EA201491724A1 - Антитела, нейтрализующие rsv, mpv и pvm, и их применения - Google Patents
Антитела, нейтрализующие rsv, mpv и pvm, и их примененияInfo
- Publication number
- EA201491724A1 EA201491724A1 EA201491724A EA201491724A EA201491724A1 EA 201491724 A1 EA201491724 A1 EA 201491724A1 EA 201491724 A EA201491724 A EA 201491724A EA 201491724 A EA201491724 A EA 201491724A EA 201491724 A1 EA201491724 A1 EA 201491724A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- mpv
- rsv
- pvm
- relates
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 210000004180 plasmocyte Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Изобретение относится к антителам и их антигенсвязывающим фрагментам, которые нейтрализуют инфекцию RSV, MPV и PVM. Изобретение также относится к нуклеиновым кислотам, которые кодируют, иммортализованным В-клеткам и культивируемым плазматическим клеткам, которые продуцируют, и к полипептидам, которые связываются с такими антителами и фрагментами антител. Кроме того, изобретение относится к применению антител, фрагментов антител и полипептидов, распознаваемых антителами по изобретению в способах скрининга, а также в диагностике, лечении и профилактике инфекции RSV или MPV и смешанной инфекции RSV и MPV.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613197P | 2012-03-20 | 2012-03-20 | |
| US201261655310P | 2012-06-04 | 2012-06-04 | |
| PCT/IB2013/000627 WO2013140247A1 (en) | 2012-03-20 | 2013-03-14 | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491724A1 true EA201491724A1 (ru) | 2015-01-30 |
| EA030319B1 EA030319B1 (ru) | 2018-07-31 |
Family
ID=48471031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491724A EA030319B1 (ru) | 2012-03-20 | 2013-03-14 | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9498531B2 (ru) |
| EP (1) | EP2828293B1 (ru) |
| JP (4) | JP6445423B2 (ru) |
| KR (1) | KR102149069B1 (ru) |
| CN (2) | CN107880121B (ru) |
| AU (1) | AU2013237087B2 (ru) |
| BR (1) | BR112014023063A2 (ru) |
| CA (1) | CA2865856C (ru) |
| DK (1) | DK2828293T3 (ru) |
| EA (1) | EA030319B1 (ru) |
| ES (1) | ES2657470T3 (ru) |
| HK (1) | HK1206367A1 (ru) |
| IL (1) | IL234710A (ru) |
| IN (1) | IN2014DN07299A (ru) |
| NZ (1) | NZ630920A (ru) |
| PL (1) | PL2828293T3 (ru) |
| WO (1) | WO2013140247A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2865856C (en) | 2012-03-20 | 2023-03-14 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| CA2899052A1 (en) | 2013-01-28 | 2014-07-31 | Evec Inc. | Human antibody specific to human metapneumovirus, or antigen-binding fragment thereof |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| WO2020160171A1 (en) * | 2019-01-29 | 2020-08-06 | Sanford Burnham Prebys Medical Discovery Institute | Topically formulated antibody compositions for reducing pathogen transmission and methods of using same |
| US20230085439A1 (en) * | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
| TW202246317A (zh) * | 2021-02-09 | 2022-12-01 | 瑞士商休曼生物醫藥股份公司 | 針對呼吸道融合病毒及其他副黏液病毒的抗體以及使用其之方法 |
| EP4297780A1 (en) * | 2021-02-26 | 2024-01-03 | Fred Hutchinson Cancer Center | Protective antibodies against respiratory viral infections |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| NZ527221A (en) | 2001-01-19 | 2006-09-29 | Vironovative B | A negative-sense single stranded RNA virus causing respiratory tract illness in susceptible mammals |
| WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| TW200501985A (en) * | 2002-07-25 | 2005-01-16 | Medimmune Inc | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| WO2004076677A2 (en) | 2003-02-26 | 2004-09-10 | Institute For Research In Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
| WO2004092207A2 (en) | 2003-04-16 | 2004-10-28 | Algonomics N.V. | Respiratory syncytial virus (rsv) peptides |
| EP1473037A1 (en) | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| JP4976376B2 (ja) * | 2005-04-08 | 2012-07-18 | メディミューン，エルエルシー | 哺乳動物メタニューモウイルスに対する抗体 |
| EP1997830A1 (en) * | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| US9347043B2 (en) | 2008-10-22 | 2016-05-24 | Institute For Research In Biomedicine | Methods for producing antibodies from plasma cells |
| MX2012000036A (es) * | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
| WO2011020079A1 (en) * | 2009-08-13 | 2011-02-17 | Calmune Corporation | Antibodies against human respiratory syncytial virus (rsv) and methods of use |
| CA3062786C (en) * | 2010-07-09 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| CA2865856C (en) * | 2012-03-20 | 2023-03-14 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
-
2013
- 2013-03-14 CA CA2865856A patent/CA2865856C/en active Active
- 2013-03-14 CN CN201711120146.XA patent/CN107880121B/zh active Active
- 2013-03-14 US US13/827,845 patent/US9498531B2/en active Active
- 2013-03-14 AU AU2013237087A patent/AU2013237087B2/en active Active
- 2013-03-14 JP JP2015501002A patent/JP6445423B2/ja active Active
- 2013-03-14 ES ES13724357.2T patent/ES2657470T3/es active Active
- 2013-03-14 PL PL13724357T patent/PL2828293T3/pl unknown
- 2013-03-14 CN CN201380026218.8A patent/CN104350069B/zh active Active
- 2013-03-14 NZ NZ630920A patent/NZ630920A/en unknown
- 2013-03-14 WO PCT/IB2013/000627 patent/WO2013140247A1/en active Application Filing
- 2013-03-14 EP EP13724357.2A patent/EP2828293B1/en active Active
- 2013-03-14 KR KR1020147029324A patent/KR102149069B1/ko active IP Right Grant
- 2013-03-14 BR BR112014023063A patent/BR112014023063A2/pt active Search and Examination
- 2013-03-14 DK DK13724357.2T patent/DK2828293T3/en active
- 2013-03-14 EA EA201491724A patent/EA030319B1/ru unknown
-
2014
- 2014-08-29 IN IN7299DEN2014 patent/IN2014DN07299A/en unknown
- 2014-09-17 IL IL234710A patent/IL234710A/en active IP Right Grant
-
2015
- 2015-07-21 HK HK15106957.1A patent/HK1206367A1/xx unknown
-
2016
- 2016-08-10 US US15/233,026 patent/US10072071B2/en active Active
-
2018
- 2018-08-09 US US16/059,408 patent/US20190153073A1/en not_active Abandoned
- 2018-11-29 JP JP2018224174A patent/JP6722264B2/ja active Active
-
2020
- 2020-05-27 US US16/885,009 patent/US11421020B2/en active Active
- 2020-06-19 JP JP2020106004A patent/JP7069251B2/ja active Active
-
2022
- 2022-05-02 JP JP2022076023A patent/JP2022132244A/ja active Pending
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