | CY1121795T1 (fr) |
DK (1) | DK2970467T3 (fr) |
DO (1) | DOP2015000211A (fr) |
EA (1) | EA031730B1 (fr) |
ES (1) | ES2710976T3 (fr) |
GT (1) | GT201500267A (fr) |
HK (1) | HK1219963A1 (fr) |
HR (1) | HRP20190085T1 (fr) |
HU (1) | HUE041796T2 (fr) |
IL (1) | IL241410A0 (fr) |
LT (1) | LT2970467T (fr) |
MA (1) | MA38485A1 (fr) |
MX (1) | MX2015012991A (fr) |
NZ (1) | NZ631473A (fr) |
PE (1) | PE20151757A1 (fr) |
PH (1) | PH12015501932A1 (fr) |
PL (1) | PL2970467T4 (fr) |
PT (1) | PT2970467T (fr) |
SG (1) | SG11201506932SA (fr) |
SI (1) | SI2970467T1 (fr) |
TN (1) | TN2015000415A1 (fr) |
TR (1) | TR201900638T4 (fr) |
TW (1) | TWI644923B (fr) |
UY (1) | UY35440A (fr) |
WO (1) | WO2014151644A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101537840B1 (ko) | 2009-05-13 | 2015-07-22 | 젠자임 코포레이션 | 항-인간 cd52 면역글루불린 |
AU2010248935B2 (en) | 2009-05-13 | 2016-12-15 | Genzyme Corporation | Methods and compositions for treating lupus |
EP3079322B1 (fr) * | 2014-01-28 | 2020-06-10 | Huawei Technologies Co., Ltd. | Procédé d'indication de transmission de données, point d'accès et terminal |
TW201841653A (zh) * | 2017-04-21 | 2018-12-01 | 美商建新公司 | 以抗-cd52抗體治療多發性硬化症 |
JP2021513540A (ja) * | 2018-02-13 | 2021-05-27 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗pd−1抗体及び抗ctla4抗体によるがんの処置方法 |
WO2021022044A1 (fr) * | 2019-07-31 | 2021-02-04 | Forty Seven, Inc. | Régimes d'appauvrissement pour une thérapie à lymphocytes t ou à cellules nk modifiés |
TW202413407A (zh) * | 2022-08-15 | 2024-04-01 | 國立大學法人東京大學 | 使用絲狀真菌之免疫球蛋白或多聚體免疫球蛋白之製造方法 |
Family Cites Families (65)
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GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
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GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
DE3783588T2 (de) | 1986-04-17 | 1993-06-09 | Kyowa Hakko Kogyo Kk | Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren. |
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JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
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GB9022547D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
GB9108056D0 (en) | 1991-04-16 | 1991-06-05 | Hale Geoffrey | Synthetic antigen |
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CA2103059C (fr) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Methode de production d'anticorps humanises |
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ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
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EP2429584A4 (fr) | 2009-05-13 | 2013-02-20 | Genzyme Corp | Procédés et compositions de traitement |
AU2010248935B2 (en) | 2009-05-13 | 2016-12-15 | Genzyme Corporation | Methods and compositions for treating lupus |
KR101537840B1 (ko) * | 2009-05-13 | 2015-07-22 | 젠자임 코포레이션 | 항-인간 cd52 면역글루불린 |
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CN105734678B (zh) * | 2010-07-16 | 2019-11-05 | 阿迪马布有限责任公司 | 合成多核苷酸文库 |
-
2014
- 2014-03-10 AR ARP140100806A patent/AR095199A1/es unknown
- 2014-03-13 LT LTEP14714135.2T patent/LT2970467T/lt unknown
- 2014-03-13 SI SI201431047T patent/SI2970467T1/sl unknown
- 2014-03-13 EP EP14714135.2A patent/EP2970467B1/fr active Active
- 2014-03-13 EA EA201591796A patent/EA031730B1/ru not_active IP Right Cessation
- 2014-03-13 PE PE2015001992A patent/PE20151757A1/es not_active Application Discontinuation
- 2014-03-13 US US14/774,911 patent/US9708407B2/en active Active
- 2014-03-13 TW TW103108914A patent/TWI644923B/zh not_active IP Right Cessation
- 2014-03-13 SG SG11201506932SA patent/SG11201506932SA/en unknown
- 2014-03-13 MA MA38485A patent/MA38485A1/fr unknown
- 2014-03-13 NZ NZ631473A patent/NZ631473A/en not_active IP Right Cessation
- 2014-03-13 HU HUE14714135A patent/HUE041796T2/hu unknown
- 2014-03-13 TR TR2019/00638T patent/TR201900638T4/tr unknown
- 2014-03-13 PT PT14714135T patent/PT2970467T/pt unknown
- 2014-03-13 PL PL14714135T patent/PL2970467T4/pl unknown
- 2014-03-13 KR KR1020157029345A patent/KR20150131286A/ko not_active Application Discontinuation
- 2014-03-13 DK DK14714135.2T patent/DK2970467T3/en active
- 2014-03-13 ES ES14714135T patent/ES2710976T3/es active Active
- 2014-03-13 CA CA2906539A patent/CA2906539A1/fr not_active Abandoned
- 2014-03-13 AU AU2014233685A patent/AU2014233685B2/en not_active Ceased
- 2014-03-13 WO PCT/US2014/026159 patent/WO2014151644A2/fr active Application Filing
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- 2014-03-13 JP JP2016502067A patent/JP6482524B2/ja not_active Expired - Fee Related
- 2014-03-13 BR BR112015022464A patent/BR112015022464A2/pt not_active Application Discontinuation
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2015
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2016
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2017
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2018
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