TW202233682A - 用於投與ＢＣＭＡｘＣＤ３結合分子之方法 - Google Patents

用於投與ＢＣＭＡｘＣＤ３結合分子之方法 Download PDF

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TW202233682A
TW202233682A TW110141852A TW110141852A TW202233682A TW 202233682 A TW202233682 A TW 202233682A TW 110141852 A TW110141852 A TW 110141852A TW 110141852 A TW110141852 A TW 110141852A TW 202233682 A TW202233682 A TW 202233682A
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安杰里 夏爾瑪
撒迦利亞 麥基弗
布哈提 梅塔
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美商安進公司
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Abstract

本發明關於用於治療BCMA陽性贅生物的抗BCMA x 抗CD3結合分子的劑量和投與。更具體地，本發明關於用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及提高該蛋白質的半衰期的第三結構域，其中將該蛋白質在至少一個週期以指定劑量方案投與。此外，本發明關於用於治療或改善BCMA陽性贅生物之方法，該方法包括投與指定劑量方案的這種結合分子，關於用於投與治療劑量的這種結合分子之方法並且涉及這種結合分子用於製造用於治療或改善BCMA陽性贅生物的藥物之用途。

Description

用於投與BCMAxCD3結合分子之方法
本發明關於用於治療BCMA陽性贅生物的抗BCMA x 抗CD3結合分子之劑量和投與。更具體地，本發明關於用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及提高該蛋白質的半衰期的第三結構域，其中將該蛋白質在至少一個週期以指定劑量方案投與。此外，本發明關於用於治療或改善BCMA陽性贅生物之方法，該方法包括投與指定劑量方案的這種結合分子，關於用於投與治療劑量的這種結合分子之方法並且關於這種結合分子用於製造用於治療或改善BCMA陽性贅生物的藥物之用途。
背景技術
多發性骨髓瘤（MM）係漿細胞的惡性腫瘤，該等漿細胞在骨髓中增殖並釋放副蛋白。所得的臨床實驗室圖片包括感染、骨破壞、骨髓衰竭、腎衰竭和高鈣血症。年齡標化年發病率正在增加，其中每100,000人中大約有6例新病例。美國黑人群體之發病率比白種人高2倍。MM的5年存活率從1975年新診斷患者的約25%增加到2006年的約45%。這種改進主要歸因於新的藥品（如蛋白酶體抑制劑和免疫調節劑（IMiD））。然而，認為用當前之方法無法治癒MM。蛋白酶體抑制劑和免疫調節劑難治的患者表現出不利的結局，其中中位總生存期為9個月。
高危人群（如具有del17p13陽性MM的亞組）的結局特別差。雖然對於MM，許多藥品正在臨床開發中，但仍需要新的治療選擇。表現出症狀性疾病的患者最初用一級誘導療法治療，隨後對符合條件的患者進行高劑量化療和自體幹細胞支持。符合強化治療的患者由年齡（65至75歲為上限）、無並存病、和完整的腎功能決定。儘管此方案改進了年輕和健壯的患者的存活率，但是中位緩解持續時間不超過3年，並且很少有患者超過10年仍不患該病。
已經測試了鞏固和維護方法以增加緩解（remission）的深度和持續時間。因為維持治療具有挑戰性（由於沒有功效或耐受性），所以仍然可以藉由向誘導、鞏固或維持方案中添加新穎治療來改進移植環境中之存活結局。不符合高劑量療法的患者通常接受與針對移植候選者的誘導方案相似的誘導方案。該等方案包括蛋白酶體抑制劑硼替佐米、或以美法侖為基礎組合沙利度胺。老年患者中美法侖-沙利度胺-強的松（Melphalan-Thalidomide-Prednisone，MPT）的中位總生存期（OS）係40個月。來那度胺與地塞米松（dexamethasone）組合係復發性/難治性MM的標準治療方案，但可能會移至移植不符合條件的患者的一線背景（first line setting）。
在復發性背景中的其他已確立的方案係重複誘導方案、或以硼替佐米或免疫調節劑為基礎聯合烷化劑的補救組合。復發性疾病患者需要改進結局（無進展生存期（PFS）和OS）。確立的治療難治的以及治療進展緩慢的患者具有令人沮喪之結局，其中進行治療OS為9個月而不進行治療為3個月。該等患者中的未滿足需求最高。
雙特異性分子（如BiTE ®（「雙特異性T細胞銜接子」）分子）係包含一個結合結構域（對靶細胞上所選擇的腫瘤相關表面抗原具有特異性）、和第二結合結構域（對CD3（T細胞上的T細胞受體複合物的亞基）具有特異性）的重組蛋白。藉由其特定設計，BiTE ®分子獨特地適合於將T細胞與靶細胞瞬時連接，並且同時強有力地激活T細胞對靶細胞的固有細胞溶解潛力。將第一代所謂的「規範」（非半衰期延長）BiTE ®分子（參見WO 99/54440和WO 2005/040220）引入臨床作為AMG 103（博納吐單抗（blinatumomab）、抗CD19 x 抗CD3）和AMG 110（索利托單抗（solitomab）、抗EpCAM x 抗CD3）。第一代規範BiTE ®分子的進一步開發係提供雙特異性多肽，該等雙特異性多肽與人和白鬢狨（ Callithrix jacchus）、絨頂檉柳猴（ Saguinus oedipus）或松鼠猴（ Saimiri sciureus）的CD3-ε鏈的N-末端處的上下文無關的表位結合（WO 2008/119567）。包含這個新的CD3-ε結合結構域（在臨床中測試過）的第一BiTE ®分子係AMG 330。
WO 2008/119567中描述的雙特異性多肽可能苦於從體內快速清除；因此，雖然它們能夠快速到達身體的大部分部位，並且快速產生並且容易處理，但是它們的體內應用可能受限於它們在體內的短暫持久性。由於這種相對小的分子的體內半衰期短，因此為實現治療效果，使用藉由連續靜脈內輸注的長期投與。然而，這種連續靜脈內輸注被分類為對患者不方便，因此，在更方便的可替代治療方法的情況下，可能妨礙了去選擇被證明在治療相應疾病方面更有效的化合物。這導致雙特異性療法的開發，該雙特異性療法保持類似治療功效，並且同時具有有利的藥物動力學特性（包括更長的半衰期）。因此，所謂的規範BiTE ®分子的重要的進一步開發係添加了另外的結構域，該結構域延長或提高多肽的半衰期。所得的分子也稱為「HLE」（半衰期延長的）BiTE ®分子，參見例如WO 2017/134140。
B細胞成熟抗原（BCMA、TNFRSF17、CD269）係屬於TNF受體超家族的跨膜蛋白。BCMA表現在晚期漿細胞分化期間選擇性誘導，並且在天然和記憶B細胞中不存在。在BCMA與其配位基、B細胞活化因子（BAFF）和增殖誘導配位基（APRIL）結合後，促進了骨髓漿細胞和漿母細胞的存活。BCMA不能維持正常的B細胞穩態，但它係長壽命漿細胞的存活所必需的。對BCMA -/- 小鼠的研究顯示長壽命骨髓漿細胞的存活受損，但B細胞發育和早期體液免疫反應在野生型小鼠中無法區分。BCMA的mRNA表現在惡性漿細胞障礙中高度升高。相比之下，正常組織中的mRNA表現非常低並且限於正常長壽命漿細胞所在的淋巴組織。據報導，BCMA蛋白表現僅限於漿細胞。BCMA的表現局限於漿母細胞和長壽命漿細胞，並且不能在其他正常人組織上檢測到。BCMA在MM細胞的細胞表面普遍表現，並且在惡性漿細胞上的表現水平相對高於在正常漿細胞上觀察到的水平。BCMA表現與MM病期、對最後治療的反應和自診斷以來的時間之間沒有相關性。T細胞和骨髓細胞或CD34+造血幹細胞均不表現BCMA。BCMA的選擇性表現使其成為對於以抗體為基礎和以嵌合抗原受體（CAR）為基礎的療法而言非常有吸引力的靶標。
AMG 420（以前稱為BI 836909）係規範雙特異性T細胞銜接子，它與靶細胞上的BCMA以及T細胞上的CD3-ε結合。它藉由將細胞毒性T淋巴細胞（CTL）的細胞溶解活性指向靶細胞，起到BCMA陽性靶細胞（如MM細胞）與CTL之間的橋樑的作用。AMG 420由兩個單鏈可變片段（scFv）（一個針對BCMA、並且另一個針對CD3）組成。每個scFv片段由與甘胺酸/絲胺酸連接子（linker）連接的VH和VL結構域組成。兩個scFv片段也與甘胺酸/絲胺酸連接子連接。半衰期延長的抗BCMA x 抗CD3多肽（例如AMG 701）詳細描述於WO 2017/134134中。對於開發用於治療BCMA陽性贅生物的療法，尤其是用這種半衰期延長的抗BCMA x 抗CD3分子的療法，存在持續的未滿足的醫療需求。
基於本文提供的揭露內容，熟悉該項技術者將認知到、或僅使用常規實驗就能夠確定本文所述發明的特定實施方式的許多等效形式。這樣的等效形式旨在為下列項目所涵蓋。
項目 1一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     在第1天投與第一劑量的該蛋白質，和 •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天。
項目 2如項目1所述使用的蛋白質，其中該第一週期進一步包括： •     在投與該第二劑量後投與目標劑量的該蛋白質，其中該目標劑量等於或超過該第二劑量並且是從約9 mg/天至約24 mg/天、較佳的是從12.5 mg/天至約24 mg/天。
項目 1a一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     投與從12.5 mg/天至約24 mg/天的目標劑量的該蛋白質。
項目 2a如項目1a所述使用的蛋白質，其中該第一週期包括： •     在第1天投與第一劑量的該蛋白質， •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天，和 •     在投與該第二劑量後投與該目標劑量的蛋白質，其中該目標劑量等於或超過該第二劑量。
項目 2b如項目1a所述使用的蛋白質，其中該第一週期進一步包括： •     在第1天投與第一劑量的該蛋白質， •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量，和 •     在該第二劑量投與日後且該目標劑量投與日前的一天視需要投與第三劑量的該蛋白質，其中該第三劑量超過該第二劑量。
項目 3如前述項目中任一項所述使用的蛋白質，其中該第二劑量在第3天或第4天、較佳的是在第3天投與。
項目 4如前述項目中任一項所述使用的蛋白質，其中該第二劑量係從約4 mg/天至約12.5 mg/天、從約4.5 mg/天至約12 mg/天、從約4 mg/天至約10 mg/天、從約4.5 mg/天至約9 mg/天、從約4 mg/天至約8 mg/天、從約4 mg/天至約7 mg/天、從約4 mg/天至約6.5 mg/天、從約4.5 mg/天至約6 mg/天、從約7 mg/天至約18 mg/天、從約7.5 mg/天至約15 mg/天、從約8 mg/天至約12 mg/天、從約8.5 mg/天至約10 mg/天或從約9 mg/天至約9.5 mg/天。
項目 5如前述項目中任一項所述使用的蛋白質，其中該第二劑量係從約8 mg/天至約10 mg/天、較佳的是約9 mg/天，並且在第3天投與。
項目 5a如前述項目中任一項所述使用的蛋白質，其中該第二劑量係從約4 mg/天至約10 mg/天、較佳的是從約4 mg/天至約7 mg/天，並且在第3天投與。
項目 6如前述項目中任一項所述使用的蛋白質，其中該第一劑量係至少約800 µg/天或係約800 µg/天。
項目 7如前述項目中任一項所述使用的蛋白質，其中該第一劑量係從約800 µg/天至約1200 µg/天、從約800 µg/天至約1100 µg/天、從約800 µg/天至約1000 µg/天或從約800 µg/天至約900 µg/天。
項目 7a如前述項目中任一項所述使用的蛋白質，其中該第三劑量係從約7 mg/天至約12 mg/天、從約8 mg/天至約11 mg/天、從約8 mg/天至約10 mg/天或約9 mg/天。
項目 7b如前述項目中任一項所述使用的蛋白質，其中該第三劑量在第5天、第6天或第7天投與。
項目 7c如前述項目中任一項所述使用的蛋白質，其中該第三劑量係從約8 mg/天至約10 mg/天並且在第5天投與。
項目 8如項目2至7中任一項所述使用的蛋白質，其中該目標劑量在從第6天至第10天中的一天、較佳的是在從第7天至第9天中的一天、更較佳的是在第8天投與。
項目 9如項目2至8中任一項所述使用的蛋白質，其中該目標劑量在第15天（+/- 一或兩天）和第22天（+/- 一或兩天）投與。（一旦在第6天至第10天中的一天達到該目標劑量，其較佳的是每7天投與一次）。
項目 10如前述項目中任一項所述使用的蛋白質，其中該目標劑量係從約14 mg/天至約22 mg/天、從約15 mg/天至約21 mg/天、從約16 mg/天至約20 mg/天、從約17 mg/天至約19 mg/天、或約18 mg/天。
項目 10a如前述項目中任一項所述使用的蛋白質，其中該目標劑量係從約16 mg/天至約20 mg/天並且在第8天投與。
項目 11如前述項目中任一項所述使用的蛋白質，其中該蛋白質在第二週期和視需要在進一步後續的週期中以目標劑量投與。
項目 12如項目11所述使用的蛋白質，其中該第二週期和視需要該進一步後續的週期包括： •     在第1天、第8天（+/- 一或兩天）、第15天（+/- 一或兩天）和第22天（+/- 一或兩天）以目標劑量投與該蛋白質。
較佳的是，該第二週期和視需要該進一步後續的週期包括每7天以目標劑量投與一次該蛋白質。
項目 13如前述項目中任一項所述使用的蛋白質，其中一個週期（即第一週期、第二週期和/或任何後續的週期）具有約25至約30天、約26至約29天、約27至約29天或約28天。
項目 13a如前述項目中任一項所述使用的蛋白質，其中該蛋白質以2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25個或更多個週期投與。
項目 14如前述項目中任一項所述使用的蛋白質，其中該第一週期包括： •       投與約800 µg/天至約1000 µg/天、較佳的是約800 µg/天的第一劑量的該蛋白質， •       投與約8 mg/天至約10 mg/天、較佳的是約9 mg/天的第二劑量的該蛋白質，和 •       投與約12 mg/天至約20 mg/天、較佳的是約16 mg/天至約20 mg/天，例如18 mg/天的目標劑量的該蛋白質。
項目 14a如前述項目中任一項所述使用的蛋白質，其中該第一週期包括： •     投與約800 µg/天至約1000 µg/天、較佳的是約800 µg/天的第一劑量的該蛋白質， •     投與約4 mg/天至約10 mg/天、較佳的是約4 mg/天至約7 mg/天或4.5 mg/天至6 mg/天的第二劑量的該蛋白質， •     視需要投與約8 mg/天至約10 mg/天、較佳的是約9 mg/天的第三劑量的該蛋白質，其中該第三劑量超過該第二劑量，和 •     投與14 mg/天至約22 mg/天、較佳的是約16 mg/天至約20 mg/天，例如18 mg/天的目標劑量的該蛋白質。
項目 15如項目14或14a所述使用的蛋白質，其中在第1天投與該第一劑量；在第3天或第4天、較佳的是在第3天投與該第二劑量；在第5天或第6天、較佳的是在第5天投與該視需要的第三劑量；並且在第8天（+/- 一天）、第15天（+/- 一天）和第22天（+/- 一天），較佳的是在第8天、第15天和第22天投與該目標劑量。
項目 15a如前述項目中任一項所述使用的蛋白質，其中該第一週期包括以下或由以下組成：三至六次或四至六次單獨投與、較佳的是四或五或六次單獨投與該蛋白質。
項目 15b如前述項目中任一項所述使用的蛋白質，其中在第1天投與800 µg/天的該第一劑量，在第3天投與6 mg/天的該第二劑量，並且在第8天、第15天和第22天投與18 mg/天的該目標劑量。
項目 15c如前述項目中任一項所述使用的蛋白質，其中在第1天投與800 µg/天的該第一劑量，在第3天投與4.5 mg/天的該第二劑量，在第5天投與9 mg/天的該第三劑量，並且在第8天、第15天和第22天投與18 mg/天的該目標劑量。
項目 16如前述項目中任一項所述使用的蛋白質，其中該蛋白質靜脈內投與，較佳的是藉由靜脈內推注注射、推注輸注或短期靜脈內輸注投與。
項目 17如前述項目中任一項所述使用的蛋白質，其中該BCMA陽性贅生物選自由以下組成之群組：多發性骨髓瘤、復發性和/或難治性多發性骨髓瘤、重鏈多發性骨髓瘤、輕鏈多發性骨髓瘤、髓外骨髓瘤、漿細胞瘤、漿細胞白血病、華氏巨球蛋白血症（Waldenström's macroglobulinemia）、和鬱積型骨髓瘤（smoldering myeloma）。
項目 17a如項目17所述使用的蛋白質，其中該BCMA陽性贅生物係多發性骨髓瘤。
項目 17b如項目17a所述使用的蛋白質，其中該多發性骨髓瘤選自由以下組成之群組：復發性和/或難治性多發性骨髓瘤、重鏈多發性骨髓瘤、輕鏈多發性骨髓瘤、髓外多發性骨髓瘤、和鬱積型多發性骨髓瘤。
項目 18如前述項目中任一項所述使用的蛋白質，其中 a)      該蛋白質係單鏈蛋白質（或「單鏈多肽」，即它由一條多肽鏈組成）或由兩條、三條或四條多肽鏈組成， b)      該第一結構域包含免疫球蛋白重鏈可變區（VH1）和免疫球蛋白輕鏈可變區（VL1）， c)      該第二結構域包含免疫球蛋白重鏈可變區（VH2）和免疫球蛋白輕鏈可變區（VL2），和/或 d)      該第三結構域包含一個或兩個免疫球蛋白鉸鏈區、一個或兩個CH2結構域和一個或兩個CH3結構域，較佳的是兩個免疫球蛋白鉸鏈區、兩個CH2結構域和兩個CH3結構域。
項目 18a如前述項目中任一項所述使用的蛋白質，其中 a)      該第一結構域包含免疫球蛋白重鏈可變區（VH1）和免疫球蛋白輕鏈可變區（VL1）， b)      該第二結構域包含免疫球蛋白重鏈可變區（VH2）和免疫球蛋白輕鏈可變區（VL2），並且 c)      該第三結構域包含兩個免疫球蛋白鉸鏈區、兩個CH2結構域和兩個CH3結構域。
項目 18b如前述項目中任一項所述使用的蛋白質，其中 a)      該蛋白質係單鏈蛋白質， b)      該第一結構域處於scFv的形式， c)      該第二結構域處於scFv的形式， d)      該第一結構域和該第二結構域經由連接子、較佳的是經由肽連接子、更較佳的是經由甘胺酸/絲胺酸連接子連接，和/或 e)      該第三結構域包含兩個Fc單體，每個單體包含免疫球蛋白鉸鏈區、CH2結構域和CH3結構域，其中該等單體較佳的是藉由肽連接子彼此融合。
項目 19如前述項目中任一項所述使用的蛋白質，其中該蛋白質與以下競爭結合BCMA或與以下結合相同的BCMA表位： a)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、和如SEQ ID NO: 173中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2、和如SEQ ID NO: 176中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 177中所描述的VH區、和如SEQ ID NO: 178中所描述的VL區； c)      蛋白質，該蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 179中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
項目 20如前述項目中任一項所述使用的蛋白質，其中該蛋白質與以下競爭結合CD3或與以下結合相同的CD3表位： a)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2、和如SEQ ID NO: 638中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 639中所描述的VH區、和如SEQ ID NO: 641中所描述的VL區； c)      蛋白質，該蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 642中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
項目 21如前述項目中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含：含有選自以下的CDR-H1、CDR-H2和CDR-H3的VH區，以及含有選自以下的CDR-L1、CDR-L2和CDR-L3的VL區： (1)      如SEQ ID NO: 1中所描述的CDR-H1、如SEQ ID NO: 2中所描述的CDR-H2、如SEQ ID NO: 3中所描述的CDR-H3、如SEQ ID NO: 4中所描述的CDR-L1、如SEQ ID NO: 5中所描述的CDR-L2和如SEQ ID NO: 6中所描述的CDR-L3； (2)      如SEQ ID NO: 11中所描述的CDR-H1、如SEQ ID NO: 12中所描述的CDR-H2、如SEQ ID NO: 13中所描述的CDR-H3、如SEQ ID NO: 14中所描述的CDR-L1、如SEQ ID NO: 15中所描述的CDR-L2和如SEQ ID NO: 16中所描述的CDR-L3； (3)      如SEQ ID NO: 21中所描述的CDR-H1、如SEQ ID NO: 22中所描述的CDR-H2、如SEQ ID NO: 23中所描述的CDR-H3、如SEQ ID NO: 24中所描述的CDR-L1、如SEQ ID NO: 25中所描述的CDR-L2和如SEQ ID NO: 26中所描述的CDR-L3； (4)      如SEQ ID NO: 31中所描述的CDR-H1、如SEQ ID NO: 32中所描述的CDR-H2、如SEQ ID NO: 33中所描述的CDR-H3、如SEQ ID NO: 34中所描述的CDR-L1、如SEQ ID NO: 35中所描述的CDR-L2和如SEQ ID NO: 36中所描述的CDR-L3； (5)      如SEQ ID NO: 41中所描述的CDR-H1、如SEQ ID NO: 42中所描述的CDR-H2、如SEQ ID NO: 43中所描述的CDR-H3、如SEQ ID NO: 44中所描述的CDR-L1、如SEQ ID NO: 45中所描述的CDR-L2和如SEQ ID NO: 46中所描述的CDR-L3； (6)      如SEQ ID NO: 51中所描述的CDR-H1、如SEQ ID NO: 52中所描述的CDR-H2、如SEQ ID NO: 53中所描述的CDR-H3、如SEQ ID NO: 54中所描述的CDR-L1、如SEQ ID NO: 55中所描述的CDR-L2和如SEQ ID NO: 56中所描述的CDR-L3； (7)      如SEQ ID NO: 61中所描述的CDR-H1、如SEQ ID NO: 62中所描述的CDR-H2、如SEQ ID NO: 63中所描述的CDR-H3、如SEQ ID NO: 64中所描述的CDR-L1、如SEQ ID NO: 65中所描述的CDR-L2和如SEQ ID NO: 66中所描述的CDR-L3； (8)      如SEQ ID NO: 71中所描述的CDR-H1、如SEQ ID NO: 72中所描述的CDR-H2、如SEQ ID NO: 73中所描述的CDR-H3、如SEQ ID NO: 74中所描述的CDR-L1、如SEQ ID NO: 75中所描述的CDR-L2和如SEQ ID NO: 76中所描述的CDR-L3； (9)      如SEQ ID NO: 81中所描述的CDR-H1、如SEQ ID NO: 82中所描述的CDR-H2、如SEQ ID NO: 83中所描述的CDR-H3、如SEQ ID NO: 84中所描述的CDR-L1、如SEQ ID NO: 85中所描述的CDR-L2和如SEQ ID NO: 86中所描述的CDR-L3； (10)     如SEQ ID NO: 91中所描述的CDR-H1、如SEQ ID NO: 92中所描述的CDR-H2、如SEQ ID NO: 93中所描述的CDR-H3、如SEQ ID NO: 94中所描述的CDR-L1、如SEQ ID NO: 95中所描述的CDR-L2和如SEQ ID NO: 96中所描述的CDR-L3； (11)     如SEQ ID NO: 101中所描述的CDR-H1、如SEQ ID NO: 102中所描述的CDR-H2、如SEQ ID NO: 103中所描述的CDR-H3、如SEQ ID NO: 104中所描述的CDR-L1、如SEQ ID NO: 105中所描述的CDR-L2和如SEQ ID NO: 106中所描述的CDR-L3； (12)     如SEQ ID NO: 111中所描述的CDR-H1、如SEQ ID NO: 112中所描述的CDR-H2、如SEQ ID NO: 113中所描述的CDR-H3、如SEQ ID NO: 114中所描述的CDR-L1、如SEQ ID NO: 115中所描述的CDR-L2和如SEQ ID NO: 116中所描述的CDR-L3； (13)     如SEQ ID NO: 121中所描述的CDR-H1、如SEQ ID NO: 122中所描述的CDR-H2、如SEQ ID NO: 123中所描述的CDR-H3、如SEQ ID NO: 124中所描述的CDR-L1、如SEQ ID NO: 125中所描述的CDR-L2和如SEQ ID NO: 126中所描述的CDR-L3； (14)     如SEQ ID NO: 131中所描述的CDR-H1、如SEQ ID NO: 132中所描述的CDR-H2、如SEQ ID NO: 133中所描述的CDR-H3、如SEQ ID NO: 134中所描述的CDR-L1、如SEQ ID NO: 135中所描述的CDR-L2和如SEQ ID NO: 136中所描述的CDR-L3； (15)     如SEQ ID NO: 141中所描述的CDR-H1、如SEQ ID NO: 142中所描述的CDR-H2、如SEQ ID NO: 143中所描述的CDR-H3、如SEQ ID NO: 144中所描述的CDR-L1、如SEQ ID NO: 145中所描述的CDR-L2和如SEQ ID NO: 146中所描述的CDR-L3； (16)     如SEQ ID NO: 151中所描述的CDR-H1、如SEQ ID NO: 152中所描述的CDR-H2、如SEQ ID NO: 153中所描述的CDR-H3、如SEQ ID NO: 154中所描述的CDR-L1、如SEQ ID NO: 155中所描述的CDR-L2和如SEQ ID NO: 156中所描述的CDR-L3； (17)     如SEQ ID NO: 161中所描述的CDR-H1、如SEQ ID NO: 162中所描述的CDR-H2、如SEQ ID NO: 163中所描述的CDR-H3、如SEQ ID NO: 164中所描述的CDR-L1、如SEQ ID NO: 165中所描述的CDR-L2和如SEQ ID NO: 166中所描述的CDR-L3； (18)     如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、如SEQ ID NO: 173中所描述的CDR-H3、如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2和如SEQ ID NO: 176中所描述的CDR-L3； (19)     如SEQ ID NO: 181中所描述的CDR-H1、如SEQ ID NO: 182中所描述的CDR-H2、如SEQ ID NO: 183中所描述的CDR-H3、如SEQ ID NO: 184中所描述的CDR-L1、如SEQ ID NO: 185中所描述的CDR-L2和如SEQ ID NO: 186中所描述的CDR-L3； (20)     如SEQ ID NO: 191中所描述的CDR-H1、如SEQ ID NO: 192中所描述的CDR-H2、如SEQ ID NO: 193中所描述的CDR-H3、如SEQ ID NO: 194中所描述的CDR-L1、如SEQ ID NO: 195中所描述的CDR-L2和如SEQ ID NO: 196中所描述的CDR-L3； (21)     如SEQ ID NO: 201中所描述的CDR-H1、如SEQ ID NO: 202中所描述的CDR-H2、如SEQ ID NO: 203中所描述的CDR-H3、如SEQ ID NO: 204中所描述的CDR-L1、如SEQ ID NO: 205中所描述的CDR-L2和如SEQ ID NO: 206中所描述的CDR-L3； (22)     如SEQ ID NO: 211中所描述的CDR-H1、如SEQ ID NO: 212中所描述的CDR-H2、如SEQ ID NO: 213中所描述的CDR-H3、如SEQ ID NO: 214中所描述的CDR-L1、如SEQ ID NO: 215中所描述的CDR-L2和如SEQ ID NO: 216中所描述的CDR-L3； (23)     如SEQ ID NO: 221中所描述的CDR-H1、如SEQ ID NO: 222中所描述的CDR-H2、如SEQ ID NO: 223中所描述的CDR-H3、如SEQ ID NO: 224中所描述的CDR-L1、如SEQ ID NO: 225中所描述的CDR-L2和如SEQ ID NO: 226中所描述的CDR-L3； (24)     如SEQ ID NO: 231中所描述的CDR-H1、如SEQ ID NO: 232中所描述的CDR-H2、如SEQ ID NO: 233中所描述的CDR-H3、如SEQ ID NO: 234中所描述的CDR-L1、如SEQ ID NO: 235中所描述的CDR-L2和如SEQ ID NO: 236中所描述的CDR-L3； (25)     如SEQ ID NO: 241中所描述的CDR-H1、如SEQ ID NO: 242中所描述的CDR-H2、如SEQ ID NO: 243中所描述的CDR-H3、如SEQ ID NO: 244中所描述的CDR-L1、如SEQ ID NO: 245中所描述的CDR-L2和如SEQ ID NO: 246中所描述的CDR-L3； (26)     如SEQ ID NO: 251中所描述的CDR-H1、如SEQ ID NO: 252中所描述的CDR-H2、如SEQ ID NO: 253中所描述的CDR-H3、如SEQ ID NO: 254中所描述的CDR-L1、如SEQ ID NO: 255中所描述的CDR-L2和如SEQ ID NO: 256中所描述的CDR-L3； (27)     如SEQ ID NO: 261中所描述的CDR-H1、如SEQ ID NO: 262中所描述的CDR-H2、如SEQ ID NO: 263中所描述的CDR-H3、如SEQ ID NO: 264中所描述的CDR-L1、如SEQ ID NO: 265中所描述的CDR-L2和如SEQ ID NO: 266中所描述的CDR-L3； (28)     如SEQ ID NO: 271中所描述的CDR-H1、如SEQ ID NO: 272中所描述的CDR-H2、如SEQ ID NO: 273中所描述的CDR-H3、如SEQ ID NO: 274中所描述的CDR-L1、如SEQ ID NO: 275中所描述的CDR-L2和如SEQ ID NO: 276中所描述的CDR-L3； (29)     如SEQ ID NO: 281中所描述的CDR-H1、如SEQ ID NO: 282中所描述的CDR-H2、如SEQ ID NO: 283中所描述的CDR-H3、如SEQ ID NO: 284中所描述的CDR-L1、如SEQ ID NO: 285中所描述的CDR-L2和如SEQ ID NO: 286中所描述的CDR-L3； (30)     如SEQ ID NO: 291中所描述的CDR-H1、如SEQ ID NO: 292中所描述的CDR-H2、如SEQ ID NO: 293中所描述的CDR-H3、如SEQ ID NO: 294中所描述的CDR-L1、如SEQ ID NO: 295中所描述的CDR-L2和如SEQ ID NO: 296中所描述的CDR-L3； (31)     如SEQ ID NO: 301中所描述的CDR-H1、如SEQ ID NO: 302中所描述的CDR-H2、如SEQ ID NO: 303中所描述的CDR-H3、如SEQ ID NO: 304中所描述的CDR-L1、如SEQ ID NO: 305中所描述的CDR-L2和如SEQ ID NO: 306中所描述的CDR-L3； (32)     如SEQ ID NO: 311中所描述的CDR-H1、如SEQ ID NO: 312中所描述的CDR-H2、如SEQ ID NO: 313中所描述的CDR-H3、如SEQ ID NO: 314中所描述的CDR-L1、如SEQ ID NO: 315中所描述的CDR-L2和如SEQ ID NO: 316中所描述的CDR-L3； (33)     如SEQ ID NO: 321中所描述的CDR-H1、如SEQ ID NO: 322中所描述的CDR-H2、如SEQ ID NO: 323中所描述的CDR-H3、如SEQ ID NO: 324中所描述的CDR-L1、如SEQ ID NO: 325中所描述的CDR-L2和如SEQ ID NO: 326中所描述的CDR-L3； (34)     如SEQ ID NO: 331中所描述的CDR-H1、如SEQ ID NO: 332中所描述的CDR-H2、如SEQ ID NO: 333中所描述的CDR-H3、如SEQ ID NO: 334中所描述的CDR-L1、如SEQ ID NO: 335中所描述的CDR-L2和如SEQ ID NO: 336中所描述的CDR-L3； (35)     如SEQ ID NO: 341中所描述的CDR-H1、如SEQ ID NO: 342中所描述的CDR-H2、如SEQ ID NO: 343中所描述的CDR-H3、如SEQ ID NO: 344中所描述的CDR-L1、如SEQ ID NO: 345中所描述的CDR-L2和如SEQ ID NO: 346中所描述的CDR-L3； (36)     如SEQ ID NO: 351中所描述的CDR-H1、如SEQ ID NO: 352中所描述的CDR-H2、如SEQ ID NO: 353中所描述的CDR-H3、如SEQ ID NO: 354中所描述的CDR-L1、如SEQ ID NO: 355中所描述的CDR-L2和如SEQ ID NO: 356中所描述的CDR-L3； (37)     如SEQ ID NO: 361中所描述的CDR-H1、如SEQ ID NO: 362中所描述的CDR-H2、如SEQ ID NO: 363中所描述的CDR-H3、如SEQ ID NO: 364中所描述的CDR-L1、如SEQ ID NO: 365中所描述的CDR-L2和如SEQ ID NO: 366中所描述的CDR-L3； (38)     如SEQ ID NO: 371中所描述的CDR-H1、如SEQ ID NO: 372中所描述的CDR-H2、如SEQ ID NO: 373中所描述的CDR-H3、如SEQ ID NO: 374中所描述的CDR-L1、如SEQ ID NO: 375中所描述的CDR-L2和如SEQ ID NO: 376中所描述的CDR-L3； (39)     如SEQ ID NO: 381中所描述的CDR-H1、如SEQ ID NO: 382中所描述的CDR-H2、如SEQ ID NO: 383中所描述的CDR-H3、如SEQ ID NO: 384中所描述的CDR-L1、如SEQ ID NO: 385中所描述的CDR-L2和如SEQ ID NO: 386中所描述的CDR-L3； (40)     如SEQ ID NO: 391中所描述的CDR-H1、如SEQ ID NO: 392中所描述的CDR-H2、如SEQ ID NO: 393中所描述的CDR-H3、如SEQ ID NO: 394中所描述的CDR-L1、如SEQ ID NO: 395中所描述的CDR-L2和如SEQ ID NO: 396中所描述的CDR-L3； (41)     如SEQ ID NO: 401中所描述的CDR-H1、如SEQ ID NO: 402中所描述的CDR-H2、如SEQ ID NO: 403中所描述的CDR-H3、如SEQ ID NO: 404中所描述的CDR-L1、如SEQ ID NO: 405中所描述的CDR-L2和如SEQ ID NO: 406中所描述的CDR-L3； (42)     如SEQ ID NO: 411中所描述的CDR-H1、如SEQ ID NO: 412中所描述的CDR-H2、如SEQ ID NO: 413中所描述的CDR-H3、如SEQ ID NO: 414中所描述的CDR-L1、如SEQ ID NO: 415中所描述的CDR-L2和如SEQ ID NO: 416中所描述的CDR-L3； (43)     如SEQ ID NO: 421中所描述的CDR-H1、如SEQ ID NO: 422中所描述的CDR-H2、如SEQ ID NO: 423中所描述的CDR-H3、如SEQ ID NO: 424中所描述的CDR-L1、如SEQ ID NO: 425中所描述的CDR-L2和如SEQ ID NO: 426中所描述的CDR-L3； (44)     如SEQ ID NO: 431中所描述的CDR-H1、如SEQ ID NO: 432中所描述的CDR-H2、如SEQ ID NO: 433中所描述的CDR-H3、如SEQ ID NO: 434中所描述的CDR-L1、如SEQ ID NO: 435中所描述的CDR-L2和如SEQ ID NO: 436中所描述的CDR-L3； (45)     如SEQ ID NO: 441中所描述的CDR-H1、如SEQ ID NO: 442中所描述的CDR-H2、如SEQ ID NO: 443中所描述的CDR-H3、如SEQ ID NO: 444中所描述的CDR-L1、如SEQ ID NO: 445中所描述的CDR-L2和如SEQ ID NO: 446中所描述的CDR-L3； (46)     如SEQ ID NO: 451中所描述的CDR-H1、如SEQ ID NO: 452中所描述的CDR-H2、如SEQ ID NO: 453中所描述的CDR-H3、如SEQ ID NO: 454中所描述的CDR-L1、如SEQ ID NO: 455中所描述的CDR-L2和如SEQ ID NO: 456中所描述的CDR-L3； (47)     如SEQ ID NO: 461中所描述的CDR-H1、如SEQ ID NO: 462中所描述的CDR-H2、如SEQ ID NO: 463中所描述的CDR-H3、如SEQ ID NO: 464中所描述的CDR-L1、如SEQ ID NO: 465中所描述的CDR-L2和如SEQ ID NO: 466中所描述的CDR-L3； (48)     如SEQ ID NO: 471中所描述的CDR-H1、如SEQ ID NO: 472中所描述的CDR-H2、如SEQ ID NO: 473中所描述的CDR-H3、如SEQ ID NO: 474中所描述的CDR-L1、如SEQ ID NO: 475中所描述的CDR-L2和如SEQ ID NO: 476中所描述的CDR-L3； (49)     如SEQ ID NO: 481中所描述的CDR-H1、如SEQ ID NO: 482中所描述的CDR-H2、如SEQ ID NO: 483中所描述的CDR-H3、如SEQ ID NO: 484中所描述的CDR-L1、如SEQ ID NO: 485中所描述的CDR-L2和如SEQ ID NO: 486中所描述的CDR-L3； (50)     如SEQ ID NO: 491中所描述的CDR-H1、如SEQ ID NO: 492中所描述的CDR-H2、如SEQ ID NO: 493中所描述的CDR-H3、如SEQ ID NO: 494中所描述的CDR-L1、如SEQ ID NO: 495中所描述的CDR-L2和如SEQ ID NO: 496中所描述的CDR-L3； (51)     如SEQ ID NO: 501中所描述的CDR-H1、如SEQ ID NO: 502中所描述的CDR-H2、如SEQ ID NO: 503中所描述的CDR-H3、如SEQ ID NO: 504中所描述的CDR-L1、如SEQ ID NO: 505中所描述的CDR-L2和如SEQ ID NO: 506中所描述的CDR-L3； (52)     如SEQ ID NO: 511中所描述的CDR-H1、如SEQ ID NO: 512中所描述的CDR-H2、如SEQ ID NO: 513中所描述的CDR-H3、如SEQ ID NO: 514中所描述的CDR-L1、如SEQ ID NO: 515中所描述的CDR-L2和如SEQ ID NO: 516中所描述的CDR-L3；和 (53)     如SEQ ID NO: 521中所描述的CDR-H1、如SEQ ID NO: 522中所描述的CDR-H2、如SEQ ID NO: 523中所描述的CDR-H3、如SEQ ID NO: 524中所描述的CDR-L1、如SEQ ID NO: 525中所描述的CDR-L2和如SEQ ID NO: 526中所描述的CDR-L3。
項目 22如前述項目中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 7、17、27、37、47、57、67、77、87、97、107、117、127、137、147、157、167、177、187、197、207、217、227、237、247、257、267、277、287、307、317、327、337、347、357、367、377、387、397、407、417、427、437、447、457、467、477、487、497、507、517、和527，較佳的是SEQ ID NO: 177中所描述的那些。
項目 23如前述項目中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 8、18、28、38、48、58、68、78、88、98、108、118、128、138、148、158、168、178、188、198、208、218、228、238、248、258、268、278、288、298、308、318、328、338、348、358、368、378、388、398、408、418、428、438、448、458、468、478、488、498、508、518、和528，較佳的是SEQ ID NO: 178中所描述的那些。
項目 24如前述項目中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含選自由以下組成之群組的VH區和VL區： (1)      如SEQ ID NO: 7中所描述的VH區和如SEQ ID NO: 8中所描述的VL區； (2)      如SEQ ID NO: 17中所描述的VH區和如SEQ ID NO: 18中所描述的VL區； (3)      如SEQ ID NO: 27中所描述的VH區和如SEQ ID NO: 28中所描述的VL區； (4)      如SEQ ID NO: 37中所描述的VH區和如SEQ ID NO: 38中所描述的VL區； (5)      如SEQ ID NO: 47中所描述的VH區和如SEQ ID NO: 48中所描述的VL區； (6)      如SEQ ID NO: 57中所描述的VH區和如SEQ ID NO: 58中所描述的VL區； (7)      如SEQ ID NO: 67中所描述的VH區和如SEQ ID NO: 68中所描述的VL區； (8)      如SEQ ID NO: 77中所描述的VH區和如SEQ ID NO: 78中所描述的VL區； (9)      如SEQ ID NO: 87中所描述的VH區和如SEQ ID NO: 88中所描述的VL區； (10)     如SEQ ID NO: 97中所描述的VH區和如SEQ ID NO: 98中所描述的VL區； (11)     如SEQ ID NO: 107中所描述的VH區和如SEQ ID NO: 108中所描述的VL區； (12)     如SEQ ID NO: 117中所描述的VH區和如SEQ ID NO: 118中所描述的VL區； (13)     如SEQ ID NO: 127中所描述的VH區和如SEQ ID NO: 128中所描述的VL區； (14)     如SEQ ID NO: 137中所描述的VH區和如SEQ ID NO: 138中所描述的VL區； (15)     如SEQ ID NO: 147中所描述的VH區和如SEQ ID NO: 148中所描述的VL區； (16)     如SEQ ID NO: 157中所描述的VH區和如SEQ ID NO: 158中所描述的VL區； (17)     如SEQ ID NO: 167中所描述的VH區和如SEQ ID NO: 168中所描述的VL區； (18)     如SEQ ID NO: 177中所描述的VH區和如SEQ ID NO: 178中所描述的VL區； (19)     如SEQ ID NO: 187中所描述的VH區和如SEQ ID NO: 188中所描述的VL區； (20)     如SEQ ID NO: 197中所描述的VH區和如SEQ ID NO: 198中所描述的VL區； (21)     如SEQ ID NO: 207中所描述的VH區和如SEQ ID NO: 208中所描述的VL區； (22)     如SEQ ID NO: 217中所描述的VH區和如SEQ ID NO: 218中所描述的VL區； (23)     如SEQ ID NO: 227中所描述的VH區和如SEQ ID NO: 228中所描述的VL區； (24)     如SEQ ID NO: 237中所描述的VH區和如SEQ ID NO: 238中所描述的VL區； (25)     如SEQ ID NO: 247中所描述的VH區和如SEQ ID NO: 248中所描述的VL區； (26)     如SEQ ID NO: 257中所描述的VH區和如SEQ ID NO: 258中所描述的VL區； (27)     如SEQ ID NO: 267中所描述的VH區和如SEQ ID NO: 268中所描述的VL區； (28)     如SEQ ID NO: 277中所描述的VH區和如SEQ ID NO: 278中所描述的VL區； (29)     如SEQ ID NO: 287中所描述的VH區和如SEQ ID NO: 288中所描述的VL區； (30)     如SEQ ID NO: 297中所描述的VH區和如SEQ ID NO: 298中所描述的VL區； (31)     如SEQ ID NO: 307中所描述的VH區和如SEQ ID NO: 308中所描述的VL區； (32)     如SEQ ID NO: 317中所描述的VH區和如SEQ ID NO: 318中所描述的VL區； (33)     如SEQ ID NO: 327中所描述的VH區和如SEQ ID NO: 328中所描述的VL區； (34)     如SEQ ID NO: 337中所描述的VH區和如SEQ ID NO: 338中所描述的VL區； (35)     如SEQ ID NO: 347中所描述的VH區和如SEQ ID NO: 348中所描述的VL區； (36)     如SEQ ID NO: 357中所描述的VH區和如SEQ ID NO: 358中所描述的VL區； (37)     如SEQ ID NO: 367中所描述的VH區和如SEQ ID NO: 368中所描述的VL區； (38)     如SEQ ID NO: 377中所描述的VH區和如SEQ ID NO: 378中所描述的VL區； (39)     如SEQ ID NO: 387中所描述的VH區和如SEQ ID NO: 388中所描述的VL區； (40)     如SEQ ID NO: 397中所描述的VH區和如SEQ ID NO: 398中所描述的VL區； (41)     如SEQ ID NO: 407中所描述的VH區和如SEQ ID NO: 408中所描述的VL區； (42)     如SEQ ID NO: 417中所描述的VH區和如SEQ ID NO: 418中所描述的VL區； (43)     如SEQ ID NO: 427中所描述的VH區和如SEQ ID NO: 428中所描述的VL區； (44)     如SEQ ID NO: 437中所描述的VH區和如SEQ ID NO: 438中所描述的VL區； (45)     如SEQ ID NO: 447中所描述的VH區和如SEQ ID NO: 448中所描述的VL區； (46)     如SEQ ID NO: 457中所描述的VH區和如SEQ ID NO: 458中所描述的VL區； (47)     如SEQ ID NO: 467中所描述的VH區和如SEQ ID NO: 468中所描述的VL區； (48)     如SEQ ID NO: 477中所描述的VH區和如SEQ ID NO: 478中所描述的VL區； (49)     如SEQ ID NO: 487中所描述的VH區和如SEQ ID NO: 488中所描述的VL區； (50)     如SEQ ID NO: 497中所描述的VH區和如SEQ ID NO: 498中所描述的VL區； (51)     如SEQ ID NO: 507中所描述的VH區和如SEQ ID NO: 508中所描述的VL區； (52)     如SEQ ID NO: 517中所描述的VH區和如SEQ ID NO: 518中所描述的VL區；和 (53)     如SEQ ID NO: 527中所描述的VH區和如SEQ ID NO: 528中所描述的VL區。
項目 25如前述項目中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的多肽或由具有選自由以下組成之群組的胺基酸序列的多肽組成：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519、和529，較佳的是SEQ ID NO: 179。
項目 26如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含：含有選自由以下組成之群組的CDR-L1、CDR-L2和CDR-L3的VL區： (a)     如SEQ ID NO: 542中所描述的CDR-L1、如SEQ ID NO: 543中所描述的CDR-L2和如SEQ ID NO: 544中所描述的CDR-L3； (b)    如SEQ ID NO: 599中所描述的CDR-L1、如SEQ ID NO: 600中所描述的CDR-L2和如SEQ ID NO: 601中所描述的CDR-L3；和 (c)     如SEQ ID NO: 621中所描述的CDR-L1、如SEQ ID NO: 622中所描述的CDR-L2和如SEQ ID NO: 623中所描述的CDR-L3。
項目 27如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含：含有選自由以下組成之群組的CDR-H1、CDR-H2和CDR-H3的VH區： (a)     如SEQ ID NO: 534中所描述的CDR-H1、如SEQ ID NO: 535中所描述的CDR-H2和如SEQ ID NO: 536中所描述的CDR-H3； (b)    如SEQ ID NO: 545中所描述的CDR-H1、如SEQ ID NO: 546中所描述的CDR-H2和如SEQ ID NO: 547中所描述的CDR-H3； (c)     如SEQ ID NO: 557中所描述的CDR-H1、如SEQ ID NO: 558中所描述的CDR-H2和如SEQ ID NO: 559中所描述的CDR-H3； (d)    如SEQ ID NO: 568中所描述的CDR-H1、如SEQ ID NO: 569中所描述的CDR-H2和如SEQ ID NO: 570中所描述的CDR-H3； (e)     如SEQ ID NO: 579中所描述的CDR-H1、如SEQ ID NO: 580中所描述的CDR-H2和如SEQ ID NO: 581中所描述的CDR-H3； (f)     如SEQ ID NO: 591中所描述的CDR-H1、如SEQ ID NO: 592中所描述的CDR-H2和如SEQ ID NO: 593中所描述的CDR-H3； (g)    如SEQ ID NO: 602中所描述的CDR-H1、如SEQ ID NO: 603中所描述的CDR-H2和如SEQ ID NO: 604中所描述的CDR-H3； (h)    如SEQ ID NO: 613中所描述的CDR-H1、如SEQ ID NO: 614中所描述的CDR-H2和如SEQ ID NO: 615中所描述的CDR-H3； (i)     如SEQ ID NO: 624中所描述的CDR-H1、如SEQ ID NO: 625中所描述的CDR-H2和如SEQ ID NO: 626中所描述的CDR-H3；和 (j)     如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2和如SEQ ID NO: 638中所描述的CDR-H3。
項目 28如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含：含有選自由以下組成之群組的CDR-L1、CDR-L2和CDR-L3的VL區，以及含有選自由以下組成之群組的CDR-H1、CDR-H2和CDR-H3的VH區： (a)     如SEQ ID NO: 531中所描述的CDR-L1、如SEQ ID NO: 532中所描述的CDR-L2、如SEQ ID NO: 533中所描述的CDR-L3、如SEQ ID NO: 534中所描述的CDR-H1、如SEQ ID NO: 535中所描述的CDR-H2和如SEQ ID NO: 536中所描述的CDR-H3； (b)    如SEQ ID NO: 542中所描述的CDR-L1、如SEQ ID NO: 543中所描述的CDR-L2、如SEQ ID NO: 544中所描述的CDR-L3、如SEQ ID NO: 545中所描述的CDR-H1、如SEQ ID NO: 546中所描述的CDR-H2和如SEQ ID NO: 547中所描述的CDR-H3； (c)     如SEQ ID NO: 554中所描述的CDR-L1、如SEQ ID NO: 555中所描述的CDR-L2、如SEQ ID NO: 556中所描述的CDR-L3、如SEQ ID NO: 557中所描述的CDR-H1、如SEQ ID NO: 558中所描述的CDR-H2和如SEQ ID NO: 559中所描述的CDR-H3； (d)    如SEQ ID NO: 565中所描述的CDR-L1、如SEQ ID NO: 566中所描述的CDR-L2、如SEQ ID NO: 567中所描述的CDR-L3、如SEQ ID NO: 568中所描述的CDR-H1、如SEQ ID NO: 569中所描述的CDR-H2和如SEQ ID NO: 570中所描述的CDR-H3； (e)     如SEQ ID NO: 576中所描述的CDR-L1、如SEQ ID NO: 577中所描述的CDR-L2、如SEQ ID NO: 578中所描述的CDR-L3、如SEQ ID NO: 579中所描述的CDR-H1、如SEQ ID NO: 580中所描述的CDR-H2和如SEQ ID NO: 581中所描述的CDR-H3； (f)     如SEQ ID NO: 588中所描述的CDR-L1、如SEQ ID NO: 589中所描述的CDR-L2、如SEQ ID NO: 590中所描述的CDR-L3、如SEQ ID NO: 591中所描述的CDR-H1、如SEQ ID NO: 592中所描述的CDR-H2和如SEQ ID NO: 593中所描述的CDR-H3； (g)    如SEQ ID NO: 599中所描述的CDR-L1、如SEQ ID NO: 600中所描述的CDR-L2、如SEQ ID NO: 601中所描述的CDR-L3、如SEQ ID NO: 602中所描述的CDR-H1、如SEQ ID NO: 603中所描述的CDR-H2和如SEQ ID NO: 604中所描述的CDR-H3； (h)    如SEQ ID NO: 610中所描述的CDR-L1、如SEQ ID NO: 611中所描述的CDR-L2、如SEQ ID NO: 612中所描述的CDR-L3、如SEQ ID NO: 613中所描述的CDR-H1、如SEQ ID NO: 614中所描述的CDR-H2和如SEQ ID NO: 615中所描述的CDR-H3； (i)     如SEQ ID NO: 621中所描述的CDR-L1、如SEQ ID NO: 622中所描述的CDR-L2、如SEQ ID NO: 623中所描述的CDR-L3、如SEQ ID NO: 624中所描述的CDR-H1、如SEQ ID NO: 625中所描述的CDR-H2和如SEQ ID NO: 626中所描述的CDR-H3；和 (j)     如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3、如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2和如SEQ ID NO: 638中所描述的CDR-H3。
項目 29如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 550、SEQ ID NO: 551、SEQ ID NO: 584、SEQ ID NO: 585、SEQ ID NO: 629和SEQ ID NO: 630，較佳的是SEQ ID NO: 629中所描述的那些。
項目 30如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 537、SEQ ID NO: 538、SEQ ID NO: 548、SEQ ID NO: 549、SEQ ID NO: 560、SEQ ID NO: 561、SEQ ID NO: 571、SEQ ID NO: 572、SEQ ID NO: 582、SEQ ID NO: 583、SEQ ID NO: 594、SEQ ID NO: 595、SEQ ID NO: 605、SEQ ID NO: 606、SEQ ID NO: 616、SEQ ID NO: 617、SEQ ID NO: 627、SEQ ID NO: 628、SEQ ID NO: 639、SEQ ID NO: 640、和SEQ ID NO: 644，較佳的是SEQ ID NO: 639中所描述的那些。
項目 31如前述項目中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含選自由以下組成之群組的VL區和VH區： (a)     如SEQ ID NO: 539或521中所描述的VL區和如SEQ ID NO: 537或538中所描述的VH區； (b)    如SEQ ID NO: 550或521中所描述的VL區和如SEQ ID NO: 548或549中所描述的VH區； (c)     如SEQ ID NO: 562或521中所描述的VL區和如SEQ ID NO: 560或561中所描述的VH區； (d)    如SEQ ID NO: 573或521中所描述的VL區和如SEQ ID NO: 571或572中所描述的VH區； (e)     如SEQ ID NO: 584或585中所描述的VL區和如SEQ ID NO: 582或583中所描述的VH區； (f)     如SEQ ID NO: 596或521中所描述的VL區和如SEQ ID NO: 594或595中所描述的VH區； (g)    如SEQ ID NO: 607或585中所描述的VL區和如SEQ ID NO: 605或606中所描述的VH區； (h)    如SEQ ID NO: 618或521中所描述的VL區和如SEQ ID NO: 616或617中所描述的VH區； (i)     如SEQ ID NO: 629或630中所描述的VL區和如SEQ ID NO: 627或628中所描述的VH區； (j)     如SEQ ID NO: 641或630中所描述的VL區和如SEQ ID NO: 639或640中所描述的VH區；和 (k)    如SEQ ID NO: 645中所描述的VL區和如SEQ ID NO: 644中所描述的VH區。
項目 32如前述項目中任一項所述使用的蛋白質，其中與CD3結合的第二結構域包含具有選自由以下組成之群組的胺基酸序列的多肽或由具有選自由以下組成之群組的胺基酸序列的多肽組成：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643、和646，較佳的是SEQ ID NO: 642中所描述的那些。
項目 33如前述項目中任一項所述使用的蛋白質，其中該蛋白質包含具有選自由以下組成之群組的胺基酸序列的多肽：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520和530中所描述的那些。
項目 34如前述項目中任一項所述使用的蛋白質，該蛋白質以N-末端至C-末端的順序包含以下或由以下組成： (a)     第一結構域； (b)     肽連接子，該肽連接子具有選自由SEQ ID NO: 687、693和694組成之群組的胺基酸序列； (c)     第二結構域； (d)     肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 686、687、688、689、690、691、692、693或694； (e)     第三結構域，其包含 (i)    第一多肽單體（較佳的是包含鉸鏈、CH2結構域和CH3結構域）； (ii)   肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 695、696、697、698或699；和 (iii)  第二多肽單體（較佳的是包含鉸鏈、CH2結構域和CH3結構域）。
項目 35如前述項目中任一項所述使用的蛋白質，該蛋白質以N-末端至C-末端的順序包含以下或由以下組成： a)      第一結構域，該第一結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519和529；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； b)      肽連接子，該肽連接子具有選自由SEQ ID NO: 687、693和694組成之群組的胺基酸序列； c)      第二結構域，該第二結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643和646；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； d)      肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 686、687、688、689、690、691、692、693和694；和 e)      第三結構域，該第三結構域具有選自由SEQ ID NO: 700-707組成之群組的胺基酸序列。
項目 36如前述項目中任一項所述使用的蛋白質，該蛋白質以N-末端至C-末端的順序包含以下或由以下組成： (a)     多肽，該多肽具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520、和530中所描述的那些； (b)    連接子，該連接子具有如SEQ ID NO: 686中所描述的胺基酸序列；和 (c)     多肽，該多肽具有如SEQ ID NO: 700中所描述的胺基酸序列。
項目 36a如前述項目中任一項所述使用的蛋白質，其中該蛋白質包含具有如SEQ ID NO: 661中所描述的胺基酸序列的多肽，或由其組成。
項目 37如前述項目中任一項所述使用的蛋白質，其中該蛋白質具有約75至約200 kDa、約80至約175 kDa、約85至約150 kDa、約90至約130 kDa、約95至約120 kDa、以及較佳的是約100至約115 kDa或約105至約110 kDa的分子量。
項目 38如前述項目中任一項所述使用的蛋白質，其中該蛋白質在人類中具有約3天至約14天、約4天至約12天、約3或4天至約10天、約3或4天至約8天、或約5至約7天、或約6天的半衰期和消除半衰期（T 1/2）。
本發明之目的是提供半衰期延長的抗BCMA x 抗CD3結合蛋白的投與方案，該投與方案提供有利的安全性和耐受性特徵，同時在BCMA陽性贅生物的患者中產生陽性功效信號。
因此，本發明關於一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     在第1天投與第一劑量的該蛋白質，和 •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天。
還設想該第一週期進一步包括： •     在投與該第二劑量後投與目標劑量的該蛋白質，其中該目標劑量等於或超過該第二劑量並且是從約9 mg/天至約24 mg/天、較佳的是從12.5 mg/天至約24 mg/天。
本發明還關於一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     投與從12.5 mg/天至約24 mg/天的目標劑量的該蛋白質。
還設想該第一週期包括： •     在第1天投與第一劑量的該蛋白質， •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天，和 •     在投與該第二劑量後投與該目標劑量的蛋白質，其中該目標劑量等於或超過該第二劑量。
本發明還關於一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     投與從12.5 mg/天至約24 mg/天的目標劑量的該蛋白質。
還設想第一週期進一步包括（除了12.5 mg/天至約24 mg/天的目標劑量以外）： •     在第1天投與第一劑量的該蛋白質， •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量，和 •     在該第二劑量投與日後且該目標劑量投與日前的一天視需要投與第三劑量的該蛋白質，其中該第三劑量超過該第二劑量。
設想在第一、第二和（視需要的）第三劑量後投與目標劑量。目標劑量可以，例如，藉由在第6天和第10天之間的一天，例如在第6天、在第7天、在第8天、在第9天或在第10天投與。設想目標劑量超過第一劑量、第二劑量以及（視需要的）第三劑量。
此外，本發明關於一種用於治療或改善BCMA陽性贅生物之方法，該方法包括向有需要的受試者投與一種蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中如上所述投與該蛋白質。本發明還關於一種向被診斷患有BCMA陽性贅生物的患者投與蛋白質之方法，其中該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，並且其中如上所述投與該蛋白質。本發明進一步關於一種蛋白質用於製造用於治療BCMA陽性贅生物的藥物之用途，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中如上所述投與該蛋白質。本發明還關於一種蛋白質用於治療或改善BCMA陽性贅生物之用途，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中如上所述投與該蛋白質。
「贅生物」係組織的異常生長，通常但不總是形成腫塊。當也形成腫塊時，通常稱之為「腫瘤」。在腦腫瘤中，細胞的不受控制的分裂意指贅生物的腫塊尺寸增加，並且在如顱內腔的受限空間中這很快造成問題，因為該腫塊侵入大腦的空間將其推到旁邊，導致腦組織壓縮和顱內壓增高以及實質破壞。根據本發明，術語「贅生物」或「腫瘤」還是指將從用如本文所述之蛋白質的治療中獲益的病症。這包括慢性和急性障礙或疾病，該等障礙或疾病包括那些使哺乳動物易患所討論的病症（贅生物或腫瘤）的病理學病症。
贅生物或腫瘤可以是良性的、潛在惡性的（癌前）、或惡性的（癌性的）。惡性贅生物/腫瘤通常被稱為癌症。它們通常侵入並破壞周圍組織，並可能形成轉移，即它們擴散到身體的其他部分、組織或器官。「原發性腫瘤」係在腫瘤進展開始並且繼續產生癌性腫塊的解剖部位生長的腫瘤。例如，當腦內形成異常細胞時，就會發生腦腫瘤。大多數癌症在其原發部位發展，但隨後繼續形成轉移或擴散到身體的其他部位（例如組織和器官）。該等進一步的腫瘤係繼發性腫瘤。大多數癌症以它們的原發部位命名，甚至在它們已經擴散到身體的其他部位後也是如此。
淋巴瘤和白血病係造血或淋巴贅生物。多發性骨髓瘤（MM）（也稱為漿細胞骨髓瘤）係漿細胞的癌症，該等漿細胞係一類通常會產生抗體的白血球。出於本發明之目的，淋巴瘤和白血病以及MM也被術語「腫瘤」、「癌症」或「贅生物」涵蓋。淋巴瘤係一組從淋巴細胞（一類白血球）發展而來的血癌。白血病係一組通常在骨髓中開始並導致大量異常白血球的癌症。該等白血球尚未完全發育，並且被稱為母細胞或白血病細胞。淋巴瘤和白血病係造血和淋巴組織腫瘤更廣泛集合的一部分。
出於本發明之目的，術語「贅生物」、「腫瘤」和「癌症」可互換地使用，並且它們包括原發性腫瘤/癌症和繼發性腫瘤/癌症（或「轉移」）兩者，以及腫塊形成贅生物（腫瘤）和淋巴贅生物（如淋巴瘤和白血病），以及MRD。
術語「微小殘留病」（MRD）係指在癌症治療後留在患者體內的少量殘留癌細胞存在的證據，例如當患者處於反應期時（患者沒有疾病症狀或跡象）。藉由常規手段通常無法檢測到極少數剩餘的癌細胞，因為用於評估或檢測癌症的標準測試沒有靈敏到足以檢測MRD。如今，MRD的分子生物學測試非常靈敏，該等測試如流動式細胞測量術、PCR和下一代定序。該等測試可以測量組織樣本中最低水平的癌細胞，有時測量百萬個正常細胞中低至一個癌細胞。在本發明之上下文中，設想無論是否檢測到MRD，贅生物的術語「預防」、「治療」或「改善」也涵蓋「預防、治療或改善MRD」。
設想本發明之BCMA陽性贅生物係B細胞贅生物或漿細胞贅生物。B細胞（也稱為B淋巴細胞）係一類淋巴細胞亞型的白血球。它們藉由分泌抗體在適應性免疫系統的體液免疫組分中起作用。另外地，B細胞呈遞抗原（它們也被分類為專職性抗原呈遞細胞）並分泌細胞介素。在哺乳動物中，B細胞在骨髓中成熟，骨髓係大多數骨骼的核心。與其他兩類淋巴細胞（T細胞和自然殺傷（NK）細胞）不同，B細胞在其細胞膜上表現B細胞受體（BCR）。BCR允許B細胞與特異性抗原結合，並將針對該抗原啟動抗體反應。漿細胞（Plasma cell）（也稱為血漿B細胞、漿細胞（plasmocyte）或效應B細胞）係分泌大量抗體的白血球。它們通常由血漿和淋巴系統運輸。漿細胞起源於骨髓。B細胞分化成漿細胞，該等漿細胞在先質B細胞受體之後產生緊密模擬的抗體分子。一旦釋放到血液和淋巴液中，該等抗體分子與靶抗原結合並開始其中和作用或破壞作用。
細胞表面上BCMA的表現水平可以藉由例如流動式細胞測量術分析來確定。選擇用於分析BCMA表現的細胞亞群（例如B細胞、漿細胞、MM細胞、CD138+細胞）可以例如用抗BCMA抗體染色，隨後用二抗染色，然後在FACS測定中分析。BCMA陰性細胞系（如K562、A549、TC71、CCRF-CEM）可以用作對照。FACS測定的變換（BCMA陰性細胞系定義0% BCMA表現）指示待分析的細胞係BCMA陽性的。表面細胞上可存在不同水平的BCMA表現，例如低、中或高表現。還參見Quinn等人, Blood [血液] (2011) 117: 890-901和Sanchez等人, Br J Heamatol [英國血液學雜誌] 2012年7月18日。
「BCMA陽性贅生物」或「（BCMA陽性）B細胞贅生物或漿細胞贅生物」可以選自以下群組，該群組包括但不限於：多發性骨髓瘤、復發性和/或難治性多發性骨髓瘤、重鏈多發性骨髓瘤、輕鏈多發性骨髓瘤、髓外骨髓瘤（髓外漿細胞瘤、髓外多發性骨髓瘤）、漿細胞瘤、漿細胞白血病、華氏巨球蛋白血症（淋巴漿細胞性淋巴瘤）、和鬱積型骨髓瘤（鬱積型多發性骨髓瘤）。因此，本揭露還關於一種蛋白質，其用於治療或改善如本文所述之多發性骨髓瘤（MM）、漿細胞瘤、漿細胞白血病和華氏巨球蛋白血症。MM可以選自由以下組成之群組或包含以下的群組：復發性和/或難治性多發性骨髓瘤、重鏈多發性骨髓瘤、輕鏈多發性骨髓瘤、髓外多發性骨髓瘤、和鬱積型多發性骨髓瘤。
「BCMA陽性贅生物」可以假定為BCMA陽性並且例如選自上文所定義的疾病的組（包括多發性骨髓瘤和其他適應症），或該贅生物確定為BCMA陽性，例如藉由分析所選細胞表面上BCMA表現水平，例如如上文所述。
本發明之蛋白質（和包含這種蛋白質的藥物組成物）可用於治療和/或改善有需要的受試者中如本文所述之BCMA陽性贅生物。術語「治療」係指治療性治療和預防性（prophylactic或preventative）措施兩者。預防性措施通常是指防止贅生物復發（反復（recidivism）/再次發生（recurrence））的情況。治療包括將蛋白質（或包含這種蛋白質的藥物組成物）投與至患者的身體、分離的組織、或來自有需要的患者或受試者的細胞（該患者或受試者患有如本文所述之BCMA陽性贅生物、具有這種贅生物的症狀、或具有對這種贅生物的傾向），目的是治癒（cure）、痊癒（heal）、減輕（alleviate）、緩解（relieve）、改變、補救（remedy）、改善（ameliorate）、改進（improve）或影響（affect）BCMA陽性贅生物、BCMA陽性贅生物的一種或多種症狀、或對該疾病的傾向或其再次發生。
術語「有需要的受試者」、「患者」或「需要治療」的那些包括已經患有BCMA陽性贅生物的那些、以及處於MRD背景的那些和要預防贅生物或其復發（反復（recidivism）/再次發生（recurrence））的那些。該等術語還包括接受預防性或治療性治療的人和其他哺乳動物受試者。因此，「患者」或「有需要的受試者」可以是哺乳動物，例如人類患者。如本文所用，術語「預防」意指藉由將根據本發明之蛋白質投與至有需要的受試者來避免如本文所指定的疾病的發生或重新發生。
如本文所用，術語「改善」係指藉由將根據本發明之蛋白質投與至有需要的患者或受試者，對這樣的患者的疾病狀態（疾病係BCMA陽性贅生物）的任何改進。這種改進可被視為減緩患者的疾病進展或阻止患者的疾病進展，和/或可被視為降低疾病症狀嚴重程度、增加疾病無症狀時間段的頻率或持續時間、或預防由於疾病導致的損傷或殘疾。
在多發性骨髓瘤的情況下，症狀和體征變化很大，因為許多器官可能受到疾病的影響。多發性骨髓瘤的常見症狀包括升高的鈣水平、腎衰竭、貧血、和骨病變（統稱「CRAB」特徵）。在晚期MM中，可能發生骨痛、出血和頻繁感染。併發症還可能包括澱粉樣變性。國際骨髓瘤工作組（IMWG）已經確立了MM的診斷標準，除了經典的CRAB特徵之外，還教導三種「骨髓瘤定義事件（MDE）」： •     骨髓檢查中60%或更多的選殖漿細胞 •     血清受累區/非受累區游離輕鏈比率為100或更高，前提係所參與的輕鏈的絕對水平為至少100 mg/L（患者的「受累的」游離輕鏈（κ或λ）係高於正常參考範圍的游離輕鏈；「未受累的」游離輕鏈典型地是在正常範圍內或低於正常範圍的游離輕鏈） •     MRI（磁共振成像）上不止一個尺寸至少為5 mm或更大的局灶性病變
認為該等標記中至少一種的存在足以診斷多發性骨髓瘤，無論是否存在症狀或CRAB特徵。還參見Palumbo A. J Clin Oncol. [臨床腫瘤學雜誌] 2014年2月20日; 32 (6): 587-600。
骨痛影響近70%的患者，並且是最常見的症狀。它通常關於脊柱和肋骨。椎骨的受累可能導致脊髓壓迫或脊柱後凸。骨髓瘤骨病係由骨髓基質過表現核因子κB配位基（RANKL）受體活化劑引起的。RANKL激活破骨細胞，破骨細胞可以吸收骨。所產生的骨病變本質上係溶解性的（即它們引起分解），並且在平片（plain radiograph）中最清楚。骨的破壞還會導致釋放鈣到血液中，這造成了高鈣血症及其相關症狀。
在骨髓瘤中發現的貧血通常是正常紅血球的和正常色素性的。它係由於藉由浸潤腫瘤細胞取代正常骨髓和藉由細胞介素抑制正常紅血球生成（造血）。
可以進行骨髓活組織檢查以估計漿細胞佔據的骨髓百分比。將此百分比用於MM的診斷標準。通常，MM患者具有 ≥ 10%的選殖骨髓漿細胞。免疫組織化學（使用針對表面蛋白的抗體染色特定細胞類型）可以檢測在細胞質中以及偶爾在細胞表面表現免疫球蛋白的漿細胞；例如，骨髓瘤細胞典型地對標記CD56、CD38、CD138、CD319呈陽性，但也可包括其他標記以定義或鑒定MM。
所謂的「副蛋白」（也稱為骨髓瘤蛋白、單株蛋白或M蛋白）係異常的免疫球蛋白片段，其藉由漿細胞的異常單株增殖過量產生（典型地在MM中）。理論上，MM患者可以產生所有類別的免疫球蛋白，但IgG副蛋白最常見，其次係IgA和IgM，而IgD和IgE骨髓瘤非常罕見。此外，抗體輕鏈和/或重鏈可以孤立地分泌：κ或λ輕鏈、或者五種類型重鏈（α、γ、δ、ε或my（µ）-重鏈）中的任一種。副蛋白的這種增殖對身體有若干種有害作用，該等有害作用包括免疫功能受損、血液黏度異常高、和腎受損。沒有副蛋白證據的患者可能患有「非分泌性」骨髓瘤（不產生免疫球蛋白）；他們代表所有MM患者的大約3%。除了患有真正非分泌性MM的患者，血清和/或尿副蛋白的存在係MM的指標。可以使用患者的尿和/或血清中的副蛋白的定量測量來建立診斷和/或監測疾病。
腎衰竭可能是急性和慢性的。MM中腎衰竭的最常見原因係由於惡性細胞分泌的蛋白質。骨髓瘤細胞產生不同類型的單株蛋白，最常見的是免疫球蛋白（抗體）和游離輕鏈，導致血液中該等蛋白質（副蛋白）的異常高水平。根據該等蛋白質的尺寸，它們可能藉由腎排泄，但腎也可能因其影響而受損。此外，增加的骨吸收導致高鈣血症並引起腎鈣鹽沈著症，從而造成腎衰竭。
MM中發生的最常見的感染係肺炎和腎盂腎炎。感染風險增加係由於免疫缺陷。儘管MM中的總免疫球蛋白水平典型地升高，但大多數抗體係來自選殖漿細胞的無效單株抗體。
設想投與蛋白質治療或改善根據本發明之BCMA陽性贅生物 •     相對於治療開始之前，即在第一次投與本發明之蛋白質之前（在此特定上下文中，「在……之前」意指在1、2、4、6、8或12小時內之前，在1、2、3、4、5或6天內之前，在1、2、3或4週內之前，或在1、2、3或4個月內之前）尿和/或血清的副蛋白或游離輕鏈的水平，分別將尿和/或血清的副蛋白或游離輕鏈的水平降低至少約50%或55%、至少約60%或65%、至少約70%或75%、至少約80%或85%、或至少約90%或95%； •     相對於治療開始之前，即在第一次投與本發明之蛋白質之前（在此特定上下文中，「在……之前」意指在1、2、4、6、8或12小時內之前，在1、2、3、4、5或6天內之前，在1、2、3或4週內之前，或在1、2、3或4個月內之前）骨髓中漿細胞的百分比，將骨髓中漿細胞的百分比降低至少約50%或55%、至少約60%或65%、至少約70%或75%、至少約80%或85%、或至少約90%或95%； •     相對於治療開始之前，即在第一次投與本發明之蛋白質之前（在此特定上下文中，「在……之前」意指在1、2、4、6、8或12小時內之前，在1、2、3、4、5或6天內之前，在1、2、3或4週內之前，或在1、2、3或4個月內之前，取決於症狀）的症狀，將誘導上文所述該等症狀中的任一項減少至少約50%或55%、至少約60%或65%、至少約70%或75%、至少約80%或85%、或至少約90%或95%； •     相對於未治療的患者或相對於未治療的細胞，將腫瘤生長或腫瘤細胞增殖抑制至少約50%或55%、至少約60%或65%、至少約70%或75%、至少約80%或85%、或至少約90%或95%；和/或 •     相對於未治療的患者或相對於未治療的細胞，將誘導至少約50%或55%、至少約60%或65%、至少約70%或75%、至少約80%或85%、或至少約90%或95%的BCMA陽性贅生物細胞的裂解。
本發明之蛋白質抑制腫瘤生長/腫瘤細胞增殖或誘導細胞裂解的能力可以在預測人腫瘤功效的動物模型中、或在體外或離體研究中被評估（如由蛋白質誘導的，藉由來自多發性骨髓瘤患者的BM抽吸物的自體T細胞的BCMA陽性細胞消減）。此外，該蛋白質的功效評估可以如下進行：可以藉由分析骨髓瘤受累百分比，藉由FISH（螢光原位雜交）以及藉由骨髓（BM）中的核型分析來完成腫瘤評估。BM核型分析和FISH的數據可以從BM樣本中獲得。血清蛋白電泳（SPEP）和尿蛋白電泳（UPEP）允許測量血清/尿M蛋白。免疫固定係檢測血清和/或尿M蛋白的另一種方法。還設想可以進行血清游離輕鏈測定和比率分析。在游離輕鏈（FLC）多發性骨髓瘤的情況下，可以在血清和尿中分析FLC（sFLC和uFLC）。可以確定受累區/非受累區FLC的水平、單株λ-FLC/κ-FLC的比率、以及單株κ-FLC/λ-FLC的比率。此外，還可以分析定量和定性免疫球蛋白（Ig），並且可以評估血清中的β-2微球蛋白。還設想可以進行骨骼調查和漿細胞瘤評估。可以進行篩選成像以評估使用全身MRI或PET/CT的髓外復發。適合於評估骨病變的成像包括但不限於CT掃描、MRI、PET、PET-CT或其他標準護理方法。還設想藉由基於下一代定序（NGS）的測定來測量微小殘留病。出於此目的，可以從懷疑係完全緩解者的受試者收集骨髓抽吸物。在收集BM MRD樣本的同時，可以另外從受試者收集血漿樣本，以評估MRD檢測對ctDNA（循環腫瘤DNA）的可行性。MRD緩解可以定義為每個FACS（根據需要，使用針對cytIgλ、cytIgκ、CD19、CD56或CD138、CD38、和CD45的抗體）中的骨髓中 ＜ 1個腫瘤細胞/10 4個正常細胞。在本發明之一個實施方式中，該等標記係在本發明之上下文中定義腫瘤細胞的充分條件。
設想患者或受試者對投與根據本發明之蛋白質的緩解以下列方式之一測量： •     定量測量尿和/或血清中的副蛋白（M蛋白）或游離輕鏈； •     確定骨髓中漿細胞的百分比；和/或 •     成像（CT，MRI）髓外表現。
本發明提供了一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     在第1天投與第一劑量的該蛋白質，和 •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天。
此外設想該第一週期包含： •     在投與該第二劑量後投與目標劑量的該蛋白質，其中該目標劑量等於或超過該第二劑量並且是從約9 mg/天至約24 mg/天、較佳的是從12.5 mg/天至約24 mg/天。
「治療週期」或「週期」係指以特定劑量和給藥間隔投與蛋白質的時間段。將本發明之蛋白質以至少一個週期投與，但也設想投與多個週期，如2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25個或更多個週期。術語「至少一個週期」意指「一個或多個週期」。根據本發明，設想「一個週期」（即，第一週期、第二週期和/或任何後續的週期）對應於約25至約30或31天、約26或27至約29天、較佳的是約28天或四個週的時間段。週期開始於在此週期的「第1天」第一次投與本發明之蛋白質。一個週期後可以緊隨後續的週期，但是也可以設想兩個週期之間有無投與的間隔。設想不同的投與週期不必完全相同。特別地，設想第一週期不同於後續的週期，特別是在該蛋白質的給藥方案方面。將第一週期設計為包含該蛋白質的階梯式給藥，直到達到該蛋白質的目標劑量。設想在第一週期（通常在最初的10天內）達到的該目標劑量將在第一週期完成期間和一個或多個後續的週期期間使用（投與）。因此，可以將第一週期認為係「起始週期」，並將後續的週期認為係「維持週期」。
當患者開始用蛋白質的療程時，較佳的是將起始週期作為第一週期向患者投與。當患者重新開始用蛋白質的療程時，例如在無治療時間段、給藥中斷（例如當患者沒有完成先前的治療週期時）或患者的贅生物復發或進展後，也可以向患者投與起始週期。儘管典型地投與一個起始週期將是足夠的，但在本發明之方法的一些實施方式中，考慮了投與兩個或更多個起始週期。在一個特定的實施方式中，僅向患者投與一個起始週期。
根據患者所需的治療持續時間，可以向該患者投與多個維持週期（例如2、3、4、5、6、7、8、9、10、11、12個或更多個週期）。例如，患者可以接受蛋白質的維持週期，直到患者達到所需緩解水平，諸如完全緩解、非常好的部分緩解或部分緩解。在一些實施方式中，向患者投與兩個或更多個維持週期。在其他實施方式中，向患者投與四個或更多個維持週期。在仍其他實施方式中，向患者投與六至十二個維持週期。在某些實施方式中，連續地投與維持週期，在維持週期之間沒有無治療時間段。如果需要中斷治療，則理想地，無治療時間段的持續時間應不大於維持週期中所採用的給藥間隔的兩倍。舉例來說，如果在維持週期中所採用的給藥間隔係每週一次，則維持週期之間的無治療時間段將較佳的是約兩個週或更短。
該蛋白質的給藥「階梯」或「劑量階梯」意指從一次投與（在一個週期（通常是第一週期）內的一天）到後續的投與（在這個週期內的較晚的一天），待投與的劑量增加。一個週期內的一個劑量階梯意指於某一天待投與的一個劑量隨後是在後續的一天待投與的更高的劑量。因此，一個週期內兩個劑量階梯意指一個劑量（例如於第1天待投與的第一劑量）隨後是高於該第一劑量並在後續的一天投與的第二劑量，並且該第二劑量隨後是高於該第二劑量並在後續的一天投與的第三劑量（例如，目標劑量）。在一個或兩個階梯的情況下，在第一週期期間待投與的（至少）最後劑量係所謂的「目標劑量」。可以將於第1天待投與的第一劑量認為係「先導劑量」或「導入劑量」，並且可以將「目標劑量」認為係「治療劑量」。因此，目標劑量係在一個周期待投與的最高劑量。換言之，目標劑量超過第二劑量，並且因此也超過第一劑量。目標劑量也超過（視需要的）第三劑量。
在第一週期期間，在第1天投與第一劑量的該蛋白質。設想第一劑量係至少約800 µg/天。該蛋白質的第一劑量可以是從約800 µg/天至約1200 µg/天、從約800 µg/天至約1100 µg/天、從約800 µg/天至約1000 µg/天、或從約800 µg/天至約900 µg/天。第一劑量可以是800 µg/天。
設想在投與的第一週期期間，在第1天後（即，第一劑量投與後）且在第8天前或在目標劑量投與前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量。根據本發明之一方面，在投與的第一週期期間，在第1天後（即，第一劑量投與後）且在第8天前（即，在目標劑量投與前）的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量並且是至少約7 mg/天。術語「至少（約）x mg/天的劑量」意指「（約）x mg/天的最低劑量」。根據此教導，待投與的劑量可以基本上不低於此限值。第二劑量可以在第2天、第3天、第4天、第5天、第6天、或第7天投與。特別地，第二劑量在第3天或第4天、較佳的是在第3天投與。第二劑量可以是從約4 mg/天至約12.5 mg/天、從約4.5 mg/天至約12 mg/天、從約4 mg/天至約10 mg/天、從約4.5 mg/天至約9 mg/天、從約4 mg/天至約8 mg/天、從約4 mg/天至約7 mg/天、從約4 mg/天至約6.5 mg/天、從約4.5 mg/天至約6 mg/天。在本發明之一個實施方式中，該第二劑量係從約4 mg/天至約10 mg/天，較佳的是從約4 mg/天至約7 mg/天，並且在第3天投與。第二劑量還可以是從約7 mg/天至約18 mg/天、從約7.5 mg/天至約15 mg/天、從約8 mg/天至約12 mg/天、從約8.5 mg/天至約10 mg/天、或從約9 mg/天至約9.5 mg/天。在本發明之一個實施方式中，該第二劑量係從約8 mg/天至約10 mg/天、較佳的是約9 mg/天，並且在第3天投與。
根據本發明之一方面，在投與的第一週期期間，在第二劑量投與日後且目標劑量投與日前的一天投與第三劑量的該蛋白質，其中該第三劑量超過該第二劑量。設想該第三劑量係從約7 mg/天至約12 mg/天、從約7 mg/天至約11 mg/天、從約8 mg/天至約10 mg/天或約9 mg/天。第三劑量可以在第5天、第6天或第7天投與。例如，該第三劑量可以是從約8 mg/天至約10 mg/天（較佳的是約9 mg/天）並且在第5天投與。
設想待投與的該蛋白質的目標劑量係從約9 mg/天至約24 mg/天或從12.5 mg/天至約24 mg/天。該目標劑量還可以是從約14 mg/天至約22 mg/天、從約15 mg/天至約21 mg/天、從約16 mg/天至約20 mg/天、從約17 mg/天至約19 mg/天、或約18 mg/天。在第一週期的過程中，目標劑量在從第6天至第10天中的一天、較佳的是在從第7天至第9天中的一天、更較佳的是在第8天第一次投與。例如，該目標劑量係從約16 mg/天至約20 mg/天並且在第8天投與。一旦在第一週期從第6天至第10天中的一天達到目標劑量（= 第一次投與），就進一步設想在第15天（+/- 一或兩天）和第22天（+/- 一或兩天）投與該目標劑量。換言之，該目標劑量較佳的是每7天投與一次。
在本發明之一個實施方式中，第一週期包括： •     投與約800 µg/天至約1000 µg/天、較佳的是約800 µg/天的第一劑量的該蛋白質， •     投與約8 mg/天至約10 mg/天、較佳的是約9 mg/天的第二劑量的該蛋白質，和 •     投與約12 mg/天至約20 mg/天、較佳的是約16 mg/天至約20 mg/天，例如18 mg/天的目標劑量的該蛋白質。
根據此實施方式，還設想在第1天投與第一劑量；在第3天或第4天、較佳的是在第3天投與第二劑量；並且在第8天（+/- 一天）、第15天（+/- 一天）和第22天（+/- 一天），較佳的是在第8天、第15天和第22天投與目標劑量。
在本發明之另一個實施方式中，第一週期包括： •     投與約800 µg/天至約1000 µg/天、較佳的是約800 µg/天的第一劑量的該蛋白質， •     投與約4 mg/天至約10 mg/天、較佳的是約4 mg/天至約7 mg/天或4.5 mg/天至6 mg/天的第二劑量的該蛋白質， •     視需要投與約8 mg/天至約10 mg/天、較佳的是約9 mg/天的第三劑量的該蛋白質，其中該第三劑量超過該第二劑量，和 •     投與約14 mg/天至約22 mg/天、較佳的是約16 mg/天至約20 mg/天，例如18 mg/天的目標劑量的該蛋白質。
根據此實施方式，還設想在第1天投與第一劑量；在第3天或第4天、較佳的是在第3天投與第二劑量；在第5天或第6天、較佳的是在第5天投與視需要的第三劑量；並且在第8天（+/- 一天）、第15天（+/- 一天）和第22天（+/- 一天），較佳的是在第8天、第15天和第22天投與目標劑量。
根據本發明之一方面，蛋白質在第一週期中如下投與：在第1天投與800 µg/天的第一劑量，在第3天投與6 mg/天的第二劑量，並且在第8天、第15天和第22天投與18 mg/天的目標劑量。根據本發明之另一方面，蛋白質在第一週期中如下投與：在第1天投與800 µg/天的第一劑量，在第3天投與4.5 mg/天的第二劑量，在第5天投與9 mg/天的第三劑量，並且在第8天、第15天和第22天投與18 mg/天的目標劑量。
根據本發明，一個週期（視需要具有約28天的長度，參見上文）包括蛋白質的至少三次單獨投與，較佳的是其包括三至六次或四至六次單獨投與（例如四或五或六次單獨投與），或由三至六次或四至六次單獨投與（例如四或五或六次單獨投與）組成。這意指有需要的受試者在一個週期期間至少接受三次（較佳的是四或五或六次）本發明之蛋白質。例如，如果一個週期由四個週組成，則可以每週一次向有需要的受試者投與該蛋白質。這特別應用於第二和/或任一後續的週期。因此，「單獨投與」意指在某一天投與如以上所定義的指定劑量。在一個週期內，這種投與或單獨投與隨後是不投與蛋白質的（通常至少一天的和通常多達六天的）時間段。還設想第一週期包括蛋白質的三至六次單獨投與（較佳的是四或五或六次單獨投與），或由蛋白質的三至六次單獨投與（較佳的是四或五或六次單獨投與）組成。設想在第一週期內的最後兩次或三次投與係以目標劑量的蛋白質投與。
設想將蛋白質在第二週期期間以及視需要在任何後續的週期期間以對應於目標劑量的恒定劑量投與。對於第二週期以及視需要對於任何後續的週期，沒有設想劑量階梯。將目標劑量設想為從約9 mg/天至約24 mg/天或從12.5 mg/天至約24 mg/天。該目標劑量還可以是從約14 mg/天至約22 mg/天、從約15 mg/天至約21 mg/天、從約16 mg/天至約20 mg/天、從約17 mg/天至約19 mg/天、或約18 mg/天。第二週期和視需要進一步後續的週期可以包括在第1天、第8天（+/- 一或兩天）、第15天（+/- 一或兩天）和第22天（+/- 一或兩天）以目標劑量投與該蛋白質。特別地，第二週期和視需要任何進一步後續的週期包括每7天（即每週一次的間隔）以目標劑量投與一次該蛋白質。術語「dx（+/- 一或兩天）」意指選自第x天減去兩天、第x天減去一天、第x天、第x天加上一天和第x天加上兩天中的任一天。例如，如果第x天係d8，那麼「d8（+/- 一或兩天）」就意指d6至d10中的任一天，即，d6、d7、d8、d9或d10。同樣地，「d8（+/- 一天）」意指d7至d9中的任一天，即d7、d8或d9。
設想根據本發明待投與的蛋白質具有約75 kDa至約200 kDa、約80 kDa至約175 kDa、約85 kDa至約150 kDa、約90 kDa至約130 kDa、約95 kDa至約120 kDa、以及較佳的是約100 kDa至約115 kDa或約105 kDa至約110 kDa的分子量。
本發明之蛋白質包含延長或提高該構建體的半衰期或消除半衰期的結構域（「第三結構域」）。術語「延長」或「提高」可以相對於或相比於相同的但不含這樣的結構域（「HLE結構域」）的蛋白質來定義。設想本發明之蛋白質的半衰期或消除半衰期比不含第三結構域的蛋白質的半衰期或消除半衰期長至少約五倍、或長至少約十倍、或長至少約15倍、或長至少約20倍。
可以將第三結構域定義為如下的結構域，該結構域為根據本發明待投與的蛋白質提供約3至約14天、約4至約12天、約3或4至約10天、約3或4至約8天、約3天至約5天、或約5天至約6或約7天的「半衰期」或「終末半衰期」或「消除半衰期」（T 1/2）。「半衰期」係將量減少到其初始值的一半所需的時間。醫學科學係指人體內（例如在血清或血漿中）物質或藥品（在此係指蛋白質）的半衰期。因此，「半衰期」有時也稱為「血清半衰期」或「血漿半衰期」。它可以藉由測量受試者的血清/血漿中所投與的蛋白質的濃度來確定。典型地，所投與的物質/藥品的消除或除去係指藉由如代謝、排泄等生物過程（還關於腎臟和肝臟的功能）進行的身體清潔。可以將「消除半衰期」定義為藥品（在此指：蛋白質）濃度到達其初始值的一半所需的時間。
通常將本發明之蛋白質設計用於特定的投與途徑和方法。藥理學中的投與途徑係將物質帶入體內的途徑。投與途徑通常根據物質的應用位置進行分類，該等位置可以是局部（topical、local）、腸內（物質的全系統作用，但藉由胃腸道遞送）、或腸胃外（物質的全身作用，但藉由胃腸道以外的途徑遞送）。通常，腸胃外投與包括但不限於靜脈內（IV）、腦內、動脈內、腹膜內、骨內和膀胱內遞送。選擇投與藥品的途徑的原因取決於多種因素，如： •     藥品的物理和化學特性。物理特性係固體、液體和氣體。化學特性係溶解度、穩定性、pH、刺激性等。 •     所需的作用部位：該作用可以是局部的以及可接近的、或普遍的並且不可接近的。 •     從不同途徑吸收藥品的速率程度。 •     患者的狀況。
本發明之蛋白質（和包含此蛋白質的藥物組成物）特別可用於腸胃外投與。腸胃外投與通常比局部或腸內投與起作用更快，並且通常伴隨高達100%的非常高的生體可用率（特別是在IV投與的情況下）。根據本發明之投與較佳的是靜脈內投與。腸胃外投與或靜脈內投與可以藉由注射（例如使用針和注射器）或藉由輸注（例如藉由導管和泵系統）進行。因此設想根據本發明之投與係經由靜脈內注射或經由靜脈內輸注。通常，IV輸注經由線、端口或導管（小的柔性管）投與，如中央靜脈內通路、或中央靜脈內導管（CVC，其係放置在大靜脈中的導管）、或外周靜脈內導管（PVC，其係放置在外周靜脈中的導管）。通常，導管或線可以放置在頸部（頸內靜脈內）、胸腔（鎖骨下靜脈內或腋靜脈內）、腹股溝（股靜脈內）或藉由胳膊中的靜脈內（也稱為PICC線，或外周插入的中央導管）。中央IV線具有它們導管，藉由靜脈內前進並流入大中央靜脈內（通常是上腔靜脈內、下腔靜脈內或甚至是心臟的右心房）。外周靜脈內（PIV）線用於外周靜脈內（手臂、手、腿和腳的靜脈內）。端口係沒有外部連接器的中央靜脈內線；相反，它具有用矽橡膠覆蓋並植入皮膚下的小儲庫。藉由放置小針穿過皮膚、刺穿矽膠、進入儲庫，間歇地投與藥物。當針頭撤回時，儲庫蓋自行重新密封。蓋在其壽命期間可以接受數百針。
本發明也提供了本發明之蛋白質的推注投與。推注係在特定可忽略的時間內（通常在1-30分鐘內）投與離散量的藥物、藥品或其他化合物。在大多數情況下，靜脈內進行推注投與。通常經由注射（例如靜脈內推注注射）投與推注，但是推注輸注（例如靜脈內推注輸注）也是可能的。短期輸注係相對小量（如50 mL至500 mL、或100 mL至250 mL）的輸注（通常是IV輸注），在最多3小時（通常30至60分鐘或約60分鐘）的時間段內投與短期輸注。本發明設想了蛋白質的短期（或短期IV）輸注。
靜脈內「間歇輸注」係在規定的時間段內（如20-120分鐘或30-60分鐘）以指定的間隔（如每4、6、8、10、12、14、16、18、20、22或24小時）輸注一定量的藥物。目的是以一定間隔投與少量的藥物。間歇藥物（與任何其他形式的輸注一樣）可以藉由重力或經由電子輸注裝置（EID）（也稱為輸液泵）投與。
在輸注的情況下，輸注泵可用於將藥物（蛋白質）輸注到患者的循環系統中。泵通常是靜脈內使用的，儘管也可以使用具有泵的動脈和硬膜外輸注。用於輸注的溶液可以在袋中製備用於IV輸注並藉由輸注線遞送。如果手動操作，輸液泵能以不可靠的方式輸送流體。例如，它們可以投與少至0.1 mL/小時注射、每分鐘注射、重複推注注射、多達每小時最大量、或體積隨天數變化的液體。也可以僅使用重力提供的壓力來投與輸注。根據本發明之不同類型的輸注包括但不限於推注輸注、短期輸注和間歇輸注。因此，本發明之蛋白質可以例如在約30至約90分鐘或約60分鐘的時間段內，例如以推注投與（推注注射或推注輸注）、注射或短期輸注進行投與。
藥物組成物可以使用醫療裝置來投與。用於藥物組成物投與的醫療裝置的實例描述在美國專利案號4,475,196；4,439,196；4,447,224；4,447,233；4,486,194；4,487,603；4,596,556；4,790,824；4,941,880；5,064,413；5,312,335；5,312,335；5,383,851；和5,399,163中。
在本發明之上下文中，設想在每次投與（或「單獨投與」）蛋白質之前，特別是在第一週期期間，投與術前用藥法。設想，在此特定上下文中，「在……之前」意指在投與蛋白質前24小時、18小時、十二小時、六小時、五小時、四小時或三小時之內，並且較佳的是在120、90、60或30分鐘之內。術前用藥法可以例如在投與蛋白質之前30-120分鐘或30-60分鐘投與。還設想在第一週期中開始投與蛋白質的同時或之後投與結合給藥法，以及視需要還在一個或多個之後的週期（根據患者需要）中開始投與的蛋白質同時或之後投與結合給藥法。設想，在此特定上下文中，「在……之後」意指在開始投與蛋白質之後24小時、18小時、十二小時、六小時、五小時、四小時或三小時之內，並且較佳的是在120、90、60、30、20、15或10分鐘之內。例如，可以在開始投與蛋白質後10-120、10-60、10-30或15-20分鐘投與結合給藥法。術前用藥法或結合給藥法的目的可以是例如預防或降低輸注相關反應的嚴重程度。術前用藥法優於結合給藥法。
術前用藥法或結合給藥法可以包括以下的任何一個或其組合： •     撲熱息痛（對乙醯胺基酚，APAP）或等效物；較佳的是口服（p.o.）或靜脈內投與；以及較佳的是以100-4000 mg、較佳的是200-3000 mg或300-2500 mg或400-2000 mg或500-1500 mg、較佳的是600-1400 mg、700-1300 mg、800-1200 mg、900-1100 mg或約1000 mg的劑量p.o.投與撲熱息痛（或等效藥物和/或另一種投與途徑的等效劑量）。技術人員知道如何鑒定撲熱息痛等效物。它們包括但不限於伊布洛芬（例如以100-3200 mg、較佳的是200-3000 mg或300-2500 mg或400-2000 mg、較佳的是500-1500 mg、600-1200 mg、700-1000 mg、750-900 mg或約800 mg的劑量投與）和安乃近（例如以100-4000 mg、較佳的是200-3000 mg或300-2500 mg或400-2000 mg、或約500-1000 mg的劑量投與） •     選自哌替啶、安乃近、二氫嗎啡酮、芬太尼和曲馬多（tramadol）的一種或多種鎮痛藥 •     抗組胺藥，較佳的是口服或靜脈內投與、以及較佳的是以相當於苯海拉明（diphenhydramine）50 mg的劑量靜脈內注射投與技術人員知道如何鑒定抗組胺藥。它們包括但不限於口服、腸胃外或直腸途徑的抗組胺藥，如：阿紮他定（最大劑量例如4 mg/天）、溴苯那敏（最大劑量例如30 mg/天）、西替利𠯤（最大劑量例如15 mg/天）、氯苯吡胺（最大劑量例如30 mg/天）、克立馬丁（最大劑量例如10 mg/天）、賽庚啶（最大劑量例如15 mg/天）、地氯雷他定（最大劑量例如7 mg/天）、右旋氯苯吡胺（最大劑量例如15 mg/天）、苯海拉明（最大劑量例如350 mg/天）、多西拉敏（最大劑量例如180 mg/天）、非索非那定（最大劑量例如200 mg/天）、氯雷他定（最大劑量例如15 mg/天）、苯茚胺（最大劑量例如180 mg/天） •     糖皮質激素，較佳的是口服或靜脈內投與，並且較佳的是以相當於2-20 mg或4-16 mg或6-12 mg或8 mg地塞米松的劑量靜脈內注射投與（等效指糖皮質激素效力）
上面列出的所有四種物質或物質組可以作為術前用藥法或結合給藥法投與、或僅兩種物質的組合或三種物質的組合投與、或僅四種物質中的一種投與。設想在第二週期開始之前投與的糖皮質激素（GC）劑量可以與在第一週期開始之前投與的GC劑量相同，或者可以降低至在第一週期開始之前投與的劑量的約50%，或者可以省略第二週期（和/或潛在地任何後續的週期）。例如，如果根據本發明之蛋白質在第一週期期間耐受性良好，沒有顯著的輸注相關反應跡象，則可以應用降低的GC劑量。此外，設想在第三週期和任何的後續週期開始之前可以進一步降低劑量。可替代地，雖然在第一週期開始之前將GC作為術前用藥法（和潛在地結合給藥法）投與，但在第二、第三、第四和/或第五週期中不投與GC術前用藥法或結合給藥法。通常，根據本發明之實施方式使用的術前用藥法或結合給藥法的劑量將取決於個體患者的情況。
糖皮質激素係一類皮質類固醇，這類皮質類固醇係一類類固醇激素。糖皮質激素係與糖皮質激素受體結合的皮質類固醇。不太常見的同義詞係糖皮質類固醇。皮質醇（當用作用藥時稱為氫化可的松）係最重要的人糖皮質激素。已經創造了多種合成的糖皮質激素（一些遠比皮質醇更具有效力）用於治療用途。它們在藥物動力學（例如吸收因子、半衰期、分佈量、清除率）和藥效學（例如糖皮質激素效力或鹽皮質激素效力）方面不同。皮質醇係糖皮質激素效力的比較標準。皮質類固醇轉換計算器或當量表可獲得自互聯網。通常開具的替代類固醇等效物的一個實例可以是強的松（5 mg）= 可的松（25 mg）= 地塞米松（0.75 mg）= 氫化可的松（20 mg）= 甲基潑尼松龍（4 mg）。該等劑量指示全身性糖皮質激素的等效藥理劑量。指示不同物質半衰期的另一種皮質類固醇比較圖表可以在例如： https://www.ncbi.nlm.nih.gov/books/NBK279156/table/adrenal_glucocorticoid-therapy-and-adrenal-suppression.T./中找到。
在本實施方式中用作術前用藥法或結合給藥法的GC的實例包括但不限於可的松、氫化可的松、強的松、潑尼松龍、甲基潑尼松龍、地塞米松、倍他米松（betamethasone）、倍氯米松（beclomethasone）、布地奈德（budesonide）、去炎松（triamcinolone）、氯潑尼醇（cloprednol）、地夫可特（deflazacort）、氟可龍（fluocortolone）、可的伐唑（cortivazol）、帕拉米松（paramethasone）、氟替卡松（fluticasone）、氟替卡松丙酸酯、曲安奈德（triamcinolone acetonide）、以及其組合和/或藥學上可接受的衍生物。在本發明之上下文中，不同的GC可以單獨使用或組合使用。地塞米松、強的松和潑尼松龍係GC的較佳的實施方式。
可以設想，已經或將要歸類為「糖皮質激素」的所有物質也可以用於本發明之上下文中。這樣的未來糖皮質激素包括特異性結合至並激活糖皮質激素受體的化合物。根據本發明，術語「特異性結合至GC受體」意味著，如與蛋白質/受體一般性締合（即，非特異性結合）相比，GC（或假定作用類似於GC的化合物）與GC受體（還稱為NR3C1）締合（例如，相互作用）至統計學上顯著的程度。在GC受體結合至糖皮質激素時，其主要作用機制係調控基因轉錄。在不存在GC的情況下，糖皮質激素受體（GR）存在於與多種蛋白質（包括熱休克蛋白90（hsp90）、熱休克蛋白70（hsp70）和蛋白FKBP52（FK506結合蛋白52））複合的胞質溶膠中。GC與糖皮質激素受體的結合導致熱休克蛋白的釋放。因此設想未來的GC或GC的藥學上可接受的衍生物或鹽能夠結合GC受體並釋放上述熱休克蛋白。然後，激活的GR複合物藉由阻止其他轉錄因子從細胞質轉運到細胞核中來上調細胞核中抗炎蛋白的表現或抑制胞質溶膠中促炎蛋白的表現。
本發明之蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域和延長/提高該蛋白質的半衰期的第三結構域。如以下更詳細地說明，該蛋白質可以是單鏈多肽的形式。還設想該蛋白質由超過一條多肽鏈組成。在這種情況下，第一結構域（與BCMA結合）可以由其部分的兩條多肽鏈構成，同樣第二結構域（與CD3結合）可以由其部分的兩條多肽鏈構成。第三結構域（延長半衰期）也可以由其部分的兩條多肽鏈構成。
肽係經由共價肽（醯胺）鍵連接的胺基酸單體的短鏈。因此，肽屬於生物寡聚物和聚合物的廣泛化學類別。作為肽或多肽鏈的一部分的胺基酸被稱為「殘基」並且可以被連續編號。除環肽外的所有肽在肽的一端具有N-末端殘基，並且在另一端具有C-末端殘基。寡肽僅由少數胺基酸（通常在兩個至二十個之間）組成。多肽係更長、連續且無支鏈的肽鏈。基於尺寸，肽與蛋白質不同；並且作為任意基準，肽可以理解為含有大約50個或更少的胺基酸。蛋白質由一個或多個多肽或多肽鏈組成，通常以生物功能方式排列。雖然應用於肽與多肽和蛋白質的實驗室技術的各方面不同（例如，電泳、層析等的特性），但是區分肽與多肽和蛋白質的大小邊界不是絕對的。儘管術語多肽和蛋白質有時互換地使用，多肽在技術上係胺基酸的聚合物，而術語蛋白質係用於正確折疊且具有功能的一個或多個多肽。
蛋白質可以由一個或多個多肽組成。因此，多肽可以形成多聚體（如二聚體、三聚體和更高級的寡聚物），其由多於一個多肽/多肽鏈組成。形成這種二聚體、三聚體等的多肽可以是相同的或不相同的。因此，這種多聚體的相應高階結構被稱為同源或異源二聚體、同源或異源三聚體等。異源多聚體的實例係抗體或免疫球蛋白分子，其天然存在形式由兩條相同的「輕鏈」和兩條相同的「重鏈」組成。術語「肽」、「多肽」和「蛋白質」還是指天然修飾的肽/多肽/蛋白質，其中修飾例如藉由翻譯後修飾（如糖基化、乙醯化、磷酸化等）來實現。當在本文中提及時，「肽」、「多肽」或「蛋白質」也可以是化學修飾的，如聚乙二醇化的。這種修飾在本領域中是熟知的。
如本文所用，術語「抗體」通常是指包含兩個輕鏈多肽（各自約25 kDa）和兩個重鏈多肽（各自約50-70 kDa）的四聚體免疫球蛋白。術語「輕鏈」或「免疫球蛋白輕鏈」係指從胺基末端至羧基末端包含單個免疫球蛋白輕鏈可變區（VL）和單個免疫球蛋白輕鏈恒定結構域（CL）的多肽。免疫球蛋白輕鏈恒定結構域（CL）可以是人kappa（κ）或人lambda（λ）恒定結構域。術語「重鏈」或「免疫球蛋白重鏈」係指從胺基末端至羧基末端包含單個免疫球蛋白重鏈可變區（VH）、免疫球蛋白重鏈恒定結構域1（CH1）、免疫球蛋白鉸鏈區、免疫球蛋白重鏈恒定結構域2（CH2）、免疫球蛋白重鏈恒定結構域3（CH3）和視需要免疫球蛋白重鏈恒定結構域4（CH4）的多肽。重鏈分類為mu（μ）、delta（Δ）、gamma（γ）、alpha（α）和epsilon（ε）鏈，並且其分別將抗體同種型定義為IgM、IgD、IgG、IgA和IgE。IgG類別和IgA類別的抗體進一步細分為數個亞類，即分別為IgG1、IgG2、IgG3和IgG4，以及IgA1和IgA2。IgG、IgA和IgD抗體中的重鏈具有三個恒定結構域（CH1、CH2和CH3），而IgM和IgE抗體中的重鏈具有四個恒定結構域（CH1、CH2、CH3和CH4）。免疫球蛋白重鏈恒定結構域可以來自任何免疫球蛋白同種型，包括亞型。抗體鏈係經由在CL結構域與CH1結構域之間（即在輕鏈與重鏈之間）和在這兩條抗體重鏈的鉸鏈區之間的多肽間二硫鍵連接在一起的。
免疫球蛋白鏈的可變區通常展現相同的總體結構，包含由三個高變區（更通常稱為「互補性決定區」或CDR）連接的相對保守的框架區（FR）。來自每個重鏈和輕鏈對的兩條鏈的CDR典型地藉由框架區對齊以形成與靶蛋白上的特定表位特異性結合的結構。從N-末端至C-末端，天然存在的輕鏈和重鏈可變區二者均典型地遵循該等元件的以下順序：FR1、CDR1、FR2、CDR2、FR3、CDR3和FR4。編號系統已經被設計為將編號指派給在該等結構域中的每一個中佔據位置的胺基酸。此編號系統定義於以下文獻中：Kabat Sequences of Proteins of Immunological Interest [免疫學感興趣的蛋白質序列]（1987和1991，NIH [美國國立衛生研究院]，馬里蘭州貝塞斯達）；或Chothia和Lesk, 1987, J. Mol. Biol.[分子生物學雜誌] 196: 901-917；Chothia等人, 1989, Nature [自然] 342: 878-883。給定抗體的CDR和FR可以使用此系統標識。用於免疫球蛋白鏈中的胺基酸的其他編號系統包括IMGT ®（國際ImMunoGeneTics資訊系統；Lefranc等人, Dev. Comp. Immunol. [發育與比較免疫學] 29: 185-203; 2005）和AHo（Honegger和Pluckthun, J. Mol. Biol. [分子生物學雜誌] 309 (3): 657-670; 2001）。
在根據本發明之「抗體」的定義內係全長抗體，還包括藉由生物技術或蛋白質工程方法或製程產生的駱駝科抗體和其他免疫球蛋白。該等全長抗體可以是例如單株抗體、重組抗體、嵌合抗體、去免疫化（deimmunized）抗體、人源化抗體和人抗體，以及來自其他物種（如小鼠、倉鼠、兔、大鼠、山羊或非人靈長類動物）的抗體。
術語「結合結構域」或「與……結合的結構域」關於本發明表徵了蛋白質的結構域，其免疫特異性結合/相互作用/識別給定靶標或抗原（本文中：在第一個結構域的情況下為BCMA，以及在第二結構域的情況下為CD3）。第一結構域（結合BCMA）的結構和功能，以及較佳的是第二結構域（結合CD3）的結構和/或功能基於抗體（例如全長免疫球蛋白分子）的結構和/或功能。因此，蛋白質的第一和/或第二（結合）結構域包含互補位，也稱為「抗原結合位點」，其被定義為識別和結合抗原，更具體地識別和結合抗原內表位的抗體部分。互補位通常是抗體Fab區域中的小區域。Fab係由兩個可變結構域（重鏈中的VH和輕鏈中的VL）和兩個恒定結構域（CH1和CL）構成。輕鏈和重鏈的配對中，兩種可變結構域二聚化以形成含有抗原結合位點的Fv片段。每個可變結構域內有六個高變環，三個在輕鏈（L1、L2和L3）中且三個在重鏈（H1、H2和H3）中，其由β折疊的框架支撐。在抗體可變結構域內的六個高變環通常被稱為互補決定區（CDR）。輕可變結構域和重可變結構域以將高變環聚在一起的形式折疊，以產生抗原結合位點或互補位。通常的做法係藉由CDR的鑒定來識別互補位。
因此，「結合結構域」或「與……結合的結構域」可以包含允許免疫特異性靶結合的抗體的最低結構要求。第一結構域的這種最小結構要求可以例如藉由至少三個輕鏈CDR（即VL區的CDR1、CDR2和CDR3）和/或三個重鏈CDR（即VH區的CDR1、CDR2和CDR3）、較佳的是全部六個CDR的存在來定義。設想第二結構域還包含允許免疫特異性靶結合的抗體的這一最低結構要求。更較佳的是，第二結構域還包含至少三個輕鏈CDR（即VL區的CDR1、CDR2和CDR3）和/或三個重鏈CDR（即VH區的CDR1、CDR2和CDR3）、較佳的是全部六個CDR。「與……結合的結構域」（或「結合結構域」）典型地可以包含抗體輕鏈可變區（VL）和抗體重鏈可變區（VH）；然而，它不必須包含兩者，但可以包含VH或VL中的僅一者。例如，Fd片段通常保留完整抗原結合結構域的一些抗原結合功能。還設想第一和/或第二結構域由兩個重鏈可變區構成，該等可變區按順序排列並提供與各自靶標的二價結合。
「與……結合的結構域」（或「結合結構域」）的形式的實例包括但不限於全長抗體的片段（如VH、VHH、VL）、(s)dAb、Fv、輕鏈（VL-CL）、Fd（VH-CH1）、重鏈、Fab、Fab’、F(ab') 2或「r IgG」（「半抗體」由重鏈和輕鏈組成）、抗體變體或衍生物（如scFv、二-scFv或二（雙）-scFv、scFv-Fc、scFv-拉鍊、scFab、Fab 2、Fab 3、雙抗體、單鏈雙抗體、串聯雙抗體（Tandab）、串聯二-scFv、串聯三-scFv、「微型抗體」（選自形式如(VH-VL-CH3) 2、(scFv-CH3) 2、((scFv) 2-CH3 + CH3)）、((scFv) 2-CH3)或(scFv-CH3-scFv) 2、多抗體（如三抗體或四抗體）、以及單結構域抗體（如奈米抗體或單可變結構域抗體）（僅包含一個可變區，其可以是VHH、VH或VL）。「與……結合的結構域」（或「結合結構域」）的形式的另外的實例包括 (1) 包含VL、VH、CL和CH1的抗體片段或變體（如Fab）；(2) 包含兩個連接的Fab片段的抗體片段或變體（如F(ab') 2）；(3) 包含VH和CH 1的抗體片段或變體（如Fd）；(4) 包含VL和CL的抗體片段或變體（如輕鏈）；(5) 包含VL和VH的抗體片段或變體（如Fv）；(6) 具有VH結構域的dAb片段（Ward等人, (1989) Nature [自然] 341: 544-546）；(7) 包含重鏈和/或輕鏈的至少三個分離的CDR的抗體變體；和 (8) 單鏈Fv（scFv）。結合結構域的實施方式的進一步實例例如描述於以下中：WO 00/006605、WO 2005/040220、WO 2008/119567、WO 2010/037838、WO 2013/026837、WO 2013/026833、US 2014/0308285、US 2014/0302037、WO 2014/144722、WO 2014/151910和WO 2015/048272。
根據本發明待投與的蛋白質包含與BCMA結合的第一結構域和CD3結合的第二結構域，且因此係「至少二價的」和「至少雙特異性的」。在某些實施方式中，本發明之方法中使用的蛋白質係多價的。該結合蛋白的價態表示該蛋白質內單個抗原結合結構域的數量。例如，在本發明之上下文中，關於蛋白質的術語「單價」、「二價」和「四價」係指分別具有一個、兩個和四個抗原結合結構域的蛋白質。因此，多價蛋白質包含兩個或更多個抗原結合結構域。根據本發明之蛋白質可以具有比特異性更多的抗原結合結構域（例如更高的價）。例如在構建體具有第一靶標（BCMA）的兩個結合結構域和第二靶標（CD3）的一個結合結構域的情況下（或反之亦然），構建體係（至少）三價和雙特異性的。因此，蛋白質可以是二價的、三價的、四價的或多價的（multivalent/polyvalent）。
術語「（特異性或免疫特異性地）結合」、「（特異性或免疫特異性地）識別」、或「與……（特異性或免疫特異性地）反應」意指根據本發明，結合結構域或包含這種結合域的蛋白質與靶分子（抗原）（本文中分別為BCMA和CD3）上的給定表位相互作用或（免疫-）特異性地相互作用。這種相互作用或結合在特定靶標上的表位中比在可替代的物質（非靶分子）中更頻繁、更快速地發生，具有更長的持續時間、具有更大的親和力、或者具有上述的一些組合。然而，由於不同物種中同源蛋白質之間的序列相似性，與免疫特異性結合其靶標（例如，人靶標）的結構域或包含這種結構域的蛋白質可以與來自不同物種（例如，來自非人靈長類動物，如獼猴）的同源靶分子交叉反應。因此，術語「特異性/免疫特異性結合」可以包括結構域或包含這種結構域的蛋白質與多於一個物種中的表位或結構相關表位的結合。
在本發明之上下文中，術語「表位」係指抗原內的如下區域或分子結構：其與副表位特異性接觸且因此由與包含這種副表位的結合結構域識別/免疫特異性識別。「表位」係抗原性的，並且因此術語表位有時也稱為「抗原結構」或「抗原決定簇」。認為特異性結合係藉由結合結構域和抗原的胺基酸序列中的特定模體實現的。因此，由於其一級、二級和/或三級結構以及所述結構的可能的二次修飾的結果，實現了結合。存在許多用於抗體表位鑒定的工具（例如X射線晶體學、肽掃描（pepscan）、噬菌體展示、表現的片段、部分蛋白質水解、質譜和誘變分析）。當談論蛋白質抗原時，許多該等方法典型地將線性延伸物鑒定為表位，而蛋白質抗原上的表位也可以是構象的或不連續的。
結合結構域與靶抗原之間的相互作用意味著結合結構域對靶抗原（本文中分別為BCMA和CD3）表現出明顯或顯著的親和力。通常，它還沒有表現出對除了對靶抗原（本文中為BCMA/CD3）以外的蛋白質或抗原的顯著親和力-儘管上文討論過與例如來自其他物種的同源靶標的交叉反應性。「顯著親和力」包括以 ≤ 10 -6M的親和力（解離常數，KD）結合。較佳的是，當結合親和力為 ≤ 10 -7M、≤ 10 -8M、≤ 10 -9M、≤ 10 -10M、或甚至 ≤ 10 -11M、或 ≤ 10 -12M時，結合被認為係特異性的。可以容易地測試結合結構域（免疫-）與靶標是否特異性地反應或結合，例如藉由將所述結合結構域（或包含該結合結構域的蛋白質）與其所需的靶蛋白或抗原的親和力與所述結合結構域與非靶蛋白或抗原（本文中分別是BCMA或CD3以外的蛋白質）的親和力進行比較。較佳的是，本發明之蛋白質分別不與BCMA或CD3以外的靶標或抗原顯著結合（即，第一結構域不與BCMA以外的蛋白質結合，並且第二結構域不與CD3以外的蛋白質結合）。例如，設想本發明之蛋白質（並且更特別的，其第一結構域）不與人BAFF-R和/或人TACI顯著結合、相互作用、識別其或與其交叉反應。
本發明之結合蛋白具有對BCMA的平衡解離常數（KD），其可以藉由斯卡查德（Scatchard）分析或藉由biacore分析來確定，如例如WO 2013/072406中所述。CD3的KD值可以例如藉由表面電漿共振分析來確定，如例如WO 2013/072406中所述。設想本發明之結合蛋白具有針對BCMA和/或CD3的KD值，其在2位或1位納莫耳範圍內或在三位或甚至兩位數皮莫耳範圍內。
術語「不顯著結合」意指包含本發明之結合結構域或包含該結合結構域的蛋白質不與BCMA或CD3以外的蛋白質或抗原結合，即，顯示與BCMA或CD3以外的蛋白質或抗原 ≤ 10%，特別地較佳的是 ≤ 9%、≤ 8%、≤ 7%、≤ 6%或 ≤ 5%反應性，由此將與BCMA或CD3的結合分別設定為100%。
根據本發明之蛋白質的一個實施方式，第一結構域和/或第二結構域處於scFv（單鏈可變片段）的形式。scFv實際上不是抗體的片段，而是免疫球蛋白的重鏈（VH）和輕鏈（VL）的可變區的融合蛋白，通常用短連接子肽連接。連接子通常富含甘胺酸以獲得柔韌性、以及富含絲胺酸或蘇胺酸以獲得溶解度。儘管除去了恒定區並引入了連接子，但scFv旨在保留原始免疫球蛋白的特異性。在scFv中，VH區和VL區以VH-VL或VL-VH的順序（從N-末端至C-末端）排列。設想第一和/或第二結合結構域的VH和VL區經由連接子、較佳的是經由肽連接子連接。根據第一和/或第二結構域的一個實施方式，VH區位於連接子的N-末端，並且VL區位於連接子的C-末端。此外，設想蛋白質的第一結構域和第二結構域經由連接子、較佳的是經由肽連接子連接。連接子較佳的是肽連接子，更較佳的是短肽連接子。實例顯示在SEQ ID NO: 686-699中。在本發明之上下文中，「短」連接子具有3個至25個胺基酸，4個至23個胺基酸、5個至22個胺基酸、6個至20個或6個至17個胺基酸。一個結合結構域的兩個可變區之間的連接子可以具有與這兩個結合結構域之間的連接子不同的長度（例如可以更長）。例如，在一個結合結構域的兩個可變區之間的連接子可以具有7個至15個胺基酸（較佳的是9個至13個胺基酸）的長度，並且在兩個結合結構域之間的連接子可以具有3個至10個（較佳的是4個至8個）胺基酸的長度。進一步設想肽連接子係甘胺酸/絲胺酸連接子，如SEQ ID NO: 687、689-699中所描述的那些。
設想本發明之蛋白質： a)    該蛋白質係單鏈多肽， b)    該第一結構域處於scFv的形式， c)    該第二結構域處於scFv的形式，和/或 d)    該第一結構域和該第二結構域經由連接子連接，較佳的是經由肽連接子連接，更較佳的是經由甘胺酸/絲胺酸連接子連接。
如果本發明之蛋白質係單鏈多肽，那就設想結構域按照以下N-末端至C-末端的順序排列： •     第一結構域 - 第二結構域 - 第三結構域（較佳的排列）， •     第一結構域 - 第三結構域 - 第二結構域， •     第二結構域 - 第一結構域 - 第三結構域， •     第二結構域 - 第三結構域 - 第一結構域， •     第三結構域 - 第一結構域 - 第二結構域，或 •     第三結構域 - 第二結構域 - 第一結構域。
本發明之蛋白質的第一結構域結合BCMA（B細胞成熟抗原、TNFRSF17、CD269）。更較佳的是，它與靶細胞表面上的BCMA結合。「靶細胞」可以是在其表面上表現BCMA的任何原核或真核細胞；較佳的是，靶細胞係作為人體或動物體的一部分的細胞，例如BCMA陽性贅生物的細胞或表現BCMA的癌症或腫瘤細胞。此外，設想第一結構域與人BCMA結合，較佳的是與靶細胞表面上的人BCMA結合。還設想第一結構域與獼猴BCMA結合，較佳的是與靶細胞表面上的獼猴BCMA結合。人BCMA的較佳的胺基酸序列描述於SEQ ID NO: 647中、獼猴BCMA的較佳的胺基酸序列描述於SEQ ID NO: 648中、人BCMA的細胞外結構域的較佳的胺基酸序列描述於SEQ ID NO: 649中、獼猴BCMA的細胞外結構域的較佳的胺基酸序列描述於SEQ ID NO: 650中。
在本發明之一個實施方式中，蛋白質的第一結構域結合BCMA的表位簇3。更較佳的是，它結合人BCMA的表位簇3。人BCMA的表位簇3的較佳的胺基酸序列描述於SEQ ID NO: 651中。具有結合所述BCMA的表位簇3的結構域的蛋白質詳細描述於WO 2013/072406中，在該專利文獻中該等蛋白質顯示具有非常有益的表位/活性關係。
此外，設想本發明之蛋白質中，與BCMA結合的第一結構域包含：含有選自以下的CDR-H1、CDR-H2和CDR-H3的VH區，以及含有選自以下的CDR-L1、CDR-L2和CDR-L3的VL區： (1)      如SEQ ID NO: 1中所描述的CDR-H1、如SEQ ID NO: 2中所描述的CDR-H2、如SEQ ID NO: 3中所描述的CDR-H3、如SEQ ID NO: 4中所描述的CDR-L1、如SEQ ID NO: 5中所描述的CDR-L2和如SEQ ID NO: 6中所描述的CDR-L3； (2)      如SEQ ID NO: 11中所描述的CDR-H1、如SEQ ID NO: 12中所描述的CDR-H2、如SEQ ID NO: 13中所描述的CDR-H3、如SEQ ID NO: 14中所描述的CDR-L1、如SEQ ID NO: 15中所描述的CDR-L2和如SEQ ID NO: 16中所描述的CDR-L3； (3)      如SEQ ID NO: 21中所描述的CDR-H1、如SEQ ID NO: 22中所描述的CDR-H2、如SEQ ID NO: 23中所描述的CDR-H3、如SEQ ID NO: 24中所描述的CDR-L1、如SEQ ID NO: 25中所描述的CDR-L2和如SEQ ID NO: 26中所描述的CDR-L3； (4)      如SEQ ID NO: 31中所描述的CDR-H1、如SEQ ID NO: 32中所描述的CDR-H2、如SEQ ID NO: 33中所描述的CDR-H3、如SEQ ID NO: 34中所描述的CDR-L1、如SEQ ID NO: 35中所描述的CDR-L2和如SEQ ID NO: 36中所描述的CDR-L3； (5)      如SEQ ID NO: 41中所描述的CDR-H1、如SEQ ID NO: 42中所描述的CDR-H2、如SEQ ID NO: 43中所描述的CDR-H3、如SEQ ID NO: 44中所描述的CDR-L1、如SEQ ID NO: 45中所描述的CDR-L2和如SEQ ID NO: 46中所描述的CDR-L3； (6)      如SEQ ID NO: 51中所描述的CDR-H1、如SEQ ID NO: 52中所描述的CDR-H2、如SEQ ID NO: 53中所描述的CDR-H3、如SEQ ID NO: 54中所描述的CDR-L1、如SEQ ID NO: 55中所描述的CDR-L2和如SEQ ID NO: 56中所描述的CDR-L3； (7)      如SEQ ID NO: 61中所描述的CDR-H1、如SEQ ID NO: 62中所描述的CDR-H2、如SEQ ID NO: 63中所描述的CDR-H3、如SEQ ID NO: 64中所描述的CDR-L1、如SEQ ID NO: 65中所描述的CDR-L2和如SEQ ID NO: 66中所描述的CDR-L3； (8)      如SEQ ID NO: 71中所描述的CDR-H1、如SEQ ID NO: 72中所描述的CDR-H2、如SEQ ID NO: 73中所描述的CDR-H3、如SEQ ID NO: 74中所描述的CDR-L1、如SEQ ID NO: 75中所描述的CDR-L2和如SEQ ID NO: 76中所描述的CDR-L3； (9)      如SEQ ID NO: 81中所描述的CDR-H1、如SEQ ID NO: 82中所描述的CDR-H2、如SEQ ID NO: 83中所描述的CDR-H3、如SEQ ID NO: 84中所描述的CDR-L1、如SEQ ID NO: 85中所描述的CDR-L2和如SEQ ID NO: 86中所描述的CDR-L3； (10)     如SEQ ID NO: 91中所描述的CDR-H1、如SEQ ID NO: 92中所描述的CDR-H2、如SEQ ID NO: 93中所描述的CDR-H3、如SEQ ID NO: 94中所描述的CDR-L1、如SEQ ID NO: 95中所描述的CDR-L2和如SEQ ID NO: 96中所描述的CDR-L3； (11)     如SEQ ID NO: 101中所描述的CDR-H1、如SEQ ID NO: 102中所描述的CDR-H2、如SEQ ID NO: 103中所描述的CDR-H3、如SEQ ID NO: 104中所描述的CDR-L1、如SEQ ID NO: 105中所描述的CDR-L2和如SEQ ID NO: 106中所描述的CDR-L3； (12)     如SEQ ID NO: 111中所描述的CDR-H1、如SEQ ID NO: 112中所描述的CDR-H2、如SEQ ID NO: 113中所描述的CDR-H3、如SEQ ID NO: 114中所描述的CDR-L1、如SEQ ID NO: 115中所描述的CDR-L2和如SEQ ID NO: 116中所描述的CDR-L3； (13)     如SEQ ID NO: 121中所描述的CDR-H1、如SEQ ID NO: 122中所描述的CDR-H2、如SEQ ID NO: 123中所描述的CDR-H3、如SEQ ID NO: 124中所描述的CDR-L1、如SEQ ID NO: 125中所描述的CDR-L2和如SEQ ID NO: 126中所描述的CDR-L3； (14)     如SEQ ID NO: 131中所描述的CDR-H1、如SEQ ID NO: 132中所描述的CDR-H2、如SEQ ID NO: 133中所描述的CDR-H3、如SEQ ID NO: 134中所描述的CDR-L1、如SEQ ID NO: 135中所描述的CDR-L2和如SEQ ID NO: 136中所描述的CDR-L3； (15)     如SEQ ID NO: 141中所描述的CDR-H1、如SEQ ID NO: 142中所描述的CDR-H2、如SEQ ID NO: 143中所描述的CDR-H3、如SEQ ID NO: 144中所描述的CDR-L1、如SEQ ID NO: 145中所描述的CDR-L2和如SEQ ID NO: 146中所描述的CDR-L3； (16)     如SEQ ID NO: 151中所描述的CDR-H1、如SEQ ID NO: 152中所描述的CDR-H2、如SEQ ID NO: 153中所描述的CDR-H3、如SEQ ID NO: 154中所描述的CDR-L1、如SEQ ID NO: 155中所描述的CDR-L2和如SEQ ID NO: 156中所描述的CDR-L3； (17)     如SEQ ID NO: 161中所描述的CDR-H1、如SEQ ID NO: 162中所描述的CDR-H2、如SEQ ID NO: 163中所描述的CDR-H3、如SEQ ID NO: 164中所描述的CDR-L1、如SEQ ID NO: 165中所描述的CDR-L2和如SEQ ID NO: 166中所描述的CDR-L3； (18)     如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、如SEQ ID NO: 173中所描述的CDR-H3、如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2和如SEQ ID NO: 176中所描述的CDR-L3； (19)     如SEQ ID NO: 181中所描述的CDR-H1、如SEQ ID NO: 182中所描述的CDR-H2、如SEQ ID NO: 183中所描述的CDR-H3、如SEQ ID NO: 184中所描述的CDR-L1、如SEQ ID NO: 185中所描述的CDR-L2和如SEQ ID NO: 186中所描述的CDR-L3； (20)     如SEQ ID NO: 191中所描述的CDR-H1、如SEQ ID NO: 192中所描述的CDR-H2、如SEQ ID NO: 193中所描述的CDR-H3、如SEQ ID NO: 194中所描述的CDR-L1、如SEQ ID NO: 195中所描述的CDR-L2和如SEQ ID NO: 196中所描述的CDR-L3； (21)     如SEQ ID NO: 201中所描述的CDR-H1、如SEQ ID NO: 202中所描述的CDR-H2、如SEQ ID NO: 203中所描述的CDR-H3、如SEQ ID NO: 204中所描述的CDR-L1、如SEQ ID NO: 205中所描述的CDR-L2和如SEQ ID NO: 206中所描述的CDR-L3； (22)     如SEQ ID NO: 211中所描述的CDR-H1、如SEQ ID NO: 212中所描述的CDR-H2、如SEQ ID NO: 213中所描述的CDR-H3、如SEQ ID NO: 214中所描述的CDR-L1、如SEQ ID NO: 215中所描述的CDR-L2和如SEQ ID NO: 216中所描述的CDR-L3； (23)     如SEQ ID NO: 221中所描述的CDR-H1、如SEQ ID NO: 222中所描述的CDR-H2、如SEQ ID NO: 223中所描述的CDR-H3、如SEQ ID NO: 224中所描述的CDR-L1、如SEQ ID NO: 225中所描述的CDR-L2和如SEQ ID NO: 226中所描述的CDR-L3； (24)     如SEQ ID NO: 231中所描述的CDR-H1、如SEQ ID NO: 232中所描述的CDR-H2、如SEQ ID NO: 233中所描述的CDR-H3、如SEQ ID NO: 234中所描述的CDR-L1、如SEQ ID NO: 235中所描述的CDR-L2和如SEQ ID NO: 236中所描述的CDR-L3； (25)     如SEQ ID NO: 241中所描述的CDR-H1、如SEQ ID NO: 242中所描述的CDR-H2、如SEQ ID NO: 243中所描述的CDR-H3、如SEQ ID NO: 244中所描述的CDR-L1、如SEQ ID NO: 245中所描述的CDR-L2和如SEQ ID NO: 246中所描述的CDR-L3； (26)     如SEQ ID NO: 251中所描述的CDR-H1、如SEQ ID NO: 252中所描述的CDR-H2、如SEQ ID NO: 253中所描述的CDR-H3、如SEQ ID NO: 254中所描述的CDR-L1、如SEQ ID NO: 255中所描述的CDR-L2和如SEQ ID NO: 256中所描述的CDR-L3； (27)     如SEQ ID NO: 261中所描述的CDR-H1、如SEQ ID NO: 262中所描述的CDR-H2、如SEQ ID NO: 263中所描述的CDR-H3、如SEQ ID NO: 264中所描述的CDR-L1、如SEQ ID NO: 265中所描述的CDR-L2和如SEQ ID NO: 266中所描述的CDR-L3； (28)     如SEQ ID NO: 271中所描述的CDR-H1、如SEQ ID NO: 272中所描述的CDR-H2、如SEQ ID NO: 273中所描述的CDR-H3、如SEQ ID NO: 274中所描述的CDR-L1、如SEQ ID NO: 275中所描述的CDR-L2和如SEQ ID NO: 276中所描述的CDR-L3； (29)     如SEQ ID NO: 281中所描述的CDR-H1、如SEQ ID NO: 282中所描述的CDR-H2、如SEQ ID NO: 283中所描述的CDR-H3、如SEQ ID NO: 284中所描述的CDR-L1、如SEQ ID NO: 285中所描述的CDR-L2和如SEQ ID NO: 286中所描述的CDR-L3； (30)     如SEQ ID NO: 291中所描述的CDR-H1、如SEQ ID NO: 292中所描述的CDR-H2、如SEQ ID NO: 293中所描述的CDR-H3、如SEQ ID NO: 294中所描述的CDR-L1、如SEQ ID NO: 295中所描述的CDR-L2和如SEQ ID NO: 296中所描述的CDR-L3； (31)     如SEQ ID NO: 301中所描述的CDR-H1、如SEQ ID NO: 302中所描述的CDR-H2、如SEQ ID NO: 303中所描述的CDR-H3、如SEQ ID NO: 304中所描述的CDR-L1、如SEQ ID NO: 305中所描述的CDR-L2和如SEQ ID NO: 306中所描述的CDR-L3； (32)     如SEQ ID NO: 311中所描述的CDR-H1、如SEQ ID NO: 312中所描述的CDR-H2、如SEQ ID NO: 313中所描述的CDR-H3、如SEQ ID NO: 314中所描述的CDR-L1、如SEQ ID NO: 315中所描述的CDR-L2和如SEQ ID NO: 316中所描述的CDR-L3； (33)     如SEQ ID NO: 321中所描述的CDR-H1、如SEQ ID NO: 322中所描述的CDR-H2、如SEQ ID NO: 323中所描述的CDR-H3、如SEQ ID NO: 324中所描述的CDR-L1、如SEQ ID NO: 325中所描述的CDR-L2和如SEQ ID NO: 326中所描述的CDR-L3； (34)     如SEQ ID NO: 331中所描述的CDR-H1、如SEQ ID NO: 332中所描述的CDR-H2、如SEQ ID NO: 333中所描述的CDR-H3、如SEQ ID NO: 334中所描述的CDR-L1、如SEQ ID NO: 335中所描述的CDR-L2和如SEQ ID NO: 336中所描述的CDR-L3； (35)     如SEQ ID NO: 341中所描述的CDR-H1、如SEQ ID NO: 342中所描述的CDR-H2、如SEQ ID NO: 343中所描述的CDR-H3、如SEQ ID NO: 344中所描述的CDR-L1、如SEQ ID NO: 345中所描述的CDR-L2和如SEQ ID NO: 346中所描述的CDR-L3； (36)     如SEQ ID NO: 351中所描述的CDR-H1、如SEQ ID NO: 352中所描述的CDR-H2、如SEQ ID NO: 353中所描述的CDR-H3、如SEQ ID NO: 354中所描述的CDR-L1、如SEQ ID NO: 355中所描述的CDR-L2和如SEQ ID NO: 356中所描述的CDR-L3； (37)     如SEQ ID NO: 361中所描述的CDR-H1、如SEQ ID NO: 362中所描述的CDR-H2、如SEQ ID NO: 363中所描述的CDR-H3、如SEQ ID NO: 364中所描述的CDR-L1、如SEQ ID NO: 365中所描述的CDR-L2和如SEQ ID NO: 366中所描述的CDR-L3； (38)     如SEQ ID NO: 371中所描述的CDR-H1、如SEQ ID NO: 372中所描述的CDR-H2、如SEQ ID NO: 373中所描述的CDR-H3、如SEQ ID NO: 374中所描述的CDR-L1、如SEQ ID NO: 375中所描述的CDR-L2和如SEQ ID NO: 376中所描述的CDR-L3； (39)     如SEQ ID NO: 381中所描述的CDR-H1、如SEQ ID NO: 382中所描述的CDR-H2、如SEQ ID NO: 383中所描述的CDR-H3、如SEQ ID NO: 384中所描述的CDR-L1、如SEQ ID NO: 385中所描述的CDR-L2和如SEQ ID NO: 386中所描述的CDR-L3； (40)     如SEQ ID NO: 391中所描述的CDR-H1、如SEQ ID NO: 392中所描述的CDR-H2、如SEQ ID NO: 393中所描述的CDR-H3、如SEQ ID NO: 394中所描述的CDR-L1、如SEQ ID NO: 395中所描述的CDR-L2和如SEQ ID NO: 396中所描述的CDR-L3； (41)     如SEQ ID NO: 401中所描述的CDR-H1、如SEQ ID NO: 402中所描述的CDR-H2、如SEQ ID NO: 403中所描述的CDR-H3、如SEQ ID NO: 404中所描述的CDR-L1、如SEQ ID NO: 405中所描述的CDR-L2和如SEQ ID NO: 406中所描述的CDR-L3； (42)     如SEQ ID NO: 411中所描述的CDR-H1、如SEQ ID NO: 412中所描述的CDR-H2、如SEQ ID NO: 413中所描述的CDR-H3、如SEQ ID NO: 414中所描述的CDR-L1、如SEQ ID NO: 415中所描述的CDR-L2和如SEQ ID NO: 416中所描述的CDR-L3； (43)     如SEQ ID NO: 421中所描述的CDR-H1、如SEQ ID NO: 422中所描述的CDR-H2、如SEQ ID NO: 423中所描述的CDR-H3、如SEQ ID NO: 424中所描述的CDR-L1、如SEQ ID NO: 425中所描述的CDR-L2和如SEQ ID NO: 426中所描述的CDR-L3； (44)     如SEQ ID NO: 431中所描述的CDR-H1、如SEQ ID NO: 432中所描述的CDR-H2、如SEQ ID NO: 433中所描述的CDR-H3、如SEQ ID NO: 434中所描述的CDR-L1、如SEQ ID NO: 435中所描述的CDR-L2和如SEQ ID NO: 436中所描述的CDR-L3； (45)     如SEQ ID NO: 441中所描述的CDR-H1、如SEQ ID NO: 442中所描述的CDR-H2、如SEQ ID NO: 443中所描述的CDR-H3、如SEQ ID NO: 444中所描述的CDR-L1、如SEQ ID NO: 445中所描述的CDR-L2和如SEQ ID NO: 446中所描述的CDR-L3； (46)     如SEQ ID NO: 451中所描述的CDR-H1、如SEQ ID NO: 452中所描述的CDR-H2、如SEQ ID NO: 453中所描述的CDR-H3、如SEQ ID NO: 454中所描述的CDR-L1、如SEQ ID NO: 455中所描述的CDR-L2和如SEQ ID NO: 456中所描述的CDR-L3； (47)     如SEQ ID NO: 461中所描述的CDR-H1、如SEQ ID NO: 462中所描述的CDR-H2、如SEQ ID NO: 463中所描述的CDR-H3、如SEQ ID NO: 464中所描述的CDR-L1、如SEQ ID NO: 465中所描述的CDR-L2和如SEQ ID NO: 466中所描述的CDR-L3； (48)     如SEQ ID NO: 471中所描述的CDR-H1、如SEQ ID NO: 472中所描述的CDR-H2、如SEQ ID NO: 473中所描述的CDR-H3、如SEQ ID NO: 474中所描述的CDR-L1、如SEQ ID NO: 475中所描述的CDR-L2和如SEQ ID NO: 476中所描述的CDR-L3； (49)     如SEQ ID NO: 481中所描述的CDR-H1、如SEQ ID NO: 482中所描述的CDR-H2、如SEQ ID NO: 483中所描述的CDR-H3、如SEQ ID NO: 484中所描述的CDR-L1、如SEQ ID NO: 485中所描述的CDR-L2和如SEQ ID NO: 486中所描述的CDR-L3； (50)     如SEQ ID NO: 491中所描述的CDR-H1、如SEQ ID NO: 492中所描述的CDR-H2、如SEQ ID NO: 493中所描述的CDR-H3、如SEQ ID NO: 494中所描述的CDR-L1、如SEQ ID NO: 495中所描述的CDR-L2和如SEQ ID NO: 496中所描述的CDR-L3； (51)     如SEQ ID NO: 501中所描述的CDR-H1、如SEQ ID NO: 502中所描述的CDR-H2、如SEQ ID NO: 503中所描述的CDR-H3、如SEQ ID NO: 504中所描述的CDR-L1、如SEQ ID NO: 505中所描述的CDR-L2和如SEQ ID NO: 506中所描述的CDR-L3； (52)     如SEQ ID NO: 511中所描述的CDR-H1、如SEQ ID NO: 512中所描述的CDR-H2、如SEQ ID NO: 513中所描述的CDR-H3、如SEQ ID NO: 514中所描述的CDR-L1、如SEQ ID NO: 515中所描述的CDR-L2和如SEQ ID NO: 516中所描述的CDR-L3；和 (53)     如SEQ ID NO: 521中所描述的CDR-H1、如SEQ ID NO: 522中所描述的CDR-H2、如SEQ ID NO: 523中所描述的CDR-H3、如SEQ ID NO: 524中所描述的CDR-L1、如SEQ ID NO: 525中所描述的CDR-L2和如SEQ ID NO: 526中所描述的CDR-L3。
還設想本發明之蛋白質中，與BCMA結合的第一結構域包含具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 8、18、28、38、48、58、68、78、88、98、108、118、128、138、148、158、168、178、188、198、208、218、228、238、248、258、268、278、288、298、308、318、328、338、348、358、368、378、388、398、408、418、428、438、448、458、468、478、488、498、508、518、和528中所描述的那些。設想第一結構域包含具有如SEQ ID NO: 178中所描述的胺基酸序列的VL區。
此外，設想與BCMA結合的第一結構域，該第一結構域包含具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 7、17、27、37、47、57、67、77、87、97、107、117、127、137、147、157、167、177、187、197、207、217、227、237、247、257、267、277、287、307、317、327、337、347、357、367、377、387、397、407、417、427、437、447、457、467、477、487、497、507、517、和527中所描述的那些。設想第一結構域包含具有如SEQ ID NO: 177中所描述的胺基酸序列的VH區。
還設想本發明之蛋白質中，與BCMA結合的第一結構域包含選自由以下組成之群組的VH區和VL區： (1)    如SEQ ID NO: 7中所描述的VH區和如SEQ ID NO: 8中所描述的VL區； (2)    如SEQ ID NO: 17中所描述的VH區和如SEQ ID NO: 18中所描述的VL區； (3)    如SEQ ID NO: 27中所描述的VH區和如SEQ ID NO: 28中所描述的VL區； (4)    如SEQ ID NO: 37中所描述的VH區和如SEQ ID NO: 38中所描述的VL區； (5)    如SEQ ID NO: 47中所描述的VH區和如SEQ ID NO: 48中所描述的VL區； (6)    如SEQ ID NO: 57中所描述的VH區和如SEQ ID NO: 58中所描述的VL區； (7)    如SEQ ID NO: 67中所描述的VH區和如SEQ ID NO: 68中所描述的VL區； (8)    如SEQ ID NO: 77中所描述的VH區和如SEQ ID NO: 78中所描述的VL區； (9)    如SEQ ID NO: 87中所描述的VH區和如SEQ ID NO: 88中所描述的VL區； (10)     如SEQ ID NO: 97中所描述的VH區和如SEQ ID NO: 98中所描述的VL區； (11)     如SEQ ID NO: 107中所描述的VH區和如SEQ ID NO: 108中所描述的VL區； (12)     如SEQ ID NO: 117中所描述的VH區和如SEQ ID NO: 118中所描述的VL區； (13)     如SEQ ID NO: 127中所描述的VH區和如SEQ ID NO: 128中所描述的VL區； (14)     如SEQ ID NO: 137中所描述的VH區和如SEQ ID NO: 138中所描述的VL區； (15)     如SEQ ID NO: 147中所描述的VH區和如SEQ ID NO: 148中所描述的VL區； (16)     如SEQ ID NO: 157中所描述的VH區和如SEQ ID NO: 158中所描述的VL區； (17)     如SEQ ID NO: 167中所描述的VH區和如SEQ ID NO: 168中所描述的VL區； (18)     如SEQ ID NO: 177中所描述的VH區和如SEQ ID NO: 178中所描述的VL區； (19)     如SEQ ID NO: 187中所描述的VH區和如SEQ ID NO: 188中所描述的VL區； (20)     如SEQ ID NO: 197中所描述的VH區和如SEQ ID NO: 198中所描述的VL區； (21)     如SEQ ID NO: 207中所描述的VH區和如SEQ ID NO: 208中所描述的VL區； (22)     如SEQ ID NO: 217中所描述的VH區和如SEQ ID NO: 218中所描述的VL區； (23)     如SEQ ID NO: 227中所描述的VH區和如SEQ ID NO: 228中所描述的VL區； (24)     如SEQ ID NO: 237中所描述的VH區和如SEQ ID NO: 238中所描述的VL區； (25)     如SEQ ID NO: 247中所描述的VH區和如SEQ ID NO: 248中所描述的VL區； (26)     如SEQ ID NO: 257中所描述的VH區和如SEQ ID NO: 258中所描述的VL區； (27)     如SEQ ID NO: 267中所描述的VH區和如SEQ ID NO: 268中所描述的VL區； (28)     如SEQ ID NO: 277中所描述的VH區和如SEQ ID NO: 278中所描述的VL區； (29)     如SEQ ID NO: 287中所描述的VH區和如SEQ ID NO: 288中所描述的VL區； (30)     如SEQ ID NO: 297中所描述的VH區和如SEQ ID NO: 298中所描述的VL區； (31)     如SEQ ID NO: 307中所描述的VH區和如SEQ ID NO: 308中所描述的VL區； (32)     如SEQ ID NO: 317中所描述的VH區和如SEQ ID NO: 318中所描述的VL區； (33)     如SEQ ID NO: 327中所描述的VH區和如SEQ ID NO: 328中所描述的VL區； (34)     如SEQ ID NO: 337中所描述的VH區和如SEQ ID NO: 338中所描述的VL區； (35)     如SEQ ID NO: 347中所描述的VH區和如SEQ ID NO: 348中所描述的VL區； (36)     如SEQ ID NO: 357中所描述的VH區和如SEQ ID NO: 358中所描述的VL區； (37)     如SEQ ID NO: 367中所描述的VH區和如SEQ ID NO: 368中所描述的VL區； (38)     如SEQ ID NO: 377中所描述的VH區和如SEQ ID NO: 378中所描述的VL區； (39)     如SEQ ID NO: 387中所描述的VH區和如SEQ ID NO: 388中所描述的VL區； (40)     如SEQ ID NO: 397中所描述的VH區和如SEQ ID NO: 398中所描述的VL區； (41)     如SEQ ID NO: 407中所描述的VH區和如SEQ ID NO: 408中所描述的VL區； (42)     如SEQ ID NO: 417中所描述的VH區和如SEQ ID NO: 418中所描述的VL區； (43)     如SEQ ID NO: 427中所描述的VH區和如SEQ ID NO: 428中所描述的VL區； (44)     如SEQ ID NO: 437中所描述的VH區和如SEQ ID NO: 438中所描述的VL區； (45)     如SEQ ID NO: 447中所描述的VH區和如SEQ ID NO: 448中所描述的VL區； (46)     如SEQ ID NO: 457中所描述的VH區和如SEQ ID NO: 458中所描述的VL區； (47)     如SEQ ID NO: 467中所描述的VH區和如SEQ ID NO: 468中所描述的VL區； (48)     如SEQ ID NO: 477中所描述的VH區和如SEQ ID NO: 478中所描述的VL區； (49)     如SEQ ID NO: 487中所描述的VH區和如SEQ ID NO: 488中所描述的VL區； (50)     如SEQ ID NO: 497中所描述的VH區和如SEQ ID NO: 498中所描述的VL區； (51)     如SEQ ID NO: 507中所描述的VH區和如SEQ ID NO: 508中所描述的VL區； (52)     如SEQ ID NO: 517中所描述的VH區和如SEQ ID NO: 518中所描述的VL區；和 (53)     如SEQ ID NO: 527中所描述的VH區和如SEQ ID NO: 528中所描述的VL區。
設想第一結構域包含具有如SEQ ID NO: 177中所描述的胺基酸序列的VH區、以及具有如SEQ ID NO: 178中所描述的胺基酸序列的VL區。
還設想本發明之蛋白質中，與BCMA結合的第一結構域包含具有選自由以下組成之群組的胺基酸序列的多肽：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519、和529。設想第一結構域包含具有如SEQ ID NO: 179中所描述的胺基酸序列的多肽。
「T細胞」或T淋巴細胞係在細胞介導的免疫中發揮核心作用的一類淋巴細胞（其本身係一類白血球）。有幾個T細胞亞組，每個亞組具有不同的功能。T細胞可以藉由細胞表面上存在T細胞受體（TCR）而與其他淋巴細胞（諸如B細胞和NK細胞）區分開。TCR負責識別與主要組織相容性複合物（MHC）分子結合的抗原，並且由兩種不同的多肽鏈構成。在95%的T細胞中，TCR由阿爾法（α）和貝塔（β）鏈組成。當TCR與抗原肽和MHC（肽/MHC複合物）接合時，T淋巴細胞藉由一系列由相關酶、共受體、特化銜接分子和激活或釋放的轉錄因子介導的生物化學事件而被激活。
「CD3」（分化簇3）係由四條鏈構成的T細胞共受體。在哺乳動物中，CD3蛋白質複合物含有CD3γ（gamma）鏈、CD3δ（delta）鏈和兩條CD3ε（epsilon）鏈。這四條鏈與T細胞受體（TCR）和所謂的ζ（zeta）鏈締合以形成「T細胞受體複合物」並且在T淋巴細胞中產生活化信號。CD3γ（gamma）、CD3δ（delta）和CD3ε（epsilon）鏈係免疫球蛋白超家族的高度相關的細胞表面蛋白，並且各自含有單個胞外免疫球蛋白結構域。CD3分子的胞內尾含有對於TCR的傳訊能力所必需的單個保守模體，稱為基於免疫受體酪胺酸的活化模體（ITAM）。CD3ε係這樣的多肽，該多肽在人中由位於11號染色體上的 CD3E基因編碼。
藉由與T細胞上的CD3和與靶細胞上的靶蛋白（本文：BCMA）結合的結合蛋白募集T細胞來將靶細胞重定向裂解通常關於溶細胞突觸形成以及穿孔素和顆粒酶的遞送。接合的T細胞能夠進行連續靶細胞裂解，並且不受干擾肽抗原加工和呈遞或選殖T細胞分化的免疫逃逸機制的影響；參見例如，WO 2007/042261。
可以以各種方式測量由抗-BCMA x 抗-CD3結合蛋白介導的細胞毒性。「半數最大有效濃度」（EC 50）通常用作生物活性分子（如本發明之蛋白質）的效力的量度。它以莫耳單位表示。在測量細胞毒性的當前情況下，EC 50值係指在基線和最大值之間的中途誘導細胞毒性反應（靶細胞裂解）的結合蛋白質的濃度。細胞毒性測定中的效應細胞可以例如是刺激的富集的（人）CD8陽性T細胞或未刺激的（人）外周血單核細胞（PBMC）。靶細胞應在細胞表面表現BCMA。較佳的是，靶細胞在細胞表面上表現（至少）BCMA的細胞外結構域。靶細胞可以是來自用BCMA（例如人BCMA）穩定或瞬時轉染的細胞系（如CHO）的細胞。可替代地，靶細胞可以是來自BCMA陽性天然表現的細胞系（如人多發性骨髓瘤細胞系L363或NCI-H929）的細胞。
在細胞毒性測定中效應細胞與靶細胞（E : T）比率通常為約10 : 1，但也可以改變。抗-BCMA x 抗-CD3結合蛋白的細胞毒性活性可以在鉻51釋放測定（例如，具有約18小時的孵育時間）中或在基於FACS的細胞毒性測定（例如，具有約48小時的孵育時間）中測量。還設想了孵育時間（細胞毒性反應）的修飾。
根據一個實施方式，在基於FACS的細胞毒性測定中測量由本發明之抗-BCMA x 抗-CD3結合蛋白介導的細胞毒性活性。EC 50值可以是 ≤ 1000 pM、≤ 900 pM、≤ 800 pM、≤ 700 pM、≤ 600 pM、≤ 500 pM、≤ 400 pM、≤ 300 pM、≤ 200 pM、≤ 100 pM、≤ 90 pM、≤ 80 pM、≤ 70 pM、≤ 60 pM、≤ 50 pM、≤ 40 pM、≤ 30 pM、≤ 20 pM、≤ 10 pM、或 ≤ 5 pM。還設想本發明之結合蛋白具有3位至1位pM範圍的EC 50值，如在基於FACS的細胞毒性測定中所確定的。可以用L363或NCI-H929細胞系或用BCMA轉染的CHO細胞作為靶細胞，以及用刺激的富集的（人）CD8陽性T細胞或未刺激的（人）PBMC作為效應細胞進行測定。還參見WO 2013/072406。
本發明之蛋白質的第二結構域與CD3結合。更較佳的是，它與T細胞表面上的CD3結合。此外，設想第二結構域與人CD3結合，較佳的是與T細胞表面上的人CD3結合。還設想第二結構域與CD3ε結合。更較佳的是，它與人CD3ε結合，例如與T細胞表面上的人CD3ε結合。人CD3ε的細胞外結構域的較佳的胺基酸序列在SEQ ID NO: 653中描述。
在本發明之一個實施方式中，蛋白質的第二結構域與人CD3ε（或T細胞表面上的人CD3ε）和與白鬢狨（ Callithrix jacchus）或松鼠猴（ Saimiri sciureus）CD3ε結合。還設想第二結構域與CD3ε的細胞外表位結合，較佳的是與人CD3ε的細胞外表位結合。還設想第二結構域與人和獼猴屬（ Macaca）CD3ε鏈的細胞外表位結合。CD3ε的一個較佳的表位包含在人CD3ε細胞外結構域的胺基酸殘基1-27內（參見SEQ ID NO: 654）。甚至更具體地，表位至少包含胺基酸序列Gln-Asp-Gly-Asn-Glu。白鬢狨係屬於狨科（ Callitrichidae）的新大陸靈長類動物，而松鼠猴係屬於捲尾猴科（ Cebidae）之新大陸靈長類動物。具有這種特徵的結合物在WO 2008/119567中有詳細描述。
針對（人）CD3或特異性針對CD3ε的抗體或（雙特異性）結合蛋白係本領域已知的，並且它們的CDR、VH和VL序列可以作為本發明之結合蛋白的第二結合結構域的基礎。例如，Kung等人在1979年報導了OKT3（Ortho Kung T3）之開發，這係識別人T細胞上的CD3（具體地，CD3的ε鏈）的第一個mAb。OKT3（莫羅單抗（muromonab））係第一種可用於人療法的鼠源性單株抗體。更新的抗CD3單株抗體包括奧特昔珠單抗（otelixizumab）（TRX4）、特普利珠單抗（teplizumab）（MGA031）、弗雷魯單抗（foralumab）和威司利珠單抗（visilizumab），均靶向CD3的ε鏈。針對（癌症）靶標和CD3的雙特異性結合蛋白也正在進行開發和（預）臨床測試，並且它們的CD3結合結構域（CDR、VH、VL）可以用作本發明之結合蛋白的第二結合結構域的基礎。實例包括但不限於博納吐單抗（Blinatumomab）、索利托單抗（Solitomab）（MT110、AMG 110）、卡妥索單抗（Catumaxomab）、度妥昔珠單抗（Duvortuxizumab）、厄妥瑪索單抗（Ertumaxomab）、洛莫索珠單抗（Mosunetuzumab）、FBTA05（Bi20、TPBs05）、CEA-TCB（RG7802、RO6958688）、AFM11、和MGD006（S80880）。例如在US 7,994,289 B2、US 7,728,114 B2、US 7,381,803 B1、US 6,706,265 B1中揭露了CD3結合結構域的其他實例。
設想本發明之蛋白質中，與CD3結合的第二結構域包含：含有選自以下的CDR-L1、CDR-L2、和CDR-L3的VL區： (a)     如SEQ ID NO: 542中所描述的CDR-L1、如SEQ ID NO: 543中所描述的CDR-L2和如SEQ ID NO: 544中所描述的CDR-L3； (b)    如SEQ ID NO: 599中所描述的CDR-L1、如SEQ ID NO: 600中所描述的CDR-L2和如SEQ ID NO: 601中所描述的CDR-L3；和 (c)     如SEQ ID NO: 621中所描述的CDR-L1、如SEQ ID NO: 622中所描述的CDR-L2和如SEQ ID NO: 623中所描述的CDR-L3。
還設想本發明之蛋白質中，與CD3結合的第二結構域包含：含有選自以下的CDR-H1、CDR-H2、和CDR-H3的VH區： (a)     如SEQ ID NO: 534中所描述的CDR-H1、如SEQ ID NO: 535中所描述的CDR-H2和如SEQ ID NO: 536中所描述的CDR-H3； (b)    如SEQ ID NO: 545中所描述的CDR-H1、如SEQ ID NO: 546中所描述的CDR-H2和如SEQ ID NO: 547中所描述的CDR-H3； (c)     如SEQ ID NO: 557中所描述的CDR-H1、如SEQ ID NO: 558中所描述的CDR-H2和如SEQ ID NO: 559中所描述的CDR-H3； (d)    如SEQ ID NO: 568中所描述的CDR-H1、如SEQ ID NO: 569中所描述的CDR-H2和如SEQ ID NO: 570中所描述的CDR-H3； (e)     如SEQ ID NO: 579中所描述的CDR-H1、如SEQ ID NO: 580中所描述的CDR-H2和如SEQ ID NO: 581中所描述的CDR-H3； (f)     如SEQ ID NO: 591中所描述的CDR-H1、如SEQ ID NO: 592中所描述的CDR-H2和如SEQ ID NO: 593中所描述的CDR-H3； (g)    如SEQ ID NO: 602中所描述的CDR-H1、如SEQ ID NO: 603中所描述的CDR-H2和如SEQ ID NO: 604中所描述的CDR-H3； (h)    如SEQ ID NO: 613中所描述的CDR-H1、如SEQ ID NO: 614中所描述的CDR-H2和如SEQ ID NO: 615中所描述的CDR-H3； (i)     如SEQ ID NO: 624中所描述的CDR-H1、如SEQ ID NO: 625中所描述的CDR-H2和如SEQ ID NO: 626中所描述的CDR-H3；和 (j)     如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2和如SEQ ID NO: 638中所描述的CDR-H3。
此外，對於本發明之蛋白質，進一步設想與CD3結合的第二結構域包含含有選自以下的CDR-L1、CDR-L2和CDR-L3的VL區，以及含有選自以下的CDR-H1、CDR-H2和CDR-H3的VH區： (a)     如SEQ ID NO: 531中所描述的CDR-L1、如SEQ ID NO: 532中所描述的CDR-L2、如SEQ ID NO: 533中所描述的CDR-L3、如SEQ ID NO: 534中所描述的CDR-H1、如SEQ ID NO: 535中所描述的CDR-H2和如SEQ ID NO: 536中所描述的CDR-H3； (b)    如SEQ ID NO: 542中所描述的CDR-L1、如SEQ ID NO: 543中所描述的CDR-L2、如SEQ ID NO: 544中所描述的CDR-L3、如SEQ ID NO: 545中所描述的CDR-H1、如SEQ ID NO: 546中所描述的CDR-H2和如SEQ ID NO: 547中所描述的CDR-H3； (c)     如SEQ ID NO: 554中所描述的CDR-L1、如SEQ ID NO: 555中所描述的CDR-L2、如SEQ ID NO: 556中所描述的CDR-L3、如SEQ ID NO: 557中所描述的CDR-H1、如SEQ ID NO: 558中所描述的CDR-H2和如SEQ ID NO: 559中所描述的CDR-H3； (d)    如SEQ ID NO: 565中所描述的CDR-L1、如SEQ ID NO: 566中所描述的CDR-L2、如SEQ ID NO: 567中所描述的CDR-L3、如SEQ ID NO: 568中所描述的CDR-H1、如SEQ ID NO: 569中所描述的CDR-H2和如SEQ ID NO: 570中所描述的CDR-H3； (e)     如SEQ ID NO: 576中所描述的CDR-L1、如SEQ ID NO: 577中所描述的CDR-L2、如SEQ ID NO: 578中所描述的CDR-L3、如SEQ ID NO: 579中所描述的CDR-H1、如SEQ ID NO: 580中所描述的CDR-H2和如SEQ ID NO: 581中所描述的CDR-H3； (f)     如SEQ ID NO: 588中所描述的CDR-L1、如SEQ ID NO: 589中所描述的CDR-L2、如SEQ ID NO: 590中所描述的CDR-L3、如SEQ ID NO: 591中所描述的CDR-H1、如SEQ ID NO: 592中所描述的CDR-H2和如SEQ ID NO: 593中所描述的CDR-H3； (g)    如SEQ ID NO: 599中所描述的CDR-L1、如SEQ ID NO: 600中所描述的CDR-L2、如SEQ ID NO: 601中所描述的CDR-L3、如SEQ ID NO: 602中所描述的CDR-H1、如SEQ ID NO: 603中所描述的CDR-H2和如SEQ ID NO: 604中所描述的CDR-H3； (h)    如SEQ ID NO: 610中所描述的CDR-L1、如SEQ ID NO: 611中所描述的CDR-L2、如SEQ ID NO: 612中所描述的CDR-L3、如SEQ ID NO: 613中所描述的CDR-H1、如SEQ ID NO: 614中所描述的CDR-H2和如SEQ ID NO: 615中所描述的CDR-H3； (i)     如SEQ ID NO: 621中所描述的CDR-L1、如SEQ ID NO: 622中所描述的CDR-L2、如SEQ ID NO: 623中所描述的CDR-L3、如SEQ ID NO: 624中所描述的CDR-H1、如SEQ ID NO: 625中所描述的CDR-H2和如SEQ ID NO: 626中所描述的CDR-H3；和 (j)     如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3、如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2和如SEQ ID NO: 638中所描述的CDR-H3。
還設想本發明之蛋白質中，與CD3結合的第二結構域包含：具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 550、SEQ ID NO: 551、SEQ ID NO: 584、SEQ ID NO: 585、SEQ ID NO: 629和SEQ ID NO: 630，較佳的是SEQ ID NO: 629中所描述的那些。
此外，設想與CD3結合的第二結構域包含：具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 537、SEQ ID NO: 538、SEQ ID NO: 548、SEQ ID NO: 549、SEQ ID NO: 560、SEQ ID NO: 561、SEQ ID NO: 571、SEQ ID NO: 572、SEQ ID NO: 582、SEQ ID NO: 583、SEQ ID NO: 594、SEQ ID NO: 595、SEQ ID NO: 605、SEQ ID NO: 606、SEQ ID NO: 616、SEQ ID NO: 617、SEQ ID NO: 627、SEQ ID NO: 628、SEQ ID NO: 639、SEQ ID NO: 640、和SEQ ID NO: 644，較佳的是SEQ ID NO: 639中所描述的那些。
還設想本發明之蛋白質中，與CD3結合的第二結構域包含選自由以下組成之群組的VL區和VH區： (a)     如SEQ ID NO: 539或521中所描述的VL區和如SEQ ID NO: 537或538中所描述的VH區； (b)    如SEQ ID NO: 550或521中所描述的VL區和如SEQ ID NO: 548或549中所描述的VH區； (c)     如SEQ ID NO: 562或521中所描述的VL區和如SEQ ID NO: 560或561中所描述的VH區； (d)    如SEQ ID NO: 573或521中所描述的VL區和如SEQ ID NO: 571或572中所描述的VH區； (e)     如SEQ ID NO: 584或585中所描述的VL區和如SEQ ID NO: 582或583中所描述的VH區； (f)     如SEQ ID NO: 596或521中所描述的VL區和如SEQ ID NO: 594或595中所描述的VH區； (g)    如SEQ ID NO: 607或585中所描述的VL區和如SEQ ID NO: 605或606中所描述的VH區； (h)    如SEQ ID NO: 618或521中所描述的VL區和如SEQ ID NO: 616或617中所描述的VH區； (i)     如SEQ ID NO: 629或630中所描述的VL區和如SEQ ID NO: 627或628中所描述的VH區； (j)     如SEQ ID NO: 641或630中所描述的VL區和如SEQ ID NO: 639或640中所描述的VH區；和 (k)    如SEQ ID NO: 645中所描述的VL區和如SEQ ID NO: 644中所描述的VH區。
還設想本發明之蛋白質中，與CD3結合的第二結構域包含具有選自由以下組成之群組的胺基酸序列的多肽或由具有選自由以下組成之群組的胺基酸序列的多肽組成：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643、和646，較佳的是SEQ ID NO: 642中所描述的那些。
還設想本發明之蛋白質與以下競爭結合CD3： a)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2、和如SEQ ID NO: 638中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 639中所描述的VH區、和如SEQ ID NO: 641中所描述的VL區； c)      蛋白質，該蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 642中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
還設想本發明之蛋白質與以下結合CD3的相同表位： a)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2、和如SEQ ID NO: 638中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 639中所描述的VH區、和如SEQ ID NO: 641中所描述的VL區； c)      蛋白質，該蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 642中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
此外，設想本發明之蛋白質包含多肽，該多肽具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520、和530中所描述的那些。設想本發明之蛋白質包含多肽，該多肽具有如SEQ ID NO: 180中所描述的胺基酸序列。
還設想本發明之蛋白質包含如下多肽或由如下多肽組成，該多肽具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520、和530中所描述的那些，並且該多肽在其N-末端或其C-末端與蛋白質純化標籤連接（較佳的是經由肽鍵（醯胺鍵））。蛋白質純化標籤在多肽的C-末端的連接係較佳的。設想蛋白質純化標籤係短肽。例如，短肽的長度可以是2-30個胺基酸、4-25個胺基酸、5-20個胺基酸或6-19個胺基酸。蛋白質純化標籤的實例包括但不限於AU1表位（例如，如SEQ ID NO: 666中所描述）、AU5表位（例如，如SEQ ID NO: 667中所描述）、T7-標籤（例如，如SEQ ID NO: 668中所描述）、V5-標籤（例如，如SEQ ID NO: 669中所描述）、B-標籤（例如，如SEQ ID NO: 670中所描述）、E2表位（例如，如SEQ ID NO: 671中所描述）、FLAG表位/FLAG標籤（例如，如SEQ ID NO: 672中所描述）、Glu-Glu標籤（例如，如SEQ ID NO: 673或674中所描述）、HA標籤、組胺酸親和力標籤（例如，如SEQ ID NO: 675中所描述）、HSV表位（例如，如SEQ ID NO: 676中所描述）、KT3表位（例如，如SEQ ID NO: 677中所描述）、Myc表位（例如，如SEQ ID NO: 678中所描述）、聚精胺酸標籤（5-6個Arg殘基）、聚天冬胺酸標籤（5-16個Asp殘基）、聚組胺酸標籤（2-10個His殘基，通常6個His殘基，參見例如，SEQ ID NO: 662-665）、聚苯丙胺酸標籤（通常11個Phe殘基）、S1標籤（例如，如SEQ ID NO: 679中所描述）、S-標籤（例如，如SEQ ID NO: 680中所描述）、Strep-標籤（例如，如SEQ ID NO: 681或682中所描述）、通用標籤（例如，如SEQ ID NO: 683中所描述）、VSV-G（例如，如SEQ ID NO: 684中所描述）、蛋白質C（例如，如SEQ ID NO: 685中所描述）和蛋白質A。組胺酸標籤係較佳的，尤其是6x His標籤（SEQ ID NO: 663）。
還設想本發明之蛋白質與以下結合BCMA的相同表位： a)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、和如SEQ ID NO: 173中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2、和如SEQ ID NO: 176中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 177中所描述的VH區、和如SEQ ID NO: 178中所描述的VL區； c)      蛋白質，該蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 179中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
無論抗體、結合結構域或包含這種結合結構域的結合蛋白是否與另一給定抗體結合靶細胞表面上的BCMA/BCMA的相同表位，結合結構域或結合蛋白可藉由不同分析（例如藉由用嵌合或突變的BCMA分子進行表位作圖，如WO 2013/072406中所述之）測量。鑒定靶標內表位的另一種可能性係丙胺酸掃描測定（參見例如Morrison KL & Weiss GA. Curr Opin Chem Biol. [化學生物學新見] 2001年6月; 5 (3): 302-7），其中待分析的靶標（本文中：BCMA）中的每個殘基被丙胺酸替換（例如經由定點誘變）。丙胺酸的使用係因為其具有非巨大的、化學惰性的甲基官能基，但仍然模仿許多其他胺基酸所具有的二級結構參考。在需要保守突變殘基的大小的情形下，有時可以使用巨大的胺基酸（如纈胺酸或白胺酸）。丙胺酸掃描通常藉由定點誘變或隨機藉由創建PCR文庫完成。此外，已經開發了基於理論丙胺酸取代來估計熱力學參數的計算方法。可以藉由IR、NMR光譜學、數學方法、生物測定等來測試數據。當然，相同的分析可以應用於其他靶標，如CD3。
還設想本發明之蛋白質與以下競爭結合BCMA： a)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、和如SEQ ID NO: 173中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2、和如SEQ ID NO: 176中所描述的CDR-L3的VL區； b)      抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 177中所描述的VH區、和如SEQ ID NO: 178中所描述的VL區； c)      蛋白質，該蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 179中所描述的胺基酸序列；或 d)      蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
可以在競爭測定中測量根據本發明之抗體或蛋白質是否與根據本發明另一給定抗體或蛋白質競爭結合BCMA/靶細胞表面上的BCMA，該競爭測定如競爭性ELISA或基於細胞的競爭測定（使用自然表現BCMA的細胞、或者用BCMA穩定或瞬時轉化的細胞）。也可以使用抗生物素蛋白偶聯的微粒（珠粒）。與抗生物素蛋白塗覆的ELISA板類似，當與生物素化蛋白質反應時，該等珠粒中的每一個都可用作可在其上進行測定的底物。將抗原塗覆在珠粒上，並且然後用第一抗體預塗覆。添加第二抗體並且確定任何另外的結合。經由流動式細胞測量術進行讀出。在本文的上下文中，術語「競爭結合」意指在兩種測試的抗體之間發生的至少50%、至少60%、至少70%、至少80%、或至少90%的競爭（如藉由上文揭露的任何一種測定所確定的）。百分比係指與對照測定相比，在第一抗體存在的情況下發生的第二抗體結合的減少，在對照測定中第一抗體不存在或被不相關的（非結合的）抗體取代，因此第二抗體在沒有任何競爭的情況下結合。相同的分析可以應用於其他靶標，如CD3。
本文所述之蛋白質包含延長或提高該蛋白質的半衰期（或「血清半衰期」）的第三結構域。延長本發明之蛋白質的血清半衰期的結構域的實例包括與蛋白質融合或以其他方式附接的肽、多肽、蛋白質或蛋白質的結構域。肽、多肽、蛋白質或蛋白質結構域的組包括在人體中以較佳的藥物動力學特徵與其他蛋白質結合的肽，如與血清白蛋白結合的肽（參見WO 2009/127691）。用於半衰期延長的另一個概念包括與抗白蛋白結合結構域（例如單結構域抗白蛋白抗體）的融合。這樣的延長半衰期的肽的替代性概念包括與新生兒Fc受體（FcRn，參見WO 2007/098420）結合的肽，其也可用於本發明之蛋白質中。附接較大蛋白質結構域、多肽或完整蛋白質的概念包括人血清白蛋白、人血清白蛋白的變體或突變體（參見WO 2011/051489、WO 2012/059486、WO 2012/150319、WO 2013/135896、WO 2014/072481、WO 2013/075066）或其結構域的融合，以及免疫球蛋白恒定區（Fc結構域）及其變體的融合。Fc結構域的這樣的變體被稱為基於Fc的結構域，並且可以進一步被優化/修飾以便允許所需的二聚體或多聚體配對，以消除Fc受體結合（例如避免ADCC或CDC）或出於其他原因。本領域中已知的延長物質或分子在人體內的半衰期的另外的概念係那些分子（如本發明之蛋白質）的聚乙二醇化。
在一個實施方式中，例如出於延長構建體的血清半衰期的目的，根據本發明之蛋白質與融合配偶體（如蛋白質、多肽或肽）連接（例如經由肽鍵）。該等融合配偶體（表示「第三結構域」）可以選自人血清白蛋白（「HSA」或「HALB」）以及其序列變體、與HSA結合的肽、與FcRn結合的肽（「FcRn BP」）、或包含（抗體或免疫球蛋白衍生的）Fc區的構建體。通常，提供延長的半衰期的融合配偶體可以直接（例如經由肽鍵）或藉由肽連接子（linker）如(GGGGS)n（其中「n」係2或更大的整數，例如2或3或4）與根據本發明之蛋白質的N-末端或C-末端連接。合適的肽連接子描述於SEQ ID NO: 686-694中。第三結構域也可以位於第一和第二結構域之間。
根據另一個實施方式，本發明之蛋白質的第三結構域包含兩個多肽單體，每個單體包含鉸鏈、CH2結構域和CH3結構域，較佳的是按所述N-末端至C-末端的順序。設想所述兩個多肽單體可以藉由肽連接子彼此融合。在一個實施方式中，第三結構域按N-末端至C-末端的順序包含：「第一多肽單體-連接子-第二多肽單體」或「鉸鏈-CH2-CH3-連接子-鉸鏈-CH2-CH3」。在SEQ ID NO: 700-707中描述了可以用於所述第三結構域的胺基酸序列。所述多肽單體中的每一種可以具有選自由SEQ ID NO: 708-715組成之群組、或與那些序列至少90%相同的胺基酸序列。在另一個實施方式中，本發明之蛋白質的第一結構域和第二結構域經由肽連接子與第三結構域融合，該肽連接子例如選自由以下組成之群組：SEQ ID NO: 686、687、688、689、690、691、692、693或694。
根據本發明，「鉸鏈」係IgG鉸鏈區。該區域可以使用Kabat編號藉由模擬來鑒定，參見例如Kabat位置223-243。與上述一致，對於「鉸鏈」的最低要求係與根據Kabat編號的D231至P243的IgG 1序列延伸物對應的胺基酸殘基。術語「CH2」和「CH3」（或「CH2結構域」和「CH3結構域」）係指免疫球蛋白重鏈恒定區2和3。該等區域也可以使用Kabat編號藉由模擬來鑒定，參見例如Kabat位置244-360（對於CH2）和Kabat位置361-478（對於CH3）。應當理解，在免疫球蛋白之間在其IgG 1Fc區、IgG 2Fc區、IgG 3Fc區、IgG 4Fc區、IgM Fc區、IgA Fc區、IgD Fc區和IgE Fc區方面存在一些變化（參見例如，Padlan, Molecular Immunology [分子免疫學], 31 (3), 169-217 (1993)）。術語Fc區係指IgA、IgD和IgG的最後兩個重鏈恒定區、以及IgE和IgM的最後三個重鏈恒定區。Fc區還可以包括該等結構域的N-末端的柔性鉸鏈。對於IgA和IgM，Fc區可以包括J鏈。對於IgG，Fc區包含免疫球蛋白結構域CH2和CH3以及鉸鏈。儘管免疫球蛋白的Fc區的邊界可以改變，但是包含功能鉸鏈、CH2和CH3結構域的人IgG重鏈Fc部分的實例可以定義為例如分別對於IgG 4包含殘基D231（鉸鏈結構域的殘基）至P476（CH3結構域的C-末端的殘基）、或D231至L476，其中編號係根據Kabat。
因此，本發明之蛋白質按N-末端至C-末端的順序可以包含： (a)     第一結構域； (b)     肽連接子，該肽連接子具有選自由SEQ ID NO: 687、693和694組成之群組的胺基酸序列； (c)     第二結構域； (d)     肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 686、687、688、689、690、691、692、693或694； (e)     第三結構域（包含鉸鏈、CH2結構域和CH3結構域）的第一多肽單體； (f)     肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 695、696、697、698或699；和 (g)     第三結構域（包含鉸鏈、CH2結構域和CH3結構域）的第二多肽單體。
還設想本發明之蛋白質按N-末端至C-末端的順序包含： f)      第一結構域，該第一結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519和529；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； g)      肽連接子，該肽連接子具有選自由SEQ ID NO: 687、693和694組成之群組的胺基酸序列； h)      第二結構域，該第二結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643和646；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； i)      肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 686、687、688、689、690、691、692、693和694；和 j)      第三結構域，該第三結構域具有選自由SEQ ID NO: 700-707組成之群組的胺基酸序列。
因此，在一個實施方式中，本發明之蛋白質按N-末端至C-末端的順序包含： (a)       多肽，該多肽具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520、和530中所描述的那些； (b)      連接子，該連接子具有SEQ ID NO: 686中所描述的胺基酸序列；和 (c)       第三結構域，該第三結構域具有如SEQ ID NO: 700中所描述的胺基酸序列。
本發明較佳的蛋白質包含具有如SEQ ID NO: 661中所描述的胺基酸序列的多肽或由具有如SEQ ID NO: 661中所描述的胺基酸序列的多肽組成。
雖然這種蛋白質可以是單鏈形式，但是根據本發明待投與的蛋白質也可以具有IgG的形式並且因此具有IgG樣結構，即與天然存在的全長免疫球蛋白的結構相似的結構。在一個實施方式中，該蛋白質可以包含裝配成抗體樣結構的兩條抗體重鏈（每一條具有VH、CH1、CH2和CH3結構域）和兩條抗體輕鏈（每一條具有VL和CL結構域），或由其組成。一條臂可以與BCMA結合（因此構成「與BCMA結合的第一結構域」），一條臂可以與CD3結合（因此構成「與CD3結合的第二結構域」），並且Fc結構域（包含CH2和CH3結構域）構成「延長蛋白質的半衰期的第三結構域」。這種蛋白質也可以包含糖基化。這種蛋白質的變體也涵蓋在本發明中，例如其中結合臂不包含輕鏈但仍然結合相應靶標（BCMA或CD3）的形式，或其中對應靶標的結合臂係二價的形式。這樣的蛋白質的實例尤其描述於Harlow和Lane, Antibodies：A laboratory manual [抗體：實驗室手冊], CSHL Press [冷泉港實驗室出版社] (1988)；Kontermann和Dübel, Antibody Engineering [抗體工程], Springer [斯普林格出版社], 第2版2010；以及Little, Recombinant Antibodies for Immunotherapy [用於免疫療法的重組抗體], Cambridge University Press [劍橋大學出版社] 2009。
因此，本發明之目的是： a)      該蛋白質係單鏈蛋白質（或「單鏈多肽」，即它由一條多肽鏈組成）或由兩條、三條或四條多肽鏈組成， b)      該第一結構域包含免疫球蛋白重鏈可變區（VH1）和免疫球蛋白輕鏈可變區（VL1）， c)      該第二結構域包含免疫球蛋白重鏈可變區（VH2）和免疫球蛋白輕鏈可變區（VL2），和/或 d)      該第三結構域包含兩個免疫球蛋白鉸鏈區、兩個CH2結構域和兩個CH3結構域。
與BCMA和CD3特異性結合的結合結構域可以衍生自針對該等抗原的已知抗體或衍生自藉由使用抗原蛋白或其片段的從頭免疫方法、藉由噬菌體展示或其他本領域已知之方法獲得的新抗體或抗體片段。衍生出蛋白質的結合結構域的抗體可以是單株抗體、重組抗體、嵌合抗體、人抗體或人源化抗體。在某些實施方式中，衍生出結合結構域的抗體係單株抗體。在該等和其他實施方式中，抗體係人抗體或人源化抗體，並且可以是IgG1型、IgG2型、IgG3型或IgG4型。
在一些實施方式中，本發明之蛋白質係「分離的」或「基本上純的」蛋白質。當用於描述本文所揭露的蛋白質時，「分離的」或「基本上純的」意味著蛋白質已經從其產生環境的組分鑒定、分離和/或回收。較佳的是，蛋白質不與或基本上不與來自其產生環境的所有其他組分締合。其產生環境的污染組分，如由重組轉染細胞產生的污染組分，係可能干擾蛋白質的診斷或治療用途的材料，並且可以包括酶、激素和其他蛋白質化合物或非蛋白質化合物。應當理解，根據情況，分離的或基本上純的蛋白質可以構成給定樣本中總蛋白質/多肽含量的以重量計從80%至99.9%。藉由使用誘導型啟動子或高表現啟動子，可以以顯著更高的濃度生產所需的蛋白質。該定義包括在本領域已知的多種生物體和/或宿主細胞中產生結合蛋白質。在某些實施方式中，將蛋白質 (1) 藉由使用旋杯式序列分析儀純化至足以獲得至少15個N-末端或內部胺基酸序列的殘基的程度，或 (2) 藉由SDS-PAGE在非還原或還原條件下使用考馬斯藍或較佳的是銀染色純化至均質。然而，通常將藉由至少一個純化步驟來製備分離的蛋白質。
典型地將本發明之蛋白質配製成藥物組成物或配製物。藥物組成物的材料通常以對於投與位點可接受的濃度配製。因此可以根據本發明對配製物和組成物進行設計，以藉由任何合適的投與途徑遞送。
如本文所用，術語「藥物組成物」關於適合投與給患者，較佳的是人類患者的組成物。本發明之較佳的藥物組成物包含通常治療有效量的一種或多種本發明之蛋白質。藥物組成物可以進一步包含一種或多種（藥學上有效的）載劑、穩定劑、賦形劑、稀釋劑、增溶劑、表面活性劑、乳化劑、防腐劑和/或佐劑的合適配製物。組成物的可接受成分典型地在所採用的劑量和濃度下是對接受者無毒性的。本發明之藥物組成物包括但不限於液體、冷凍和凍乾組成物。如果藥物組成物已被凍乾，則在投與之前將凍乾材料在適當液體中重構。可以將凍乾材料在例如抑菌注射用水（BWFI）、生理鹽水、磷酸鹽緩衝鹽水（PBS）或與冷凍乾燥前蛋白質所處於的相同配製物中重構。
該等組成物可以包含藥學上可接受的載劑。通常，如本文所用，「藥學上可接受的載劑」意指與藥物投與，特別是腸胃外投與相容的任何和所有的水性和非水性溶液、無菌溶液、溶劑、緩衝劑（例如磷酸鹽緩衝鹽水（PBS）溶液）、水、懸浮液、乳液（如油/水乳液）、各種類型的潤濕劑、脂質體、分散介質和包衣。這樣的介質和藥劑在藥物組成物中的使用在本領域中是熟知的，並且包含這樣的載劑的組成物可以藉由熟知的常規方法配製。
某些實施方式提供了藥物組成物，該等藥物組成物包含本發明之蛋白質和其他一種或多種賦形劑。賦形劑可用於多種目的，如調整配製物的物理、化學或生物特性，如調整黏度和或本發明之方法以改進有效性和/或穩定這樣的配製物和方法，以防止例如由於在製造、運輸、儲存、使用前準備、投與和之後期間發生的壓力而導致的降解和腐壞。通常將賦形劑以其最低有效濃度使用。
在某些實施方式中，藥物組成物還可以含有出於修飾、保持或保存組成物的以下某些特徵（如pH、滲透壓、黏度、透明度、顏色、等滲性、氣味、無菌性、穩定性、溶解或釋放速率、吸附性或滲透性）的目的的配製材料/物質（參見Remington’s Pharmaceutical Sciences [雷明登氏藥學全書], 第18"版, 1990, Mack Publishing Company [馬克出版公司]）。
如本文所用，除非上下文另外明確指示，否則單數形式「一個」、「一種」和「該」也包括複數指示物。因此，例如，對「一種試劑」的提及包括這樣的不同試劑中的一種或多種，並且對「該方法」的提及包括提及熟悉該項技術者已知的可以修改或取代本文所述之方法的等效步驟和方法。
除非另外指示，否則在一系列元素前面的術語「至少」應被理解為指該系列中的每一個元素。熟悉該項技術者僅使用常規實驗就將認識到或能夠確定本文所述之本發明之特定實施方式的許多等效物。這樣的等效物旨在涵蓋在本發明中。
術語「和/或」在本文使用時包括「和」、「或」和「由所述術語連接的要素的全部或任何其他組合」的含義。
如本文所用，術語「約」或「大約」意指在給定值或範圍的 ± 20%內、較佳的是在15%內、更較佳的是在10%內、並且最較佳的是在5%內。它還包括具體值，例如「約50」包括值「50」。
貫穿本說明書及申請專利範圍，除非上下文另外要求，否則詞語「包含/包括（comprise以及變型如comprises和comprising）」應當被理解成隱含包括所陳述的整體或步驟、或者整體或步驟的群組，但不排除任何其他整體或步驟、或者整體或步驟的群組。當在本文中使用時，術語「包含/包括」可以用術語「含有」或「包括」來取代，或者有時在本文中使用時用術語「具有」取代。
當在本文中使用時，「由……組成」時，排除了在請求項要素中未指定的任何要素、步驟或成分。當在本文中使用時，「基本上由……組成」並不排除不實質性地影響請求項的基本和新穎特徵的材料或步驟。
在本文的每個例子中，術語「包含/包括」、「基本上由……組成」和「由……組成」中的任何一個可以用其他兩個術語中的任一個替代。
應當理解，以上說明和以下實例提供了示例性安排，但是本發明不限於本文所述之特定方法、技術、方案、材料、試劑、物質等，並且因此可以變化。本文使用的術語僅用於描述特定實施方式之目的，而不打算限制僅由請求項限定的本發明之範圍。在獨立請求項中提供了本發明之方面。在從屬請求項中提供了本發明之一些可選特徵。
本說明書引用的所有出版物和專利（包括所有專利、專利申請、科學出版物、製造商的說明書、說明書等），無論是上文還是下文，均據此藉由引用以其全文特此併入。本文沒有任何內容應解釋為承認，由於先前發明，本發明無權先於這樣的揭露內容。藉由引用併入的材料在一定程度上與本說明書發生衝突或不一致時，本說明書將替代任何這樣的材料。應理解，所揭露之發明不限於所描述之特定方法、方案和材料，因為這些可以變化。還應理解，本文使用的術語僅用於描述特定實施方式之目的，並不旨在限制所附請求項之範圍。
將從以下實例中獲得對本發明及其優點的更好理解，該等實例僅用於說明目的。該等實例並不打算並不應該被解釋為以任何方式限制本發明之範圍。 實例
背景：AMG 701（與多發性骨髓瘤（MM）細胞上的BCMA和T細胞上的CD3結合的HLE BiTE®分子）在MM臨床前模型中具有活性。這項首次在人類中進行的研究的目標包括評估患有復發性/難治性（R/R）多發性骨髓瘤患者中AMG 701的安全性和估算其最大耐受劑量（MTD）（NCT 03287908）。
方法 ：在為期4週的週期內每週投與短期IV輸注AMG 701，直至患者受益，首先投與至單一患者的群組（5、15、45 μg），然後是 ≥ 3名患者的群組（140、400、800、1200 μg），以及高劑量群組（1600、3000、4500、6500、9000、12000、180000 μg）的可能多達10名患者。符合條件的患者在接受≥2線的蛋白酶體抑制劑、IMiD和抗CD38 MAb（已批准並可獲得）後或對其不耐受的情況下，MM復發。排除僅患有髓外疾病（允許後續劑量擴大）、CNS受累，接受先前BCMA定向療法和免疫抑制療法的患者。在1600 μg的細胞介素釋放綜合症（CRS）的3級劑量限制性毒性（DLT）之後，對於所有 ≥ 1200 μg的目標劑量，均添加了800 μg的初始導入劑量，隨後在一個或兩個步驟中遞增至目標劑量，以目標劑量每週投與。如根據FDA授權的下一代定序測定法所測量的，將MRD定義為 ＜ 1/10 5個細胞。
結果（至數據截止時間Q3-2020）：中位年齡係64歲，25%的患者患有髓外疾病，患者具有中位數為六的先前治療線，82%的患者有既往幹細胞移植。93%的患者三重暴露於PI、IMiD和抗CD38 Ab，且62%的患者對PI、IMiD和抗CD38 Ab具有三重難治性。未檢測到抗AMG 701抗體。接受治療的所有82名患者中，總緩解率（ORR）為26%，17%具有 ≥ VGPR的緩解。在用3 mg至18 mg的目標劑量治療的55名患者，ORR增加至36%。在第8天前接受9 mg的目標劑量的患者組中（n = 6），5/6（83%）有緩解；該等緩解者中的80%（4/5）係三重難治性的，50%具有 ≥ VGPR的緩解。參見圖2。正在評估第8天前12 mg目標劑量的緩解數據。在d8接受18 mg目標劑量（d1的導入劑量為800 µg）的四名患者，目前為止一名出現PR，一名出現VGPR，但最終數據仍在評估。另一組在d3接受9 mg的額外劑量（即，d1 - 800 µg/d3 - 9 mg/d8 - 18 mg，隨後每週給藥18 mg目標劑量）的患者仍在評估。
[表1]：該表示出了9 mg目標劑量的群組。該表中示出的所有患者在d1接受800 µg的導入劑量，然後在d3和d8接受目標劑量。接受這種方案的5/6患者示出緩解。該表不包括在d1接受800 µg的導入劑量，隨後在d8接受9 mg的目標劑量的四名患者。sCR：嚴格完全緩解。
群組： 目標劑量（µg）* 劑量下的患者數量 至目標劑量的天數 最佳 緩解 任何緩解（月）
開始時間 持續時間
13: 9000 6 3 sCR 0.95 5.59
PR 1.88 2.80
VGPR 0.95 3.52
VGPR 0.99 0.03
PR 0.95 2.11
總體研究證明： •     可管理的安全性特徵：所有3級CRS事件係可逆的，中位持續時間為2天；50%的3級CRS指示係由瞬時LFT增加驅動的 •     在第8天前達到9 mg目標劑量的給藥方案下，出現了令人鼓舞的活性，在深度預治療患者（4/5緩解者具有三重難治性）中有83% ORR •     持續多達26個月的緩解 •     在6名患者中測試了MRD，該等患者使用的劑量為0.8 mg（n = 1）、3 mg（n = 1）、4.5 mg（n = 1）、6.5 mg（n = 2）、12 mg（n = 1），最佳緩解為3個sCR、2個CR、1個VGPR；除一名患者外，所有患者均為MRD陰性，MRD陰性持續多達22個月 •     支持每週一次給藥的IV PK特徵
更新的結果：
1.     基於從總計22個單獨AMG 701劑量遞增群組收集的數據（包括無階梯式給藥，和第1天à第8天階梯式給藥和第1天à第3天à（第5天）à第8天階梯式給藥），認為第3天投與第二劑量的給藥方案非常安全，目前有七個群組按這個方案治療患者（參見表2）。
2.     截止2021年10月19日，用這種給藥方案已經治療50名患者（即，第3天施用第二劑量）： a.       20名患者仍在治療 b.      中位年齡係66歲，且大多數為男性（54%），與先前報告的數據具有相似基線特徵 c.       對於接受治療的患者，ORR為54%，而對於可評估緩解的患者，ORR為60% d.      BOR分佈顯示於下表2 e.       儘管最後兩個群組（15B和15C）的數據仍係未成熟的，但安全性特徵看起來與先前報告的數據一致。CRS（細胞介素釋放綜合症）發病率已改善，尤其是在群組15C內（仍在招募）中：在最後兩個群組（15B和15C）中，未報告3級或更高級。
[表2]：第1天/第3天/（第5天）/第8天投與方案的群組的最佳總體緩解（BOR）分佈（數字「n」和百分比）。sCR = 嚴格完全緩解。CR = 完全緩解。VGPR = 非常好的部分緩解。PR = 部分緩解。MR = 最小緩解。SD = 疾病穩定。PD =進展性疾病。NE = 無法評估。
   群組 12擴展： 800 μg/6.5 mg （N = 6） 群組 13擴展： 800 μg/9 mg （N = 6） 群組 14擴展： 800 μg/12 mg （N = 9） 群組 14A： 800 μg/9 mg/12 mg （N = 4） 群組 15A： 800 μg/9 mg/18 mg （N = 8） 群組 15B： 800 μg/6 mg/18 mg （N = 10） 群組 15C： 800 μg/4.5 mg/9 mg/18 mg （N = 7） d3第2次劑量的總計       （N = 50） 總體 總計 （N = 116）
sCR 1 (16.7) 1 (16.7) 1 (11.1) 0 (0.0) 1 (12.5) 1 (10.0) 0 (0.0) 5 (10.0) 10 (8.6)
CR 1 (16.7) 0 (0.0) 3 (33.3) 2 (50.0) 3 (37.5) 0 (0.0) 1 (14.3) 10 (20.0) 12 (10.3)
VGPR 0 (0.0) 1 (16.7) 0 (0.0) 0 (0.0) 2 (25.0) 3 (30.0) 0 (0.0) 6 (12.0) 10 (8.6)
PR 0 (0.0) 3 (50.0) 1 (11.1) 0 (0.0) 0 (0.0) 1 (10.0) 1 (14.3) 6 (12.0) 9 (7.8)
MR 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (0.9)
SD 3 (50.0) 0 (0.0) 3 (33.3) 0 (0.0) 2 (25.0) 3 (30.0) 1 (14.3) 12 (24.0) 36 (31.0)
PD 1 (16.7) 1 (16.7) 1 (11.1) 0 (0.0) 0 (0.0) 2 (20.0) 1 (14.3) 6 (12.0) 18 (15.5)
NE 0 (0.0) 0 (0.0) 0 (0.0) 2 (50.0) 0 (0.0) 0 (0.0) 3 (42.9) 5 (10.0) 20 (17.2)
階梯式給藥群組和它們的ORR和CRS結果也參見圖3。
完全緩解的IMWG緩解標準（CR，還參見http://imwg.myeloma.org/international-myeloma-working-group-imwg-uniform-response-criteria-for-multiple-myeloma/）係： •     對血清和尿的M蛋白免疫固定陰性， •     不存在任何軟組織漿細胞瘤，和 •     骨髓中漿細胞 ＜ 5%
部分緩解（PR）的IMWG緩解標準係： •     M蛋白電泳：血清M蛋白降低 ≥ 50%，以及24小時內尿M蛋白降低 ≥ 90%或達到 ＜ 200 mg/24 h •     游離輕鏈（FLC）：如果血清和尿M蛋白不可測量，則需要受累和未受累的FLC水平之間的差異降低 ≥ 50%來代替M蛋白標準 •     如果無法進行血清和尿M蛋白檢測以及血清游離輕鏈測定：漿細胞需降低 ≥ 50%，以代替M蛋白，前提係基線骨髓漿細胞百分比 ≥ 30% •     除上文列出的標準之外，如果目前在基線水平，則還需軟組織漿細胞瘤的尺寸降低 ≥ 50%
很好的部分緩解的IMWG緩解標準（VGPR）係： •     可藉由免疫固定檢測到血清和尿M蛋白，但不能藉由電泳檢測到或血清M蛋白降低 ≥ 90%且尿M蛋白水平 ＜ 100 mg/24 h
無
[圖1]示出了第1週階梯式給藥優化方案。如圖1中所命名的「階梯劑量」對應於第一劑量，「階梯劑量2」對應於第二劑量。
[圖2]示出了AMG 701臨床試驗的總緩解率（數據截止時間：Q3-2020）。
[圖3]示出了AMG 701臨床試驗群組（cohort）的更新版本（數據截止時間：2021九月），群組15B和15C正在進行。ORR = 總緩解率。CRS = 細胞介素釋放綜合症。
無
 

          <![CDATA[<110>  美商安進公司（Amgen Inc.）]]>
          <![CDATA[<120>  用於投與BCMAxCD3結合分子之方法]]>
          <![CDATA[<130>  32243/55257]]>
          <![CDATA[<140>  TW 110141852]]>
          <![CDATA[<141>  2021-11-10]]>
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          Asn Tyr Asp Met Ala 
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          Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 
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          Gly 
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          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
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          <![CDATA[<210>  4]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<400>  4]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
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          <![CDATA[<210>  5]]>
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          <![CDATA[<212>  PRT]]>
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          <![CDATA[<400>  5]]>
          Gly Ala Ser Asn Arg His Thr 
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          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
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          <![CDATA[<210>  7]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<400>  7]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  8]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<400>  8]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  9]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  9]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  10]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  10]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  11]]>
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          <![CDATA[<400>  11]]>
          Asn Tyr Asp Met Ala 
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          <![CDATA[<210>  12]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<220>]]>
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          <![CDATA[<400>  12]]>
          Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  13]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  13]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  14]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<220>]]>
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          <![CDATA[<400>  14]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
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          <![CDATA[<210>  15]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  15]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  16]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
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          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  16]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  17]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  17]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  18]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  18]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  19]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  19]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  20]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  20]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  21]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  21]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  22]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  22]]>
          Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  23]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  23]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  24]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  24]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  25]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  25]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  26]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  26]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  27]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  27]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  28]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  28]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  29]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  29]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  30]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  30]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  31]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  31]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  32]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  32]]>
          Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  33]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  33]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  34]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  34]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  35]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  35]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  36]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  36]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  37]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  37]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  38]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  38]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  39]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  39]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  40]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  40]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  41]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  41]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  42]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  42]]>
          Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  43]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  43]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  44]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  44]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  45]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  45]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  46]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  46]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  47]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  47]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  48]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  48]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  49]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  49]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  50]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  50]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  51]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  51]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  52]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  52]]>
          Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  53]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  53]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  54]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  54]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  55]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  55]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  56]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  56]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  57]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  57]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  58]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  58]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  59]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  59]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  60]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  60]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  61]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  61]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  62]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  62]]>
          Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  63]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  63]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  64]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  64]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  65]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  65]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  66]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  66]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  67]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  67]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  68]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  68]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  69]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  69]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  70]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  70]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  71]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  71]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  72]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  72]]>
          Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  73]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  73]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  74]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  74]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  75]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  75]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  76]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  76]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  77]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  77]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  78]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  78]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  79]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  79]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  80]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  80]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  81]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  81]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  82]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  82]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  83]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  83]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  84]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  84]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  85]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  85]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  86]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  86]]>
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  87]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  87]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  88]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  88]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  89]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  89]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  90]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  90]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  91]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  91]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  92]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  92]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  93]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  93]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  94]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  94]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  95]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  95]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  96]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  96]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  97]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  97]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  98]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  98]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  99]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  99]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  100]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  100]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  101]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  101]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  102]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  102]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  103]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  103]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  104]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  104]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  105]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  105]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  106]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  106]]>
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  107]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  107]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  108]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  108]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  109]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  109]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  110]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  110]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  111]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  111]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  112]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  112]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  113]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  113]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  114]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  114]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  115]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  115]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  116]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  116]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  117]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  117]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  118]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  118]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  119]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  119]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  120]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  120]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  121]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  121]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  122]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  122]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  123]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  123]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  124]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  124]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  125]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  125]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  126]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  126]]>
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  127]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  127]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  128]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  128]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  129]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  129]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  130]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  130]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  131]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  131]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  132]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  132]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  133]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  133]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  134]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  134]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  135]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  135]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  136]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  136]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  137]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  137]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  138]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  138]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  139]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  139]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  140]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  140]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  141]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  141]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  142]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  142]]>
          Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  143]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  143]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  144]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  144]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  145]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  145]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  146]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  146]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  147]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  147]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  148]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  148]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  149]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  149]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  150]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  150]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  151]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  151]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  152]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  152]]>
          Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  153]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  153]]>
          Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  154]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  154]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  155]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  155]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  156]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  156]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  157]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  157]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  158]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  158]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  159]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  159]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  160]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  160]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  161]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  161]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  162]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  162]]>
          Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  163]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  163]]>
          Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  164]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  164]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  165]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  165]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  166]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  166]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  167]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  167]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  168]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  168]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  169]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  169]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  170]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  170]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  171]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  171]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  172]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  172]]>
          Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  173]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  173]]>
          Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  174]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  174]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  175]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  175]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  176]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  176]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  177]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  177]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  178]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  178]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Pro 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  179]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  179]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  180]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  180]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  181]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  181]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  182]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  182]]>
          Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  183]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  183]]>
          Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  184]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  184]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  185]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  185]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  186]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  186]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  187]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  187]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  188]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  188]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Pro 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  189]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  189]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  190]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  190]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  191]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  191]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  192]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  192]]>
          Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  193]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  193]]>
          Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  194]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  194]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  195]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  195]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  196]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  196]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  197]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  197]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  198]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  198]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Ser Phe Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  199]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  199]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  200]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  200]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  201]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  201]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  202]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  202]]>
          Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  203]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  203]]>
          Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  204]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  204]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  205]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  205]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  206]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  206]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  207]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  207]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  208]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  208]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Ser Phe Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  209]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  209]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  210]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  210]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  211]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  211]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  212]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  212]]>
          Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  213]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  213]]>
          Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  214]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  214]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  215]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  215]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  216]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  216]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  217]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  217]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  218]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  218]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  219]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  219]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  220]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  220]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  221]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  221]]>
          Asn His Ile Ile His 
          1               5   
          <![CDATA[<210>  222]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  222]]>
          Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe Gln 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  223]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  223]]>
          Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  224]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  224]]>
          Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  225]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  225]]>
          Tyr Thr Ser Arg Leu His Thr 
          1               5           
          <![CDATA[<210>  226]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  226]]>
          Gln Gln Gly Asn Thr Leu Pro Trp Thr 
          1               5                   
          <![CDATA[<210>  227]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  227]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  228]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  228]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 
          65                  70                  75                  80  
          Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  229]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  229]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  230]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  230]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 
              50                  55                  60                  
          Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  231]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  231]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  232]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  232]]>
          Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  233]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  233]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  234]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  234]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  235]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  235]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  236]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  236]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  237]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  237]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  238]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  238]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  239]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  239]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  240]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  240]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  241]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  241]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  242]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  242]]>
          Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  243]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  243]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  244]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  244]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  245]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  245]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  246]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  246]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  247]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  247]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  248]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  248]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  249]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  249]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  250]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  250]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  251]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  251]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  252]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  252]]>
          Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  253]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  253]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  254]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  254]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  255]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  255]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  256]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  256]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  257]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  257]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  258]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  258]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  259]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  259]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  260]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  260]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  261]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  261]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  262]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  262]]>
          Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  263]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  263]]>
          His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  264]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  264]]>
          Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 
          1               5                   10      
          <![CDATA[<210>  265]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  265]]>
          Gly Ala Ser Asn Arg His Thr 
          1               5           
          <![CDATA[<210>  266]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  266]]>
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr 
          1               5                   
          <![CDATA[<210>  267]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  267]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  268]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  268]]>
          Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
          1               5                   10                  15      
          Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 
                      20                  25                  30          
          Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
          65                  70                  75                  80  
          Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 
                          85                  90                  95      
          Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
                      100                 105         
          <![CDATA[<210>  269]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  269]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys 
          <![CDATA[<210>  270]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  270]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 
          145                 150                 155                 160 
          Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 
                      180                 185                 190         
          Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
          225                 230                 235                 240 
          Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  271]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  271]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  272]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  272]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  273]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  273]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  274]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  274]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  275]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  275]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  276]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  276]]>
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  277]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  277]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  278]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  278]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  279]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  279]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  280]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  280]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  281]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  281]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  282]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  282]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  283]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  283]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  284]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  284]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  285]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  285]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  286]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  286]]>
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  287]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  287]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  288]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  288]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  289]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  289]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  290]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  290]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  291]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  291]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  292]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  292]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  293]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  293]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  294]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  294]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  295]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  295]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  296]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  296]]>
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  297]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  297]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  298]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  298]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  299]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  299]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  300]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  300]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  301]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  301]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  302]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  302]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  303]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  303]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  304]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  304]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  305]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  305]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  306]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  306]]>
          Ala Gly Pro His Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  307]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  307]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  308]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  308]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  309]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  309]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  310]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  310]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  311]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  311]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  312]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  312]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  313]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  313]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  314]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  314]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  315]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  315]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  316]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  316]]>
          Ala Gly Pro His Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  317]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  317]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  318]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  318]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  319]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  319]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  320]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  320]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  321]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  321]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  322]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  322]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  323]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  323]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  324]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  324]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  325]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  325]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  326]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  326]]>
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr 
          1               5                   
          <![CDATA[<210>  327]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  327]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  328]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  328]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  329]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  329]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  330]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  330]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  331]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  331]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  332]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  332]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  333]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  333]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  334]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  334]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  335]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  335]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  336]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  336]]>
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr 
          1               5                   
          <![CDATA[<210>  337]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  337]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  338]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  338]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  339]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  339]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  340]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  340]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  341]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  341]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  342]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  342]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  343]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  343]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  344]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  344]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  345]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  345]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  346]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  346]]>
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr 
          1               5                   
          <![CDATA[<210>  347]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  347]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  348]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  348]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  349]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  349]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  350]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  350]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  351]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  351]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  352]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  352]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  353]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  353]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  354]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  354]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  355]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  355]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  356]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  356]]>
          Ala Gly Pro His Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  357]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  357]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  358]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  358]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  359]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  359]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  360]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  360]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  361]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  361]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  362]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  362]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  363]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  363]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  364]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  364]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  365]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  365]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  366]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  366]]>
          Ala Gly Pro His Lys Tyr Pro Leu Thr 
          1               5                   
          <![CDATA[<210>  367]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  367]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  368]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  368]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  369]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  369]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  370]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  370]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  371]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  371]]>
          Asn Tyr Asp Met Ala 
          1               5   
          <![CDATA[<210>  372]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  372]]>
          Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  373]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  373]]>
          Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 
          1               5                   10          
          <![CDATA[<210>  374]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  374]]>
          Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 
          1               5                   10      
          <![CDATA[<210>  375]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  375]]>
          Gly Ala Ser Ser Leu Gln Asp 
          1               5           
          <![CDATA[<210>  376]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  376]]>
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr 
          1               5                   
          <![CDATA[<210>  377]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  377]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  378]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  378]]>
          Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 
                      20                  25                  30          
          Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
                  35                  40                  45              
          Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 
          65                  70                  75                  80  
          Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  379]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  379]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  380]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  380]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  381]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  381]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  382]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  382]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  383]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  383]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  384]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  384]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  385]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  385]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  386]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  386]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  387]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  387]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  388]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  388]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  389]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  389]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  390]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  390]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  391]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  391]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  392]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  392]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  393]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  393]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  394]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  394]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  395]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  395]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  396]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  396]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  397]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  397]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  398]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  398]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  399]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  399]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  400]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  400]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  401]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  401]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  402]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  402]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  403]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  403]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  404]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  404]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  405]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  405]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  406]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  406]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  407]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  407]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  408]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  408]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  409]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  409]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  410]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  410]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  411]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  411]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  412]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  412]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  413]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  413]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  414]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  414]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
          1               5                   10      
          <![CDATA[<210>  415]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  415]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  416]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  416]]>
          Met Gly Gln Thr Ile Ser Ser Tyr Thr 
          1               5                   
          <![CDATA[<210>  417]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  417]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  418]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  418]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  419]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  419]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  420]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  420]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  421]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  421]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  422]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  422]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  423]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  423]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  424]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  424]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  425]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  425]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  426]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  426]]>
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  427]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  427]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  428]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  428]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Phe Gln Gln Lys Pro Gly Arg Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  429]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  429]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  430]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  430]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  431]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  431]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  432]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  432]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  433]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  433]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  434]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  434]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  435]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  435]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  436]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  436]]>
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  437]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  437]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  438]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  438]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  439]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  439]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  440]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  440]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  441]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  441]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  442]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  442]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  443]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  443]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  444]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  444]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  445]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  445]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  446]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  446]]>
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  447]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  447]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  448]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  448]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  449]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  449]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  450]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  450]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  451]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  451]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  452]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  452]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  453]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  453]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  454]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  454]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  455]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  455]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  456]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  456]]>
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  457]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  457]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  458]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  458]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  459]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  459]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  460]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  460]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  461]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  461]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  462]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  462]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  463]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  463]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  464]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  464]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  465]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  465]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  466]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  466]]>
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  467]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  467]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  468]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  468]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Phe Gln Gln Lys Pro Gly Arg Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  469]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  469]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  470]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  470]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  471]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  471]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  472]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  472]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  473]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  473]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  474]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  474]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  475]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  475]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  476]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  476]]>
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  477]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  477]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  478]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  478]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  479]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  479]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  480]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  480]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  481]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  481]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  482]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  482]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  483]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  483]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  484]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  484]]>
          Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 
          1               5                   10      
          <![CDATA[<210>  485]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  485]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  486]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  486]]>
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  487]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  487]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  488]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  488]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  489]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  489]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  490]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  490]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  491]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  491]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  492]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  492]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  493]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  493]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  494]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  494]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
          1               5                   10      
          <![CDATA[<210>  495]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  495]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  496]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  496]]>
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  497]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  497]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  498]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  498]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  499]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  499]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  500]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  500]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  501]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  501]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  502]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  502]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  503]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  503]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  504]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  504]]>
          Arg Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn 
          1               5                   10      
          <![CDATA[<210>  505]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  505]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  506]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  506]]>
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  507]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  507]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  508]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  508]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  509]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  509]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  510]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  510]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  511]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  511]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  512]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  512]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  513]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  513]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  514]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  514]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
          1               5                   10      
          <![CDATA[<210>  515]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  515]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  516]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  516]]>
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  517]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  517]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  518]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  518]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  519]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  519]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  520]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  520]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  521]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  521]]>
          Asn Phe Asp Met Ala 
          1               5   
          <![CDATA[<210>  522]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  522]]>
          Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  523]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  523]]>
          His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 
          1               5                   10          
          <![CDATA[<210>  524]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  524]]>
          Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 
          1               5                   10      
          <![CDATA[<210>  525]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  525]]>
          Tyr Thr Ser Asn Leu Gln Ser 
          1               5           
          <![CDATA[<210>  526]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  526]]>
          Gln Gln Phe Ala His Leu Pro Tyr Thr 
          1               5                   
          <![CDATA[<210>  527]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  527]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120     
          <![CDATA[<210>  528]]>
          <![CDATA[<211>  107]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  528]]>
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
          1               5                   10                  15      
          Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 
                      20                  25                  30          
          Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
                  35                  40                  45              
          Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
              50                  55                  60                  
          Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
          65                  70                  75                  80  
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Ala His Leu Pro Tyr 
                          85                  90                  95      
          Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                      100                 105         
          <![CDATA[<210>  529]]>
          <![CDATA[<211>  243]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  529]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Ala His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys 
          <![CDATA[<210>  530]]>
          <![CDATA[<211>  498]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  530]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
                      20                  25                  30          
          Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
                  35                  40                  45              
          Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
          145                 150                 155                 160 
          Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
                  195                 200                 205             
          Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Phe Ala His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu 
          <![CDATA[<210>  531]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  531]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  532]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  532]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  533]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  533]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  534]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  534]]>
          Ile Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  535]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  535]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Ser 
          <![CDATA[<210>  536]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  536]]>
          His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  537]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  537]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  538]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  538]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  539]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  539]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  540]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  540]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  541]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  541]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  542]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  542]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  543]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  543]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  544]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  544]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  545]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  545]]>
          Lys Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  546]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  546]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Asp 
          <![CDATA[<210>  547]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  547]]>
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  548]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  548]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  549]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  549]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  550]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  550]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  551]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  551]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  552]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  552]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  553]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  553]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  554]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  554]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  555]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  555]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  556]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  556]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  557]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  557]]>
          Ser Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  558]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  558]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Gly 
          <![CDATA[<210>  559]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  559]]>
          His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  560]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  560]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  561]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  561]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  562]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  562]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  563]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  563]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  564]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  564]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Phe Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  565]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  565]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  566]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  566]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  567]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  567]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  568]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  568]]>
          Arg Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  569]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  569]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Gly 
          <![CDATA[<210>  570]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  570]]>
          His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  571]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  571]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  572]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  572]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  573]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  573]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  574]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  574]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  575]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  575]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Tyr Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  576]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  576]]>
          Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  577]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  577]]>
          Ala Thr Asp Met Arg Pro Ser 
          1               5           
          <![CDATA[<210>  578]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  578]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  579]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  579]]>
          Val Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  580]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  580]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Lys 
          <![CDATA[<210>  581]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  581]]>
          His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  582]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  582]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  583]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  583]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  584]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  584]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  585]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  585]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  586]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  586]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
                      180                 185                 190         
          Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  587]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  587]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Leu Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
                      180                 185                 190         
          Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  588]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  588]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  589]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  589]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  590]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  590]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  591]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  591]]>
          Lys Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  592]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  592]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Ser 
          <![CDATA[<210>  593]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  593]]>
          His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  594]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  594]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  595]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  595]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  596]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  596]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  597]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  597]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  598]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  598]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Thr Ser Tyr Tyr 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  599]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  599]]>
          Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  600]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  600]]>
          Ala Thr Asp Met Arg Pro Ser 
          1               5           
          <![CDATA[<210>  601]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  601]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  602]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  602]]>
          Gly Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  603]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  603]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Glu 
          <![CDATA[<210>  604]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  604]]>
          His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  605]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  605]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  606]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  606]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  607]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  607]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Ala Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  608]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  608]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
                      180                 185                 190         
          Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  609]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  609]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Glu Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Arg Asn Phe Gly Asn Ser Tyr Leu Ser Trp Phe 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Ala 
                      180                 185                 190         
          Thr Asp Met Arg Pro Ser Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  610]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  610]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  611]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  611]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  612]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  612]]>
          Ala Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  613]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  613]]>
          Val Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  614]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  614]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Lys 
          <![CDATA[<210>  615]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  615]]>
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  616]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  616]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  617]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  617]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  618]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  618]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  619]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  619]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  620]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  620]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Lys Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  621]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  621]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  622]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  622]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  623]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  623]]>
          Val Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  624]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  624]]>
          Ser Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  625]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  625]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Gly 
          <![CDATA[<210>  626]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  626]]>
          His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  627]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  627]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  628]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  628]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  629]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  629]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  630]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  630]]>
          Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  631]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  631]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  632]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  632]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  633]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  633]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  634]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  634]]>
          Gly Thr Lys Phe Leu Ala Pro 
          1               5           
          <![CDATA[<210>  635]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  635]]>
          Val Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  636]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  636]]>
          Lys Tyr Ala Met Asn 
          1               5   
          <![CDATA[<210>  637]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  637]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Asp 
          <![CDATA[<210>  638]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  638]]>
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  639]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  639]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  640]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  640]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  641]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  641]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  642]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  642]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  643]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  643]]>
          Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  644]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  644]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  645]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  645]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  646]]>
          <![CDATA[<211>  249]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  646]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
              130                 135                 140                 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
          145                 150                 155                 160 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                          165                 170                 175     
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                      180                 185                 190         
          Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                  195                 200                 205             
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
              210                 215                 220                 
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
          225                 230                 235                 240 
          Gly Gly Gly Thr Lys Leu Thr Val Leu 
                          245                 
          <![CDATA[<210>  647]]>
          <![CDATA[<211>  184]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<400>  647]]>
          Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
          1               5                   10                  15      
          Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
                      20                  25                  30          
          Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
                  35                  40                  45              
          Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
              50                  55                  60                  
          Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
          65                  70                  75                  80  
          Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                          85                  90                  95      
          Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
                      100                 105                 110         
          Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
                  115                 120                 125             
          Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
              130                 135                 140                 
          Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
          145                 150                 155                 160 
          Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                          165                 170                 175     
          Ile Glu Lys Ser Ile Ser Ala Arg 
                      180                 
          <![CDATA[<210>  648]]>
          <![CDATA[<211>  183]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  恒河猴]]>
          <![CDATA[<400>  648]]>
          Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
          1               5                   10                  15      
          Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
                      20                  25                  30          
          Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
                  35                  40                  45              
          Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile 
              50                  55                  60                  
          Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser 
          65                  70                  75                  80  
          Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu 
                          85                  90                  95      
          Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile 
                      100                 105                 110         
          Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
                  115                 120                 125             
          Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
              130                 135                 140                 
          Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
          145                 150                 155                 160 
          Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile 
                          165                 170                 175     
          Glu Lys Ser Ile Ser Ala Arg 
                      180             
          <![CDATA[<210>  649]]>
          <![CDATA[<211>  54]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<400>  649]]>
          Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
          1               5                   10                  15      
          Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
                      20                  25                  30          
          Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
                  35                  40                  45              
          Val Lys Gly Thr Asn Ala 
              50                  
          <![CDATA[<210>  650]]>
          <![CDATA[<211>  53]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  恒河猴]]>
          <![CDATA[<400>  650]]>
          Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
          1               5                   10                  15      
          Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
                      20                  25                  30          
          Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
                  35                  40                  45              
          Lys Gly Met Asn Ala 
              50              
          <![CDATA[<210>  651]]>
          <![CDATA[<211>  18]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<400>  651]]>
          Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg 
          1               5                   10                  15      
          Tyr Cys 
          <![CDATA[<210>  652]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  恒河猴]]>
          <![CDATA[<400>  652]]>
          Cys Gln Leu Arg Cys Ser Ser Thr Pro Pro Leu Thr Cys Gln Arg Tyr 
          1               5                   10                  15      
          Cys 
          <![CDATA[<210>  653]]>
          <![CDATA[<211>  105]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<400>  653]]>
          Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
                      20                  25                  30          
          Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
                  35                  40                  45              
          Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
              50                  55                  60                  
          Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
          65                  70                  75                  80  
          Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                          85                  90                  95      
          Val Cys Glu Asn Cys Met Glu Met Asp 
                      100                 105 
          <![CDATA[<210>  654]]>
          <![CDATA[<211>  27]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  智人]]>
          <![CDATA[<400>  654]]>
          Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
                      20                  25          
          <![CDATA[<210>  655]]>
          <![CDATA[<211>  96]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  普通狨（Callithrix jacchus）]]>
          <![CDATA[<400>  655]]>
          Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
                      20                  25                  30          
          Gly His Glu Ile Lys Trp Leu Val Asn Ser Gln Asn Lys Glu Gly His 
                  35                  40                  45              
          Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
              50                  55                  60                  
          Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Ala Glu Glu Ala Ser His 
          65                  70                  75                  80  
          Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                          85                  90                  95      
          <![CDATA[<210>  656]]>
          <![CDATA[<211>  27]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  普通狨]]>
          <![CDATA[<400>  656]]>
          Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
                      20                  25          
          <![CDATA[<210>  657]]>
          <![CDATA[<211>  96]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  絨頂檉柳猴（Saguinus oedipus）]]>
          <![CDATA[<400>  657]]>
          Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
                      20                  25                  30          
          Gly His Glu Ile Lys Trp Leu Val Asn Ser Gln Asn Lys Glu Gly His 
                  35                  40                  45              
          Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
              50                  55                  60                  
          Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Ala Glu Glu Ala Ser His 
          65                  70                  75                  80  
          Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                          85                  90                  95      
          <![CDATA[<210>  658]]>
          <![CDATA[<211>  27]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  絨頂檉柳猴]]>
          <![CDATA[<400>  658]]>
          Gln Asp Gly Asn Glu Glu Met Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
                      20                  25          
          <![CDATA[<210>  659]]>
          <![CDATA[<211>  96]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  松鼠猴（Saimiri sciureus）]]>
          <![CDATA[<400>  659]]>
          Gln Asp Gly Asn Glu Glu Ile Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr Cys Pro Arg Tyr Asp 
                      20                  25                  30          
          Gly Gln Glu Ile Lys Trp Leu Val Asn Asp Gln Asn Lys Glu Gly His 
                  35                  40                  45              
          Glu Asp His Leu Leu Leu Glu Asp Phe Ser Glu Met Glu Gln Ser Gly 
              50                  55                  60                  
          Tyr Tyr Ala Cys Leu Ser Lys Glu Thr Pro Thr Glu Glu Ala Ser His 
          65                  70                  75                  80  
          Tyr Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val Glu Val Asp 
                          85                  90                  95      
          <![CDATA[<210>  660]]>
          <![CDATA[<211>  27]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  松鼠猴]]>
          <![CDATA[<400>  660]]>
          Gln Asp Gly Asn Glu Glu Ile Gly Asp Thr Thr Gln Asn Pro Tyr Lys 
          1               5                   10                  15      
          Val Ser Ile Ser Gly Thr Thr Val Thr Leu Thr 
                      20                  25          
          <![CDATA[<210>  661]]>
          <![CDATA[<211>  986]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  661]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
          1               5                   10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
                      20                  25                  30          
          Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
                  35                  40                  45              
          Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 
              50                  55                  60                  
          Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
          145                 150                 155                 160 
          Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
              210                 215                 220                 
          Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly Thr Lys Val 
          225                 230                 235                 240 
          Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
          385                 390                 395                 400 
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                          405                 410                 415     
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
                      420                 425                 430         
          Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
                  435                 440                 445             
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
              450                 455                 460                 
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                          485                 490                 495     
          Val Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                      500                 505                 510         
          Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                  515                 520                 525             
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
              530                 535                 540                 
          Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
          545                 550                 555                 560 
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
                          565                 570                 575     
          Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
                      580                 585                 590         
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                  595                 600                 605             
          Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
              610                 615                 620                 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
          625                 630                 635                 640 
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                          645                 650                 655     
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                      660                 665                 670         
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                  675                 680                 685             
          Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
              690                 695                 700                 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
          705                 710                 715                 720 
          Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
                          725                 730                 735     
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      740                 745                 750         
          Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                  755                 760                 765             
          Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
              770                 775                 780                 
          Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
          785                 790                 795                 800 
          Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                          805                 810                 815     
          Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu 
                      820                 825                 830         
          Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu 
                  835                 840                 845             
          His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
              850                 855                 860                 
          Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
          865                 870                 875                 880 
          Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                          885                 890                 895     
          Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                      900                 905                 910         
          Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                  915                 920                 925             
          Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
              930                 935                 940                 
          Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
          945                 950                 955                 960 
          Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                          965                 970                 975     
          Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                      980                 985     
          <![CDATA[<210>  662]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  662]]>
          His His His His His 
          1               5   
          <![CDATA[<210>  663]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  663]]>
          His His His His His His 
          1               5       
          <![CDATA[<210>  664]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  664]]>
          His His His His His His His 
          1               5           
          <![CDATA[<210>  665]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  665]]>
          His His His His His His His His 
          1               5               
          <![CDATA[<210>  666]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  666]]>
          Asp Thr Tyr Arg Tyr Ile 
          1               5       
          <![CDATA[<210>  667]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  667]]>
          Thr Asp Phe Tyr Leu Lys 
          1               5       
          <![CDATA[<210>  668]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  668]]>
          Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
          1               5                   10      
          <![CDATA[<210>  669]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  669]]>
          Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
          1               5                   10                  
          <![CDATA[<210>  670]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  670]]>
          Gln Tyr Pro Ala Leu Thr 
          1               5       
          <![CDATA[<210>  671]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  671]]>
          Ser Ser Thr Ser Ser Asp Phe Arg Asp Arg 
          1               5                   10  
          <![CDATA[<210>  672]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  672]]>
          Asp Tyr Lys Asp Asp Asp Lys 
          1               5           
          <![CDATA[<210>  673]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  673]]>
          Glu Tyr Met Pro Met Glu 
          1               5       
          <![CDATA[<210>  674]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  674]]>
          Glu Phe Met Pro Met Glu 
          1               5       
          <![CDATA[<210>  675]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  675]]>
          Lys Asp His Leu Ile His Asn Val His Lys Glu Phe His Ala His Ala 
          1               5                   10                  15      
          His Asn Lys 
          <![CDATA[<210>  676]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  676]]>
          Gln Pro Glu Leu Ala Pro Glu Asp 
          1               5               
          <![CDATA[<210>  677]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  677]]>
          Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
          1               5                   10      
          <![CDATA[<210>  678]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  678]]>
          Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
          1               5                   10      
          <![CDATA[<210>  679]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  679]]>
          Asn Ala Asn Asn Pro Asp Trp Asp Phe 
          1               5                   
          <![CDATA[<210>  680]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  680]]>
          Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
          1               5                   10                  15  
          <![CDATA[<210>  681]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  681]]>
          Trp Ser His Pro Gln Phe Glu Lys 
          1               5               
          <![CDATA[<210>  682]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  682]]>
          Ala Trp Ala His Pro Gln Pro Gly Gly 
          1               5                   
          <![CDATA[<210>  683]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  683]]>
          His Thr Thr Pro His His 
          1               5       
          <![CDATA[<210>  684]]>
          <![CDATA[<211>  11]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  684]]>
          Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
          1               5                   10      
          <![CDATA[<210>  685]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  685]]>
          Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
          1               5                   10          
          <![CDATA[<210>  686]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  686]]>
          Gly Gly Gly Gly 
          1               
          <![CDATA[<210>  687]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  687]]>
          Gly Gly Gly Gly Ser 
          1               5   
          <![CDATA[<210>  688]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  688]]>
          Gly Gly Gly Gly Gln 
          1               5   
          <![CDATA[<210>  689]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  689]]>
          Ser Gly Gly Gly Gly Ser 
          1               5       
          <![CDATA[<210>  690]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  690]]>
          Pro Gly Gly Gly Gly Ser 
          1               5       
          <![CDATA[<210>  691]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  691]]>
          Pro Gly Gly Asp Gly Ser 
          1               5       
          <![CDATA[<210>  692]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  692]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Ser 
          1               5                   
          <![CDATA[<210>  693]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  693]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   10  
          <![CDATA[<210>  694]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  694]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  695]]>
          <![CDATA[<211>  20]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  695]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser 
                      20  
          <![CDATA[<210>  696]]>
          <![CDATA[<211>  25]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  696]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      20                  25  
          <![CDATA[<210>  697]]>
          <![CDATA[<211>  30]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  697]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      20                  25                  30  
          <![CDATA[<210>  698]]>
          <![CDATA[<211>  35]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  698]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                      20                  25                  30          
          Gly Gly Ser 
                  35  
          <![CDATA[<210>  699]]>
          <![CDATA[<211>  40]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  699]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
          1               5                   10                  15      
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                      20                  25                  30          
          Gly Gly Ser Gly Gly Gly Gly Ser 
                  35                  40  
          <![CDATA[<210>  700]]>
          <![CDATA[<211>  484]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  700]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          245                 250                 255     
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                      260                 265                 270         
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                  275                 280                 285             
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
              290                 295                 300                 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
          305                 310                 315                 320 
          Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr 
                          325                 330                 335     
          Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                      340                 345                 350         
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                  355                 360                 365             
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
              370                 375                 380                 
          Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
          385                 390                 395                 400 
          Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                          405                 410                 415     
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                      420                 425                 430         
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                  435                 440                 445             
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
              450                 455                 460                 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
          465                 470                 475                 480 
          Ser Pro Gly Lys 
          <![CDATA[<210>  701]]>
          <![CDATA[<211>  480]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  701]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          225                 230                 235                 240 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                          245                 250                 255     
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                      260                 265                 270         
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                  275                 280                 285             
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
              290                 295                 300                 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
          305                 310                 315                 320 
          Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
                          325                 330                 335     
          Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                      340                 345                 350         
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                  355                 360                 365             
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
              370                 375                 380                 
          Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
          385                 390                 395                 400 
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                          405                 410                 415     
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                      420                 425                 430         
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                  435                 440                 445             
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
              450                 455                 460                 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
          465                 470                 475                 480 
          <![CDATA[<210>  702]]>
          <![CDATA[<211>  484]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  702]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          245                 250                 255     
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                      260                 265                 270         
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                  275                 280                 285             
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
              290                 295                 300                 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
          305                 310                 315                 320 
          Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                          325                 330                 335     
          Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                      340                 345                 350         
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                  355                 360                 365             
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
              370                 375                 380                 
          Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
          385                 390                 395                 400 
          Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                          405                 410                 415     
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                      420                 425                 430         
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                  435                 440                 445             
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
              450                 455                 460                 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
          465                 470                 475                 480 
          Ser Pro Gly Lys 
          <![CDATA[<210>  703]]>
          <![CDATA[<211>  480]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  703]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          225                 230                 235                 240 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                          245                 250                 255     
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                      260                 265                 270         
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                  275                 280                 285             
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
              290                 295                 300                 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
          305                 310                 315                 320 
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                          325                 330                 335     
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                      340                 345                 350         
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                  355                 360                 365             
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
              370                 375                 380                 
          Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
          385                 390                 395                 400 
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                          405                 410                 415     
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                      420                 425                 430         
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                  435                 440                 445             
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
              450                 455                 460                 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
          465                 470                 475                 480 
          <![CDATA[<210>  704]]>
          <![CDATA[<211>  484]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  704]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          245                 250                 255     
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                      260                 265                 270         
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                  275                 280                 285             
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
              290                 295                 300                 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
          305                 310                 315                 320 
          Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr 
                          325                 330                 335     
          Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                      340                 345                 350         
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                  355                 360                 365             
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
              370                 375                 380                 
          Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
          385                 390                 395                 400 
          Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                          405                 410                 415     
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                      420                 425                 430         
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                  435                 440                 445             
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
              450                 455                 460                 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
          465                 470                 475                 480 
          Ser Pro Gly Lys 
          <![CDATA[<210>  705]]>
          <![CDATA[<211>  480]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  705]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          225                 230                 235                 240 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                          245                 250                 255     
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                      260                 265                 270         
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                  275                 280                 285             
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
              290                 295                 300                 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
          305                 310                 315                 320 
          Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
                          325                 330                 335     
          Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                      340                 345                 350         
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                  355                 360                 365             
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
              370                 375                 380                 
          Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
          385                 390                 395                 400 
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                          405                 410                 415     
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                      420                 425                 430         
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                  435                 440                 445             
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
              450                 455                 460                 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
          465                 470                 475                 480 
          <![CDATA[<210>  706]]>
          <![CDATA[<211>  484]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  706]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
          225                 230                 235                 240 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          245                 250                 255     
          Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                      260                 265                 270         
          Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                  275                 280                 285             
          Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
              290                 295                 300                 
          His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
          305                 310                 315                 320 
          Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr 
                          325                 330                 335     
          Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                      340                 345                 350         
          Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                  355                 360                 365             
          Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
              370                 375                 380                 
          Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
          385                 390                 395                 400 
          Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                          405                 410                 415     
          Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                      420                 425                 430         
          Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                  435                 440                 445             
          Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
              450                 455                 460                 
          Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
          465                 470                 475                 480 
          Ser Pro Gly Lys 
          <![CDATA[<210>  707]]>
          <![CDATA[<211>  480]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  707]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          225                 230                 235                 240 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                          245                 250                 255     
          Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                      260                 265                 270         
          Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                  275                 280                 285             
          Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
              290                 295                 300                 
          Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
          305                 310                 315                 320 
          Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                          325                 330                 335     
          Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                      340                 345                 350         
          Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                  355                 360                 365             
          Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
              370                 375                 380                 
          Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
          385                 390                 395                 400 
          Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                          405                 410                 415     
          Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                      420                 425                 430         
          Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                  435                 440                 445             
          Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
              450                 455                 460                 
          Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
          465                 470                 475                 480 
          <![CDATA[<210>  708]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  708]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  709]]>
          <![CDATA[<211>  225]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  709]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro 
          225 
          <![CDATA[<210>  710]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  710]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  711]]>
          <![CDATA[<211>  225]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  711]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro 
          225 
          <![CDATA[<210>  712]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  712]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  713]]>
          <![CDATA[<211>  225]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  713]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro 
          225 
          <![CDATA[<210>  714]]>
          <![CDATA[<211>  227]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  714]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro Gly Lys 
          225         
          <![CDATA[<210>  715]]>
          <![CDATA[<211>  225]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成多肽]]>
          <![CDATA[<400>  715]]>
          Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
          1               5                   10                  15      
          Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                      20                  25                  30          
          Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                  35                  40                  45              
          Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
              50                  55                  60                  
          His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Asn Ser Thr Tyr 
          65                  70                  75                  80  
          Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                          85                  90                  95      
          Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                      100                 105                 110         
          Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                  115                 120                 125             
          Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
              130                 135                 140                 
          Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
          145                 150                 155                 160 
          Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                          165                 170                 175     
          Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                      180                 185                 190         
          Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                  195                 200                 205             
          His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
              210                 215                 220                 
          Pro 
          225
Figure 12_A0101_SEQ_0001
Figure 12_A0101_SEQ_0002
Figure 12_A0101_SEQ_0003
Figure 12_A0101_SEQ_0004
Figure 12_A0101_SEQ_0005
Figure 12_A0101_SEQ_0006
Figure 12_A0101_SEQ_0007
Figure 12_A0101_SEQ_0008
Figure 12_A0101_SEQ_0009
Figure 12_A0101_SEQ_0010
Figure 12_A0101_SEQ_0011
Figure 12_A0101_SEQ_0012
Figure 12_A0101_SEQ_0013
Figure 12_A0101_SEQ_0014
Figure 12_A0101_SEQ_0015
Figure 12_A0101_SEQ_0016
Figure 12_A0101_SEQ_0017
Figure 12_A0101_SEQ_0018
Figure 12_A0101_SEQ_0019
Figure 12_A0101_SEQ_0020
Figure 12_A0101_SEQ_0021
Figure 12_A0101_SEQ_0022
Figure 12_A0101_SEQ_0023
Figure 12_A0101_SEQ_0024
Figure 12_A0101_SEQ_0025
Figure 12_A0101_SEQ_0026
Figure 12_A0101_SEQ_0027
Figure 12_A0101_SEQ_0028
Figure 12_A0101_SEQ_0029
Figure 12_A0101_SEQ_0030
Figure 12_A0101_SEQ_0031
Figure 12_A0101_SEQ_0032
Figure 12_A0101_SEQ_0033
Figure 12_A0101_SEQ_0034
Figure 12_A0101_SEQ_0035
Figure 12_A0101_SEQ_0036
Figure 12_A0101_SEQ_0037
Figure 12_A0101_SEQ_0038
Figure 12_A0101_SEQ_0039
Figure 12_A0101_SEQ_0040
Figure 12_A0101_SEQ_0041
Figure 12_A0101_SEQ_0042
Figure 12_A0101_SEQ_0043
Figure 12_A0101_SEQ_0044
Figure 12_A0101_SEQ_0045
Figure 12_A0101_SEQ_0046
Figure 12_A0101_SEQ_0047
Figure 12_A0101_SEQ_0048
Figure 12_A0101_SEQ_0049
Figure 12_A0101_SEQ_0050
Figure 12_A0101_SEQ_0051
Figure 12_A0101_SEQ_0052
Figure 12_A0101_SEQ_0053
Figure 12_A0101_SEQ_0054
Figure 12_A0101_SEQ_0055
Figure 12_A0101_SEQ_0056
Figure 12_A0101_SEQ_0057
Figure 12_A0101_SEQ_0058
Figure 12_A0101_SEQ_0059
Figure 12_A0101_SEQ_0060
Figure 12_A0101_SEQ_0061
Figure 12_A0101_SEQ_0062
Figure 12_A0101_SEQ_0063
Figure 12_A0101_SEQ_0064
Figure 12_A0101_SEQ_0065
Figure 12_A0101_SEQ_0066
Figure 12_A0101_SEQ_0067
Figure 12_A0101_SEQ_0068
Figure 12_A0101_SEQ_0069
Figure 12_A0101_SEQ_0070
Figure 12_A0101_SEQ_0071
Figure 12_A0101_SEQ_0072
Figure 12_A0101_SEQ_0073
Figure 12_A0101_SEQ_0074
Figure 12_A0101_SEQ_0075
Figure 12_A0101_SEQ_0076
Figure 12_A0101_SEQ_0077
Figure 12_A0101_SEQ_0078
Figure 12_A0101_SEQ_0079
Figure 12_A0101_SEQ_0080
Figure 12_A0101_SEQ_0081
Figure 12_A0101_SEQ_0082
Figure 12_A0101_SEQ_0083
Figure 12_A0101_SEQ_0084
Figure 12_A0101_SEQ_0085
Figure 12_A0101_SEQ_0086
Figure 12_A0101_SEQ_0087
Figure 12_A0101_SEQ_0088
Figure 12_A0101_SEQ_0089
Figure 12_A0101_SEQ_0090
Figure 12_A0101_SEQ_0091
Figure 12_A0101_SEQ_0092
Figure 12_A0101_SEQ_0093
Figure 12_A0101_SEQ_0094
Figure 12_A0101_SEQ_0095
Figure 12_A0101_SEQ_0096
Figure 12_A0101_SEQ_0097
Figure 12_A0101_SEQ_0098
Figure 12_A0101_SEQ_0099
Figure 12_A0101_SEQ_0100
Figure 12_A0101_SEQ_0101
Figure 12_A0101_SEQ_0102
Figure 12_A0101_SEQ_0103
Figure 12_A0101_SEQ_0104
Figure 12_A0101_SEQ_0105
Figure 12_A0101_SEQ_0106
Figure 12_A0101_SEQ_0107
Figure 12_A0101_SEQ_0108
Figure 12_A0101_SEQ_0109
Figure 12_A0101_SEQ_0110
Figure 12_A0101_SEQ_0111
Figure 12_A0101_SEQ_0112
Figure 12_A0101_SEQ_0113
Figure 12_A0101_SEQ_0114
Figure 12_A0101_SEQ_0115
Figure 12_A0101_SEQ_0116
Figure 12_A0101_SEQ_0117
Figure 12_A0101_SEQ_0118
Figure 12_A0101_SEQ_0119
Figure 12_A0101_SEQ_0120
Figure 12_A0101_SEQ_0121
Figure 12_A0101_SEQ_0122
Figure 12_A0101_SEQ_0123
Figure 12_A0101_SEQ_0124
Figure 12_A0101_SEQ_0125
Figure 12_A0101_SEQ_0126
Figure 12_A0101_SEQ_0127
Figure 12_A0101_SEQ_0128
Figure 12_A0101_SEQ_0129
Figure 12_A0101_SEQ_0130
Figure 12_A0101_SEQ_0131
Figure 12_A0101_SEQ_0132
Figure 12_A0101_SEQ_0133
Figure 12_A0101_SEQ_0134
Figure 12_A0101_SEQ_0135
Figure 12_A0101_SEQ_0136
Figure 12_A0101_SEQ_0137
Figure 12_A0101_SEQ_0138
Figure 12_A0101_SEQ_0139
Figure 12_A0101_SEQ_0140
Figure 12_A0101_SEQ_0141
Figure 12_A0101_SEQ_0142
Figure 12_A0101_SEQ_0143
Figure 12_A0101_SEQ_0144
Figure 12_A0101_SEQ_0145
Figure 12_A0101_SEQ_0146
Figure 12_A0101_SEQ_0147
Figure 12_A0101_SEQ_0148
Figure 12_A0101_SEQ_0149
Figure 12_A0101_SEQ_0150
Figure 12_A0101_SEQ_0151
Figure 12_A0101_SEQ_0152
Figure 12_A0101_SEQ_0153
Figure 12_A0101_SEQ_0154
Figure 12_A0101_SEQ_0155
Figure 12_A0101_SEQ_0156
Figure 12_A0101_SEQ_0157
Figure 12_A0101_SEQ_0158
Figure 12_A0101_SEQ_0159
Figure 12_A0101_SEQ_0160
Figure 12_A0101_SEQ_0161
Figure 12_A0101_SEQ_0162
Figure 12_A0101_SEQ_0163
Figure 12_A0101_SEQ_0164
Figure 12_A0101_SEQ_0165
Figure 12_A0101_SEQ_0166
Figure 12_A0101_SEQ_0167
Figure 12_A0101_SEQ_0168
Figure 12_A0101_SEQ_0169
Figure 12_A0101_SEQ_0170
Figure 12_A0101_SEQ_0171
Figure 12_A0101_SEQ_0172
Figure 12_A0101_SEQ_0173
Figure 12_A0101_SEQ_0174
Figure 12_A0101_SEQ_0175
Figure 12_A0101_SEQ_0176
Figure 12_A0101_SEQ_0177
Figure 12_A0101_SEQ_0178
Figure 12_A0101_SEQ_0179
Figure 12_A0101_SEQ_0180
Figure 12_A0101_SEQ_0181
Figure 12_A0101_SEQ_0182
Figure 12_A0101_SEQ_0183
Figure 12_A0101_SEQ_0184
Figure 12_A0101_SEQ_0185
Figure 12_A0101_SEQ_0186
Figure 12_A0101_SEQ_0187
Figure 12_A0101_SEQ_0188
Figure 12_A0101_SEQ_0189
Figure 12_A0101_SEQ_0190
Figure 12_A0101_SEQ_0191
Figure 12_A0101_SEQ_0192
Figure 12_A0101_SEQ_0193
Figure 12_A0101_SEQ_0194
Figure 12_A0101_SEQ_0195
Figure 12_A0101_SEQ_0196
Figure 12_A0101_SEQ_0197
Figure 12_A0101_SEQ_0198
Figure 12_A0101_SEQ_0199
Figure 12_A0101_SEQ_0200
Figure 12_A0101_SEQ_0201
Figure 12_A0101_SEQ_0202
Figure 12_A0101_SEQ_0203
Figure 12_A0101_SEQ_0204
Figure 12_A0101_SEQ_0205
Figure 12_A0101_SEQ_0206
Figure 12_A0101_SEQ_0207
Figure 12_A0101_SEQ_0208
Figure 12_A0101_SEQ_0209
Figure 12_A0101_SEQ_0210
Figure 12_A0101_SEQ_0211
Figure 12_A0101_SEQ_0212
Figure 12_A0101_SEQ_0213
Figure 12_A0101_SEQ_0214
Figure 12_A0101_SEQ_0215
Figure 12_A0101_SEQ_0216
Figure 12_A0101_SEQ_0217
Figure 12_A0101_SEQ_0218
Figure 12_A0101_SEQ_0219
Figure 12_A0101_SEQ_0220
Figure 12_A0101_SEQ_0221
Figure 12_A0101_SEQ_0222
Figure 12_A0101_SEQ_0223
Figure 12_A0101_SEQ_0224
Figure 12_A0101_SEQ_0225
Figure 12_A0101_SEQ_0226
Figure 12_A0101_SEQ_0227
Figure 12_A0101_SEQ_0228
Figure 12_A0101_SEQ_0229
Figure 12_A0101_SEQ_0230
Figure 12_A0101_SEQ_0231
Figure 12_A0101_SEQ_0232
Figure 12_A0101_SEQ_0233
Figure 12_A0101_SEQ_0234
Figure 12_A0101_SEQ_0235
Figure 12_A0101_SEQ_0236
Figure 12_A0101_SEQ_0237
Figure 12_A0101_SEQ_0238
Figure 12_A0101_SEQ_0239
Figure 12_A0101_SEQ_0240
Figure 12_A0101_SEQ_0241
Figure 12_A0101_SEQ_0242
Figure 12_A0101_SEQ_0243
Figure 12_A0101_SEQ_0244
Figure 12_A0101_SEQ_0245
Figure 12_A0101_SEQ_0246
Figure 12_A0101_SEQ_0247
Figure 12_A0101_SEQ_0248
Figure 12_A0101_SEQ_0249
Figure 12_A0101_SEQ_0250
Figure 12_A0101_SEQ_0251
Figure 12_A0101_SEQ_0252
Figure 12_A0101_SEQ_0253
Figure 12_A0101_SEQ_0254
Figure 12_A0101_SEQ_0255
Figure 12_A0101_SEQ_0256
Figure 12_A0101_SEQ_0257
Figure 12_A0101_SEQ_0258
Figure 12_A0101_SEQ_0259
Figure 12_A0101_SEQ_0260
Figure 12_A0101_SEQ_0261
Figure 12_A0101_SEQ_0262
Figure 12_A0101_SEQ_0263
Figure 12_A0101_SEQ_0264
Figure 12_A0101_SEQ_0265
Figure 12_A0101_SEQ_0266
Figure 12_A0101_SEQ_0267
Figure 12_A0101_SEQ_0268
Figure 12_A0101_SEQ_0269
Figure 12_A0101_SEQ_0270
Figure 12_A0101_SEQ_0271
Figure 12_A0101_SEQ_0272
Figure 12_A0101_SEQ_0273
Figure 12_A0101_SEQ_0274
Figure 12_A0101_SEQ_0275
Figure 12_A0101_SEQ_0276
Figure 12_A0101_SEQ_0277
Figure 12_A0101_SEQ_0278
Figure 12_A0101_SEQ_0279
Figure 12_A0101_SEQ_0280
Figure 12_A0101_SEQ_0281
Figure 12_A0101_SEQ_0282
Figure 12_A0101_SEQ_0283
Figure 12_A0101_SEQ_0284
Figure 12_A0101_SEQ_0285
Figure 12_A0101_SEQ_0286
Figure 12_A0101_SEQ_0287
Figure 12_A0101_SEQ_0288
Figure 12_A0101_SEQ_0289
Figure 12_A0101_SEQ_0290
Figure 12_A0101_SEQ_0291
Figure 12_A0101_SEQ_0292
Figure 12_A0101_SEQ_0293
Figure 12_A0101_SEQ_0294
Figure 12_A0101_SEQ_0295
Figure 12_A0101_SEQ_0296
Figure 12_A0101_SEQ_0297
Figure 12_A0101_SEQ_0298
Figure 12_A0101_SEQ_0299
Figure 12_A0101_SEQ_0300
Figure 12_A0101_SEQ_0301
Figure 12_A0101_SEQ_0302
Figure 12_A0101_SEQ_0303
Figure 12_A0101_SEQ_0304
Figure 12_A0101_SEQ_0305
Figure 12_A0101_SEQ_0306
Figure 12_A0101_SEQ_0307
Figure 12_A0101_SEQ_0308
Figure 12_A0101_SEQ_0309
Figure 12_A0101_SEQ_0310
Figure 12_A0101_SEQ_0311
Figure 12_A0101_SEQ_0312
Figure 12_A0101_SEQ_0313
Figure 12_A0101_SEQ_0314
Figure 12_A0101_SEQ_0315
Figure 12_A0101_SEQ_0316
Figure 12_A0101_SEQ_0317
Figure 12_A0101_SEQ_0318
Figure 12_A0101_SEQ_0319
Figure 12_A0101_SEQ_0320
Figure 12_A0101_SEQ_0321
Figure 12_A0101_SEQ_0322
Figure 12_A0101_SEQ_0323
Figure 12_A0101_SEQ_0324
Figure 12_A0101_SEQ_0325
Figure 12_A0101_SEQ_0326
Figure 12_A0101_SEQ_0327
Figure 12_A0101_SEQ_0328
Figure 12_A0101_SEQ_0329
Figure 12_A0101_SEQ_0330
Figure 12_A0101_SEQ_0331
Figure 12_A0101_SEQ_0332
Figure 12_A0101_SEQ_0333
Figure 12_A0101_SEQ_0334
Figure 12_A0101_SEQ_0335
Figure 12_A0101_SEQ_0336
Figure 12_A0101_SEQ_0337
Figure 12_A0101_SEQ_0338
Figure 12_A0101_SEQ_0339
Figure 12_A0101_SEQ_0340
Figure 12_A0101_SEQ_0341
Figure 12_A0101_SEQ_0342
Figure 12_A0101_SEQ_0343
Figure 12_A0101_SEQ_0344
Figure 12_A0101_SEQ_0345
Figure 12_A0101_SEQ_0346
Figure 12_A0101_SEQ_0347
Figure 12_A0101_SEQ_0348
Figure 12_A0101_SEQ_0349
Figure 12_A0101_SEQ_0350
Figure 12_A0101_SEQ_0351
Figure 12_A0101_SEQ_0352
Figure 12_A0101_SEQ_0353
Figure 12_A0101_SEQ_0354
Figure 12_A0101_SEQ_0355
Figure 12_A0101_SEQ_0356
Figure 12_A0101_SEQ_0357
Figure 12_A0101_SEQ_0358
Figure 12_A0101_SEQ_0359
Figure 12_A0101_SEQ_0360
Figure 12_A0101_SEQ_0361
Figure 12_A0101_SEQ_0362
Figure 12_A0101_SEQ_0363
Figure 12_A0101_SEQ_0364
Figure 12_A0101_SEQ_0365
Figure 12_A0101_SEQ_0366
Figure 12_A0101_SEQ_0367
Figure 12_A0101_SEQ_0368
Figure 12_A0101_SEQ_0369
Figure 12_A0101_SEQ_0370
Figure 12_A0101_SEQ_0371
Figure 12_A0101_SEQ_0372
Figure 12_A0101_SEQ_0373
Figure 12_A0101_SEQ_0374
Figure 12_A0101_SEQ_0375
Figure 12_A0101_SEQ_0376
Figure 12_A0101_SEQ_0377
Figure 12_A0101_SEQ_0378
Figure 12_A0101_SEQ_0379
Figure 12_A0101_SEQ_0380
Figure 12_A0101_SEQ_0381
Figure 12_A0101_SEQ_0382
Figure 12_A0101_SEQ_0383
Figure 12_A0101_SEQ_0384
Figure 12_A0101_SEQ_0385
Figure 12_A0101_SEQ_0386
Figure 12_A0101_SEQ_0387
Figure 12_A0101_SEQ_0388
Figure 12_A0101_SEQ_0389
Figure 12_A0101_SEQ_0390
Figure 12_A0101_SEQ_0391
Figure 12_A0101_SEQ_0392
Figure 12_A0101_SEQ_0393
Figure 12_A0101_SEQ_0394
Figure 12_A0101_SEQ_0395
Figure 12_A0101_SEQ_0396
Figure 12_A0101_SEQ_0397
Figure 12_A0101_SEQ_0398
Figure 12_A0101_SEQ_0399
Figure 12_A0101_SEQ_0400
Figure 12_A0101_SEQ_0401
Figure 12_A0101_SEQ_0402
Figure 12_A0101_SEQ_0403
Figure 12_A0101_SEQ_0404
Figure 12_A0101_SEQ_0405
Figure 12_A0101_SEQ_0406
Figure 12_A0101_SEQ_0407
Figure 12_A0101_SEQ_0408
Figure 12_A0101_SEQ_0409
Figure 12_A0101_SEQ_0410
Figure 12_A0101_SEQ_0411
Figure 12_A0101_SEQ_0412
Figure 12_A0101_SEQ_0413
Figure 12_A0101_SEQ_0414
Figure 12_A0101_SEQ_0415
Figure 12_A0101_SEQ_0416
Figure 12_A0101_SEQ_0417
Figure 12_A0101_SEQ_0418
Figure 12_A0101_SEQ_0419
Figure 12_A0101_SEQ_0420
Figure 12_A0101_SEQ_0421
Figure 12_A0101_SEQ_0422
Figure 12_A0101_SEQ_0423
Figure 12_A0101_SEQ_0424
Figure 12_A0101_SEQ_0425
Figure 12_A0101_SEQ_0426
Figure 12_A0101_SEQ_0427
Figure 12_A0101_SEQ_0428
Figure 12_A0101_SEQ_0429
Figure 12_A0101_SEQ_0430
Figure 12_A0101_SEQ_0431
Figure 12_A0101_SEQ_0432
Figure 12_A0101_SEQ_0433
Figure 12_A0101_SEQ_0434
Figure 12_A0101_SEQ_0435
Figure 12_A0101_SEQ_0436
Figure 12_A0101_SEQ_0437
Figure 12_A0101_SEQ_0438
Figure 12_A0101_SEQ_0439
Figure 12_A0101_SEQ_0440
Figure 12_A0101_SEQ_0441
Figure 12_A0101_SEQ_0442
Figure 12_A0101_SEQ_0443
Figure 12_A0101_SEQ_0444
Figure 12_A0101_SEQ_0445
Figure 12_A0101_SEQ_0446
Figure 12_A0101_SEQ_0447
Figure 12_A0101_SEQ_0448
Figure 12_A0101_SEQ_0449
Figure 12_A0101_SEQ_0450
Figure 12_A0101_SEQ_0451
Figure 12_A0101_SEQ_0452
Figure 12_A0101_SEQ_0453
Figure 12_A0101_SEQ_0454
Figure 12_A0101_SEQ_0455
Figure 12_A0101_SEQ_0456
Figure 12_A0101_SEQ_0457
Figure 12_A0101_SEQ_0458
Figure 12_A0101_SEQ_0459
Figure 12_A0101_SEQ_0460
Figure 12_A0101_SEQ_0461
Figure 12_A0101_SEQ_0462
Figure 12_A0101_SEQ_0463
Figure 12_A0101_SEQ_0464
Figure 12_A0101_SEQ_0465
Figure 12_A0101_SEQ_0466
Figure 12_A0101_SEQ_0467
Figure 12_A0101_SEQ_0468
Figure 12_A0101_SEQ_0469
Figure 12_A0101_SEQ_0470
Figure 12_A0101_SEQ_0471
Figure 12_A0101_SEQ_0472
Figure 12_A0101_SEQ_0473
Figure 12_A0101_SEQ_0474
Figure 12_A0101_SEQ_0475
Figure 12_A0101_SEQ_0476
Figure 12_A0101_SEQ_0477
Figure 12_A0101_SEQ_0478
Figure 12_A0101_SEQ_0479
Figure 12_A0101_SEQ_0480
Figure 12_A0101_SEQ_0481
Figure 12_A0101_SEQ_0482
Figure 12_A0101_SEQ_0483
Figure 12_A0101_SEQ_0484
Figure 12_A0101_SEQ_0485
Figure 12_A0101_SEQ_0486
Figure 12_A0101_SEQ_0487
Figure 12_A0101_SEQ_0488
Figure 12_A0101_SEQ_0489
Figure 12_A0101_SEQ_0490
Figure 12_A0101_SEQ_0491
Figure 12_A0101_SEQ_0492
Figure 12_A0101_SEQ_0493
Figure 12_A0101_SEQ_0494
Figure 12_A0101_SEQ_0495
Figure 12_A0101_SEQ_0496
Figure 12_A0101_SEQ_0497
Figure 12_A0101_SEQ_0498
Figure 12_A0101_SEQ_0499
Figure 12_A0101_SEQ_0500
Figure 12_A0101_SEQ_0501
Figure 12_A0101_SEQ_0502
Figure 12_A0101_SEQ_0503
Figure 12_A0101_SEQ_0504
Figure 12_A0101_SEQ_0505
Figure 12_A0101_SEQ_0506
Figure 12_A0101_SEQ_0507
Figure 12_A0101_SEQ_0508
Figure 12_A0101_SEQ_0509
Figure 12_A0101_SEQ_0510
Figure 12_A0101_SEQ_0511
Figure 12_A0101_SEQ_0512
Figure 12_A0101_SEQ_0513
Figure 12_A0101_SEQ_0514
Figure 12_A0101_SEQ_0515
Figure 12_A0101_SEQ_0516
Figure 12_A0101_SEQ_0517
Figure 12_A0101_SEQ_0518
Figure 12_A0101_SEQ_0519
Figure 12_A0101_SEQ_0520
Figure 12_A0101_SEQ_0521
Figure 12_A0101_SEQ_0522
Figure 12_A0101_SEQ_0523
Figure 12_A0101_SEQ_0524
Figure 12_A0101_SEQ_0525
Figure 12_A0101_SEQ_0526
Figure 12_A0101_SEQ_0527
Figure 12_A0101_SEQ_0528
Figure 12_A0101_SEQ_0529
Figure 12_A0101_SEQ_0530
Figure 12_A0101_SEQ_0531
Figure 12_A0101_SEQ_0532
Figure 12_A0101_SEQ_0533
Figure 12_A0101_SEQ_0534
Figure 12_A0101_SEQ_0535
Figure 12_A0101_SEQ_0536
Figure 12_A0101_SEQ_0537

Claims (35)

  1. 一種用於治療或改善BCMA陽性贅生物的蛋白質，該蛋白質包含與BCMA結合的第一結構域、與CD3結合的第二結構域、以及延長該蛋白質的半衰期的第三結構域，其中該蛋白質在第一週期中投與，該週期包括： •     投與從12.5 mg/天至約24 mg/天的目標劑量的該蛋白質。
  2. 如請求項1所述使用的蛋白質，其中該第一週期進一步包括： •     在第1天投與第一劑量的該蛋白質， •     在第1天後且第8天前的一天投與第二劑量的該蛋白質，其中該第二劑量超過該第一劑量，和 •     在該第二劑量投與日後且該目標劑量投與日前的一天視需要投與第三劑量的該蛋白質，其中該第三劑量超過該第二劑量。
  3. 如請求項2所述使用的蛋白質，其中該第二劑量在第3天或第4天、較佳的是在第3天投與。
  4. 如請求項2或3所述使用的蛋白質，其中該第二劑量係從約4 mg/天至約12.5 mg/天、從約4.5 mg/天至約12 mg/天、從約4 mg/天至約10 mg/天、從約4.5 mg/天至約9 mg/天、從約4 mg/天至約8 mg/天、從約4 mg/天至約7 mg/天、從約4 mg/天至約6.5 mg/天、從約4.5 mg/天至約6 mg/天、從約7 mg/天至約18 mg/天、從約7.5 mg/天至約15 mg/天、從約8 mg/天至約12 mg/天、從約8.5 mg/天至約10 mg/天或從約9 mg/天至約9.5 mg/天。
  5. 如請求項2至4中任一項所述使用的蛋白質，其中該第二劑量係從約4 mg/天至約10 mg/天、較佳的是從約4 mg/天至約7 mg/天，並且在第3天投與。
  6. 如請求項2至5中任一項所述使用的蛋白質，其中該第一劑量係從約800 µg/天至約1200 µg/天、從約800 µg/天至約1100 µg/天、從約800 µg/天至約1000 µg/天或從約800 µg/天至約900 µg/天。
  7. 如請求項2至6中任一項所述使用的蛋白質，其中該第三劑量係從約7 mg/天至約12 mg/天、從約8 mg/天至約10 mg/天或約9 mg/天。
  8. 如請求項2至7中任一項所述使用的蛋白質，其中該第三劑量在第5天、第6天或第7天投與。
  9. 如請求項2至8中任一項所述使用的蛋白質，其中該第三劑量係從約8 mg/天至約10 mg/天並且在第5天投與。
  10. 如前述請求項中任一項所述使用的蛋白質，其中該目標劑量在從第6天至第10天中的一天、較佳的是在從第7天至第9天中的一天、更較佳的是在第8天投與。
  11. 如請求項10所述使用的蛋白質，其中該目標劑量在第15天（+/- 一或兩天）和第22天（+/- 一或兩天）投與。
  12. 如前述請求項中任一項所述使用的蛋白質，其中該目標劑量係從約14 mg/天至約22 mg/天、從約15 mg/天至約21 mg/天、從約16 mg/天至約20 mg/天、從約17 mg/天至約19 mg/天、或約18 mg/天。
  13. 如前述請求項中任一項所述使用的蛋白質，其中該目標劑量係從約16 mg/天至約20 mg/天並且在第8天投與。
  14. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質在第二週期和視需要在進一步後續的週期中以目標劑量投與。
  15. 如請求項14所述使用的蛋白質，其中該第二週期和視需要該進一步後續的週期包括： •       在第1天、第8天（+/- 一或兩天）、第15天（+/- 一或兩天）和第22天（+/- 一或兩天）以目標劑量投與該蛋白質。
  16. 如前述請求項中任一項所述使用的蛋白質，其中一個週期具有約25至約30天、約26至約29天、約27至約29天、或約28天。
  17. 如前述請求項中任一項所述使用的蛋白質，其中該第一週期包括： •       投與約800 µg/天至約1000 µg/天、較佳的是約800 µg/天的第一劑量的該蛋白質， •       投與約4 mg/天至約10 mg/天、較佳的是約4 mg/天至約7 mg/天或4.5 mg/天至6 mg/天的第二劑量的該蛋白質， •       視需要投與約8 mg/天至約10 mg/天、較佳的是約9 mg/天的第三劑量的該蛋白質和 •       投與約14 mg/天至約22 mg/天、較佳的是約16 mg/天至約20 mg/天，例如18 mg/天的目標劑量的該蛋白質。
  18. 如請求項17所述使用的蛋白質，其中在第1天投與該第一劑量；在第3天或第4天、較佳的是在第3天投與該第二劑量；在第5天或第6天、較佳的是在第5天投與該視需要的第三劑量；並且在第8天（+/- 一天）、第15天（+/- 一天）和第22天（+/- 一天），較佳的是在第8天、第15天和第22天投與該目標劑量。
  19. 如請求項2至18中任一項所述使用的蛋白質，其中在第1天投與800 µg/天的該第一劑量，在第3天投與6 mg/天的該第二劑量，並且在第8天、第15天和第22天投與18 mg/天的該目標劑量。
  20. 如請求項2至18中任一項所述使用的蛋白質，其中在第1天投與800 µg/天的該第一劑量，在第3天投與4.5 mg/天的該第二劑量，在第5天投與9 mg/天的該第三劑量，並且在第8天、第15天和第22天投與18 mg/天的該目標劑量。
  21. 如前述請求項中任一項所述使用的蛋白質，其中將該蛋白質靜脈內投與，較佳的是藉由靜脈內推注注射、推注輸注或短期靜脈內輸注投與。
  22. 如前述請求項中任一項所述使用的蛋白質，其中該BCMA陽性贅生物選自由以下組成之群組：多發性骨髓瘤、復發性和/或難治性多發性骨髓瘤、重鏈多發性骨髓瘤、輕鏈多發性骨髓瘤、髓外骨髓瘤、漿細胞瘤、漿細胞白血病、華氏巨球蛋白血症、和鬱積型骨髓瘤。
  23. 如前述請求項中任一項所述使用的蛋白質，其中 a)     該蛋白質係單鏈蛋白質或由兩條、三條或四條多肽鏈組成， b)     該第一結構域包含免疫球蛋白重鏈可變區（VH1）和免疫球蛋白輕鏈可變區（VL1）， c)     該第二結構域包含免疫球蛋白重鏈可變區（VH2）和免疫球蛋白輕鏈可變區（VL2），和/或 d)     該第三結構域包含一個或兩個免疫球蛋白鉸鏈區、一個或兩個CH2結構域和一個或兩個CH3結構域。
  24. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質與以下競爭結合BCMA或與以下結合相同的BCMA表位： a)     抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 171中所描述的CDR-H1、如SEQ ID NO: 172中所描述的CDR-H2、和如SEQ ID NO: 173中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 174中所描述的CDR-L1、如SEQ ID NO: 175中所描述的CDR-L2、和如SEQ ID NO: 176中所描述的CDR-L3的VL區； b)     抗體或蛋白質，該抗體或蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 177中所描述的VH區、和如SEQ ID NO: 178中所描述的VL區； c)     蛋白質，該蛋白質包含與靶細胞表面上的BCMA結合的結構域，其中所述結構域包含如SEQ ID NO: 179中所描述的胺基酸序列；或 d)     蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
  25. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質與以下競爭結合CD3或與以下結合相同的CD3表位： a)     抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含：含有如SEQ ID NO: 636中所描述的CDR-H1、如SEQ ID NO: 637中所描述的CDR-H2、和如SEQ ID NO: 638中所描述的CDR-H3的VH區，以及含有如SEQ ID NO: 633中所描述的CDR-L1、如SEQ ID NO: 634中所描述的CDR-L2、如SEQ ID NO: 635中所描述的CDR-L3的VL區； b)     抗體或蛋白質，該抗體或蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 639中所描述的VH區、和如SEQ ID NO: 641中所描述的VL區； c)     蛋白質，該蛋白質包含與T細胞表面上的CD3結合的結構域，其中所述結構域包含如SEQ ID NO: 642中所描述的胺基酸序列；或 d)     蛋白質，該蛋白質具有如SEQ ID NO: 661中所描述的胺基酸序列。
  26. 如前述請求項中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 7、17、27、37、47、57、67、77、87、97、107、117、127、137、147、157、167、177、187、197、207、217、227、237、247、257、267、277、287、307、317、327、337、347、357、367、377、387、397、407、417、427、437、447、457、467、477、487、497、507、517、和527，較佳的是SEQ ID NO: 177中所描述的那些。
  27. 如前述請求項中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 8、18、28、38、48、58、68、78、88、98、108、118、128、138、148、158、168、178、188、198、208、218、228、238、248、258、268、278、288、298、308、318、328、338、348、358、368、378、388、398、408、418、428、438、448、458、468、478、488、498、508、518、和528，較佳的是SEQ ID NO: 178中所描述的那些。
  28. 如前述請求項中任一項所述使用的蛋白質，其中與BCMA結合的該第一結構域包含具有選自由以下組成之群組的胺基酸序列的多肽或由具有選自由以下組成之群組的胺基酸序列的多肽組成：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519、和529，較佳的是SEQ ID NO: 179。
  29. 如前述請求項中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含具有選自由以下組成之群組的胺基酸序列的VL區：SEQ ID NO: 550、SEQ ID NO: 551、SEQ ID NO: 584、SEQ ID NO: 585、SEQ ID NO: 629和SEQ ID NO: 630，較佳的是SEQ ID NO: 629中所描述的那些。
  30. 如前述請求項中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含具有選自由以下組成之群組的胺基酸序列的VH區：SEQ ID NO: 537、SEQ ID NO: 538、SEQ ID NO: 548、SEQ ID NO: 549、SEQ ID NO: 560、SEQ ID NO: 561、SEQ ID NO: 571、SEQ ID NO: 572、SEQ ID NO: 582、SEQ ID NO: 583、SEQ ID NO: 594、SEQ ID NO: 595、SEQ ID NO: 605、SEQ ID NO: 606、SEQ ID NO: 616、SEQ ID NO: 617、SEQ ID NO: 627、SEQ ID NO: 628、SEQ ID NO: 639、SEQ ID NO: 640、和SEQ ID NO: 644，較佳的是SEQ ID NO: 639中所描述的那些。
  31. 如前述請求項中任一項所述使用的蛋白質，其中與CD3結合的該第二結構域包含具有選自由以下組成之群組的胺基酸序列的多肽或由具有選自由以下組成之群組的胺基酸序列的多肽組成：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643、和646，較佳的是SEQ ID NO: 642中所描述的那些。
  32. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質包含具有選自由以下組成之群組的胺基酸序列的多肽：SEQ ID NO: 10、20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、260、270、280、290、300、310、320、330、340、350、360、370、380、390、400、410、420、430、440、450、460、470、480、490、500、510、520、和530中所描述的那些。
  33. 如前述請求項中任一項所述使用的蛋白質，該蛋白質以N-末端至C-末端的順序包含以下或由以下組成： a)     第一結構域，該第一結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 9、19、29、39、49、59、69、79、89、109、129、139、149、159、169、179、189、199、209、219、229、239、249、259、269、279、289、299、309、319、329、339、349、359、369、379、389、399、409、419、429、439、449、459、469、479、489、499、519和529；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； b)     肽連接子，該肽連接子具有選自由SEQ ID NO: 687、693和694組成之群組的胺基酸序列； c)     第二結構域，該第二結構域具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 540、541、552、553、563、564、574、575、586、587、597、598、608、609、619、620、631、632、642、643和646；其中包含在那些序列中並具有SEQ ID NO: 694的肽連接子可以被SEQ ID NO: 686-693和695-699中的任何一個替代； d)     肽連接子，該肽連接子具有選自由以下組成之群組的胺基酸序列：SEQ ID NO: 686、687、688、689、690、691、692、693和694；和 e)     第三結構域，該第三結構域具有選自由SEQ ID NO: 700-707組成之群組的胺基酸序列。
  34. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質具有約75至約200 kDa、約80至約175 kDa、約85至約150 kDa、約90至約130 kDa、約95至約120 kDa、以及較佳的是約100至約115 kDa或約105至約110 kDa的分子量。
  35. 如前述請求項中任一項所述使用的蛋白質，其中該蛋白質具有約3天至約14天、約4天至約12天、約3或4天至約10天、約3或4天至約8天、或約5至約7天、或約6天的消除半衰期（T 1/2）。
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