DK0952772T3 - Fremgangsmåder til anvendelse af mononukleare phagocytter til at fremme axonal regeneration - Google Patents
Fremgangsmåder til anvendelse af mononukleare phagocytter til at fremme axonal regenerationInfo
- Publication number
- DK0952772T3 DK0952772T3 DK96932991T DK96932991T DK0952772T3 DK 0952772 T3 DK0952772 T3 DK 0952772T3 DK 96932991 T DK96932991 T DK 96932991T DK 96932991 T DK96932991 T DK 96932991T DK 0952772 T3 DK0952772 T3 DK 0952772T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- mononuclear phagocytes
- mammal
- axonal regeneration
- nervous system
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000002864 mononuclear phagocyte Anatomy 0.000 title abstract 4
- 230000003376 axonal effect Effects 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title abstract 2
- 238000011069 regeneration method Methods 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 3
- 230000000735 allogeneic effect Effects 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 3
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000004207 dermis Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46432—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52884595A | 1995-09-15 | 1995-09-15 | |
| US08/695,351 US5800812A (en) | 1995-09-15 | 1996-08-09 | Methods of use of mononuclear phagocytes to promote axonal regeneration |
| PCT/US1996/014578 WO1997009885A1 (en) | 1995-09-15 | 1996-09-12 | Compositions and methods of use of mononuclear phagocytes to promote axonal regeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0952772T3 true DK0952772T3 (da) | 2005-07-18 |
Family
ID=27062850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96932991T DK0952772T3 (da) | 1995-09-15 | 1996-09-12 | Fremgangsmåder til anvendelse af mononukleare phagocytter til at fremme axonal regeneration |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5800812A (da) |
| EP (1) | EP0952772B1 (da) |
| JP (1) | JP4100707B2 (da) |
| AT (1) | ATE290789T1 (da) |
| AU (1) | AU714205B2 (da) |
| CA (1) | CA2232262A1 (da) |
| DE (1) | DE69634499T2 (da) |
| DK (1) | DK0952772T3 (da) |
| ES (1) | ES2241002T3 (da) |
| IL (1) | IL123642A (da) |
| NZ (1) | NZ319365A (da) |
| PT (1) | PT952772E (da) |
| WO (1) | WO1997009885A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267955B1 (en) | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
| US20010007657A1 (en) * | 1997-08-04 | 2001-07-12 | Reid James Steven | Compositions and methods for manipulating glial progenitor cells and treating neurological deficits |
| US7795202B2 (en) | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
| CN1273534A (zh) | 1997-08-04 | 2000-11-15 | 加利福尼亚大学董事会 | 治疗神经缺损的方法 |
| WO1999060021A2 (en) * | 1998-05-19 | 1999-11-25 | Yeda Research And Development Co. Ltd. | Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system |
| US6541247B1 (en) | 1998-06-25 | 2003-04-01 | Neuronova Ab | Method of isolating ependymal neural stem cells |
| SE9802264D0 (sv) | 1998-06-25 | 1998-06-25 | Neuronova Ab | A method of isolating cells |
| IL125983A0 (en) * | 1998-08-30 | 1999-04-11 | Yeda Res & Dev | Pharmaceutical composition comprising factor xiiia |
| US20040120925A1 (en) * | 2001-03-12 | 2004-06-24 | Masahiro Toda | Remedies for nerve damages |
| US8377692B2 (en) * | 2001-11-21 | 2013-02-19 | Yeda Research And Development Co., Ltd. | Process for the manufacturing of human mononuclear phagocytic leukocytes |
| CN1705438A (zh) * | 2002-06-14 | 2005-12-07 | 耶达研究及发展有限公司 | 用于神经保护和神经再生的抗原呈递细胞 |
| US20090010873A1 (en) * | 2004-11-29 | 2009-01-08 | Yeda Research And Development Co. Ltd. | Methods of Cell Therapy, Neurogenesis and Oligodendrogenesis |
| CN107595889A (zh) * | 2008-09-12 | 2018-01-19 | 克里奥普拉斯低温生物有限公司 | 缺血性组织的细胞疗法 |
| ES2604356T3 (es) | 2011-12-14 | 2017-03-06 | Yeda Research And Development Co. Ltd. | Subpoblación de monocitos humanos para el tratamiento de lesiones del sistema nervioso central |
| US10188679B2 (en) | 2013-05-22 | 2019-01-29 | Yeda Research And Development Co. Ltd | Human monocyte sub-population for treatment of eye diseases and disorders |
| EP3615568A4 (en) * | 2017-04-25 | 2021-01-20 | Purdue Research Foundation | TISSUE RESTORATION THREE-DIMENSIONAL (3D) ARTIFICIAL MUSCLE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5157024A (en) * | 1977-10-16 | 1992-10-20 | Strategic Medical Research Corporation | Method of enhancing the activity of phagocytes including macrophages, modulating the cellular or humoral immune response, and reducing the adverse effects of stress in warm blooded animals |
| IL71440A0 (en) * | 1984-04-04 | 1984-07-31 | Univ Ramot | Composition for nerve regeneration |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| IL97365A0 (en) * | 1991-02-27 | 1992-05-25 | Yeda Res & Dev | Pharmaceutical compositions comprising a lymphokine |
| IL91459A0 (en) * | 1989-08-28 | 1990-04-29 | Yeda Res & Dev | Oligodendrocyte inhibitory factor |
-
1996
- 1996-08-09 US US08/695,351 patent/US5800812A/en not_active Expired - Lifetime
- 1996-09-12 ES ES96932991T patent/ES2241002T3/es not_active Expired - Lifetime
- 1996-09-12 JP JP51207797A patent/JP4100707B2/ja not_active Expired - Fee Related
- 1996-09-12 WO PCT/US1996/014578 patent/WO1997009885A1/en active IP Right Grant
- 1996-09-12 AT AT96932991T patent/ATE290789T1/de not_active IP Right Cessation
- 1996-09-12 NZ NZ319365A patent/NZ319365A/xx not_active IP Right Cessation
- 1996-09-12 DE DE69634499T patent/DE69634499T2/de not_active Expired - Lifetime
- 1996-09-12 DK DK96932991T patent/DK0952772T3/da active
- 1996-09-12 PT PT96932991T patent/PT952772E/pt unknown
- 1996-09-12 CA CA002232262A patent/CA2232262A1/en not_active Abandoned
- 1996-09-12 AU AU71572/96A patent/AU714205B2/en not_active Ceased
- 1996-09-12 EP EP96932991A patent/EP0952772B1/en not_active Expired - Lifetime
- 1996-09-12 IL IL12364296A patent/IL123642A/xx not_active IP Right Cessation
-
1997
- 1997-03-14 US US08/818,818 patent/US6117424A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0952772B1 (en) | 2005-03-16 |
| US6117424A (en) | 2000-09-12 |
| ATE290789T1 (de) | 2005-04-15 |
| JP4100707B2 (ja) | 2008-06-11 |
| JPH11513370A (ja) | 1999-11-16 |
| EP0952772A1 (en) | 1999-11-03 |
| PT952772E (pt) | 2005-07-29 |
| DE69634499D1 (de) | 2005-04-21 |
| NZ319365A (en) | 1999-08-30 |
| DE69634499T2 (de) | 2006-01-05 |
| AU7157296A (en) | 1997-04-01 |
| ES2241002T3 (es) | 2005-10-16 |
| US5800812A (en) | 1998-09-01 |
| IL123642A0 (en) | 1998-10-30 |
| WO1997009885A1 (en) | 1997-03-20 |
| IL123642A (en) | 2005-08-31 |
| AU714205B2 (en) | 1999-12-23 |
| CA2232262A1 (en) | 1997-03-20 |
| EP0952772A4 (en) | 2002-01-02 |
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