HUP0105090A2 - Kóros elhízás elleni fehérjék expressziója és exportja Fc fúziós fehérje formájában - Google Patents
Kóros elhízás elleni fehérjék expressziója és exportja Fc fúziós fehérje formájábanInfo
- Publication number
- HUP0105090A2 HUP0105090A2 HU0105090A HUP0105090A HUP0105090A2 HU P0105090 A2 HUP0105090 A2 HU P0105090A2 HU 0105090 A HU0105090 A HU 0105090A HU P0105090 A HUP0105090 A HU P0105090A HU P0105090 A2 HUP0105090 A2 HU P0105090A2
- Authority
- HU
- Hungary
- Prior art keywords
- obesity
- proteins
- fusion proteins
- export
- expression
- Prior art date
Links
- 230000003579 anti-obesity Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 108091006020 Fc-tagged proteins Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000016267 Leptin Human genes 0.000 abstract 1
- 108010092277 Leptin Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000012696 congenital leptin deficiency Diseases 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000001022 morbid obesity Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A tal lm ny t rgy t ltal noss gban kóros elhíz s elleni fehérjéttartalmazó fúziós fehérjék elő llít s ra szolg ló elj r sok, tov bbalkalmaz sukhoz szükséges készítmények képezik. K"zelebbről, a tal lmny t rgy t fúziós fehérjék elő llít s ra szolg ló elj r sok valamintazok alkalmaz s hoz szükséges készítmények képezik, amelyekben afúziós fehérjék immunglobulin Fc régiót és leptin kóros elhíz s ellenifehérjét tartalmaznak. A tal lm ny szerinti megold s alkalmas kóroselhíz s megelőzésére és kezelésére. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11507999P | 1999-01-07 | 1999-01-07 | |
PCT/US2000/000352 WO2000040615A2 (en) | 1999-01-07 | 2000-01-07 | EXPRESSION AND EXPORT OF ANTI-OBESITY PROTEINS AS Fc FUSION PROTEINS |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0105090A2 true HUP0105090A2 (hu) | 2002-04-29 |
Family
ID=22359200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0105090A HUP0105090A2 (hu) | 1999-01-07 | 2000-01-07 | Kóros elhízás elleni fehérjék expressziója és exportja Fc fúziós fehérje formájában |
Country Status (16)
Country | Link |
---|---|
US (1) | US20040053366A1 (hu) |
EP (1) | EP1141013A2 (hu) |
JP (1) | JP2002534962A (hu) |
KR (1) | KR20020007287A (hu) |
CN (1) | CN1341121A (hu) |
AU (1) | AU778939B2 (hu) |
BR (1) | BR0007414A (hu) |
CA (1) | CA2356401A1 (hu) |
CZ (1) | CZ20012406A3 (hu) |
HU (1) | HUP0105090A2 (hu) |
ID (1) | ID30327A (hu) |
MX (1) | MXPA01006922A (hu) |
NO (1) | NO20013371L (hu) |
SK (1) | SK9432001A3 (hu) |
WO (1) | WO2000040615A2 (hu) |
ZA (1) | ZA200105352B (hu) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
MXPA00010070A (es) * | 1998-04-15 | 2004-03-10 | Lexigen Pharm Corp | Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis. |
SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
AU778611B2 (en) * | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
JP5179689B2 (ja) * | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
RU2272644C2 (ru) * | 2000-06-29 | 2006-03-27 | Мерк Патент Гмбх | Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина |
US7189830B2 (en) * | 2001-02-19 | 2007-03-13 | Merck Patent Gmbh | Anti-KSA/IL-2 fusion proteins with reduced immunogenicity |
ES2309167T3 (es) | 2001-02-19 | 2008-12-16 | Merck Patent Gmbh | Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida. |
PL206701B1 (pl) * | 2001-03-07 | 2010-09-30 | Merck Patent Gmbh | Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
DE60239454D1 (de) * | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
BR0214650A (pt) * | 2001-12-04 | 2005-05-03 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
MXPA05006384A (es) * | 2002-12-17 | 2005-08-29 | Merck Patent Gmbh | Anticuerpo humanizado (h14.18) del anticuerpo 14.18 de raton enlazado a gd2 y su fusion con il-2. |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
AU2004290070A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
AU2004282984B2 (en) * | 2003-11-13 | 2011-07-14 | Hanmi Science Co., Ltd. | Protein complex using immunoglobulin fragment andmethod for the preparation thereof |
AU2004309050B2 (en) | 2003-12-30 | 2010-10-14 | Merck Patent Gmbh | IL-7 fusion proteins |
BRPI0417916A (pt) * | 2003-12-31 | 2007-04-10 | Merck Patent Gmbh | proteìna de fusão de fc-eritropoietina com farmacocinética melhorada |
US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
PT1706428E (pt) | 2004-01-22 | 2009-12-29 | Merck Patent Gmbh | Anticorpos anticancerígenos com fixação de complemento reduzida |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
EP1819728B1 (en) * | 2004-12-09 | 2010-04-21 | MERCK PATENT GmbH | Il-7 variants with reduced immunogenicity |
EP1838736B1 (en) | 2005-01-05 | 2013-03-06 | Biogen Idec MA Inc. | Cripto binding molecules |
US7566456B2 (en) * | 2005-06-23 | 2009-07-28 | Haiming Chen | Allergen vaccine proteins for the treatment and prevention of allergic diseases |
WO2007018619A2 (en) * | 2005-07-29 | 2007-02-15 | Amprotein Corporation | Chimeric therapeutic agents |
US8227408B2 (en) * | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
EP1801121A1 (en) * | 2005-12-23 | 2007-06-27 | CONARIS research institute AG | Soluble gp130 molecule variants useful as a medicament |
EP1966238B1 (en) | 2005-12-30 | 2012-04-25 | Merck Patent GmbH | Interleukin-12p40 variants with improved stability |
PT1966245E (pt) * | 2005-12-30 | 2011-08-31 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
US7846434B2 (en) * | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
US20080227669A1 (en) * | 2007-03-12 | 2008-09-18 | Halliburton Energy Services, Inc. | Corrosion-inhibiting additives, treatment fluids, and associated methods |
EP2326339A4 (en) | 2008-05-21 | 2012-06-20 | Neurotez Inc | METHOD FOR TREATING PROGRESSIVE COGNITIVE DISORDER IN CONNECTION WITH NEUROFIBRILLARY TANGLES |
EP2352510A4 (en) | 2008-11-04 | 2012-08-29 | Neurotez Inc | LEPTIN COMPOSITIONS AND METHODS OF TREATING PROGRESSIVE COGNITIVE DISORDERS DUE TO THE ASSEMBLY OF NEUROFIBRILLARY BUNNELS AND AMYLOID BETA |
KR20120030383A (ko) | 2009-04-22 | 2012-03-28 | 메르크 파텐트 게엠베하 | 변형된 FcRn 결합 자리를 갖는 항체 융합 단백질 |
EP2694092B1 (en) | 2011-04-08 | 2017-01-04 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
PL2880170T3 (pl) * | 2012-08-02 | 2017-02-28 | F.Hoffmann-La Roche Ag | SPOSÓB WYTWARZANIA ROZPUSZCZALNEGO FcR JAKO FUZJI Fc Z OBOJĘTNYM REGIONEM Fc IMMUNOGLOBULINY I JEGO ZASTOSOWANIA |
JP6388581B2 (ja) * | 2012-08-02 | 2018-09-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 単量体および多量体分子を生産するための方法およびその使用 |
CA2880929A1 (en) * | 2012-09-07 | 2014-03-13 | Sanofi | Fusion proteins for treating a metabolic syndrome |
PT3027642T (pt) | 2013-07-31 | 2020-10-30 | Amgen Inc | Construtos do fator 15 de diferenciação de crescimento (gdf-15) |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
CA3014498A1 (en) | 2016-03-21 | 2017-09-28 | Children's Medical Center Corporation | Compositions and methods for inhibiting wnt signaling |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
CN110267674A (zh) * | 2016-07-08 | 2019-09-20 | 奥美药业有限公司 | 包含瘦素的融合蛋白及其生产和使用方法 |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
AU2019253462A1 (en) | 2018-04-09 | 2020-11-26 | Amgen Inc. | Growth differentiation factor 15 fusion proteins |
US11197910B1 (en) * | 2020-08-19 | 2021-12-14 | Vitruviae LLC | Fusion proteins for the diagnosis, prophylaxis and treatment of infectious diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
AU5539596A (en) * | 1995-04-06 | 1996-10-23 | Amylin Pharmaceuticals, Inc. | Anti-obesity agents |
GB9511935D0 (en) * | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
-
2000
- 2000-01-07 CN CN00804274A patent/CN1341121A/zh active Pending
- 2000-01-07 CZ CZ20012406A patent/CZ20012406A3/cs unknown
- 2000-01-07 CA CA002356401A patent/CA2356401A1/en not_active Abandoned
- 2000-01-07 MX MXPA01006922A patent/MXPA01006922A/es unknown
- 2000-01-07 WO PCT/US2000/000352 patent/WO2000040615A2/en not_active Application Discontinuation
- 2000-01-07 KR KR1020017008580A patent/KR20020007287A/ko not_active Application Discontinuation
- 2000-01-07 AU AU26025/00A patent/AU778939B2/en not_active Ceased
- 2000-01-07 BR BR0007414-4A patent/BR0007414A/pt not_active IP Right Cessation
- 2000-01-07 HU HU0105090A patent/HUP0105090A2/hu unknown
- 2000-01-07 ID IDW00200101488A patent/ID30327A/id unknown
- 2000-01-07 EP EP00904239A patent/EP1141013A2/en not_active Withdrawn
- 2000-01-07 JP JP2000592323A patent/JP2002534962A/ja not_active Withdrawn
- 2000-01-07 SK SK943-2001A patent/SK9432001A3/sk unknown
-
2001
- 2001-06-28 ZA ZA200105352A patent/ZA200105352B/en unknown
- 2001-07-06 NO NO20013371A patent/NO20013371L/no not_active Application Discontinuation
-
2003
- 2003-04-18 US US10/419,058 patent/US20040053366A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU778939B2 (en) | 2004-12-23 |
WO2000040615A3 (en) | 2000-11-23 |
CN1341121A (zh) | 2002-03-20 |
MXPA01006922A (es) | 2002-04-24 |
NO20013371L (no) | 2001-09-04 |
KR20020007287A (ko) | 2002-01-26 |
CA2356401A1 (en) | 2000-07-13 |
NO20013371D0 (no) | 2001-07-06 |
ID30327A (id) | 2001-11-22 |
EP1141013A2 (en) | 2001-10-10 |
BR0007414A (pt) | 2001-10-16 |
WO2000040615A2 (en) | 2000-07-13 |
US20040053366A1 (en) | 2004-03-18 |
SK9432001A3 (en) | 2003-02-04 |
ZA200105352B (en) | 2002-06-28 |
CZ20012406A3 (cs) | 2002-03-13 |
AU2602500A (en) | 2000-07-24 |
JP2002534962A (ja) | 2002-10-22 |
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