BRPI0417916A - proteìna de fusão de fc-eritropoietina com farmacocinética melhorada - Google Patents
proteìna de fusão de fc-eritropoietina com farmacocinética melhoradaInfo
- Publication number
- BRPI0417916A BRPI0417916A BRPI0417916-1A BRPI0417916A BRPI0417916A BR PI0417916 A BRPI0417916 A BR PI0417916A BR PI0417916 A BRPI0417916 A BR PI0417916A BR PI0417916 A BRPI0417916 A BR PI0417916A
- Authority
- BR
- Brazil
- Prior art keywords
- epo
- improved pharmacokinetics
- fusion protein
- fusion proteins
- increased
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"PROTEìNA DE FUSãO DE Fc-ERITROPOIETINA COM FARMACOCINéTICA MELHORADA". A presente invenção refere-se a novas proteínas de fusão de FcEPO altamente sialiladas preferivelmente compreendendo algumas modificações na porção de Fc como também na porção de EPO e tendo farmacocinética melhorada. Especificamente, as proteínas de Fc-EPO têm uma meia-vida em soro prolongada e potência in vivo aumentada. As proteínas de fusão de Fc-EPO sintetizadas em células de BHK têm meias-vidas dramaticamente prolongadas em soro e potência in vivo aumentada quando comparadas às proteínas de fusão de Fc-EPO correspondentes produzidas em outras linhagens celulares, como, por exemplo, células de NS/0.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53385803P | 2003-12-31 | 2003-12-31 | |
PCT/EP2004/014608 WO2005063808A1 (en) | 2003-12-31 | 2004-12-22 | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417916A true BRPI0417916A (pt) | 2007-04-10 |
Family
ID=34738878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417916-1A BRPI0417916A (pt) | 2003-12-31 | 2004-12-22 | proteìna de fusão de fc-eritropoietina com farmacocinética melhorada |
Country Status (13)
Country | Link |
---|---|
US (2) | US7465447B2 (pt) |
EP (1) | EP1699821B1 (pt) |
JP (2) | JP2008504008A (pt) |
KR (1) | KR20060124656A (pt) |
CN (1) | CN1902222A (pt) |
AU (1) | AU2004309063B2 (pt) |
BR (1) | BRPI0417916A (pt) |
CA (1) | CA2551916C (pt) |
DK (1) | DK1699821T3 (pt) |
ES (1) | ES2387028T3 (pt) |
PT (1) | PT1699821E (pt) |
RU (1) | RU2370276C2 (pt) |
WO (1) | WO2005063808A1 (pt) |
Families Citing this family (183)
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DE60239454D1 (de) | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
US6900292B2 (en) * | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
BR0214650A (pt) * | 2001-12-04 | 2005-05-03 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
WO2003106484A1 (en) * | 2002-06-17 | 2003-12-24 | Chr. Hansen A/S | Improved method of producing an aspartic protease in a recombinant host organism |
MXPA05006384A (es) | 2002-12-17 | 2005-08-29 | Merck Patent Gmbh | Anticuerpo humanizado (h14.18) del anticuerpo 14.18 de raton enlazado a gd2 y su fusion con il-2. |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
AU2004309050B2 (en) | 2003-12-30 | 2010-10-14 | Merck Patent Gmbh | IL-7 fusion proteins |
BRPI0417916A (pt) * | 2003-12-31 | 2007-04-10 | Merck Patent Gmbh | proteìna de fusão de fc-eritropoietina com farmacocinética melhorada |
EP1819728B1 (en) * | 2004-12-09 | 2010-04-21 | MERCK PATENT GmbH | Il-7 variants with reduced immunogenicity |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
PT1966245E (pt) * | 2005-12-30 | 2011-08-31 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
EP1966238B1 (en) * | 2005-12-30 | 2012-04-25 | Merck Patent GmbH | Interleukin-12p40 variants with improved stability |
CN101346395A (zh) * | 2005-12-30 | 2009-01-14 | 默克专利有限公司 | 阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体 |
CA2656700A1 (en) * | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
-
2004
- 2004-12-22 BR BRPI0417916-1A patent/BRPI0417916A/pt not_active IP Right Cessation
- 2004-12-22 ES ES04804204T patent/ES2387028T3/es active Active
- 2004-12-22 KR KR1020067012656A patent/KR20060124656A/ko not_active Application Discontinuation
- 2004-12-22 AU AU2004309063A patent/AU2004309063B2/en not_active Ceased
- 2004-12-22 CN CNA2004800396709A patent/CN1902222A/zh active Pending
- 2004-12-22 EP EP04804204A patent/EP1699821B1/en not_active Not-in-force
- 2004-12-22 RU RU2006127554/15A patent/RU2370276C2/ru not_active IP Right Cessation
- 2004-12-22 PT PT04804204T patent/PT1699821E/pt unknown
- 2004-12-22 CA CA2551916A patent/CA2551916C/en not_active Expired - Fee Related
- 2004-12-22 DK DK04804204.8T patent/DK1699821T3/da active
- 2004-12-22 JP JP2006546058A patent/JP2008504008A/ja active Pending
- 2004-12-22 WO PCT/EP2004/014608 patent/WO2005063808A1/en active Application Filing
- 2004-12-30 US US11/026,998 patent/US7465447B2/en not_active Expired - Fee Related
-
2008
- 2008-09-26 US US12/238,840 patent/US20090092607A1/en not_active Abandoned
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2012
- 2012-02-17 JP JP2012032557A patent/JP2012107042A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20060124656A (ko) | 2006-12-05 |
US7465447B2 (en) | 2008-12-16 |
CA2551916A1 (en) | 2005-07-14 |
RU2006127554A (ru) | 2008-02-10 |
WO2005063808A1 (en) | 2005-07-14 |
CN1902222A (zh) | 2007-01-24 |
JP2012107042A (ja) | 2012-06-07 |
US20090092607A1 (en) | 2009-04-09 |
AU2004309063B2 (en) | 2010-10-28 |
PT1699821E (pt) | 2012-08-23 |
AU2004309063A1 (en) | 2005-07-14 |
ES2387028T3 (es) | 2012-09-12 |
US20050192211A1 (en) | 2005-09-01 |
RU2370276C2 (ru) | 2009-10-20 |
JP2008504008A (ja) | 2008-02-14 |
DK1699821T3 (da) | 2012-07-16 |
EP1699821A1 (en) | 2006-09-13 |
CA2551916C (en) | 2014-04-29 |
EP1699821B1 (en) | 2012-06-20 |
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