BR0214650A - Imunocitoquinas com seletividade modulada - Google Patents
Imunocitoquinas com seletividade moduladaInfo
- Publication number
- BR0214650A BR0214650A BR0214650-9A BR0214650A BR0214650A BR 0214650 A BR0214650 A BR 0214650A BR 0214650 A BR0214650 A BR 0214650A BR 0214650 A BR0214650 A BR 0214650A
- Authority
- BR
- Brazil
- Prior art keywords
- fusion proteins
- immunocytokines
- cytokine
- binding
- selectivity
- Prior art date
Links
- 229940127130 immunocytokine Drugs 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 108020001507 fusion proteins Proteins 0.000 abstract 4
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 231100001274 therapeutic index Toxicity 0.000 abstract 2
- 102000003675 cytokine receptors Human genes 0.000 abstract 1
- 108010057085 cytokine receptors Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"IMUNOCITOQUINAS COM SELETIVIDADE MODULADA". A invenção fornece proteínas de fusão de citocina, com um maior índice terapêutico e métodos para aumentar o índice terapêutico de tais proteínas de fusão. As proteínas de fusão da invenção são capazes de se ligarem a mais do que um tipo de receptor de citocina expresso sobre células e também de se ligar a mais do que um tipo de célula. Além disso, as proteínas de fusão da invenção exibem uma meia-vida de circulação mais longa no corpo de um paciente do que a citocina correspondente que ocorre naturalmente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33711301P | 2001-12-04 | 2001-12-04 | |
US37196602P | 2002-04-12 | 2002-04-12 | |
PCT/US2002/038780 WO2003048334A2 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0214650A true BR0214650A (pt) | 2005-05-03 |
Family
ID=26990541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0214650-9A BR0214650A (pt) | 2001-12-04 | 2002-12-04 | Imunocitoquinas com seletividade modulada |
Country Status (18)
Country | Link |
---|---|
US (3) | US7186804B2 (pt) |
EP (2) | EP2354791A1 (pt) |
JP (1) | JP4795640B2 (pt) |
KR (1) | KR100988180B1 (pt) |
CN (1) | CN100390282C (pt) |
AT (1) | ATE542137T1 (pt) |
AU (1) | AU2002357784B2 (pt) |
BR (1) | BR0214650A (pt) |
CA (1) | CA2469151C (pt) |
DK (1) | DK1454138T3 (pt) |
ES (1) | ES2381025T3 (pt) |
HU (1) | HU229098B1 (pt) |
MX (1) | MXPA04005266A (pt) |
PL (1) | PL206975B1 (pt) |
PT (1) | PT1454138E (pt) |
RU (1) | RU2312677C9 (pt) |
WO (1) | WO2003048334A2 (pt) |
ZA (1) | ZA200405247B (pt) |
Families Citing this family (154)
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