EA201591814A1 - БИСПЕЦИФИЧЕСКИЕ МОЛЕКУЛЫ Fc - Google Patents

БИСПЕЦИФИЧЕСКИЕ МОЛЕКУЛЫ Fc

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Publication number
EA201591814A1
EA201591814A1 EA201591814A EA201591814A EA201591814A1 EA 201591814 A1 EA201591814 A1 EA 201591814A1 EA 201591814 A EA201591814 A EA 201591814A EA 201591814 A EA201591814 A EA 201591814A EA 201591814 A1 EA201591814 A1 EA 201591814A1
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Eurasian Patent Office
Prior art keywords
molecules
methods
bispecific molecules
nucleic acids
contemplated
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EA201591814A
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English (en)
Inventor
Луис Г. Боргес
Патрик А. Беюрле
Вэй ЯНЬ
Марк Л. Майклз
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Эмджен Инк.
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Publication of EA201591814A1 publication Critical patent/EA201591814A1/ru

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/04Antibacterial agents
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
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    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P37/02Immunomodulators
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    • AHUMAN NECESSITIES
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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Abstract

В описании описана биспецифическая молекула, содержащая полипептидную цепь Fc и вариабельные области иммуноглобулина. Также предусматриваются фармацевтические составы, содержащие такие молекулы, нуклеиновые кислоты, кодирующие такие молекулы, клетки-хозяева, содержащие такие нуклеиновые кислоты, способы получения таких молекул и способы применения таких молекул.
EA201591814A 2013-03-15 2014-03-14 БИСПЕЦИФИЧЕСКИЕ МОЛЕКУЛЫ Fc EA201591814A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791424P 2013-03-15 2013-03-15
PCT/US2014/029253 WO2014144722A2 (en) 2013-03-15 2014-03-14 BISPECIFIC-Fc MOLECULES

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EA201591814A1 true EA201591814A1 (ru) 2016-03-31

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US (5) US20140302037A1 (ru)
EP (1) EP2970477B1 (ru)
JP (2) JP6535654B2 (ru)
KR (1) KR20150139531A (ru)
CN (1) CN105229031A (ru)
AP (1) AP2015008773A0 (ru)
AU (1) AU2014228829B2 (ru)
BR (1) BR112015023431A2 (ru)
CA (1) CA2902961C (ru)
CL (1) CL2015002756A1 (ru)
CR (1) CR20150573A (ru)
EA (1) EA201591814A1 (ru)
HK (1) HK1214275A1 (ru)
IL (1) IL241354A0 (ru)
MA (1) MA38400A1 (ru)
MX (2) MX2015012187A (ru)
PE (1) PE20151998A1 (ru)
PH (1) PH12015502083A1 (ru)
SG (1) SG11201506647SA (ru)
TN (1) TN2015000379A1 (ru)
WO (1) WO2014144722A2 (ru)

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