ATE290789T1 - Verwendungsmethoden von einkernigen phagozyten zur förderung der axonalen regeneration - Google Patents
Verwendungsmethoden von einkernigen phagozyten zur förderung der axonalen regenerationInfo
- Publication number
- ATE290789T1 ATE290789T1 AT96932991T AT96932991T ATE290789T1 AT E290789 T1 ATE290789 T1 AT E290789T1 AT 96932991 T AT96932991 T AT 96932991T AT 96932991 T AT96932991 T AT 96932991T AT E290789 T1 ATE290789 T1 AT E290789T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- phagocytes
- mammal
- axonal regeneration
- uninural
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000003376 axonal effect Effects 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title abstract 2
- 238000011069 regeneration method Methods 0.000 title abstract 2
- 210000001539 phagocyte Anatomy 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 230000000735 allogeneic effect Effects 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 3
- 210000002864 mononuclear phagocyte Anatomy 0.000 abstract 3
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000004207 dermis Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/17—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/414—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Secondary Cells (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52884595A | 1995-09-15 | 1995-09-15 | |
| US08/695,351 US5800812A (en) | 1995-09-15 | 1996-08-09 | Methods of use of mononuclear phagocytes to promote axonal regeneration |
| PCT/US1996/014578 WO1997009885A1 (en) | 1995-09-15 | 1996-09-12 | Compositions and methods of use of mononuclear phagocytes to promote axonal regeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290789T1 true ATE290789T1 (de) | 2005-04-15 |
Family
ID=27062850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96932991T ATE290789T1 (de) | 1995-09-15 | 1996-09-12 | Verwendungsmethoden von einkernigen phagozyten zur förderung der axonalen regeneration |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5800812A (de) |
| EP (1) | EP0952772B1 (de) |
| JP (1) | JP4100707B2 (de) |
| AT (1) | ATE290789T1 (de) |
| AU (1) | AU714205B2 (de) |
| CA (1) | CA2232262A1 (de) |
| DE (1) | DE69634499T2 (de) |
| DK (1) | DK0952772T3 (de) |
| ES (1) | ES2241002T3 (de) |
| IL (1) | IL123642A (de) |
| NZ (1) | NZ319365A (de) |
| PT (1) | PT952772E (de) |
| WO (1) | WO1997009885A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267955B1 (en) * | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
| US7795202B2 (en) | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
| US7790669B1 (en) * | 1997-08-04 | 2010-09-07 | Neurorepair, Inc. | Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α) |
| US20010007657A1 (en) * | 1997-08-04 | 2001-07-12 | Reid James Steven | Compositions and methods for manipulating glial progenitor cells and treating neurological deficits |
| CA2328612A1 (en) * | 1998-05-19 | 1999-11-25 | Yeda Research And Development Co., Ltd. | Activated t cells, nervous system-specific antigens and their uses |
| US6541247B1 (en) | 1998-06-25 | 2003-04-01 | Neuronova Ab | Method of isolating ependymal neural stem cells |
| SE9802264D0 (sv) | 1998-06-25 | 1998-06-25 | Neuronova Ab | A method of isolating cells |
| IL125983A0 (en) * | 1998-08-30 | 1999-04-11 | Yeda Res & Dev | Pharmaceutical composition comprising factor xiiia |
| CA2441434A1 (en) * | 2001-03-12 | 2002-09-19 | Institute Of Gene And Brain Science | Remedies for nerve damages |
| IL162094A0 (en) * | 2001-11-21 | 2005-11-20 | Yeda Res & Dev | Process for the manufacture of human mononuclear phagocytic leukocytes |
| AU2003231909A1 (en) * | 2002-06-14 | 2003-12-31 | Yeda Research And Development Co. Ltd. | Antigen-presenting cells for neuroprotection and nerve regeneration |
| WO2006056998A2 (en) * | 2004-11-29 | 2006-06-01 | Yeda Research And Development Co. Ltd. | Methods of cell therapy, neurogenesis and oligodendrogenesis |
| US8784802B2 (en) * | 2008-09-12 | 2014-07-22 | Cryopraxis Criobiologia Ltda. | Ischemic tissue cell therapy |
| CN104159590A (zh) | 2011-12-14 | 2014-11-19 | 耶达研究与开发有限公司 | 用于治疗中枢神经系统损伤的人单核细胞亚群 |
| CN105377273A (zh) | 2013-05-22 | 2016-03-02 | 耶达研究与发展公司 | 用于治疗眼睛疾病或病症的人类单核细胞亚群 |
| WO2018200750A1 (en) * | 2017-04-25 | 2018-11-01 | Purdue Research Foundation | 3-dimensional (3d) tissue-engineered muscle for tissue restoration |
| CN115335035A (zh) | 2020-01-27 | 2022-11-11 | 格尼菲斯公司 | 用于恢复和再生组织的生物填充物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5157024A (en) * | 1977-10-16 | 1992-10-20 | Strategic Medical Research Corporation | Method of enhancing the activity of phagocytes including macrophages, modulating the cellular or humoral immune response, and reducing the adverse effects of stress in warm blooded animals |
| IL71440A0 (en) * | 1984-04-04 | 1984-07-31 | Univ Ramot | Composition for nerve regeneration |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| IL91459A0 (en) * | 1989-08-28 | 1990-04-29 | Yeda Res & Dev | Oligodendrocyte inhibitory factor |
| IL97365A0 (en) * | 1991-02-27 | 1992-05-25 | Yeda Res & Dev | Pharmaceutical compositions comprising a lymphokine |
-
1996
- 1996-08-09 US US08/695,351 patent/US5800812A/en not_active Expired - Lifetime
- 1996-09-12 PT PT96932991T patent/PT952772E/pt unknown
- 1996-09-12 DK DK96932991T patent/DK0952772T3/da active
- 1996-09-12 CA CA002232262A patent/CA2232262A1/en not_active Abandoned
- 1996-09-12 AU AU71572/96A patent/AU714205B2/en not_active Ceased
- 1996-09-12 JP JP51207797A patent/JP4100707B2/ja not_active Expired - Fee Related
- 1996-09-12 NZ NZ319365A patent/NZ319365A/xx not_active IP Right Cessation
- 1996-09-12 IL IL12364296A patent/IL123642A/xx not_active IP Right Cessation
- 1996-09-12 DE DE69634499T patent/DE69634499T2/de not_active Expired - Lifetime
- 1996-09-12 AT AT96932991T patent/ATE290789T1/de not_active IP Right Cessation
- 1996-09-12 WO PCT/US1996/014578 patent/WO1997009885A1/en not_active Ceased
- 1996-09-12 ES ES96932991T patent/ES2241002T3/es not_active Expired - Lifetime
- 1996-09-12 EP EP96932991A patent/EP0952772B1/de not_active Expired - Lifetime
-
1997
- 1997-03-14 US US08/818,818 patent/US6117424A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2241002T3 (es) | 2005-10-16 |
| US5800812A (en) | 1998-09-01 |
| CA2232262A1 (en) | 1997-03-20 |
| US6117424A (en) | 2000-09-12 |
| AU7157296A (en) | 1997-04-01 |
| NZ319365A (en) | 1999-08-30 |
| JPH11513370A (ja) | 1999-11-16 |
| EP0952772B1 (de) | 2005-03-16 |
| JP4100707B2 (ja) | 2008-06-11 |
| EP0952772A1 (de) | 1999-11-03 |
| DE69634499D1 (de) | 2005-04-21 |
| EP0952772A4 (de) | 2002-01-02 |
| IL123642A (en) | 2005-08-31 |
| PT952772E (pt) | 2005-07-29 |
| IL123642A0 (en) | 1998-10-30 |
| WO1997009885A1 (en) | 1997-03-20 |
| DK0952772T3 (da) | 2005-07-18 |
| DE69634499T2 (de) | 2006-01-05 |
| AU714205B2 (en) | 1999-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0952772 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |