SE9802264D0 - A method of isolating cells - Google Patents

A method of isolating cells

Info

Publication number
SE9802264D0
SE9802264D0 SE9802264A SE9802264A SE9802264D0 SE 9802264 D0 SE9802264 D0 SE 9802264D0 SE 9802264 A SE9802264 A SE 9802264A SE 9802264 A SE9802264 A SE 9802264A SE 9802264 D0 SE9802264 D0 SE 9802264D0
Authority
SE
Sweden
Prior art keywords
notch
ependymal
cell
relates
surface protein
Prior art date
Application number
SE9802264A
Other languages
English (en)
Inventor
Jonas Frisen
Ann Marie Janson
Clas Johansson
Stefan Momma
Diana Clarke
Ming Zhao
Urban Lendahl
Kioumars Delfani
Johan Holmberg
Original Assignee
Neuronova Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuronova Ab filed Critical Neuronova Ab
Priority to SE9802264A priority Critical patent/SE9802264D0/sv
Publication of SE9802264D0 publication Critical patent/SE9802264D0/sv
Priority to BR9911509-3A priority patent/BR9911509A/pt
Priority to CA002330175A priority patent/CA2330175A1/en
Priority to AT99933396T priority patent/ATE293160T1/de
Priority to PCT/SE1999/001157 priority patent/WO1999067363A1/en
Priority to MXPA00012078A priority patent/MXPA00012078A/es
Priority to DE69924728T priority patent/DE69924728T2/de
Priority to KR1020007014792A priority patent/KR20010071601A/ko
Priority to CNB998078697A priority patent/CN1325637C/zh
Priority to EP99933396A priority patent/EP1090105B1/en
Priority to JP2000556008A priority patent/JP2002518043A/ja
Priority to AU49459/99A priority patent/AU770501B2/en
Priority to ES99933396T priority patent/ES2241297T3/es
Priority to US10/183,728 priority patent/US7320872B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SE9802264A 1998-06-25 1998-06-25 A method of isolating cells SE9802264D0 (sv)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SE9802264A SE9802264D0 (sv) 1998-06-25 1998-06-25 A method of isolating cells
ES99933396T ES2241297T3 (es) 1998-06-25 1999-06-24 Celulas madre no embrionarias neuronales ependinales y metodo que sirvve para aislar estas.
DE69924728T DE69924728T2 (de) 1998-06-25 1999-06-24 Nicht-embryonale ependymale neuronale stammzellen und methoden zu ihrer isolierung
CA002330175A CA2330175A1 (en) 1998-06-25 1999-06-24 Ependymal neural stem cells and method for their isolation
AT99933396T ATE293160T1 (de) 1998-06-25 1999-06-24 Nicht-embryonale ependymale neuronale stammzellen und methoden zu ihrer isolierung
PCT/SE1999/001157 WO1999067363A1 (en) 1998-06-25 1999-06-24 Ependymal neural stem cells and method for their isolation
MXPA00012078A MXPA00012078A (es) 1998-06-25 1999-06-24 Celulas ependimarias del tallo neural y metodo para su aislamiento.
BR9911509-3A BR9911509A (pt) 1998-06-25 1999-06-24 Células tronco neurais ependimárias e processo para seu isolamento
KR1020007014792A KR20010071601A (ko) 1998-06-25 1999-06-24 뇌실막 신경 간세포 및 이의 분리 방법
CNB998078697A CN1325637C (zh) 1998-06-25 1999-06-24 室管膜神经干细胞及其分离方法
EP99933396A EP1090105B1 (en) 1998-06-25 1999-06-24 Non-embryonic ependymal neural stem cells and method for their isolation
JP2000556008A JP2002518043A (ja) 1998-06-25 1999-06-24 上衣神経幹細胞とその分離方法
AU49459/99A AU770501B2 (en) 1998-06-25 1999-06-24 Ependymal neural stem cells and method for their isolation
US10/183,728 US7320872B2 (en) 1998-06-25 2002-06-27 Ependymal neural stem cells and method for their isolation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9802264A SE9802264D0 (sv) 1998-06-25 1998-06-25 A method of isolating cells

Publications (1)

Publication Number Publication Date
SE9802264D0 true SE9802264D0 (sv) 1998-06-25

Family

ID=20411839

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9802264A SE9802264D0 (sv) 1998-06-25 1998-06-25 A method of isolating cells

Country Status (14)

Country Link
US (1) US7320872B2 (sv)
EP (1) EP1090105B1 (sv)
JP (1) JP2002518043A (sv)
KR (1) KR20010071601A (sv)
CN (1) CN1325637C (sv)
AT (1) ATE293160T1 (sv)
AU (1) AU770501B2 (sv)
BR (1) BR9911509A (sv)
CA (1) CA2330175A1 (sv)
DE (1) DE69924728T2 (sv)
ES (1) ES2241297T3 (sv)
MX (1) MXPA00012078A (sv)
SE (1) SE9802264D0 (sv)
WO (1) WO1999067363A1 (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541247B1 (en) * 1998-06-25 2003-04-01 Neuronova Ab Method of isolating ependymal neural stem cells
ATE342723T1 (de) * 2000-04-13 2006-11-15 Univ Texas Behandlung von neurodegenerativen gastrointestinalen krankheiten durch implantation von neuralen stammzellen und/oder deren nachkommen in gastrointestinalorgane
GB0013260D0 (en) * 2000-05-31 2000-07-19 Neuronova Ab Method
US20030036195A1 (en) * 2001-04-20 2003-02-20 Lorenz Studer Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use
WO2004018655A2 (en) * 2002-08-26 2004-03-04 Neuronova Ab Method for culturing stem cells
CA2588908C (en) * 2004-11-29 2014-09-23 Yeda Research And Development Co. Ltd Induction of neurogenesis and stem cell therapy in combination with copolymer 1
US20100015615A1 (en) * 2008-04-30 2010-01-21 Sloan-Kettering Institute For Cancer Research Identification and Isolation of Adult Stem Cells and Related Methods of Use
US8962314B2 (en) 2008-11-26 2015-02-24 The Regents Of The University Of California Lateral ventricle cell compositions and use for treating neural degenerative diseases
JP6243119B2 (ja) * 2009-07-21 2017-12-06 エイビーティー ホールディング カンパニー 白血球溢出を低下させる幹細胞の使用
ES2402308B2 (es) * 2011-09-27 2013-12-27 Universidad De Málaga Procedimiento de obtención de un cultivo puro de células ependimarias multiciliadas.
CN110402285A (zh) * 2018-02-23 2019-11-01 再生生物医疗公司 用于将干细胞和药物滴注入人脑室系统的方法、装置和系统
CN111440768B (zh) * 2020-04-23 2022-09-02 青岛海尔生物科技有限公司 重组人Notch1蛋白在制备神经干细胞及皮层神经元中的应用
CN113777296A (zh) * 2021-09-16 2021-12-10 复旦大学附属中山医院 一种全量组织免疫荧光方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
WO1994002593A1 (en) * 1992-07-27 1994-02-03 California Institute Of Technology Mammalian multipotent neural stem cells
JP3952508B2 (ja) * 1993-11-09 2007-08-01 ニューロスフィアーズ ホウルディングス リミテッド 中枢神経系の幹細胞の原位置修飾及び操作
CN1161744A (zh) * 1994-09-23 1997-10-08 纽罗斯菲里斯控股有限公司 中枢神经系统(cns)功能和机能障碍的体外模型
US5753505A (en) * 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US5800812A (en) 1995-09-15 1998-09-01 Yeda Research And Development Co. Ltd. Methods of use of mononuclear phagocytes to promote axonal regeneration
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6093531A (en) * 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
US6541247B1 (en) * 1998-06-25 2003-04-01 Neuronova Ab Method of isolating ependymal neural stem cells

Also Published As

Publication number Publication date
AU770501B2 (en) 2004-02-26
BR9911509A (pt) 2001-03-20
DE69924728D1 (de) 2005-05-19
EP1090105B1 (en) 2005-04-13
ES2241297T3 (es) 2005-10-16
EP1090105A1 (en) 2001-04-11
AU4945999A (en) 2000-01-10
WO1999067363A9 (en) 2000-03-16
US20030092176A1 (en) 2003-05-15
US7320872B2 (en) 2008-01-22
JP2002518043A (ja) 2002-06-25
ATE293160T1 (de) 2005-04-15
CN1307632A (zh) 2001-08-08
CA2330175A1 (en) 1999-12-29
WO1999067363A1 (en) 1999-12-29
MXPA00012078A (es) 2005-06-20
KR20010071601A (ko) 2001-07-28
CN1325637C (zh) 2007-07-11
DE69924728T2 (de) 2006-03-09

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