CN115298216A - 抗体或其抗原结合片段、其制备方法及医药用途 - Google Patents

抗体或其抗原结合片段、其制备方法及医药用途 Download PDF

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Publication number
CN115298216A
CN115298216A CN202180021548.2A CN202180021548A CN115298216A CN 115298216 A CN115298216 A CN 115298216A CN 202180021548 A CN202180021548 A CN 202180021548A CN 115298216 A CN115298216 A CN 115298216A
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CN
China
Prior art keywords
seq
antibody
cancer
gpc
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180021548.2A
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English (en)
Inventor
花海清
余华星
何娟梅
包如迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
Original Assignee
Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
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Filing date
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Application filed by Jiangsu Hansoh Pharmaceutical Group Co Ltd, Shanghai Hansoh Biomedical Co Ltd filed Critical Jiangsu Hansoh Pharmaceutical Group Co Ltd
Publication of CN115298216A publication Critical patent/CN115298216A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

提供了抗体或其抗原结合片段、其制备方法及其医药用途。具体地，提供了包含抗GPC3抗体CDR区的嵌合抗体、人源化抗体，以及包含抗GPC3抗体或其抗原结合片段的药物组合物，及其作为抗癌药物的用途。尤其地，提供了一种人源化的抗GPC3抗体、及其在制备用于治疗GPC3介导的疾病或病症的药物中的用途，以及用于细胞生长抑制剂、用于肿瘤检测和诊断中的用途。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN202180021548.2A 2020-04-20 2021-04-15 抗体或其抗原结合片段、其制备方法及医药用途 Pending CN115298216A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010314338X 2020-04-20
CN202010314338 2020-04-20
CN202010936093 2020-09-08
CN2020109360934 2020-09-08
PCT/CN2021/087549 WO2021213245A1 (zh) 2020-04-20 2021-04-15 抗体或其抗原结合片段、其制备方法及医药用途

Publications (1)

Publication Number Publication Date
CN115298216A true CN115298216A (zh) 2022-11-04

Family

ID=78270294

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180021548.2A Pending CN115298216A (zh) 2020-04-20 2021-04-15 抗体或其抗原结合片段、其制备方法及医药用途

Country Status (3)

Country Link
CN (1) CN115298216A (zh)
TW (1) TW202144433A (zh)
WO (1) WO2021213245A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478771A (zh) * 2021-12-14 2022-05-13 英诺湖医药(杭州)有限公司 Ox40抗体及其医药用途
WO2023246574A1 (zh) * 2022-06-24 2023-12-28 四川科伦博泰生物医药股份有限公司 靶向gpc3的抗体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016036973A1 (en) * 2014-09-04 2016-03-10 The Trustees Of The University Of Pennsylvania Glypican-3 antibody and uses thereof
WO2016191675A2 (en) * 2015-05-27 2016-12-01 La Jolla Biologics, Inc. Antibodies against glypican-3 and their uses in cancer diagnosis and treatment
ES2883240T3 (es) * 2015-08-03 2021-12-07 Cafa Therapeutics Ltd Anticuerpo contra glipicano-3 y aplicación del mismo
CN108164600B (zh) * 2016-12-07 2024-04-02 上海吉倍生物技术有限公司 一种抗gpc3抗体及其制备方法和用途
JP7382922B2 (ja) * 2017-09-20 2023-11-17 中外製薬株式会社 Ｐｄ－１系結合アンタゴニストおよびｇｐｃ３標的化剤を使用する併用療法のための投与レジメン

Also Published As

Publication number Publication date
TW202144433A (zh) 2021-12-01
WO2021213245A1 (zh) 2021-10-28

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