ATE271606T1 - Die aktivierung von rezeptoren durch gas6 - Google Patents
Die aktivierung von rezeptoren durch gas6Info
- Publication number
- ATE271606T1 ATE271606T1 AT96908671T AT96908671T ATE271606T1 AT E271606 T1 ATE271606 T1 AT E271606T1 AT 96908671 T AT96908671 T AT 96908671T AT 96908671 T AT96908671 T AT 96908671T AT E271606 T1 ATE271606 T1 AT E271606T1
- Authority
- AT
- Austria
- Prior art keywords
- gas6
- receptors
- activation
- polypeptides
- growth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/402,253 US6211142B1 (en) | 1995-03-10 | 1995-03-10 | Compositions comprising gas6 polypeptides and articles of manufacture comprising the same |
US43886195A | 1995-05-10 | 1995-05-10 | |
PCT/US1996/003031 WO1996028548A1 (en) | 1995-03-10 | 1996-03-05 | Receptor activation by gas6 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE271606T1 true ATE271606T1 (de) | 2004-08-15 |
Family
ID=27017784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96908671T ATE271606T1 (de) | 1995-03-10 | 1996-03-05 | Die aktivierung von rezeptoren durch gas6 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6169070B1 (de) |
EP (1) | EP0815224B1 (de) |
JP (1) | JP3342873B2 (de) |
AT (1) | ATE271606T1 (de) |
AU (1) | AU712585B2 (de) |
CA (1) | CA2214629C (de) |
DE (1) | DE69632949T2 (de) |
ES (1) | ES2225874T3 (de) |
IL (1) | IL117425A0 (de) |
MX (1) | MX9706827A (de) |
WO (1) | WO1996028548A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1489100B1 (de) | 1997-12-08 | 2016-06-15 | Merck Patent GmbH | Heterodimäre Fusionsproteine zur Verwendung für gezielte Immuntherapie und allgemeine Immunerregung |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
WO1999049894A1 (en) * | 1998-04-01 | 1999-10-07 | Genentech, Inc. | Antagonists to growth arrest specific gene 6 to treat insulin-resistant disorders |
AU758860B2 (en) * | 1998-04-15 | 2003-04-03 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
EP2278003B2 (de) * | 1999-04-09 | 2020-08-05 | Kyowa Kirin Co., Ltd. | Verfahren zur Steuerung der Aktivität von immunologisch funktionellen Molekülen |
US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
CA2372400C (en) * | 1999-05-19 | 2010-04-27 | Lexigen Pharmaceuticals Corp. | Expression and export of interferon-alpha proteins as fc fusion proteins |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
CN1235911C (zh) * | 1999-08-09 | 2006-01-11 | 利思进药品公司 | 多细胞因子-抗体复合物 |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
AU2001260214A1 (en) * | 2000-04-13 | 2001-10-30 | D. Collen Research Foudation Vzw | Use of inhibition of a gas6 function or of a gas6 receptor for preventing and treating a cardiovascular disease |
EP1199081A1 (de) * | 2000-10-20 | 2002-04-24 | Vlaams Interuniversitair Instituut voor Biotechnologie | Inhibierung von gas6 (growth arrest-specific gene) oder gas6 Rezeptor Fonction für die Prevention und Behandlung von thromboembolischen Erkrankungen |
EP1294401B1 (de) * | 2000-06-29 | 2007-08-01 | EMD Lexigen Research Center Corp. | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
KR20090010127A (ko) * | 2001-03-07 | 2009-01-28 | 메르크 파텐트 게엠베하 | 하이브리드 이소타입 항체 부분구조를 포함하는 단백질을 위한 발현 기술 |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
PL205352B1 (pl) * | 2001-05-03 | 2010-04-30 | Merck Patent Gmbh | Rekombinowane przeciwciało specyficzne dla nowotworu |
GB2378899A (en) * | 2001-08-25 | 2003-02-26 | Thromb X N V | Treatment of anemia |
RU2312677C9 (ru) * | 2001-12-04 | 2008-03-27 | Мерк Патент Гмбх | Иммуноцитокины с модулированной селективностью |
US7691568B2 (en) | 2002-04-09 | 2010-04-06 | Kyowa Hakko Kirin Co., Ltd | Antibody composition-containing medicament |
WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
WO2004108748A2 (en) * | 2002-09-24 | 2004-12-16 | Dow, Kenneth, Centocor, Inc. | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses |
AU2003276958A1 (en) * | 2002-09-24 | 2004-04-19 | Centocor, Inc. | Epitope-tagged recombinant growth arrest specific gene 6 protein |
PL211180B1 (pl) * | 2002-12-17 | 2012-04-30 | Merck Patent Gmbh | Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków |
WO2005007183A2 (en) * | 2003-07-17 | 2005-01-27 | Thromb-X Nv | Treatment of anemia |
DK1698640T4 (da) | 2003-10-01 | 2019-09-02 | Kyowa Hakko Kirin Co Ltd | Fremgangsmåde til stabilisering af antistof og antistofpræparat som stabiliseret opløsning. |
AU2004309050B2 (en) | 2003-12-30 | 2010-10-14 | Merck Patent Gmbh | IL-7 fusion proteins |
BRPI0417916A (pt) * | 2003-12-31 | 2007-04-10 | Merck Patent Gmbh | proteìna de fusão de fc-eritropoietina com farmacocinética melhorada |
CA2552590A1 (en) * | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
DE602005020837D1 (de) * | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | Il-7-varianten mit reduzierter immunogenität |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
RU2457854C2 (ru) * | 2005-12-30 | 2012-08-10 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи Лимитед | Длительное высвобождение нейрегулина для улучшения сердечной функции |
WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
CA2703519C (en) * | 2007-11-09 | 2017-04-18 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
US20120230991A1 (en) * | 2008-07-29 | 2012-09-13 | Douglas Kim Graham | Methods and compounds for enhancing anti-cancer therapy |
EA201171259A1 (ru) * | 2009-04-22 | 2012-05-30 | Мерк Патент Гмбх | Антительные гибридные белки с модифицированными сайтами связывания fcrn |
WO2012149018A1 (en) * | 2011-04-25 | 2012-11-01 | The Regents Of The University Of Colorado | Mer tyrosine kinase inhibitors and methods of making and using the same |
WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
WO2023212664A1 (en) * | 2022-04-27 | 2023-11-02 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Synapse surgery tools and associated methods for neural circuit-specific synapse ablation and modification |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585269A (en) * | 1994-06-02 | 1996-12-17 | The University Of North Carolina At Chapel Hill | Isolated DNA encoding c-mer protooncogene |
US5538861A (en) * | 1994-07-29 | 1996-07-23 | Amgen Inc. | DNA encoding a stimulating factor for the axl receptor |
US6211142B1 (en) * | 1995-03-10 | 2001-04-03 | Genentech, Inc. | Compositions comprising gas6 polypeptides and articles of manufacture comprising the same |
US5721139A (en) * | 1995-05-10 | 1998-02-24 | Genentech, Inc. | Isolating and culturing schwann cells |
-
1996
- 1996-03-05 AT AT96908671T patent/ATE271606T1/de active
- 1996-03-05 DE DE69632949T patent/DE69632949T2/de not_active Expired - Lifetime
- 1996-03-05 CA CA002214629A patent/CA2214629C/en not_active Expired - Lifetime
- 1996-03-05 ES ES96908671T patent/ES2225874T3/es not_active Expired - Lifetime
- 1996-03-05 WO PCT/US1996/003031 patent/WO1996028548A1/en active IP Right Grant
- 1996-03-05 JP JP52769896A patent/JP3342873B2/ja not_active Expired - Fee Related
- 1996-03-05 MX MX9706827A patent/MX9706827A/es unknown
- 1996-03-05 AU AU51836/96A patent/AU712585B2/en not_active Expired
- 1996-03-05 EP EP96908671A patent/EP0815224B1/de not_active Expired - Lifetime
- 1996-03-05 US US08/628,747 patent/US6169070B1/en not_active Expired - Lifetime
- 1996-03-10 IL IL11742596A patent/IL117425A0/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2214629A1 (en) | 1996-09-19 |
EP0815224B1 (de) | 2004-07-21 |
CA2214629C (en) | 2001-07-10 |
DE69632949D1 (de) | 2004-08-26 |
JP3342873B2 (ja) | 2002-11-11 |
AU712585B2 (en) | 1999-11-11 |
DE69632949T2 (de) | 2005-07-28 |
JPH10505507A (ja) | 1998-06-02 |
ES2225874T3 (es) | 2005-03-16 |
US6169070B1 (en) | 2001-01-02 |
IL117425A0 (en) | 1996-07-23 |
EP0815224A1 (de) | 1998-01-07 |
AU5183696A (en) | 1996-10-02 |
WO1996028548A1 (en) | 1996-09-19 |
MX9706827A (es) | 1997-11-29 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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