MX357655B - Mediador soluble. - Google Patents

Mediador soluble.

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Publication number
MX357655B
MX357655B MX2014005688A MX2014005688A MX357655B MX 357655 B MX357655 B MX 357655B MX 2014005688 A MX2014005688 A MX 2014005688A MX 2014005688 A MX2014005688 A MX 2014005688A MX 357655 B MX357655 B MX 357655B
Authority
MX
Mexico
Prior art keywords
soluble
present disclosure
glycoprotein
soluble mediator
relates
Prior art date
Application number
MX2014005688A
Other languages
English (en)
Other versions
MX2014005688A (es
Inventor
Bandala Sanchez Esther
Dromey James
Charles Harrison Leonard
Zhang Yuxia
Rashidi Maryam
Original Assignee
Walter & Eliza Hall Inst Medical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter & Eliza Hall Inst Medical Res filed Critical Walter & Eliza Hall Inst Medical Res
Publication of MX2014005688A publication Critical patent/MX2014005688A/es
Publication of MX357655B publication Critical patent/MX357655B/es

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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Abstract

La presente invención se refiere a una composición farmacéutica para suprimir una función de células T efectoras y/o para reducir una respuesta inmunitaria, tal como una respuesta inmunitaria a un auto-antígeno, caracterizada porque comprende cualquiera de uno o más de: i) glicoproteína CD52 soluble, ii) una proteína de fusión que comprende glicoproteína CD52 como una primera proteína, y una segunda proteína, iii) un polinucleótido que codifica la porción de péptido de glicoproteína CD52 soluble de la parte i) o la proteína de fusión de la parte ii); iv) un vector que comprende el polinucleótido de la parte iii); v) una célula aislada que comprende el polinucleótido de la parte iii) o el vector de la parte iv); vi) una célula CD52 hi aislada capaz de producir glicoproteína CD52 soluble; vii) una población de células aisladas que comprende una pluralidad de células CD52hi capaces de producir glicoproteína CD52 soluble; y viii) medio de cultivo celular, o una fracción del mismo que comprende glicoproteína CD52 soluble, aislado de un cultivo de la parte vi) o la población celular de la parte vii); y un portador farmacéuticamente aceptable.
MX2014005688A 2011-11-15 2012-11-15 Mediador soluble. MX357655B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161560254P 2011-11-15 2011-11-15
US201261705633P 2012-09-26 2012-09-26
PCT/AU2012/001411 WO2013071355A1 (en) 2011-11-15 2012-11-15 Soluble mediator

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EP3935073A4 (en) * 2019-03-07 2022-11-23 The Walter and Eliza Hall Institute of Medical Research IMMUNOSUPPRESSIVE GLYCOFORMS OF SOLUBLE CD52
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US10010582B2 (en) 2018-07-03
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EP2750690A1 (en) 2014-07-09
US20190192624A1 (en) 2019-06-27
RU2014122847A (ru) 2015-12-27
US20200078440A1 (en) 2020-03-12
KR20140091597A (ko) 2014-07-21
EP3456338A1 (en) 2019-03-20
HK1199618A1 (en) 2015-07-10
SG11201402310SA (en) 2014-06-27
BR112014011758A2 (pt) 2017-05-09
EP2750690B1 (en) 2018-11-07
US10413589B2 (en) 2019-09-17
US20170232061A1 (en) 2017-08-17
WO2013071355A1 (en) 2013-05-23
EP3456338B1 (en) 2020-07-29
JP2015500797A (ja) 2015-01-08
US20140308209A1 (en) 2014-10-16
HRP20182001T1 (hr) 2019-01-25
AU2012339618A1 (en) 2014-05-29
CA2890797A1 (en) 2014-05-22
US10328124B2 (en) 2019-06-25
LT2750690T (lt) 2019-01-10
JP6004594B2 (ja) 2016-10-12
MX2014005688A (es) 2014-07-28
CA2852133A1 (en) 2013-05-23
PT2750690T (pt) 2019-01-10
ES2703236T3 (es) 2019-03-07
EP2750690A4 (en) 2015-06-10
ES2814300T3 (es) 2021-03-26
KR102134326B1 (ko) 2020-07-17
US9585969B2 (en) 2017-03-07
RU2660580C2 (ru) 2018-07-06
AU2012339618B2 (en) 2017-09-07
CN103930123A (zh) 2014-07-16
CA2890797C (en) 2021-12-07

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