DK1131410T3 - Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf - Google Patents

Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf

Info

Publication number
DK1131410T3
DK1131410T3 DK99962807T DK99962807T DK1131410T3 DK 1131410 T3 DK1131410 T3 DK 1131410T3 DK 99962807 T DK99962807 T DK 99962807T DK 99962807 T DK99962807 T DK 99962807T DK 1131410 T3 DK1131410 T3 DK 1131410T3
Authority
DK
Denmark
Prior art keywords
tissue constructs
processes
preparation
tissue structures
cultured
Prior art date
Application number
DK99962807T
Other languages
English (en)
Inventor
Michael P Murphy
Vincent Ronfard
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Application granted granted Critical
Publication of DK1131410T3 publication Critical patent/DK1131410T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK99962807T 1998-11-19 1999-11-19 Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf DK1131410T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10924798P 1998-11-19 1998-11-19
US33963299A 1999-06-24 1999-06-24
PCT/US1999/027505 WO2000029553A1 (en) 1998-11-19 1999-11-19 Bioengineered tissue constructs and methods for producing and using them

Publications (1)

Publication Number Publication Date
DK1131410T3 true DK1131410T3 (da) 2005-10-31

Family

ID=26806787

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99962807T DK1131410T3 (da) 1998-11-19 1999-11-19 Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf

Country Status (15)

Country Link
US (2) US7824913B2 (da)
EP (3) EP1131410B1 (da)
JP (2) JP2002530069A (da)
CN (2) CN102051343A (da)
AT (1) ATE305967T1 (da)
AU (3) AU769637B2 (da)
BR (1) BR9915476A (da)
CA (1) CA2351396C (da)
DE (1) DE69927600T2 (da)
DK (1) DK1131410T3 (da)
ES (2) ES2249928T3 (da)
HK (1) HK1040740A1 (da)
IL (1) IL143243A0 (da)
PT (1) PT1612265E (da)
WO (1) WO2000029553A1 (da)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1131410T3 (da) * 1998-11-19 2005-10-31 Organogenesis Inc Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20040018226A1 (en) * 1999-02-25 2004-01-29 Wnek Gary E. Electroprocessing of materials useful in drug delivery and cell encapsulation
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US7198641B2 (en) * 2000-08-08 2007-04-03 Aderans Research Institute, Inc. Scaffolds for tissue engineered hair
CA2457162A1 (en) * 2000-09-01 2002-03-07 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed fibrin-based matrices and tissues
EP1832300A3 (en) * 2000-09-18 2008-02-27 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
ES2288995T3 (es) 2000-09-18 2008-02-01 Organogenesis Inc. Metodo para el tratamiento de un paciente que utiliza una construccion de tejido conjuntivo cultivado.
JP4366075B2 (ja) * 2000-09-21 2009-11-18 株式会社資生堂 角質細胞の成熟度の評価方法
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
JP4822635B2 (ja) * 2001-09-05 2011-11-24 株式会社 資生堂 人工毛球部及びその製造方法、並びに、人工毛球部を用いた薬剤の評価方法
EP1444994B1 (en) 2001-10-15 2014-07-30 Japan Science and Technology Agency Method of forming normal regenerated tissue, the normal regenerated tissue, and method of calibrating senstivity and so on
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10220472A1 (de) * 2002-05-07 2003-11-27 Hans-Guenther Machens Bioartifizielle Haut
NZ538071A (en) * 2002-07-16 2007-05-31 Biogentis Inc Method for fusing adjacent layers of living tissue in a multi-layered engineered tissue construct
GB0304918D0 (en) * 2003-03-05 2003-04-09 Celltran Ltd Cell culture
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
EP1644011A1 (en) 2003-06-25 2006-04-12 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
EP1688484B1 (en) * 2003-10-06 2017-06-28 Shiseido Company, Ltd. Method of preparing hair papilla cell preparation, composition and method for regenerating hair follicle and animal having regenerated hair follicle
JP2005218445A (ja) * 2004-01-09 2005-08-18 Technology Seed Incubation Co Ltd 培養皮膚細胞とこれを原料として用いた移植用材及び遺伝子解析用材並びに培養皮膚細胞の製造方法
CA2559275C (en) * 2004-03-09 2020-02-18 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
JP2007528252A (ja) * 2004-03-09 2007-10-11 ジャン−エリック ダブリュー． アルフォース， オートジェネシス生体足場および生体組織マトリックス；方法およびその使用
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
WO2006053291A2 (en) 2004-11-09 2006-05-18 Proxy Biomedical Limited Tissue scaffold
AU2006247317B2 (en) * 2005-05-16 2012-04-05 Purdue Research Foundation Engineered extracellular matrices
EP1945757B1 (en) * 2005-10-17 2017-12-06 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
SI1948259T1 (sl) 2005-10-26 2017-07-31 Genesis Technologies Limited Acelularni bioabsorbljivi tkivni regeneracijski matriksi, proizvedeni z inkubiranjem acelularnih proizvodov krvi
TW200800240A (en) 2005-11-22 2008-01-01 Aderans Res Inst Inc Hair follicle graft from tissue engineered skin
AU2007212002B2 (en) * 2006-02-07 2013-05-16 Organogenesis, Inc. Bioengineered tissue constructs and cardiac uses thereof
US7780635B2 (en) * 2006-02-09 2010-08-24 Aderans Research Institute, Inc. Apparatus and methods for delivering fluid and material to a subject
EP2007877B1 (en) 2006-02-28 2013-04-17 The Trustees of Columbia University in the City of New York Methods for compact aggregation of dermal cells
JP2009528856A (ja) * 2006-03-03 2009-08-13 オルガノジェネシス インク． 口腔組織の再生および修復
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
US20090175922A1 (en) * 2006-05-16 2009-07-09 Voytik-Harbin Sherry L Three dimensional purified collagen matrices
US20070269476A1 (en) * 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
GB2455041B (en) 2006-09-21 2012-03-07 Purdue Research Foundation Collagen preparation and method of isolation
WO2008060822A2 (en) * 2006-10-20 2008-05-22 Keracure, Inc. Devices with cells cultured on flexible supports
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
DK2079490T3 (da) * 2006-10-23 2012-12-10 Cook Biotech Inc Bearbejdede ECM-materialer med forbedrede komponentprofiler
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
JPWO2008105454A1 (ja) 2007-02-28 2010-06-03 千寿製薬株式会社 ラクリチン高発現細胞
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
CA2706855A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
AU2008335152B2 (en) * 2007-12-10 2013-09-12 Indiana University Research And Technology Corporation Collagen-based matrices with stem cells
WO2009086535A2 (en) * 2007-12-27 2009-07-09 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
WO2009097559A1 (en) * 2008-01-30 2009-08-06 Histogen, Inc. Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
RU2523339C2 (ru) 2008-11-14 2014-07-20 Хистоджен, Инк. Композиции внеклеточного матрикса для лечения рака
US20100166822A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Adhesive cartilage implant
KR101753797B1 (ko) 2009-06-04 2017-07-04 더 제너럴 하스피탈 코포레이션 생인공 폐
US8986377B2 (en) * 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US20110046639A1 (en) * 2009-08-24 2011-02-24 Konstantinos Giotis Method of direct hair implantation
CA2781309A1 (en) * 2009-12-04 2011-06-09 Euclid Systems Corporation Composition and methods for the prevention and treatment of macular degeneration, diabetic retinopathy, and diabetic macular edema
WO2011088365A1 (en) 2010-01-14 2011-07-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
US20120100110A1 (en) * 2010-04-20 2012-04-26 International Stem Cell Corporation Physiological methods for isolation of high purity cell populations
JP6071875B2 (ja) * 2010-06-18 2017-02-08 ザ ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン，インコーポレイティド 毛包新生
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
GB201112922D0 (en) * 2011-07-27 2011-09-14 Univ Durham Micro-organ
BR112014005746A2 (pt) * 2011-09-12 2017-03-28 Organovo Inc tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos
CN103958665A (zh) * 2011-11-11 2014-07-30 基本药品有限责任公司 包含血清替代物和不稳定因子的试剂盒
EP3081189B1 (en) 2012-01-13 2018-07-04 Lifecell Corporation Breast prostheses and methods of manufacturing breast prostheses
EP2822659A2 (en) * 2012-03-07 2015-01-14 Fibrocell Technologies, Inc. Topical dermal formulations and methods of personalized treatment of skin
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
EP2841010B1 (en) 2012-04-24 2023-08-23 Harvard Apparatus Regenerative Technology, Inc. Supports for engineered tissue scaffolds
AU2013277350B2 (en) 2012-06-21 2017-06-29 Lifecell Corporation Implantable prosthesis having acellular tissue attachments
EP2903562A1 (en) 2012-10-04 2015-08-12 Lifecell Corporation Surgical template and delivery device
DE102012223061A1 (de) 2012-12-13 2014-06-18 Henkel Ag & Co. Kgaa Altershautmodell
US11284987B2 (en) 2013-01-09 2022-03-29 Biostage, Inc. Synthetic scaffolds
WO2014127047A1 (en) 2013-02-12 2014-08-21 Replicel Life Sciences Inc. Compositions and methods for treating and repairing tendons
WO2014179559A1 (en) 2013-05-03 2014-11-06 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
CN103497892B (zh) * 2013-09-03 2015-12-02 中山大学 一种细胞培养基材及其制备方法和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
TW201538730A (zh) 2014-02-12 2015-10-16 Replicel Life Sciences Inc 用於治療骨骼、關節及軟骨之組合物及方法
WO2015138999A1 (en) 2014-03-14 2015-09-17 The General Hospital Corporation Lung bioreactor
JP6218238B2 (ja) * 2014-07-10 2017-10-25 国立大学法人大阪大学 人工皮膚及びその製造方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
WO2016186803A1 (en) 2015-05-15 2016-11-24 Lifecell Corporation Tissue matrices for plastic surgery
WO2016209089A1 (en) * 2015-06-25 2016-12-29 Peter Roderick Dunbar Tissue culture apparatus and method
WO2017024090A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
AU2016310471B2 (en) 2015-08-21 2021-05-20 Lifecell Corporation Breast treatment device
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
CA3024424A1 (en) 2016-05-16 2017-11-23 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
PT3506854T (pt) 2016-08-31 2020-11-24 Lifecell Corp Dispositivo para tratamento mamário
MX2016012375A (es) * 2016-09-23 2018-03-22 Univ Mexico Nac Autonoma Metodo para preparar un suplemento a partir de cultivos de celulas mesenquimales de gelatina de wharton y usos del mismo.
CN106544281B (zh) * 2016-12-07 2019-07-02 哈尔滨工业大学 一种基于蛋白质和多糖构筑生物体保护层的制备方法
WO2018200750A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
CN109663148A (zh) * 2018-12-17 2019-04-23 太阳雨林（厦门）生物医药有限公司 一种细胞外基质高分子材料生物复合血管
US11298220B2 (en) 2019-05-03 2022-04-12 Lifecell Corporation Breast treatment device
CA3144252A1 (en) 2019-06-18 2020-12-24 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN111100838B (zh) * 2019-12-27 2023-05-09 广东博溪生物科技有限公司 低温保存运输培养基
US20230357684A1 (en) * 2020-09-18 2023-11-09 University Of Virginia Patent Foundation 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication
WO2024030601A1 (en) * 2022-08-05 2024-02-08 The Texas A&M University System Fabricated engineered skin dermis compositions and methods thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
DE3317550C2 (de) 1983-05-13 1985-08-22 Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5026649A (en) 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
JPS6410983A (en) * 1987-02-19 1989-01-13 Takeda Chemical Industries Ltd Artificial tissue and production thereof
EP0282746A1 (en) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Method for producing artificial cultured tissue
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH051280Y2 (da) 1987-10-12 1993-01-13
IL94611A (en) 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5374515A (en) 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5366893A (en) 1993-01-13 1994-11-22 Becton, Dickinson And Company Culture vessel
JPH07178A (ja) * 1993-06-11 1995-01-06 New Japan Chem Co Ltd 細胞培養用担体
US5518878A (en) 1993-09-15 1996-05-21 Organogenesis Inc. Cryopreservation of cultured skin or cornea equivalents with agitation
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5731417A (en) * 1994-04-25 1998-03-24 Becton, Dickinson And Company Cell culture substrates and method of making
WO1995031473A1 (en) 1994-05-11 1995-11-23 Organogenesis Inc. Collagen from cell cultures
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5618718A (en) 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5665391A (en) * 1995-10-12 1997-09-09 Spectral Diagnostics Inc. Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5689961A (en) 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5766937A (en) 1996-02-15 1998-06-16 Becton Dickinson And Company Culture vessel and assembly
US6497875B1 (en) * 1996-04-26 2002-12-24 Case Western Reserve University Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
DK1131410T3 (da) * 1998-11-19 2005-10-31 Organogenesis Inc Gensplejsede vævskonstruktioner og fremgangsmåde til fremstilling og anvendelse deraf
US6733530B1 (en) * 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
CN100345452C (zh) * 2003-10-16 2007-10-24 华为技术有限公司 一种确定移动通信系统中用于加密同步的计数器检查发起时机的方法

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DE69927600D1 (de) 2005-11-10
WO2000029553A9 (en) 2000-11-09
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JP2010187680A (ja) 2010-09-02
CN102051343A (zh) 2011-05-11
EP1612265A2 (en) 2006-01-04
AU2004201787A1 (en) 2004-05-27
CA2351396A1 (en) 2000-05-25
CA2351396C (en) 2012-08-14
ATE305967T1 (de) 2005-10-15
EP1131410B1 (en) 2005-10-05
JP5484975B2 (ja) 2014-05-07
EP1612265B1 (en) 2013-01-16
AU1917100A (en) 2000-06-05
DE69927600T2 (de) 2006-07-06
US20080108134A1 (en) 2008-05-08
AU2010201787B2 (en) 2012-09-13
IL143243A0 (en) 2002-04-21
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EP1612265A3 (en) 2006-03-01
ES2249928T3 (es) 2006-04-01
JP2002530069A (ja) 2002-09-17
AU769637B2 (en) 2004-01-29
WO2000029553A1 (en) 2000-05-25
EP2295540A1 (en) 2011-03-16
AU2010201787A1 (en) 2010-05-27
BR9915476A (pt) 2002-01-02
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EP1131410A1 (en) 2001-09-12

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